International journal of Advanced Biological and Biomedical Research最新文献_第10页

Evaluation of the Expression of the CK-18 Tumor Marker in Blood Samples of Breast Cancer Patients using Real-Time PCR Real-Time PCR检测乳腺癌患者血液中CK-18肿瘤标志物的表达

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-04-01 DOI: 10.33945/SAMI/IJABBR.2019.2.5

A. Gharibi, Roudabeh Behzadi Andouhjerdi

{"title":"Evaluation of the Expression of the CK-18 Tumor Marker in Blood Samples of Breast Cancer Patients using Real-Time PCR","authors":"A. Gharibi, Roudabeh Behzadi Andouhjerdi","doi":"10.33945/SAMI/IJABBR.2019.2.5","DOIUrl":"https://doi.org/10.33945/SAMI/IJABBR.2019.2.5","url":null,"abstract":"Background: Cytokeratins (CK) are the largest subgroup of interstitial proteins, and their expression changes during the development of cancer. Cytokeratin (CK-18) is one of the major proteins of the epithelial cell skeleton. The expression potential of the CK-18 gene was studied in this research as a molecular biomarker for the diagnosis of breast cancer in the circulatory system using the Real-Time PCR technique. Methods: Blood samples of breast cancer patients and healthy individuals (as the control group) were collected from the Cancer Institute of Imam Khomeini Hospital, Tehran, Iran and their RNA was extracted. In the next step, the cDNA molecule was synthesized using a reverse transcriptase enzyme (RT), and gene-specific primers were designed and synthesized. Then, the expression of CK-18 tumor marker was evaluated by the real-time PCR technique; finally, the data obtained from the cancer samples and the control group was analyzed by the SPSS software. Results: CK-18 expression was observed and measured in the patients, serum .In addition, according to the disease grade, the CK-18 expression was different in the patients, serum. Conclusions: The findings of this research can be used in future studies exploring the mechanism of action of this gene as a suitable target for the treatment of breast cancer.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88951571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression of FGF19 gene as an effective gene for the invasive behavior of cancer cells in patients with colorectal cancer FGF19基因在结直肠癌患者中作为癌细胞侵袭行为有效基因的表达

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-04-01 DOI: 10.33945/SAMI/IJABBR.2019.2.6

R. Yavari, S. Bostanabad, A. Gharibi

{"title":"Expression of FGF19 gene as an effective gene for the invasive behavior of cancer cells in patients with colorectal cancer","authors":"R. Yavari, S. Bostanabad, A. Gharibi","doi":"10.33945/SAMI/IJABBR.2019.2.6","DOIUrl":"https://doi.org/10.33945/SAMI/IJABBR.2019.2.6","url":null,"abstract":"Introduction Colorectal cancer is the second and third most common cancer in women and men respectively. Early diagnosis of illness will reduce pain and costs for patients. In this study, the expression of fgf19 gene in different individuals with colorectal cancer, and also the relationship between the expression of this gene and the degree and stage of cancer cells, will be evaluated.Methods A total of 60 samples were collected by a surgeon from cancerous tissue and healthy marginal tissue of patients with colorectal cancer. Extraction of RNA was accomplished by a Trizol solution. In the next step, cDNA molecule was synthesized using reverse transcriptase enzyme (RT), and gene-specific primers were designed and synthesized. Then the expression of FGF19 gene was evaluated by Real-time PCR technique. Finally, the data obtained from cancerous tissue and healthy marginal tissue were analyzed by spss software.Result The expression of fgf19 in tumor tissue and healthy marginal tissue was measured quantitatively, which increased by 56.7 percent.Conclusion The results of this study indicate that fgf19 as a molecular biomarker plays a significant role in the progression of cancer, and therefore can be considered as a factor in the screening, early detection, prognosis and predictor of the tumor.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80198546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Effect of Eating Even or Odd Number of Dates, on Blood Glucose Level 吃偶数或奇数个枣对血糖水平的影响

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-04-01 DOI: 10.33945/SAMI/IJABBR.2019.2.9

