International journal of biochemistry and molecular biology最新文献_第2页

Stem cell therapy: An emerging hope in regenerative medicine 干细胞疗法:再生医学的新希望

International journal of biochemistry and molecular biology Pub Date : 2023-01-01 DOI: 10.33545/26646501.2023.v5.i1a.41

Jolly Kumari, Deoraj Sharma

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Comparison of BTP, NGAL, KIM-1, & ADMA biomarkers in CKD and non-CKD subjects. BTP、NGAL、KIM-1和ADMA生物标志物在CKD和非CKD受试者中的比较。

International journal of biochemistry and molecular biology Pub Date : 2023-01-01

Abhishek Bansal, Shreya Nigoskar, Mohit Thalquotra

{"title":"Comparison of BTP, NGAL, KIM-1, & ADMA biomarkers in CKD and non-CKD subjects.","authors":"Abhishek Bansal, Shreya Nigoskar, Mohit Thalquotra","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: New biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), a member of the lipocalin family, and kidney injury molecule-1 (KIM-1) have been utilised in recent years to identify the development of chronic kidney disease (CKD). However, attempts to use them as broad markers to check for renal injury in patients and to pinpoint the kidney injury site have been unsuccessful. Therefore the search for an ideal panel of biomarkers predicting progression of CKD is still ongoing. The present study is designed to evaluate the biomarkers for CKD from NGAL, KIM-1, Beta trace protein (BTP) and Asymmetric dimethylarginine (ADMA).Materials and methods: For this case-control study, 100 participants were selected on the basis of inclusion and exclusion criteria at the Index Medical College Hospital and Research Centre, Madhya Pradesh, there were 67 male subjects and 33 female CKD subjects and 100 non-CKD subjects (60 male and 40 female) matched for age and sex were taken from the hospital.Results: Between the CKD and non-CKD participants, the levels of BTP, plasma NGAL, KIM-1, and ADMA were compared and found to be substantially higher than those in the controls.Conclusion: Abnormal renal function is linked to disturbed blood levels of BTP, NGAL, KIM-1, and ADMA. Strong correlations exist between increased blood levels of BTP, NGAL, KIM-1, and ADMA and reduced kidney function. They might thus be used to estimate the decline of renal function and the progression of CKD.","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"14 3","pages":"32-39"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349297/pdf/ijbmb0014-0032.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9823095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of the some components in blood before and after cupping therapy 拔火罐前后血中某些成分的比较

International journal of biochemistry and molecular biology Pub Date : 2023-01-01 DOI: 10.33545/26646501.2023.v5.i1a.42

I. H. Dhefer

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Melatonin ameliorates high glucose-induced autophagy in Schwann cells. 褪黑素改善高糖诱导的雪旺细胞自噬。

International journal of biochemistry and molecular biology Pub Date : 2023-01-01

Hagar Mohamed Ahmed Salem, Kian Chung Chok, Rhun Yian Koh, Pei Ying Ng, Yee Lian Tiong, Soi Moi Chye

{"title":"Melatonin ameliorates high glucose-induced autophagy in Schwann cells.","authors":"Hagar Mohamed Ahmed Salem, Kian Chung Chok, Rhun Yian Koh, Pei Ying Ng, Yee Lian Tiong, Soi Moi Chye","doi":"","DOIUrl":"","url":null,"abstract":"Diabetic neuropathy (DN) is a condition in which nerve fibers are continually exposed to high glucose-induced free radicals. Recent discoveries demonstrated that melatonin is an indole hormone that contributes to neuroprotection through the modulation of autophagy. Herein, this study aims to examine the neuroprotective effects of melatonin on Schwann cells under high glucose conditions. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay was used to measure cell viability. The activation of autophagosomes was determined using acridine orange staining (AO). Western blot assay was used to measure the expression of proteins involved in autophagy and endoplasmic reticulum (ER) stress. Our results demonstrated that melatonin at 1 µM has the highest protective effects on high glucose-induced cell death. Melatonin concentrations of 5 and 10 µM were found to be the most effective in reducing autophagy induced by high glucose. Under high glucose conditions, the protein expressions of LC3, ATF4, ATF6, CHOP, PERK and eIF2-α were up-regulated in Schwann cells. However, melatonin attenuated these changes by downregulating LC3 and the ER stress markers ATF4, ATF6, CHOP, PERK and eIF2-α protein expressions in Schwann cells. In conclusion, melatonin alleviates high glucose-induced autophagy in Schwann cells through PERK-eIF2α-ATF4-CHOP signaling pathways.","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"14 3","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349298/pdf/ijbmb0014-0025.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9828442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of phytochemicals and antioxidant activity of custard apple fruit pulp (Annona squamosa Linn.) 乳苹果果肉的植物化学成分及抗氧化活性评价

International journal of biochemistry and molecular biology Pub Date : 2023-01-01 DOI: 10.33545/26646501.2023.v5.i1a.40

M. Samad, Mithila Farzana, Md. Alomgir Hossain, M. A. Rahman, A. Asad

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Bio-efficacy of new insecticides against diamond back moth (Plutella xylostella) on cabbage 新型杀虫剂对白菜小菜蛾生物功效的研究

International journal of biochemistry and molecular biology Pub Date : 2023-01-01 DOI: 10.33545/26646501.2023.v5.i1a.34

Saurabh Kumar, AK Singh, BK Singh

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Honey and its health benefits in our day-to-day life 蜂蜜及其在我们日常生活中的健康益处

International journal of biochemistry and molecular biology Pub Date : 2023-01-01 DOI: 10.33545/26646501.2023.v5.i1a.38

Kirthana C, Luqman Ahmed Hashim, Deoraj Sharma

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Spider abundance and Diversity around in Yercaudhils Salem, Tamil Nadu, South India 南印度泰米尔纳德邦耶考迪希尔塞勒姆附近蜘蛛的数量和多样性

International journal of biochemistry and molecular biology Pub Date : 2023-01-01 DOI: 10.33545/26646501.2023.v5.i1a.32

Karthick Muniraj, P. Saha, S. K, Ashwini V, Sumangala Rao

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Study on the extraction and characterization of polymer obtained from scales of Channa striatus, exoskeleton of Barytelphusa guerini, Macrobrachium rosenbergii and fresh water mussel from fresh water bodies of Bhopal, Madhya Pradesh 中央邦博帕尔淡水水体中纹状鱼鳞、guerini Barytelphusa外骨骼、罗氏沼虾和淡水贻贝中聚合物的提取与表征研究

International journal of biochemistry and molecular biology Pub Date : 2023-01-01 DOI: 10.33545/26646501.2023.v5.i1a.35

S. Shah, Tehleel Ahmed, S. Manohar, Dr. Rajendra Chauhan

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Prepared hair oil from Arnica montana- Q in castor and mustard base oil in definite proportion with standardization 以山金车Q为原料，在蓖麻和芥末基础油中按一定比例标准配制发油

International journal of biochemistry and molecular biology Pub Date : 2023-01-01 DOI: 10.33545/26646501.2023.v5.i2a.43

Suraj Singh Bhadoria, Pramanick Monimala, Desai Poorav, D. B. P. Panda, Sharma Gaurav, Roy Mayank, Chakraborthy Gs

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