International journal of clinical and experimental medicine最新文献_第3页

Diagnostic value of IMP3 in pancreatic cancer: a meta-analysis [Retraction]. IMP3在胰腺癌中的诊断价值:荟萃分析[撤回]。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2016-06-15 eCollection Date: 2016-01-01

引用次数: 0

Lentivirus-mediated TPD52L2 depletion inhibits the proliferation of liver cancer cells in vitro [Retraction]. 慢病毒介导的TPD52L2耗尽在体外抑制肝癌细胞的增殖[撤回]。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2016-06-15 eCollection Date: 2016-01-01

引用次数: 0

Parathyroid hormone plus alendronate in osteoporosis: a meta-analysis of randomized controlled trials [Retraction]. 甲状旁腺激素加阿仑膦酸钠治疗骨质疏松:一项随机对照试验的荟萃分析[撤回]。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2016-01-15 eCollection Date: 2016-01-01

引用次数: 0

Effect of early external X-ray radiation on arterial restenosis post percutaneous transluminal angioplasty [Retraction]. 早期x线外照射对经皮腔内血管成形术后动脉再狭窄的影响。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2016-01-15 eCollection Date: 2016-01-01

引用次数: 0

Upregulation of PSMD10 caused by the JMJD2A histone demethylase. JMJD2A 组蛋白去甲基化酶导致 PSMD10 上调。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2016-01-01 Epub Date: 2016-06-30

Tae-Dong Kim, Sangphil Oh, Stan A Lightfoot, Sook Shin, Jonathan D Wren, Ralf Janknecht

{"title":"Upregulation of PSMD10 caused by the JMJD2A histone demethylase.","authors":"Tae-Dong Kim, Sangphil Oh, Stan A Lightfoot, Sook Shin, Jonathan D Wren, Ralf Janknecht","doi":"","DOIUrl":"","url":null,"abstract":"PSMD10, also known as gankyrin, is associated with the proteasome and has been shown to be an oncoprotein in the liver. Here, we report that PSMD10 expression is stimulated by the histone demethylase JMJD2A/KDM4A and its interaction partner, the ETV1 transcription factor, in LNCaP prostate cancer cells. Global analysis of expression patterns revealed that PSMD10 mRNA levels are positively correlated with those of both JMJD2A and ETV1. In human prostate tumors, PSMD10 is highly overexpressed at the protein level and correlates with JMJD2A overexpression; further, PSMD10 expression is enhanced in the prostates of transgenic JMJD2A mice. Moreover, PSMD10 is particularly overexpressed in high Gleason score prostate tumors. Downregulation of PSMD10 in LNCaP prostate cancer cells impaired their growth, indicating that PSMD10 may exert a pro-oncogenic function in the prostate. Lastly, we observed that PSMD10 expression is correlated to YAP1, a component of the Hippo signaling pathway and whose gene promoter is regulated by JMJD2A, and that PSMD10 can cooperate with YAP1 in stimulating LNCaP cell growth. Altogether, these data indicate that PSMD10 is a novel downstream effector of JMJD2A and suggest that inhibition of the JMJD2A histone demethylase by small molecule drugs may be effective to curtail the oncogenic activity of PSMD10 in various PSMD10-overexpressing tumors.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"9 6","pages":"10123-10134"},"PeriodicalIF":0.1,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584593/pdf/nihms884312.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35388264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of autophagy in chronic kidney diseases. 自噬在慢性肾病中的作用

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-12-15 eCollection Date: 2015-01-01

Song Mao, Jianhua Zhang

引用次数: 0

Differences of prevalence of dyslipidemia and risk factors related to LDL-c in the patients with abnormal fasting glucose between Uygur and Han in Xinjiang. 新疆维吾尔族和汉族空腹血糖异常患者血脂异常患病率及LDL-c相关危险因素的差异。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-12-15 eCollection Date: 2015-01-01

Li Quan, Lin Hu, Li Zhang, Sheng Jiang

{"title":"Differences of prevalence of dyslipidemia and risk factors related to LDL-c in the patients with abnormal fasting glucose between Uygur and Han in Xinjiang.","authors":"Li Quan, Lin Hu, Li Zhang, Sheng Jiang","doi":"","DOIUrl":"","url":null,"abstract":"Aims: To evaluate the incidence of dyslipidemia among Uygur and Han patients with impaired fasting glucose (IFG). To investigate the influence factors on LDL-c in this population.Methods: This cross-sectional study included a total of 4709 participants, consisting of Uygurs patients (n=2053) and Han patients (n=2656) from Xinjiang province, who were screened for diabetes mellitus. A stratified multistage sampling design was used to collect the participants. The influence factors on LDL-c were analyzed by Logistic regression analysis.Results: Among the IFG patients (n=1757), Uighur IFG group had a higher prevalence of dyslipidemia than that of Han IFG group, 99.8% vs. 63.7%, P<0.05. Similar trends were existed in the prevalence of hypercholesteremia, hypertriglyceridemia, high LDL-c and low HDL-c (all P<0.05). Among the Uighur groups, IFG group had higher dyslipidemia rate than that of euglycemia group (74%). However, there was no such difference in the Han groups. Logistic regression analysis revealed that risk factors associated with LDL-c were age, total cholesterol and 2 h postprandial blood glucose for the Uighur IFG patients. However, gender and total cholesterol were risk factors for Han IFG patients.Conclusions: Uighur IFG patients had higher incidence of dyslipidemia than that of Han IFG patients. For Uyghur IFG patients, closing follow-up of total cholesterol and 2 h postprandial blood glucose were necessary. As to the Han IFG patients, we should pay more attention to male and total cholesterol in order to lower LDL-c levels. So, appropriately preventive and therapeutic measures should be chosen based on the characteristics of abnormal lipid profiles in different nationality.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 12","pages":"22403-10"},"PeriodicalIF":0.1,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71434228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human pituitary homeobox-3 gene in congenital cataract in a Chinese family. 一个中国家庭中的人类垂体homeobox-3基因与先天性白内障的关系。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-12-15 eCollection Date: 2015-01-01

