International Journal of Bipolar Disorders最新文献

{"title":"Somatic morbidity in bipolar disorders.","authors":"Christine Takami, Suvi Savinen, Arvid Sjölander, Zheng Chang, Isabell Brikell, Ralf Kuja-Halkola, Brian M D'Onofrio, Soffia Gudbjornsdottir, Miguel Garcia-Argibay, Henrik Larsson, Erik Pettersson, Paul Lichtenstein, Mikael Landén","doi":"10.1186/s40345-026-00427-9","DOIUrl":"https://doi.org/10.1186/s40345-026-00427-9","url":null,"abstract":"<p><strong>Objective: </strong>This Swedish nationwide cohort study used large-scale data to investigate the associations between bipolar disorder and somatic disorders and whether these risks differ by subtype, sex, or exposure to compulsory care.</p><p><strong>Methods: </strong>61,071 individuals diagnosed with bipolar disorder in inpatient (from 1973) or outpatient care (from 2001) care were compared with the general population without bipolar disorder. The cohort included individuals born in 1932 or later, with follow-up from 1973 to 2020. Cox regression models estimated associations with a range of somatic conditions, including cardiovascular, endocrine, neurological, and infectious diseases. Subtype-specific analyses were conducted in individuals with type 1 (n = 8,352) or type 2 (n = 9,674), and in those with a history of compulsory care (n = 6,748).</p><p><strong>Results: </strong>Bipolar disorder was associated with significantly increased risks for most examined somatic conditions. The highest hazard ratios (HRs) were observed for sleep disorders (HR 3.79; 95% CI, 3.71-3.87) and dementias (HR 4.32; 95% CI, 3.82-4.79). Type 2 diabetes risk was elevated, while no association was found for type 1 diabetes. Most risks were comparable across bipolar subtypes, though certain conditions-such as migraine and fibromyalgia-were more strongly associated with type 2. Individuals with a history of compulsory psychiatric care showed elevated risks for several conditions.</p><p><strong>Conclusions: </strong>Regardless of sex or subtype, bipolar disorder is associated with substantially higher lifetime risks of a broad range of somatic conditions. Integrated psychiatric and somatic health care may help reduce morbidity and improve outcomes.</p>","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":"14 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147837694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SSRI versus SNRI initiation and incident bipolar disorder in tertiary psychiatric care: an active-comparator cohort study from the United Arab Emirates.","authors":"Syed Ali Bokhari, Abdulhameed Omer Elnour, Muhanad Elnoor","doi":"10.1186/s40345-026-00426-w","DOIUrl":"https://doi.org/10.1186/s40345-026-00426-w","url":null,"abstract":"","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline NMR lipoprotein profiles in lithium-naïve bipolar disorder patients who later showed weight gain during lithium therapy: a pilot study.","authors":"Elena Schönthaler, Frederike T Fellendorf, Tobias Madl, Hansjörg Habisch, Susanne Bengesser, Nina Dalkner, Eva Fleischmann, Johanna Georgi, Alfred Häussl, Dino Hasic, Julia Ilic, Amrei Lässer, Melanie Lenger, Alexander Maget, Claudia Mittmannsgruber, Darja Popkova, Robert Queissner, Anna Ramirez-Obermayer, Stefan Smolle, Tatjana Stross, Adelina Tmava-Berisha, Eva Z Reininghaus","doi":"10.1186/s40345-026-00425-x","DOIUrl":"https://doi.org/10.1186/s40345-026-00425-x","url":null,"abstract":"","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium effects on renal functioning: an expert opinion and management algorithm.","authors":"Charlotte Strandhave, Hans August Stengaard Hansen, Martin Alda, Michael Bauer, Michael Berk, Pichit Buspavanich, Lasse Brandt, Andre F Carvalho, Anne Duffy, Orestes Forlenza, Mathilde Frahm Laursen, Mark Frye, Michael Gitlin, Fabiano Alves Gomes, Ana Gonzalez-Pinto, Paul Grof, Tomas Hajek, Sanne V Hovgesen, Lars Vedel Kessing, Ralph