International Journal of Diabetes and Endocrinology最新文献

{"title":"Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome","authors":"N. Akter, Z. Latif","doi":"10.11648/j.ijde.20210602.15","DOIUrl":"https://doi.org/10.11648/j.ijde.20210602.15","url":null,"abstract":"Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities characterized by central obesity, hyperglycemia plus insulin resistance, hypertriglyceridaemia plus low high density lipoprotein (HDL) cholesterol and hypertension. This cluster of metabolic syndrome is associated with some of the endocrine disorders prominently thyroid dysfunction. Thyroid dysfunction and metabolic syndrome are both associated with cardiovascular disease risk conversely increasing both morbidity and mortality. Objectives: This study was carried out to evaluate thyroid function in patients with metabolic syndrome and to assess its relationship with the components of metabolic syndrome in a tertiary care hospital. Methods: A cross sectional study was carried out among metabolic syndrome patients attending Hormone and Diabetes clinic in a tertiary care hospital, Dhaka, Bangladesh during June 2019 to March 2020. We included 346 patients who fulfilled National Cholesterol Education Program-Adult Treatment Panel (NCEP ATP) III criteria. Anthropometric parameters include; height, weight and waist circumference were measured and blood pressure were taken in standard conditions. Fasting blood samples were analyzed to measure glucose, triglyceride (TG), high density lipoprotein (HDL) cholesterol and thyroid hormones [Thyroid stimulating hormone (TSH) and Free Thyroxine (FT4)]. Patients categorized as euthyroid if all thyroid hormone levels fell within normal reference range [TSH: 0.47-5.0mIU/L; FT4: 0.71-1.85 ng/dL]. Subclinical hypothyroidism (SCH) was considered if TSH >5.0mIU/L and free T4 is within normal reference value (0.71-1.85 ng/dL). Conversely, overt hypothyroidism was diagnosed if TSH >5.0 mIU/L and freeT4<0.71 ng/dL. Results: Among study population 22.8% were males and 77.2% were females, with mean age of 42.61±9.13 years. Average body mass index (BMI) of the study subjects was 26.37±3.78 kg/m2. Thyroid dysfunction was seen in 47.1% of metabolic syndrome patients. The prime thyroid dysfunction was subclinical hypothyroidism (34.4%) followed by overt hypothyroidism (12.7%). Thyroid dysfunction was much common in females (37.3%) than males (9.9%) but was not statistically significant; [p=0.19]. Triglyceride showed significant positive correlation with TSH level (r=0.168, p<0.05) but negative correlation with free T4 (r=-0.200, p=<0.001). However, HDL cholesterol showed significant negative correlation with TSH level (r=-0.150, p<0.05). Conclusions: Our study recognizes thyroid dysfunction in metabolic syndrome patients; subclinical hypothyroidism was the commonest followed by overt hypothyroidism. The current study also correlates thyroid function with some components of metabolic syndrome (high density lipoprotein cholesterol and triglycerides).","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84090801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Centenary Celebrations-Insulin and Diabetes.","authors":"G. Tomkin","doi":"10.46715/IJDE2021.05.1000113","DOIUrl":"https://doi.org/10.46715/IJDE2021.05.1000113","url":null,"abstract":"Most people will know the word diabetes. Few people will not know it has something to do with sugar. Diabetes mellitus is the complete name for the condition, mellitus meaning sweet or honey taste found in the urine. Not to be confused with Diabetes insipidus, a condition of the pituitary gland, the kidney or the Psyche where water cannot be retained by the body and very severe thirst and huge polyuria (passing a huge amount of urine occurs). The condition Diabetes mellitus was known in Egyptian times and in recent times has become so much more prevalent. Alas most people will have a relation with the condition and will be aware that complications can occur such as blindness. Even today with all our new medications and all our new knowledge, still diabetes shortens life span by 10 or so years but this figure is rapidly getting less due to earlier diagnosis and better treatment for high blood sugar, cholesterol and high blood pressure. \u0000\u0000To go back more than 100 years obese patients who developed diabetes could cure the symptoms which include thirst, passing a lot of urine, tiredness and genital itch by weight reduction and exercise. The reason for this improvement is now known in much more detail than it was then. The hormone insulin which is secreted by the islet cells in the pancreas lowers blood sugar. A deficiency of insulin leads to a rising blood sugar and the high blood sugars are the cause of the thirst. The high blood sugar is no longer able to be contained by the kidney and is secreted in the urine. The high concentration of sugar in the urine pulls out sugar by osmosis, drags with it, water, so the higher the glucose in the blood and urine the more water is pulled through the kidneys which are filters. The increased amount of water thus lost, results