International journal of Advanced Biological and Biomedical Research最新文献_第6页

The recent development in synthesis and pharmacological evaluation of small molecule to treat Alzheimer's diseases: A review 小分子治疗阿尔茨海默病的合成及药理评价研究进展

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-06-01 DOI: 10.33945/sami/ijabbr.2020.2.4

Masome Rahmati

{"title":"The recent development in synthesis and pharmacological evaluation of small molecule to treat Alzheimer's diseases: A review","authors":"Masome Rahmati","doi":"10.33945/sami/ijabbr.2020.2.4","DOIUrl":"https://doi.org/10.33945/sami/ijabbr.2020.2.4","url":null,"abstract":"Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. A neurodegenerative type of dementia, the disease starts mild and gets progressively worse. Like all types of dementia, Alzheimer's is caused by brain cell death. The most common presentation marking Alzheimer's dementia is where symptoms of memory loss are the most prominent, especially in the area of learning and recalling new information.Alzheimer's disease is not simple to diagnose. There is no single test for it. For this reason, the first thing doctors do is to rule out other problems before confirming whether mental signs and symptoms are severe enough to be a kind of dementia or something else. Genetic test is possible in some settings to indicate the likelihood of someone having or developing the disease but this is controversial and not entirely reliable. There are no disease-modifying drugs available for Alzheimer's disease but some options may reduce its symptoms and help improve quality of life. A different kind of drug, memantine, an NMDA receptor antagonist, may also be used, alone or in combination with a cholinesterase inhibitor. This review highlights the several reports that attempt to design and synthesis of some classes of selective Alzheimer's disease inhibitors.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"12 1","pages":"134-145"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82484209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reinforcement of a decellularized extracellular matrix-derived hydrogel using nanofibers for cardiac tissue engineering 用纳米纤维增强脱细胞细胞外基质水凝胶用于心脏组织工程

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-05-01 DOI: 10.33945/sami/ijabbr.2020.3.8

S. Mashayekhan, M. Jahanshahi, S. Moghadam

{"title":"Reinforcement of a decellularized extracellular matrix-derived hydrogel using nanofibers for cardiac tissue engineering","authors":"S. Mashayekhan, M. Jahanshahi, S. Moghadam","doi":"10.33945/sami/ijabbr.2020.3.8","DOIUrl":"https://doi.org/10.33945/sami/ijabbr.2020.3.8","url":null,"abstract":"The role of heart disease in increasing worldwide death and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate functional and implantable constructs. One of these strategies is to develop a biologically similar heart tissue scaffold, in which two types of fiber and hydrogel are commonly used. Toward this goal, taking advantage of both hydrogels properties and fibers features with excellent mechanical properties can be considered as a promising method. The purpose of this study is to develop a fiber/hydrogel composite of gelatin, poly-caprolactone (PCL), cardiac extracellular matrix (ECM), and chitosan. The fibrous scaffolds of PCL and gelatin were characterized by SEM, water drop contact angle test, FTIR, and mechanical tests. The results showed that the average diameter of nanofibers, hydrophilicity and mechanical properties of the fibrous scaffolds increased with increasing the gelatin content in the spinning solution. Furthermore, the results of mechanical tests indicated that by integrating fibers with gelatin to PCL mass ratio of 2 in the hydrogel of chitosan and ECM with a mass ratio equal to 1, we obtained a construct with similar mechanical properties to native heart tissue, which may be proposed as an appropriate scaffold for heart tissue engineering.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"11 1","pages":"302-313"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91129136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effectiveness of Group Logo-Therapy Program on Existential Anxiety among Patients with Metabolic Syndrome 团体标识疗法对代谢综合征患者存在焦虑的疗效观察

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-05-01 DOI: 10.33945/SAMI/IJABBR.2020.3.5

