International journal of clinical and experimental pathology最新文献

{"title":"Ploidy status analysis in small cell lung cancer cells and its use in cytopathological diagnosis.","authors":"Shiyin He, Jiamin Zhang, Tao Wan, Hongli Deng, Dairong Li","doi":"10.62347/UINT5317","DOIUrl":"10.62347/UINT5317","url":null,"abstract":"<p><strong>Objective: </strong>To explore the characteristics of the ploidy status of Small Cell Lung Cancer (SCLC) cells and assesses its efficacy in cytopathological diagnosis of SCLC.</p><p><strong>Methods: </strong>A retrospective analysis was performed on patients who agreed to DNA image cytometry (DNA ICM) and serum tumor biomarker testing. Samples for ploidy assessment, all from bronchial procedures, were analyzed using DNA ICM. Data on demographic features, pathological characteristics, staging results, biomarkers such as neuron specific enolase (NSE) and Pro-gastrin-releasing peptide (ProGRP) data, and ploidy status across different groups were collected. Corresponding statistical analyses were conducted to examine differences in aneuploid status among the groups. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic efficacy of DNA ICM and tumor markers for diagnosing SCLC.</p><p><strong>Results: </strong>A total of 74 patients with SCLC, 108 patients with NSCLC, and 74 patients with benign lesions were included. The age range of all patients was 26 to 85 years, with 69% being male and 31% female. In terms of ploidy status, single aneuploid cell peaks and double aneuploid peaks were observed in both SCLC and NSCLC groups. The proportions of two types of aneuploid cell peaks differed significantly between the two groups (<i>P</i>=0.008). The aneuploid cell ratio showed a high accuracy for small-cell lung cancer, with a sensitivity of 91.2% and a specificity of 88.1%. There was no statistical difference in ploidy status between limited and extensive stages of SCLC. As for biomarkers, the AUC (area under the curve) values were 0.921 for NSE and 0.928 for ProGRP, with a significant difference in NSE between two stages of SCLC (<i>P</i>=0.015), while no significant difference was observed in ProGRP.</p><p><strong>Conclusion: </strong>Aneuploid cell peaks in SCLC patients are mostly distributed in the near triploid range, possibly serving as a specific cytological marker for SCLC. DNA ICM is a highly sensitive tool that may be an adjunct for SCLC diagnosis.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 2","pages":"77-88"},"PeriodicalIF":1.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of machine learning application for the identification of lipid metabolism-associated diagnostic model in ischemic stroke.","authors":"Xiangtian Meng, Runping Xu, Haoheng Wang, Junle Zhu, Jingliang Ye, Chun Luo","doi":"10.62347/BDIP4409","DOIUrl":"10.62347/BDIP4409","url":null,"abstract":"<p><strong>Introduction: </strong>Ischemic Stroke (IS) is characterized by complex molecular alterations involving disruptions in lipid metabolism and immune interactions. However, the roles of lipid metabolism-associated genes in the pathogenesis of IS through immune regulation interaction are rarely explored. In this study, we aimed to explore the intricate correlation between lipid metabolism-associated immune changes and IS through a machine-learning algorithm.</p><p><strong>Materials and methods: </strong>We downloaded the GSE16561, GSE22255, and GSE37587 datasets from NCBI. Using the GSE16561 dataset, we analyzed differential gene expression profiles related to lipid metabolism with the \"Limma\" R package. We constructed a diagnostic model employing techniques such as Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression and Random Forest (RF), which was further validated using the independent GSE22255 and GSE37587 datasets. Correlations between model genes and immune cell percentages were examined by Spearman analysis. We further validated the diagnostic value of these model genes in 28 clinical samples using RT-qPCR.