International journal of clinical and experimental medicine最新文献_第3页

Role of autophagy in chronic kidney diseases. 自噬在慢性肾病中的作用

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International journal of clinical and experimental medicine Pub Date : 2015-12-15 eCollection Date: 2015-01-01

Song Mao, Jianhua Zhang

引用次数: 0

Differences of prevalence of dyslipidemia and risk factors related to LDL-c in the patients with abnormal fasting glucose between Uygur and Han in Xinjiang. 新疆维吾尔族和汉族空腹血糖异常患者血脂异常患病率及LDL-c相关危险因素的差异。

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International journal of clinical and experimental medicine Pub Date : 2015-12-15 eCollection Date: 2015-01-01

Li Quan, Lin Hu, Li Zhang, Sheng Jiang

{"title":"Differences of prevalence of dyslipidemia and risk factors related to LDL-c in the patients with abnormal fasting glucose between Uygur and Han in Xinjiang.","authors":"Li Quan, Lin Hu, Li Zhang, Sheng Jiang","doi":"","DOIUrl":"","url":null,"abstract":"Aims: To evaluate the incidence of dyslipidemia among Uygur and Han patients with impaired fasting glucose (IFG). To investigate the influence factors on LDL-c in this population.Methods: This cross-sectional study included a total of 4709 participants, consisting of Uygurs patients (n=2053) and Han patients (n=2656) from Xinjiang province, who were screened for diabetes mellitus. A stratified multistage sampling design was used to collect the participants. The influence factors on LDL-c were analyzed by Logistic regression analysis.Results: Among the IFG patients (n=1757), Uighur IFG group had a higher prevalence of dyslipidemia than that of Han IFG group, 99.8% vs. 63.7%, P<0.05. Similar trends were existed in the prevalence of hypercholesteremia, hypertriglyceridemia, high LDL-c and low HDL-c (all P<0.05). Among the Uighur groups, IFG group had higher dyslipidemia rate than that of euglycemia group (74%). However, there was no such difference in the Han groups. Logistic regression analysis revealed that risk factors associated with LDL-c were age, total cholesterol and 2 h postprandial blood glucose for the Uighur IFG patients. However, gender and total cholesterol were risk factors for Han IFG patients.Conclusions: Uighur IFG patients had higher incidence of dyslipidemia than that of Han IFG patients. For Uyghur IFG patients, closing follow-up of total cholesterol and 2 h postprandial blood glucose were necessary. As to the Han IFG patients, we should pay more attention to male and total cholesterol in order to lower LDL-c levels. So, appropriately preventive and therapeutic measures should be chosen based on the characteristics of abnormal lipid profiles in different nationality.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71434228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human pituitary homeobox-3 gene in congenital cataract in a Chinese family. 一个中国家庭中的人类垂体homeobox-3基因与先天性白内障的关系。

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International journal of clinical and experimental medicine Pub Date : 2015-12-15 eCollection Date: 2015-01-01

Xiangyu Ye, Guangbin Zhang, Nuo Dong, Yan Meng

{"title":"Human pituitary homeobox-3 gene in congenital cataract in a Chinese family.","authors":"Xiangyu Ye, Guangbin Zhang, Nuo Dong, Yan Meng","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: Congenital cataract is the common cause of world blindness. It is generally inherited as an autosomal recessive trait and has various phenotypes. This study aimed to explore the gene responsible for autosomal recessive congenital cataract in a Chinese family, and to investigate the functional and cellular consequences of the mutation.Methods: A four-generation Chinese family with autosomal recessive congenital cataract was included in the study. A genome wide scan and linkage analysis were performed in the chromosomal region of Pituitary homeobox 3 (PITX3) to identify the linked region of the genome. And sequence analysis of PITX3 gene was also investigated using BigDye Terminator mix 3.0 and SeqScape Software 2.5.Results: The genome wide scan and linkage analysis identified a disease-haplotype interva. The maximum logarithm of odds LOD score was (Zmax) 3.11 at marker D10S1693 (θmax=0.00), flanked by D10S1680 and D10S467, which included the PITX3 gene. Sequencing revealed a splice site mutation, G→A, at D10S1680 and D10S467, which co-segregated with all the affected members of this family.Conclusions: The 543delG is a novel mutation in PITX3 causing an autosomal recessive congenital cataract.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extramedullary relapse in lumbar spine of patient with acute promyelocytic leukemia after remission for 16 years: a case report and literature review. 急性早幼粒细胞白血病缓解16年后腰椎髓外复发1例并文献复习。