Masoumeh Alimohammadi, Parviz Sharifi-Daramadi, Shahnaz Noohi

{"title":"Effectiveness of Group Logo-Therapy Program on Existential Anxiety among Patients with Metabolic Syndrome","authors":"Masoumeh Alimohammadi, Parviz Sharifi-Daramadi, Shahnaz Noohi","doi":"10.33945/SAMI/IJABBR.2020.3.5","DOIUrl":"https://doi.org/10.33945/SAMI/IJABBR.2020.3.5","url":null,"abstract":"Metabolic syndrome is one of the most common diseases both in Iran and in the world, which has been widely reported to be associated with anxiety and distress in the metabolic syndrome group. The purpose of the present study was to determine the effectiveness of an educational group logotherapy on existential anxiety in patients with metabolic syndrome. This study was a quasi-experimental pretest-posttest with a control group. The study population consisted of adult women aged between 25 to 60 years old with Metabolic Syndrome that referred to the health center of Semnan County in 2018. The sample included 30 (15 for each group) patients with Metabolic Syndrome who were selected as an available and randomly recruits to each of the groups. Then, the participants in the experimental group participated in 10 sessions of 90 min of Group Logo-Therapy Program, while the control group did not receive any intervention. The instrument for gathering data was the Existential Anxiety Questionnaire. To analyze the data, SPSS.v21 software and statistical tests such as MANCOVA and paired t-test were applied. The results indicated that the group logo-therapy program had a statistically significant impact on components of meaning anxiety and death anxiety, but no difference between control and experimental group in term of loneliness anxiety and responsive anxiety was observed. Also, the results indicated that there was stability at the follow-up stage for death anxiety and loneliness anxiety. According to the results, the group logic training program has been effective in changing some of the variable dimensions of existential anxiety and has increased the ability of individuals to face logic and consequently responsibility for life. And, considering the transient existence of the world in place of insecurity and isolation, it calls for human effort and activity, so it is recommended to use this intervention for people with existential anxiety.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"7 1","pages":"268-282"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88864802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of emamectin benzoate combined with acetamiprid, eforia and hexaflumuron against Tuta absoluta (Lep.: Gelechiidae) 苯甲酸埃维菌素联用对乙酰氨虫啉、依福瑞亚和六氟虫隆对大蠊的防治作用。:麦蛾科)

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-03-01 DOI: 10.33945/sami/ijabbr.2020.2.8

mohsen talleh, H. R. Dastjerdi, Bahram Nasser, A. S. Garjan, K. Jahromi

{"title":"Effects of emamectin benzoate combined with acetamiprid, eforia and hexaflumuron against Tuta absoluta (Lep.: Gelechiidae)","authors":"mohsen talleh, H. R. Dastjerdi, Bahram Nasser, A. S. Garjan, K. Jahromi","doi":"10.33945/sami/ijabbr.2020.2.8","DOIUrl":"https://doi.org/10.33945/sami/ijabbr.2020.2.8","url":null,"abstract":"Tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most destructive pests of tomato in many parts of the world including Iran. The toxicity of emamectin benzoate alone and combined with acetamiprid, eforia (thiamethoxam + lambda-cyhalotrin) and hexaflumuron was evaluated against 2nd instar larvae of Tuta absoluta (Meyrick) under 25 ± 1 °C, the relative humidity of 75 ± 5% and a photoperiod of 16:8 (L:D). Also the mixtures of tested insecticides with emamectin benzoate at LC15:LC15 ratio were evaluated on the activity of general esterase enzyme and total protein content of 2nd instar larvae. After 96 hour, emamectin benzoate had the highest toxicity (LC50 = 0.52 mg A.I./L), followed by acetamiprid (LC50 = 56.39 mg A.I./L) and eforia (LC50 = 312.01 mg A.I./L). Hexaflumuron showed no toxicity against larvae. The combination of emamectin benzoate with acetamiprid at LC50:LC50 ratio produced synergistic effects and all of the other ratios showed additive effects. The emamectin benzoate combined with either eforia or hexaflumuron at all of the ratios produced additive and antagonistic effects, respectively. Esterase activity of larvae increased when emamectin benzoate was mixed with either acetamiprid or eforia, but no significant differences were seen between emamectin benzoate alone and its mixture with hexaflumuron. The combination of emamectin benzoate with tested insecticides significantly reduced the total protein content of larvae. According to the results of this study, the mixtures of acetamiprid and eforia with emamectin benzoate showed higher negative impacts against 2nd instar larvae than emamectin benzoate alone","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"25 1","pages":"180-192"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89383189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

PI3K/Akt/mTOR and CDK4 combined inhibition enhanced apoptosis of thyroid cancer cell lines PI3K/Akt/mTOR和CDK4联合抑制可促进甲状腺癌细胞的凋亡

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-03-01 DOI: 10.33945/sami/ijabbr.2020.2.10

N. Hamidipour, M. Fazeli, M. Hedayati, M. Dehghani, R. Gerami

引用次数: 3

Soybean seeds treated with single walled carbon nanotubes (SwCNTs) showed enhanced drought tolerance during germination 单壁碳纳米管(SwCNTs)处理的大豆种子在萌发过程中表现出增强的抗旱性