in frequency of passing water which is now full of glucose. The loss of water is recognised by the thirst mechanism which gets switched on and being very thirsty the patient with diabetes starts to drink and drink to make up for the loss of water in the urine. Sometimes the patient who might have been keen on lemonade or other sweet drinks just drinks more and more not realising that the drinks are heavily laden with sugar. This results in increasing the blood sugar even higher and even more thirst until the whole system collapses. The patient becomes unconscious very dehydrated and will die unless given intravenous fluids and then insulin. One such lady was a patient of mine. The African lady was so complicated that after she recovered we wrote up her case in one of the medical journals to inform others of the problems we faced and the treatments we gave which resulted in her recovery. Hyperosmolar coma is the name of the condition and thankfully rare. I can of course remember other patients who we were not successful in saving but they are too painful to relate.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78089706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secular Changes in Mean Height of Children in Japan and South Korea-Suspension in Height Increases and BMI","authors":"H. Mori","doi":"10.46715/IJDE2021.05.1000112","DOIUrl":"https://doi.org/10.46715/IJDE2021.05.1000112","url":null,"abstract":"Japan and South Korea achieved marvelous economic progress after WWII. Food consumption increased in quantity and quality, with animal-sourced products conspicuously augmented. Children grew in height unprecedentedly. Japanese children, however, ceased to grow taller in the 1990s, while supply of animal protein was still increasing. Korean children kept growing taller to overtake their Japanese peers by 3 cm in the mid-2000s, but they also stopped to grow any taller afterwards, while animal products kept increasing vigorously toward the end of the 2010s. Children in Japan started to turn away from fruit in the mid-1970s, to eat in the 2000s less than 10% of fruit by the older generations. Children in Korea started to steer away from vegetables in the early 1990s, to eat less than 10% of vegetables eaten by the older generations in their 50s-60s in the mid-2010s. Consuming sufficient animal-sourced products with very little vegetables/fruit, children, particularly in South Korea have been increasing in BMS in the past two decades, with a sign of declining height. \u0000\u0000Keywords: Animal Protein; BMS; Japan; Teens; South Korea; Vegetables/Fruit","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88689134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone App to Deliver Virtual Follow-up Care for Children with Type 1 Diabetes During the COVID-19 Pandemic: Experience in a Resource-Limited Setup","authors":"L. Rohilla, P. Walia, G. Kaur, Saniya Gupta, Atul Gupta, Arti Yadav, P. Nanda, Jaivinder Yadav, Rakesh Kumar, N. Sahni, D. Dayal","doi":"10.11648/J.IJDE.20210602.12","DOIUrl":"https://doi.org/10.11648/J.IJDE.20210602.12","url":null,"abstract":"COVID-19 pandemic has forced the medical fraternity to quickly adopt telemedicine for patient care. However, the feasibility and utility of smartphone app-based telecare for children with type 1 diabetes (T1D) in resource-limited settings is scarcely reported. A web-based survey, developed with “Google forms”, was sent to parents via the smartphone app WhatsApp, and the responses to the 12 coded questionnaire items were analyzed. The multiple-choice questions were related to the experiences, satisfaction, and expectations regarding the follow-up care delivered to children with T1D between April and November 2020. A total of 578 queries were resolved through WhatsApp during the study period. These were mostly related to reviewing reports, insulin titration, or other minor ailments. From 332 participants in the two WhatsApp groups, 183 responses (55.1%) were collected. The majority of respondents found the WhatsApp telecare model as easy to learn (69.4), simple to use (68.3%) and were overall satisfied (64.5%). None of the families reported that they would recommend against the use of telecare through WhatsApp. Most of them (45.9%) felt that this model could be used in addition to their physical follow-up visits. However, only 15.3% felt that this model could replace all clinic visits in the future. Only 12% of the respondents reported technical difficulties. In conclusion, virtual follow-up care delivered through WhatsApp is feasible and acceptable to families of children with T1D. The minor challenges related to internet access and low literacy levels were easily overcome. WhatsApp-based virtual visits may complement physical visits to the clinic, especially for patients from remote areas.