Kupka, Ute Lewitzka, Rasmus W Licht, Rodrigo Machado-Vieira, Gin S Malhi, Mirko Manchia, Robert M Post, Andrea Murru, Andrew A Nierenberg, Eline Regeer, Eva Reininghaus, Phillip Ritter, Janusz Rybakowski, Balwinder Singh, Gabriele Sani, Christian Simhandl, Rebecca Strawbridge, Trisha Suppes, Mauricio Tohen, Leonardo Tondo, Eduard Vieta, Allan H Young, René Ernst Nielsen","doi":"10.1186/s40345-026-00423-z","DOIUrl":"https://doi.org/10.1186/s40345-026-00423-z","url":null,"abstract":"","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the associations between manic symptoms and cognitive performance in bipolar disorders: evidence from a cross-sectional replication study in the FACE-BD cohort.","authors":"Nathan Vidal, Eric Brunet-Gouet, Solène Frileux, Raoul Belzeaux, Philippe Courtet, Thierry D'Amato, Caroline Dubertret, Bruno Etain, Emmanuel Haffen, Dominique Januel, Marion Leboyer, Antoine Lefrere, Pierre-Michel Llorca, Emeline Marlinge, Paula Martinez, Katia M'Bailara, Emilie Olié, Mircea Polosan, Raymund Schwan, Michel Walter, Christine Passerieux, Paul Roux","doi":"10.1186/s40345-026-00420-2","DOIUrl":"10.1186/s40345-026-00420-2","url":null,"abstract":"<p><p>Studies examining the effect of mania on cognition in Bipolar Disorders (BD) have yielded contradictory results. Koenders and collaborators showed in 2014 that, among 189 adults with BD, adults with subclinical manic symptoms perform a task measuring divided attention significantly better than adults with less or more severe manic symptoms. We aimed to replicate this finding in a larger sample. We included adults from the FACE-BD cohort with a BD diagnosis based on the DSM-IV-R criteria. We excluded adults with a current characterized depressive or manic episode or with other possible sources of cognitive impairment. We assessed the associations between the YMRS score and cognitive functions involved in divided attention using linear regression models, adjusting for the same covariates as the original study. We found no significant linear or quadratic associations between the YMRS total score and attention, working memory, and executive performance in the bivariable models nor after adjusting for covariates in 2,739 adults with BD. We were unable to replicate the findings reported by Koenders and collaborators. The low variance and mean severity of manic symptoms in our sample may partly explain the absence of significant associations. Our results suggest that subclinical hypomanic symptoms neither enhance nor impair cognitive performance in adults with BD, calling into question the benefit of residual hypomanic symptoms on patients' cognitive functioning.</p>","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":"14 1","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid peroxidase antibodies in bipolar disorder: implications for clinical sub-phenotypes and lithium response.","authors":"Bishnu D Pathak, Mete Ercis, Melissa Solares-Bravo, Nik Ghafouri, Balwinder Singh, Aysegul Ozerdem, Jin Hong Park, Deniz Ceylan, Brandon J Coombes, Francisco Romo-Nava, Marin Veldic, Alfredo Cuellar-Barboza, Manuel Gardea-Resendez, Matthew L Baum, Katherine E Burdick, Marius N Stan, Susan L McElroy, Joanna M Biernacka, Mark A Frye","doi":"10.1186/s40345-026-00419-9","DOIUrl":"https://doi.org/10.1186/s40345-026-00419-9","url":null,"abstract":"","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep fluctuations precede self-reported mood changes in bipolar disorder: results from the BipoSense study.","authors":"Andrea Ulrichsen, Esther Mühlbauer, Vera Miriam Ludwig, Emanuel Severus, Anthony Cleare, Sameer Jauhar, Michael Bauer, Ulrich W Ebner-Priemer","doi":"10.1186/s40345-026-00416-y","DOIUrl":"10.1186/s40345-026-00416-y","url":null,"abstract":"","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13066072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D and calcium metabolism