Xiangyu Ye, Guangbin Zhang, Nuo Dong, Yan Meng

{"title":"Human pituitary homeobox-3 gene in congenital cataract in a Chinese family.","authors":"Xiangyu Ye, Guangbin Zhang, Nuo Dong, Yan Meng","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: Congenital cataract is the common cause of world blindness. It is generally inherited as an autosomal recessive trait and has various phenotypes. This study aimed to explore the gene responsible for autosomal recessive congenital cataract in a Chinese family, and to investigate the functional and cellular consequences of the mutation.Methods: A four-generation Chinese family with autosomal recessive congenital cataract was included in the study. A genome wide scan and linkage analysis were performed in the chromosomal region of Pituitary homeobox 3 (PITX3) to identify the linked region of the genome. And sequence analysis of PITX3 gene was also investigated using BigDye Terminator mix 3.0 and SeqScape Software 2.5.Results: The genome wide scan and linkage analysis identified a disease-haplotype interva. The maximum logarithm of odds LOD score was (Zmax) 3.11 at marker D10S1693 (θmax=0.00), flanked by D10S1680 and D10S467, which included the PITX3 gene. Sequencing revealed a splice site mutation, G→A, at D10S1680 and D10S467, which co-segregated with all the affected members of this family.Conclusions: The 543delG is a novel mutation in PITX3 causing an autosomal recessive congenital cataract.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 12","pages":"22435-9"},"PeriodicalIF":0.1,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extramedullary relapse in lumbar spine of patient with acute promyelocytic leukemia after remission for 16 years: a case report and literature review. 急性早幼粒细胞白血病缓解16年后腰椎髓外复发1例并文献复习。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-12-15 DOI: 10.3760/CMA.J.ISSN.1671-7368.2016.01.018

Zheng-mei He, Shan-dong Tao, Yuan Deng, Yue Chen, Lixiao Song, Bang-he Ding, Kankan Chen, Liang Yu, Chun-ling Wang

{"title":"Extramedullary relapse in lumbar spine of patient with acute promyelocytic leukemia after remission for 16 years: a case report and literature review.","authors":"Zheng-mei He, Shan-dong Tao, Yuan Deng, Yue Chen, Lixiao Song, Bang-he Ding, Kankan Chen, Liang Yu, Chun-ling Wang","doi":"10.3760/CMA.J.ISSN.1671-7368.2016.01.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-7368.2016.01.018","url":null,"abstract":"Acute promyelocytic leukemia (APL) is a common myeloid leukemia. At the newly diagnosed stage, it can be fatal because of the serious complication-disseminated intravascular coagulation. With the advent and early application of all-trans retinoic acid, most APL patients can achieve a long-term survival, and only a minority of patients will develop extramedullary relapse after remission. The most common site of extramedullary relapse is central nervous system, while other sites are relatively rare. Here, we report a particularly rare APL patient who experienced extramedullary relapse with lumbar spine as the isolated site after a rather long time of remission for 16 years. At the time of relapse, the main clinical manifestations of the patient are obvious low back pain, weakness in lower limbs and limitation of activity. After treatment of local radiotherapy combined with ATRA and arsenic trioxide, the patient achieved and maintained a second complete remission by now.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 12 1","pages":"22430-4"},"PeriodicalIF":0.1,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70001017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Ginkgo biloba extract induce cell apoptosis and G0/G1 cycle arrest in gastric cancer cells. 银杏叶提取物可诱导胃癌细胞凋亡和 G0/G1 周期停滞。

IF 0.1

International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Yu Bai, Feng Zhao, Yan Li, Lei Wang, Xiang-Jie Fang, Chen-Yu Wang

{"title":"Ginkgo biloba extract induce cell apoptosis and G0/G1 cycle arrest in gastric cancer cells.","authors":"Yu Bai, Feng Zhao, Yan Li, Lei Wang, Xiang-Jie Fang, Chen-Yu Wang","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Previous studies have shown that the Ginkgo biloba extract (EGb761) can be used to anti-cancer. However, the mechanism by which EGb761 mediate this effect is still unclear. In the present study, EGb761 inhibited cell proliferation and induced cell apoptosis in gastric cancer cell was explored.Methods: The cell viability was detected by the CCK8 assay. The cell cycle and apoptosis was assessed by flow cytometry. The protein expression of caspase-3, p53 and Bcl-2 were analyzed by western blot.Results: Treatment of human gastric cancer cells with EGb761 induced cell death in a dose-dependent manner by using CCK8 assay. Consistent with the CCK8 assay, the flow cytometry results showed that gastric cancer cells were accumulated in G0/G1 phase when exposed to EGb761. Furthermore, the proportion of apoptosis cells was increased after EGb761 treatment as compared to untreated group. In addition, our results showed that the treatment of AGS cells with EGb761 significantly increased the expression of caspase3 and p53, and decreased the anti-apoptotic Bcl-2 level.Conclusions: Our results demonstrated that EGb761 could inhibit gastric cancer proliferation through adjusting cell cycle and inducing cell apoptosis.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 11","pages":"20977-82"},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0