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International journal of clinical and experimental medicine Pub Date : 2015-12-15 DOI: 10.3760/CMA.J.ISSN.1671-7368.2016.01.018

Zheng-mei He, Shan-dong Tao, Yuan Deng, Yue Chen, Lixiao Song, Bang-he Ding, Kankan Chen, Liang Yu, Chun-ling Wang

{"title":"Extramedullary relapse in lumbar spine of patient with acute promyelocytic leukemia after remission for 16 years: a case report and literature review.","authors":"Zheng-mei He, Shan-dong Tao, Yuan Deng, Yue Chen, Lixiao Song, Bang-he Ding, Kankan Chen, Liang Yu, Chun-ling Wang","doi":"10.3760/CMA.J.ISSN.1671-7368.2016.01.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-7368.2016.01.018","url":null,"abstract":"Acute promyelocytic leukemia (APL) is a common myeloid leukemia. At the newly diagnosed stage, it can be fatal because of the serious complication-disseminated intravascular coagulation. With the advent and early application of all-trans retinoic acid, most APL patients can achieve a long-term survival, and only a minority of patients will develop extramedullary relapse after remission. The most common site of extramedullary relapse is central nervous system, while other sites are relatively rare. Here, we report a particularly rare APL patient who experienced extramedullary relapse with lumbar spine as the isolated site after a rather long time of remission for 16 years. At the time of relapse, the main clinical manifestations of the patient are obvious low back pain, weakness in lower limbs and limitation of activity. After treatment of local radiotherapy combined with ATRA and arsenic trioxide, the patient achieved and maintained a second complete remission by now.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70001017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Ginkgo biloba extract induce cell apoptosis and G0/G1 cycle arrest in gastric cancer cells. 银杏叶提取物可诱导胃癌细胞凋亡和 G0/G1 周期停滞。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Yu Bai, Feng Zhao, Yan Li, Lei Wang, Xiang-Jie Fang, Chen-Yu Wang

{"title":"Ginkgo biloba extract induce cell apoptosis and G0/G1 cycle arrest in gastric cancer cells.","authors":"Yu Bai, Feng Zhao, Yan Li, Lei Wang, Xiang-Jie Fang, Chen-Yu Wang","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Previous studies have shown that the Ginkgo biloba extract (EGb761) can be used to anti-cancer. However, the mechanism by which EGb761 mediate this effect is still unclear. In the present study, EGb761 inhibited cell proliferation and induced cell apoptosis in gastric cancer cell was explored.Methods: The cell viability was detected by the CCK8 assay. The cell cycle and apoptosis was assessed by flow cytometry. The protein expression of caspase-3, p53 and Bcl-2 were analyzed by western blot.Results: Treatment of human gastric cancer cells with EGb761 induced cell death in a dose-dependent manner by using CCK8 assay. Consistent with the CCK8 assay, the flow cytometry results showed that gastric cancer cells were accumulated in G0/G1 phase when exposed to EGb761. Furthermore, the proportion of apoptosis cells was increased after EGb761 treatment as compared to untreated group. In addition, our results showed that the treatment of AGS cells with EGb761 significantly increased the expression of caspase3 and p53, and decreased the anti-apoptotic Bcl-2 level.Conclusions: Our results demonstrated that EGb761 could inhibit gastric cancer proliferation through adjusting cell cycle and inducing cell apoptosis.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of uneventful cesarean section in terms of hemorrhage. 从出血角度看无痛剖宫产的安全性。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Serkan Bodur, Ismet Gun, Ozkan Ozdamar, Mustafa Alparslan Babayigit