</p><p><strong>Results: </strong>We identified 26 lipid metabolism genes with significant expression disparities between normal and diseased groups, closely linked to immune cell populations. Seven signature genes (ACSS1, ADSL, CYP27A1, MTF1, SOAT1, STAT3, and SUMF2) were identified using LASSO and RF algorithms for a potential diagnostic model, effectively distinguishing healthy and IS samples in both training and validation (AUC = 0.725) datasets. The mRNA expression levels of these model genes were further validated as a blood biomarker for IS patients in our clinical samples. Single-cell analysis further revealed high expression of Cyp27a1 in dendritic cells and macrophages, and decreasing expression of Soat in progenitor cells as the disease progressed. The expression of Stat3 in most immune cells was upregulated in progenitor cells as the disease progressed. Additionally, a regulatory network identified transcription factors regulating genes such as STAT3.</p><p><strong>Conclusion: </strong>This study identified novel lipid metabolism biomarkers for IS, enhancing our understanding of IS by shedding light on lipid metabolism and immune interactions. This may facilitate innovative diagnostic approaches to IS.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 2","pages":"63-76"},"PeriodicalIF":1.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete response to anti-PD1 therapy and chemotherapy in a patient with ALK-rearranged non-small cell lung cancer.","authors":"Haoyue Hu, Min Min, Hongchun Dai, Youpan Tang, Jun He","doi":"10.62347/XWHW6190","DOIUrl":"10.62347/XWHW6190","url":null,"abstract":"<p><p>Targeted therapies are effective in non-small cell lung cancer (NSCLC) patients with driver gene mutations. Chemotherapy combined with immunotherapy is also a common treatment strategy in lung cancer. However, in previous studies, patients with ALK (Anaplastic Lymphoma Kinase) rearranged had a low response to immune checkpoint inhibitor (ICI) and the role of immunotherapy in ALK-positive NSCLC patients is unclear. Here, we report a case of a young man with ALK rearranged who demonstrated a complete response to anti-PD1 combination with chemotherapy, which suggests some ALK-rearranged patients with high expression of PD-L1 may permanently benefit from immunotherapy.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 1","pages":"37-41"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ABCB1 gene polymorphisms with aspirin or clopidogrel resistance in ischemic stroke: a meta-analysis.","authors":"Junjie Lv, Aiqin Chen, Chang Xu, Gaofeng Shao, Mingfei Zhao","doi":"10.62347/IBGQ2413","DOIUrl":"10.62347/IBGQ2413","url":null,"abstract":"<p><strong>Objective: </strong>Ischemic stroke (IS) is a major public health concern worldwide. In this study, we aimed to investigate the relationship between <i>ABCB1</i> gene polymorphisms and antiplatelet resistance in patients with IS.</p><p><strong>Methods: </strong>We performed a comprehensive search of the PubMed, China National Knowledge Infrastructure, Web of Science, and WANFANG databases for articles published until February 2024. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the association between <i>ABCB1</i> polymorphisms and antiplatelet resistance in patients with IS. All the statistical analyses were performed using STATA version 11.0.</p><p><strong>Results: </strong>Eleven studies containing 2,228 cases and 2,556 controls met the inclusion criteria. Our results showed that aspirin resistance in patients with IS was significantly correlated with the polymorphism of <i>ABCB1</i> rs1045642 (Allele model: OR=1.5, 95% CI [1.10, 2.05], P=0.010; Homozygote model: OR=2.02, 95% CI [1.01, 4.05], P=0.047; Heterozygote model: OR=1.37, 95% CI [0.91, 2.08], P=0.132; Dominant model: OR=1.75, 95% CI [1.09, 2.81], P=0.021; Recessive model: OR=1.61, 95% CI [1.01, 2.57], P=0.045). Meanwhile, we found that <i>ABCB1</i> rs1045642 polymorphism might be significantly associated with clopidogrel resistance in IS (A. Homozygote model: OR=3.35, 95% CI [1.99, 5.63], P=0.000; B. Heterozygote model: OR=0.81, 95% CI [0.54, 1.21], P=0.895; C. Dominant model: OR=1.41, 95% CI [0.59, 3.36], P=0.435; D. Recessive model: OR=3.43, 95% CI [2.14, 5.51], P=0.000).</p><p><strong>Conclusion: </strong>This meta-analysis suggests a potential link between <i>ABCB1</i> rs1045642 polymorphism and resistance to clopidogrel or aspirin in patients with IS.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 1","pages":"1-11"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: LncRNA CCND2-AS1 is up-regulated and regulates proliferation, migration, and invasion in breast cancer.","authors":"Chengze Chen, Erjie Xia, Adheesh Bhandari, Yinghao Wang, Yanyan Shen, Namita Sindan, Yuehlung Lin, Xiaoshang Wang, Fan Yang, Ouchen Wang","doi":"10.62347/FOCJ5790","DOIUrl":"https://doi.org/10.62347/FOCJ5790","url":null,"abstract":"<p><p>[This corrects the article on p. 1453 in vol. 11, PMID: 31938243.].