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-03-01 DOI: 10.33945/sami/ijabbr.2020.1.2

Wenli Sun, M. H. Shahrajabian, Qi-man Huang

{"title":"Soybean seeds treated with single walled carbon nanotubes (SwCNTs) showed enhanced drought tolerance during germination","authors":"Wenli Sun, M. H. Shahrajabian, Qi-man Huang","doi":"10.33945/sami/ijabbr.2020.1.2","DOIUrl":"https://doi.org/10.33945/sami/ijabbr.2020.1.2","url":null,"abstract":"Drought cause yield loss of soybean production is the major reason to yield losing of soybean. To improve the germination and growth of soybean seeds under drought stress; We studied the effect of the single walled carbon nanotubes (SwCNTs) material in seed germination and the physiological changes occurred under drought condition, performed SwCNTs treatments in soybean (Zhonghuang 35) seeds at PEG drought stress, evaluated the germination, root and shoot length, fresh weight, the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and the contents of maleic dialdehyde (MDA), ascorbic acid (AsA) and H2O2. The results showed that under osmotic potentials of 0, -0.3, -0.6 with PEG 6000, the germination percentage of SwCNTs-treated seeds was higher than the control treatment (SwCNTs-untreated seeds). The fresh weight of SwCNTs-treated seeds were evidently higher than that of the controls under the osmotic potentials of 0, -0.3, -0.6 MPa. The root and shoot length were also longer than control in SwCNTs-treated seeds at 0,-0.3, -0.6 MPa (P","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"82 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88206782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Alfa-Glucosidase inhibitory and antioxidant activity of hexane extract of flowers, leave and stems of Haplophyllum acutifolium DC. and Ferula haussknechtii Wolff ex Rech. 金针叶花、叶、茎己烷提取物α -葡萄糖苷酶抑制及抗氧化活性研究和阿魏(haussknechtii Wolff ex Rech)。

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-03-01 DOI: 10.33945/sami/ijabbr.2020.2.6

M. Zarei, Hero Ghafaryan

{"title":"Alfa-Glucosidase inhibitory and antioxidant activity of hexane extract of flowers, leave and stems of Haplophyllum acutifolium DC. and Ferula haussknechtii Wolff ex Rech.","authors":"M. Zarei, Hero Ghafaryan","doi":"10.33945/sami/ijabbr.2020.2.6","DOIUrl":"https://doi.org/10.33945/sami/ijabbr.2020.2.6","url":null,"abstract":"Background:α-Glucosidase Inhibition can significantly prevent glucose uptake after meal, and helps in controlling of some adverse effects in diabetics. So determination of α-Glucosidase inhibitory effect and antioxidant activity of the Haplophyllum acutifolium and Ferula haussknechtii aerial organs was the aim of this study.Methods:Inhibitory effect of hexane extracts from different organs was investigated in several concentrations at 405 nm wavelength using a microplate reader. Antioxidant activity of hexane extracts of various organs was also measured using DPPH and iron reduction tests. Results;The highest inhibitory activity of F.haussknechtii was observed at the 0.1 g/ml concentration of flower extract (100% inhibition and IC50= 0.1 μg /ml) and the most inhibitory activity of H.acutifolium, was related to the 1 g/ml concentration of flower extract (100% inhibition and IC50 = 10 μg /ml) and leaf extract (100% inhibition and IC50 = 60 μg /ml). Extract of H.acutifolium flower and leaves showed Non-competitive inhibition pattern and F.haussknechtii flower showed mixed (Competitive -Non-Competitive) inhibitory pattern at 0.001 g/ml and exhibit uncompetitive inhibitory pattern at the 0.1 g/ml. The results of antioxidant potential showed EC50 for F.haussknechtii flower and H.acutifolium leaves equalled 2.37 and 0.96 mg/ml, respectively. Conclusions:The hexane extract of the F.haussknechtii flower, and H.acutifolium flower and leaf organ have a significant inhibitory effect on the activity of α-Glucosidase, DPPH free radical scavenging activities and reducing power. So they are good resources for extraction of medicinal compounds to control blood level of glucose after meal, in diabetic patients.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"20 1","pages":"153-164"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85665959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Study of Changes in Activity of Wheat Antioxidant Enzymes under Stress Residue of Imazethapyr Herbicide 异吡唑吡除草剂胁迫残留对小麦抗氧化酶活性的影响

