Association of ABCB1 gene polymorphisms with aspirin or clopidogrel resistance in ischemic stroke: a meta-analysis.

IF 1.1 Q4 ONCOLOGY

International journal of clinical and experimental pathology Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI:10.62347/IBGQ2413

Junjie Lv, Aiqin Chen, Chang Xu, Gaofeng Shao, Mingfei Zhao

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引用次数: 0

Abstract

Objective: Ischemic stroke (IS) is a major public health concern worldwide. In this study, we aimed to investigate the relationship between ABCB1 gene polymorphisms and antiplatelet resistance in patients with IS.

Methods: We performed a comprehensive search of the PubMed, China National Knowledge Infrastructure, Web of Science, and WANFANG databases for articles published until February 2024. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the association between ABCB1 polymorphisms and antiplatelet resistance in patients with IS. All the statistical analyses were performed using STATA version 11.0.

Results: Eleven studies containing 2,228 cases and 2,556 controls met the inclusion criteria. Our results showed that aspirin resistance in patients with IS was significantly correlated with the polymorphism of ABCB1 rs1045642 (Allele model: OR=1.5, 95% CI [1.10, 2.05], P=0.010; Homozygote model: OR=2.02, 95% CI [1.01, 4.05], P=0.047; Heterozygote model: OR=1.37, 95% CI [0.91, 2.08], P=0.132; Dominant model: OR=1.75, 95% CI [1.09, 2.81], P=0.021; Recessive model: OR=1.61, 95% CI [1.01, 2.57], P=0.045). Meanwhile, we found that ABCB1 rs1045642 polymorphism might be significantly associated with clopidogrel resistance in IS (A. Homozygote model: OR=3.35, 95% CI [1.99, 5.63], P=0.000; B. Heterozygote model: OR=0.81, 95% CI [0.54, 1.21], P=0.895; C. Dominant model: OR=1.41, 95% CI [0.59, 3.36], P=0.435; D. Recessive model: OR=3.43, 95% CI [2.14, 5.51], P=0.000).

Conclusion: This meta-analysis suggests a potential link between ABCB1 rs1045642 polymorphism and resistance to clopidogrel or aspirin in patients with IS.

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来源期刊

International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

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0.00%

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审稿时长

1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.