</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 1","pages":"44-45"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female adnexal tumor of probable Wolffian origin (FATWO): a case report and literature review.","authors":"Yu Yan, Dong-Ni Liang, Wei Wang, Ying He","doi":"10.62347/JQLB5802","DOIUrl":"10.62347/JQLB5802","url":null,"abstract":"<p><p>Female adnexal tumor of probable Wolffian origin (FATWO) is a rare gynecologic tumor. We describe a case of 53-year-old female patient in whom an adnexal mass was found. Microscopic examination revealed that the tumor arose in the adnexal soft tissue, composed of bland cells with an admixture of solid and sieve-like patterning, while presenting a high mitotic activity. Tumor cells were positive for Vimentin, CD10, and hormone receptors, while showing variable expression for sex cord-stromal markers, and was negative for GATA binding protein 3 (GATA-3), and thyroid transcription factor 1 (TTF1). The definitive diagnosis was FATWO. Subsequently, we conducted next-generation sequencing (NGS) in this case, and a CTNNB1 (c.98C>G, p.S33C) mutation was detected. The patient underwent tumor resection, hysterectomy, and bilateral adnexectomy, followed by annual computed tomography scans for monitoring. No evidence of recurrence or metastasis was observed at the 2-year postoperative follow-up. To the best of our knowledge, this is the fourth study having performed NGS on a FATWO. To further elucidate this rare neoplasm and improve the accuracy of diagnosis, we conducted a comparative analysis of the clinicopathological, immunohistochemical, and molecular features of our case with those previously reported in the literature, subsequently discussing the differential diagnosis.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 1","pages":"30-36"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth <i>in vitro</i> and <i>in vivo</i>.","authors":"Zhi-Dong Lv, Xiang-Ping Liu, Wei-Jun Zhao, Qian Dong, Fu-Nian Li, Hai-Bo Wang, Bin Kong","doi":"10.62347/UEHK2077","DOIUrl":"https://doi.org/10.62347/UEHK2077","url":null,"abstract":"<p><p>[This corrects the article on p. 2818 in vol. 7, PMID: 25031701.].</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 1","pages":"42-43"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel combined tumor autoantibody detection in serological diagnosis of gastric cancer.","authors":"Zixin Yu, Hushan Zhang, Sheng Li, Qingwen Huo, Han Ling, Ke Chen, Zhiming Wang","doi":"10.62347/XMAW3065","DOIUrl":"10.62347/XMAW3065","url":null,"abstract":"<p><strong>Objective: </strong>Gastric cancer (GC) is a highly prevalent malignancy, yet its early diagnosis rate is generally low. Therefore, we have established a serum-based combined detection method based on tumor autoantibodies aimed at improving the diagnostic rate of gastric cancer.</p><p><strong>Methods: </strong>Through clinical studies, we selected a series of proteins aberrantly expressed in gastric cancer patients, including RalA, Survivin, NY-ESO-1, p53, Cyclin B1, and Koc, and expressed and purified them using prokaryotic expression and nickel column chromatography.</p><p><strong>Results: </strong>The levels of autoantibodies in the serum of gastric cancer patients and healthy individuals were measured using enzyme-linked immunosorbent assay (ELISA), and the diagnostic value of the combined detection of tumor autoantibodies for gastric cancer was evaluated through receiver operating characteristic (ROC) curve analysis. The levels of autoantibodies against RalA, Survivin, NY-ESO-1, p53, and Cyclin B1 in the serum of gastric cancer patients were significantly higher than those in healthy individuals (P < 0.05), while the level of Koc showed no significant difference between the two groups (P > 0.05), suggesting that Koc may not be suitable for serological diagnosis of gastric cancer. ROC analysis of the combined levels of autoantibodies against RalA, Survivin, NY-ESO-1, p53, and Cyclin B1 for gastric cancer diagnosis achieved a sensitivity of 73.68% and specificity of 78.13%, with an AUC value of 0.8767.</p><p><strong>Conclusion: </strong>The combined tumor autoantibody detection established in this study may have promising potential applications in early screening and diagnosis of gastric cancer.