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-03-01 DOI: 10.33945/sami/ijabbr.2020.2.7

R. Fakhari, A. Tobeh, M. Alebrahim, M. Mehdizadeh, H. Khiavi

{"title":"Study of Changes in Activity of Wheat Antioxidant Enzymes under Stress Residue of Imazethapyr Herbicide","authors":"R. Fakhari, A. Tobeh, M. Alebrahim, M. Mehdizadeh, H. Khiavi","doi":"10.33945/sami/ijabbr.2020.2.7","DOIUrl":"https://doi.org/10.33945/sami/ijabbr.2020.2.7","url":null,"abstract":"In order to investigate physiological and biochemical changes of wheat under stress residue of Imazethapyr herbicide (Imazethapyr), an experiment was conducted in a completely randomized design with four replications in greenhouse conditions at university of Mohaghegh Ardebili. The treatments consisted of five dose levels of herbicide Imazethapyr (0, 0.011, 0.022, 0.033 and 0.044 micrograms of herbicide) per kilogram of soil. The analysis of variance showed that the content of the main and auxiliary pigments of leaf, proline, sugar content, protein, activity of catalase enzymes, peroxidase, polyphenol oxidase, root and shoot dry weight were significantly affected by herbicide. The results showed the Imazethapyr herbicide stopped the production of valine leucine and isoleucine amino acids. As a result, the rapid reduction in the volume of these amino acids led to a reduction in protein synthesis in wheat plant. Therefore, the application of doses of 0.011, 0.022, 0.033 and 0.044 micrograms of herbicides decreased 14, 26, 44 and 47 percent of leaf protein content, respectively, compared with control treatment. Further, theapplication of these doses resulted in the reduction of 2.8, 5, 27 and 64% of activity of catalase enzyme, 3.5, 39, 49 and 52% peroxidase enzyme activity and 13, 24, 35 and 46% activity of polyphenol oxidase enzyme, compared with control treatment. The results revealed that Imazethapyr herbicide activates wheat antioxidant enzymes to reduce plant tolerance from damage caused by herbicide residues; therefore, it can be used as a marker or index of herbicide damage rate in physiological research.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"110 1","pages":"165-179"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76104069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of crop residue and nitrogen levels in yield and yield attributing traits of rice under Rice-Wheat Cropping System 作物残茬和氮素水平对稻麦套作制度下水稻产量及产量性状的影响

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-03-01 DOI: 10.33945/sami/ijabbr.2020.2.5

N. Khatri

{"title":"Effect of crop residue and nitrogen levels in yield and yield attributing traits of rice under Rice-Wheat Cropping System","authors":"N. Khatri","doi":"10.33945/sami/ijabbr.2020.2.5","DOIUrl":"https://doi.org/10.33945/sami/ijabbr.2020.2.5","url":null,"abstract":"A 3- years (2015, 2016 and 2017) field study was carried out at National Wheat Research Program, Bhirahawa, Rupandehi, Nepal to evaluate the influence of crop residues and nitrogen levels on rice. The experiment was conducted in split plot design with three replications. Main plots were two crop residue levels (with crop residues of 30 cm wheat stubble and without crop residues) and sub plots consisted of seven nitrogen levels (0, 25, 50, 75, 100, 125 and 150 kg N ha-1). Combined analysis of three years data revealed that crop residue levels did not differ significantly in terms of grain yield; however crop residues incorporation increased the rice grain yield slightly. Significant difference was observed with application of different nitrogen levels in grain yield and yield attributing characters viz; tillers m-2, panicle length, number of filled grains per panicle and thousands grain weight. Rice grain yield was found at increasing rate with increased level of nitrogen @ 150 kg ha-1. Application of nitrogen @ 150 kg ha-1 gave highest grain yield of 4831kg ha-1 which was found at par with nitrogen @ 125 kg ha-1 with grain yield of 4722 kg ha-1. Crop residues with nitrogen @ 125 kg ha-1 resulted in 216 kg ha-1 higher rice grain yield than residues removed treatment. The overall conclusion is that an improved crop residue management with 125 kg N ha-1 increases the grain yield of rice in long run.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"31 1","pages":"146-152"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89054525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Variability and Yield Performance of Sorghum 高粱的遗传变异与产量性能

International journal of Advanced Biological and Biomedical Research Pub Date : 2020-03-01 DOI: 10.33945/sami/ijabbr.2020.2.9

Chalacew Endalemaw, Zigale Semahegn

引用次数: 1