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77269381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute Thyroiditis Associated with COVID-19: A Case Report","authors":"O. Mehta, S. Rauniyar, M. Afzal, Rakshya Upreti, Shri Kant Kushwaha","doi":"10.11648/J.IJDE.20210601.19","DOIUrl":"https://doi.org/10.11648/J.IJDE.20210601.19","url":null,"abstract":"Background: Subacute Thyroiditis is a self-limiting thyroidal illness caused by viral infection with clinical course divided into three phases: hyperthyroidism, hypothyroidism followed by euthyroidism. Several viral infections have been linked to be associated with subacute thyroiditis but often no etiology can be found. Objective: The aim of this study is to explore a possible link between subacute thyroiditis and Coronavirus disease (COVID-19) infection. Method: Here we describe a case of subacute thyroiditis which occurred during the recovery phase of initial flu like illness. The initial illness was mild and was treated symptomatically. Later, the patient presented with features of hyperthyroidism and neck pain during recovery of initial flu like illness. Result: Two weeks after the onset of initial illness, the patient presented with neck pain, palpitation, sweating, and weight loss along with mid-line tenderness in neck. Thyroid function test revealed suppressed TSH and elevated free T4 along with reduced uptake on radionuclide thyroid scan. He was treated with NSAIDs and B-blocker which resulted in dramatic improvement in neck pain. Conclusion: Since Subacute thyroiditis is a self limiting disorder, it is often under reported. But It is important to recognize the disorder as it can directly impact on the morbidity and mortality related to other associated primary disorder like respiratory illness. Clinician must be aware about the possibility of thyroiditis in patient developing fever and neck pain and look for it.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83804166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The National Jordanian Experts Consensus on Diagnosis and Treatment of Prediabetes","authors":"Mohamad Omar Abu Hijleh, F. Annabi, M. Abujbara, Abdelkarim Alkhawaldeh, F. Haddad, J. Haddad, Muwafaq Alhyari, H. Howlett, N. Jarrah, N. Shegem, Murad Al-Naqshbandi","doi":"10.11648/J.IJDE.20210601.18","DOIUrl":"https://doi.org/10.11648/J.IJDE.20210601.18","url":null,"abstract":"Background and aims: The prevalence of prediabetes is increasing in Jordan and the Middle East region, which is leading to increased risk of type 2 diabetes and micro- and macro-complications. The aims of the expert panel were to understand and evaluate the current prediabetes situation and practice in Jordan and make recommendations to standardize the management of patients with prediabetes in Jordan. Methods: A panel of diabetes experts met to discuss and review all the current literature related to the region and international guidelines on prediabetes. The panel evaluated and developed a comprehensive understanding, addressing the definition, screening, diagnosis, pharmacological treatment, and management of prediabetes with consideration of local factors. Results: The experts relied on international data to establish criteria with cut-off values for screening and diagnosis to identify asymptomatic patients with prediabetes and diabetes. The panel made protocol recommendations, including lifestyle modifications, and developed potential treatment algorithms to provide guidance on the overall management for Jordanian prediabetic patients. Conclusion: The panel of experts reached consensus recommendations with a tailored detection, screening, and treatment algorithm in anticipation for a country wide adoption and implementation. These recommendations would help increase awareness of prediabetes in Jordan and create local guidelines to better serve Jordanian physicians in the management of patients with prediabetes.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74631954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Calcium or Vitamin D Intake and Type 2 Diabetes Mellitus Incidence: A Dose-Response Meta-analysis","authors":"Lingling Li, Qianwen Li, Junhao Wang, Hao Wang, Yongjuan Xin, Shenshen Zhang, Ying Cao, Mengya Zhou, Wenjie Yang","doi":"10.11648/J.IJDE.20210601.17","DOIUrl":"https://doi.org/10.11648/J.IJDE.20210601.17","url":null,"abstract":"Background: Dietary Calcium and vitamin D intake may have effects on the onset risk of type 2 diabetes mellitus (T2DM), whereas the results of existing studies are inconsistent. We performed a meta-analysis of prospective studies to evaluate the association between dietary calcium orvitamin D intakeand the onset risk of T2DM. Methods: We searched PubMed, Web of Science, and Embase for relevant studies published through 5 Jan 2021. The relative risks (RRs) with 95% confidence intervals (CIs) of T2DM in relation to dietary calcium and vitamin D intake were pooled with a fix or random-effects model. Results: 22 cohort studies were included in this meta-analysis, which comprising 31027 cases and 448578 participants. We found dietary calcium (RR: 0.84; 95% CI: 0.76–0.93) rather than dietary vitamin D (RR: 1.00; 95% CI: 0.92–1.08) reduced the onset risk of T2DM. Subgroup analysis showed the efficacy of dietary calcium intake is only in Asian, women and older population. Dose-response analysis revealed that each 300 mg/day increase in dietary calcium intake reduces the risk of T2DM by 8%. However, the increasing dietary vitamin D intake does not affect the risk of T2DM. Conclusions: Dietary calcium intake reduces the onset risk of T2DM but dietary vitamin D has no effect.