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 1","pages":"23-29"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of serum HIF-1α, VEGF, and uPA levels on clinicopathologic findings and prognosis in oral squamous cell carcinoma.","authors":"Kedan Xu, Cheng Lou","doi":"10.62347/CXDC6773","DOIUrl":"10.62347/CXDC6773","url":null,"abstract":"<p><strong>Objective: </strong>To determine circulating levels of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), and urokinase-type plasminogen activator (uPA) in the peripheral blood of patients with oral squamous cell carcinoma (OSCC) and to explore their relationship with clinicopathologic features and prognosis, in order to facilitate treatment.</p><p><strong>Methods: </strong>160 OSCC patients and 51 control subjects were prospectively recruited, and serum HIF-1α, VEGF, and uPA levels were measured by enzyme-linked immunosorbent assay (ELISA). Preoperative threshold values of HIF-1α, VEGF, and uPA were determined by ROC curves. Kaplan-Meier curves were analyzed for overall survival and progression-free survival of patients. Univariate and multivariate Cox risk regression analyzed prognostic factors.</p><p><strong>Results: </strong>Serum HIF-1α, VEGF, and uPA were higher in OSCC patients compared to control subjects (P < 0.001). Critical values of HIF-1α, VEGF, and uPA were 99.8 pg/mL, 130.4 pg/mL, and 142.9 pg/mL, respectively. Serum levels of HIF-1α, VEGF, and uPA were associated with the overall pathologic status (TNM staging), neural invasion, extranodal extension, lymphovascular invasion, depth of invasion, and degree of cellular differentiation (P < 0.05). Patients with higher serum HIF-1α, VEGF, and uPA levels had poorer overall survival and shorter progression-free survival. Higher-than-threshold serum HIF-1α, VEGF, and uPA were independent prognostic factors for overall survival (P < 0.001, P < 0.001, P = 0.006) of and progression-free survival (P < 0.012, P < 0.001, P = 0.010).</p><p><strong>Conclusion: </strong>Higher circulating levels of HIF-1α, VEGF, and uPA were associated with clinicopathologic correlations of lymph nodes, metastasis, and were independent risk factors for survival and progression-free survival.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"18 1","pages":"12-22"},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effect of sulforaphane on hyperglycemia-induced cognitive dysfunction through the Nrf2/HO-1 pathway.","authors":"Gengyin Wang, Liping Wang, Xiaohan Zhang, Zifeng Wei, Kunpeng Wang, Jinhua Wang","doi":"10.62347/CHBJ5517","DOIUrl":"10.62347/CHBJ5517","url":null,"abstract":"<p><strong>Objectives: </strong>Sulforaphane (SFN), an isothiocyanate in cruciferous plants, has been reported to be effective in treating central nervous system diseases. However, how SFN protects the central nervous system needs further study. The aim of this study was to investigate the neuroprotective effect of SFN and its possible mechanism of action.</p><p><strong>Methods: </strong>Sprague-Dawley rats were used to develop a cognitive impairment model. The Morris water maze (MWM) was used to evaluate the effect of SFN on learning and memory, and haematoxylin-eosin (H&E) staining and terminal transferase deoxyuridine nick-end labelling (TUNEL) were used to observe morphologic changes in neurons and neuronal apoptosis in the hippocampus and cortex. An oxidative stress marker kit was used to detect the content and activity of SFN, and the expressions of nuclear factor drythroid-2 related Factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone oxidoreductase 1 (NQO-1) were measured by RT-PCR.</p><p><strong>Results: </strong>SFN treatment significantly improved cognition, increased the number of neurons, and suppressed neuronal apoptosis. In addition, SFN significantly decreased the content of malondialdehyde (MDA) and enhanced the antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the hippocampus and cortex. Furthermore, SFN elevated the expression of Nrf-2, HO-1, and NQO-1.</p><p><strong>Conclusions: </strong>SFN ameliorated diabetes-induced cognitive dysfunction by activating the Nrf2/HO-1 pathway, providing a new perspective for SFN therapy to delay cognitive impairment in diabetes patients.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"17 12","pages":"469-476"},"PeriodicalIF":1.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}