in bipolar disorder: a scoping review of contradictory evidence.","authors":"Amirzhan Kulmagambetov, Adelina Tmava-Berisha, Frederike T Fellendorf, Melanie Lenger, Tatjana Stross, Marko Stijic, Eva Fleischmann, Julia Ilić, Alexander Finner, Anna Ramirez-Obermayer, Johanna Georgi, Alexander Maget, Amrei Lässer, Claudia Mittmannsgruber, Stefan Smolle, Alfred Häussl, Jonas Schuller, Dino Hasic, Susanne Bengesser, Robert Queissner, Nina Dalkner, Eva Z Reininghaus","doi":"10.1186/s40345-026-00422-0","DOIUrl":"10.1186/s40345-026-00422-0","url":null,"abstract":"<p><strong>Background: </strong>This scoping review synthesized evidence on vitamin D, parathyroid hormone (PTH), and serum calcium in bipolar disorder (BD) to evaluate their potential clinical utility.</p><p><strong>Methods: </strong>A systematic PubMed search identified original studies examining calcium metabolism biomarkers (vitamin D, PTH, serum calcium) exclusively in BD populations. Findings were synthesized narratively due to substantial methodological heterogeneity.</p><p><strong>Results: </strong>Fourteen studies met inclusion criteria, with small sample sizes (median n = 55) and predominantly cross-sectional designs. Vitamin D comparisons between BD patients and controls yielded contradictory results: three studies reported significantly lower levels in BD patients, two found significantly higher levels, and three found no differences. Vitamin D deficiency definitions varied widely (< 25 to < 50 nmol/L), precluding meaningful comparisons. Four cognition studies showed inconsistent associations with vitamin D, with negative correlations, age-dependent effects, or no associations reported. Two small vitamin D supplementation studies in bipolar spectrum disorders yielded contradictory results in distinct populations, with one in youth and the other in adults. Data on PTH and calcium were sparse and inconsistent.</p><p><strong>Limitations: </strong>Study limitations included a single database search, substantial study heterogeneity, and inadequate control for confounders, including seasonal variation.</p><p><strong>Conclusions: </strong>Evidence on calcium metabolism biomarkers in BD is contradictory and methodologically limited. Fundamental inconsistencies in vitamin D status between BD patients and controls, combined with conflicting supplementation data, preclude clinical recommendations. Routine vitamin D screening specifically for BD management cannot be supported. Large-scale, standardized studies are needed before clinical application.</p>","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of smartphone-based monitoring and treatment including clinical feedback in progressed bipolar disorder: the SmartBipolar trial randomised controlled parallel-group trial.","authors":"Maria Faurholt-Jepsen, Asbjørn Risom, Malene Schwarz Dyreholt, Natacha Blauenfeldt Kyster, Ellen Margrethe Christensen, Birte Smidt, Ulla Knorr, Kim Brøndmark, Anja Mathiesen, Denis Cululejevic, Rene Sjaelland, Henrik Nørbak-Emig, Lotte Linnemann Sponsor, Darius Mardosas, Jens Drachmann Bukh, Trine Vøgg Heller, Nanna Iversen, Maj Vinberg, Esben Budtz-Jørgensen, Lars Vedel Kessing","doi":"10.1186/s40345-026-00418-w","DOIUrl":"10.1186/s40345-026-00418-w","url":null,"abstract":"","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147498748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing high cognitive performance in persons with mood disorders and their unaffected relatives: associations with emotional cognition, functioning, and clinical outcomes.","authors":"Hanne Lie Kjaerstad, Bjørn Ole Barkholt Nordseth, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak","doi":"10.1186/s40345-026-00417-x","DOIUrl":"10.1186/s40345-026-00417-x","url":null,"abstract":"","PeriodicalId":13944,"journal":{"name":"International Journal of Bipolar Disorders","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}