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82451926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Parathyroid Adenoma at the Same Site Importance of ROLL","authors":"A. Ammar, Kahkashan Bashir, M. Faheem, Sadaf Batool, Noreen Marwat, N. Ahmed, S. Fatima","doi":"10.11648/J.IJDE.20210601.13","DOIUrl":"https://doi.org/10.11648/J.IJDE.20210601.13","url":null,"abstract":"Background: Recurrent hyperparathyroidism is defined by the re-appearance of parathyroid hormone (PTH) and high blood calcium levels more than 6 months after successful initial surgery for primary hyperparathyroidism. Many causes are associated with recurrent hyperparathyroidism and one of the main reasons is the presence of parathyroid adenoma. Radio-guided occult lesion localization (ROLL) has emergent role in per-operative localization of pathological lesions. ROLL has established role in breast cancer, axillary and thyroid surgery. ROLL is a valuable addition in parathyroid exploration especially in small sized parathyroid adenomas. ROLL is safe and efficient techniques helping in more accurate lesion centricity. Case presentation A 35 years old female was referred to our Nuclear Medicine department due to recurrently raised Calcium and PTH levels. She had complaints of generalized aches and pains with no visible neck nodule. Her Ultrasound neck showed no abnormal lesion while 99m Tc MIBIscan showed an area of increased radiotracer uptake in the right side of neck. Focused surgical neck exploration was done and a parathyroid adenoma was removed. Conclusions Parathyroid adenoma is a most common cause of primary hyperparathyroidism and usually presents symptomatically with high calcium and parathyroid hormone levels. Parathyroid adenoma is diagnosed by imaging and laboratory studies. One stop management is the surgical removal of 3 and a half removal of parathyroid gland and only sparing half of the gland.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76027165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Determining Thyroid Status in Pregnant Women in Bulgaria","authors":"A. Borissova, B. Trifonova, L. Dakovska, E. Michaylova, M. Vukov","doi":"10.11648/J.IJDE.20200504.17","DOIUrl":"https://doi.org/10.11648/J.IJDE.20200504.17","url":null,"abstract":"Thyroid dysfunction occurs in 5-18% of pregnant women and is associated with a higher risk of various gynecological and obstetric complications and these differences are due to the specific characteristic of the study population. The aim of the present study is to analyze the population of pregnant women in Bulgaria regarding the main parameters that are relevant to their thyroid status - age, sequence of pregnancy, reproductive problems, family history of thyroid disease, body mass index. Material: We studied 547 pregnant women, mean age 30±5 years. The study was conducted as a cross-sectional multicenter population-based in 10 regions of Bulgaria or a total of 84 settlements. Methods: An individual Questionnaire was completed, determined in a central laboratory with ECLIA method TSH, FT4, TPOAb and ultrasound examination of the cervical region was conducted. Statistical processing of the material was performed using the standard SPSS 13.0 for Windows. Results: TSH levels are negatively correlated with age, P<0.07. The thyroid volume for the group of women with first pregnancy (n-245, 44.8%) is 8.67±2.23 mL, median 8.35 mL, and the thyroid volume in the remaining 302 (55.2%) women with another pregnancy is 9.15±2.85 mL, median 8.96 mL (P<0.01). Reproductive problems were reported in 119 (21.8%) pregnant women, but the correlation with TSH levels was weak, P<0.009. In 25% of women with family history of thyroid pathology there are abnormalities in thyroid function (in 96.4% hypothyroidism and in 3.6% hyperthyroidism). While in euthyroid pregnant women previous obesity was present in 8.6% (30/350), in hypothyroid pregnant women it was found in 12.7% (14/110), P<0.035. In other words, BMI before pregnancy is a significant predictor of hypothyroidism, proven during pregnancy. Conclusion: The preliminary in-depth study and presentation of the characteristics of the studied Bulgarian population of pregnant women is the basis for a proper assessment of the condition of the thyroid gland.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84058551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-stage Hyperglycemia-induced Gut Microbial Changes Are Partially Associated with Mechanical Allodynia in <i>db/db</i> Mice","authors":"Xinting Wang, Jihong Wu, Simin Qi, Rui Huang, Xiaoping Wu, Lin Tian, Peili Wang, Shenglan Wang","doi":"10.11648/j.ijde.20210604.15","DOIUrl":"https://doi.org/10.11648/j.ijde.20210604.15","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"383 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79222205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}