{"title":"Safety of uneventful cesarean section in terms of hemorrhage.","authors":"Serkan Bodur, Ismet Gun, Ozkan Ozdamar, Mustafa Alparslan Babayigit","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Hemorrhage still continues to be reported as one of the leading causes of maternal mortality and morbidity. Intraoperative estimation of the blood loss seems to be complex and misleading as it is impaired by the amount of amniotic fluid and blood from the placenta. The present study was aimed to investigate the safety of intraoperative deciding on an uneventful cesarean section in a low risk patient population.Material and methods: One hundred patients free from hemorrhage risks and experienced an uneventful elective cesarean section, were included to the study. The decline in hemoglobin and hematocrit values, calculated blood loss, transfusion rate and presence of hemorrhage related symptoms and signs were accepted as the main outcomes of the study.Results: The average preoperative and postoperative hemoglobin values were detected as 12.09±0.18 g/dl and 10.72±1.39 g/dl, respectively. The average decrease in hemoglobin was 1.36±1.06 g/dl. The observed decrease in hemoglobin values were less than 10% in 34.4% of the patients. The average blood loss was calculated to be 517.06±417.55 ml. There were no patients with signs and symptoms of hemorrhage. Cross match transfusion ratio, transfusion probability and transfusion index was calculated as zero.Conclusion: The decision of uneventful cesarean section provides obstetricians a safe postoperative and postpartum period after following standardized surgical procedures in terms of hemorrhage and related complications.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of ginsenoside Rg2 against H2O2-induced injury and apoptosis in H9c2 cells. 人参皂苷 Rg2 对 H9c2 细胞 H2O2 诱导的损伤和凋亡的保护作用

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Wenwen Fu, Dayun Sui, Xiaofeng Yu, Dongxia Gou, Yifa Zhou, Huali Xu

引用次数: 0

FibroScan, aspartate aminotransferase and alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factor (FIB-4), and their combinations in the assessment of liver fibrosis in patients with hepatitis B. FibroScan、天冬氨酸转氨酶和丙氨酸转氨酶比值（AAR）、天冬氨酸酯转氨酶与血小板比值指数（APRI）、基于4因子的纤维化指数（FIB-4）及其组合在评估乙型肝炎患者肝纤维化中的作用。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Deping Ding, Hongbing Li, Ping Liu, Lingli Chen, Jian Kang, Yinhua Zhang, Deqiang Ma, Yue Chen, Jie Luo, Zhongji Meng

{"title":"FibroScan, aspartate aminotransferase and alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factor (FIB-4), and their combinations in the assessment of liver fibrosis in patients with hepatitis B.","authors":"Deping Ding, Hongbing Li, Ping Liu, Lingli Chen, Jian Kang, Yinhua Zhang, Deqiang Ma, Yue Chen, Jie Luo, Zhongji Meng","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: The aim of this study was to assess the effects of FibroScan, aspartate aminotransferase and alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factor (FIB-4) and their combinations on liver fibrosis in patients with hepatitis B.Methods: 406 hospitalized patients with chronic hepatitis B (CHB) and cirrhosis in our hospital were analyzed retrospectively and collected patients clinical indicators, including liver stiffness (LS), AAR, APRI and FIB-4, and then compared the differences of these indicators between CHB group and hepatitis B with cirrhosis group. Receiver operating curve (ROC) was used to evaluate the differentiating capacity of these indicators on CHB and liver cirrhosis.Results: Four indicators related to liver cirrhosis had a statistical significance between two groups (P < 0.01); the under ROC curve areas of LS, AAR, APRI and FIB-4 for differential diagnosis of CHB and liver cirrhosis were 0.866, 0.772, 0.632 and 0.885, respectively. The under ROC curve areas of LS, AAR, APRI and FIB-4 for differential diagnosis of liver cirrhosis at compensatory stage and de-compensatory stage were 0.627, 0.666, 0.795 and 0.820, respectively.Conclusion: LS, AAR, APRI and FIB-4 were good indicators as clinical diagnosis and differential diagnosis on hepatitis B related cirrhosis.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71434227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composite tissue flap at perforating branches of saphenous artery: a new design for repairing composite tissue defects in anterior knee. 隐动脉穿支复合组织瓣：修复膝关节前部复合组织缺损的新设计。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Guangfeng Sun, Kaiyu Nie, Wenhu Jin, Zairong Wei, Jianping Qi, Dali Wang

{"title":"Composite tissue flap at perforating branches of saphenous artery: a new design for repairing composite tissue defects in anterior knee.","authors":"Guangfeng Sun, Kaiyu Nie, Wenhu Jin, Zairong Wei, Jianping Qi, Dali Wang","doi":"","DOIUrl":"","url":null,"abstract":"So far it has been difficult to repair and reconstruct the composite tissue defects in knee. Saphenous artery flap has been widely used to repair complex wounds, but the design and clinical application of composite tissue flap at perforating branches of saphenous artery were not reported. In this research, we design a new composite tissue flap by carrying fascial flap in the medial gastrocnemius muscle with perforators flap in saphenous artery to repair and reconstruct the composite tissue defects in knee. By anatomic observation and analysis, we find that there exists blood-supply in netty form among saphenous arteries, medial artery below the knee, intermuscular branch in high-order position of posterior tibial artery and perforating branch in medial artery of calf. We chose saphenous artery as blood-supplying artery; utilized the netty blood-supplying mode in middle-up and medial part of shank; cut the composite tissue flap at perforating branches of saphenous artery with fascial flap carried in the medial gastrocnemius muscle; reconstructed the ligamentum patellae using medial head of gastrocnemius muscle and Achilles's tendon; and covered the wounds at front side of knee with flap. Composite tissues were survived completely, free from infection at wounds and exosmosis of joint fluid. Motion function of knee-joint proved satisfactory, and ambulatory function was recovered. There was no complication in donor site. Composite tissue flap at perforating branches of saphenous artery with fascial flap carried in the medial gastrocnemius muscle is one of the most ideal solutions for repairing the composite tissue defects at front side of knee joint. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of mandibular border and functional movement protocols using an electromagnetic articulograph (EMA). 使用电磁关节图（EMA）确定下颌骨边界和功能运动协议。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Ramon Fuentes, Pablo Navarro, Aldo Curiqueo, Nicolas E Ottone

{"title":"Determination of mandibular border and functional movement protocols using an electromagnetic articulograph (EMA).","authors":"Ramon Fuentes, Pablo Navarro, Aldo Curiqueo, Nicolas E Ottone","doi":"","DOIUrl":"","url":null,"abstract":"The electromagnetic articulograph (EMA) is a device that can collect movement data by positioning sensors at multiple points, measuring displacements of the structure in real time, as well as the acoustics and mechanics of speech using a microphone connected to the measurement system. The aim of this study is to describe protocols for the generation, measurement and visualization of mandibular border and functional movements in the three spatial planes (frontal, sagittal and horizontal) using the EMA. The EMA has transmitter coils that determine magnetic fields to collect information about movements from sensors located on different structures (tongue, palate, mouth, incisors, skin, etc.) and in every direction in an area of 300 mm. After measurement with the EMA, the information is transferred to a computer and read with the Visartico software to visualize the recording of the mandibular movements registered by the EMA. The sensors placed in the space between the three axes XYZ are observed, and then the plots created from the mandibular movements included in the corresponding protocol can be visualized, enabling interpretation of these data. Four protocols for the obtaining of images of the opening and closing mandibular movements were defined and developed, as well as border movements in the frontal, sagittal and horizontal planes, managing to accurately reproduce Posselt's diagram and Gothic arch on the latter two axes. Measurements with the EMA will allow more exact data to be collected in relation to the mandibular clinical physiology and morphology, which will permit more accurate diagnoses and application of more precise and adjusted treatments in the future. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0