M. Al-Nuaimi, Yossra K. Al-Robaiaay, T. F. Al-Auqbi

{"title":"The Effect of Eating Even or Odd Number of Dates, on Blood Glucose Level","authors":"M. Al-Nuaimi, Yossra K. Al-Robaiaay, T. F. Al-Auqbi","doi":"10.33945/SAMI/IJABBR.2019.2.9","DOIUrl":"https://doi.org/10.33945/SAMI/IJABBR.2019.2.9","url":null,"abstract":"Objectives: There is a common belief among Muslims, to consume dates in odd number rather than even, based on cultural and religious claims; although nobody knows its effect on blood glucose level or other metabolic effects in the body.The aim of our study is to illuminate the changes that affect the 2-hrs postprandial serum glucose level after the consumption of an odd number of dates among healthy young persons and even number. Method: Intervention study was used to compare 2 groups, Fasting glucose levels was measured for all participants; group A (42 participants), who consumed even number of dates all at Tamer-stage, (net weight about 50 grams); and group B, (42 participants), presumed to consume an odd number of dates (net weight about 40 grams). Two-hrs postprandial blood glucose levels were measured altogether. Blood glucose levels were determined and compared as a means. Statistical analyses were performed using SPSS version 22.Result: The fasting serum glucose of group A and B participants were 91.65±13.61 and 93.69±8.79 mg/dl, respectively, with an insignificant statistical difference between groups (P= 0.42327). Subsequently, the 2hrs Postprandial Glucose measurements of group A and B were 99.58±19.56 and 100.33±12.204 respectively; indicated an insignificant statistical difference between groups, (P=0.83553). All the participants were remaining within normal ranges of serum glucose level. Conclusion: There is no difference between ingestion of the odd and even number of dates fleshes from the glycemic point of view on the glucose level in fasting and postprandial states.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80791251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Therapeutic Effect of Statins on Survival of Patients with Gastrointestinal Cancer: a Review 他汀类药物对胃肠道肿瘤患者生存的影响综述

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-03-15 DOI: 10.33945/SAMI/IJABBR.2019.7.203215

A. Olfati, Nasrollah Moradi-kor

{"title":"The Therapeutic Effect of Statins on Survival of Patients with Gastrointestinal Cancer: a Review","authors":"A. Olfati, Nasrollah Moradi-kor","doi":"10.33945/SAMI/IJABBR.2019.7.203215","DOIUrl":"https://doi.org/10.33945/SAMI/IJABBR.2019.7.203215","url":null,"abstract":"Cancer -can significantly have ruining effects on very high of human beings, social, and economic condition. Gastrointestinal (GI) cancer has been reported as one of the most prevalent cancers and the incidence rates of this disorder is increasing across the world. This review explains practical recommendations for the management and improvement of patients with GI cancer by statins. Statins, a group of lipoproteins drugs, are used in medicine to treatment of lipid disorder, hypercholesterolemia reduction and cardiovascular risk. The exact mechanisms of anticancer activity of statins are still unknown. However, in some preclinical and epidemiological studies have reported them to have anticancer properties and therapeutic consequences for GI cancer based on preclinical evidence of their including antihypoxic processes, anti-invasive, induction of growth arrest and proapoptotic, radiosensitizing, angiogenesis and inhibition metastasis. The main objectives of this review paper are: 1. Explain the importance of sickness understanding and prognostic awareness in patients with cell proliferation, induction cell apoptosis, metastasis, angiogenesis, immunity and inflammatory GI cancers receiving statins groups. 2. Explain the importance of statins therapy in low- and middle- risk patients with GI cancers.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"178 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77413652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Investigating the Prevalence of Childhood Asthma Symptoms in Khomein Town, Markazi Province, Iran: A Cross-Sectional Study 调查伊朗马卡齐省霍梅因镇儿童哮喘症状的患病率:一项横断面研究

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-03-01 DOI: 10.26655/IJABBR.2019.3.1

B. Abdolkarimi, Javad Javaheri, I. Sedighi, Mahshid Garmsiri, S. Sedighi

{"title":"Investigating the Prevalence of Childhood Asthma Symptoms in Khomein Town, Markazi Province, Iran: A Cross-Sectional Study","authors":"B. Abdolkarimi, Javad Javaheri, I. Sedighi, Mahshid Garmsiri, S. Sedighi","doi":"10.26655/IJABBR.2019.3.1","DOIUrl":"https://doi.org/10.26655/IJABBR.2019.3.1","url":null,"abstract":"Asthma is the most common cause of recurrent wheezing, cough and dyspnea in childhood. Delay in diagnosis and lack of appropriate treatment can cause sustained changes which decrease respiratory capacity of children in future. Therefore, identifying the symptoms relating to asthma is the key for timely diagnosis and treatment of this disease. This study was done to investigate asthma incidence in khomein and compare it to other cities of Iran susceptible to asthma, including Tehran. The present study was a descriptive cross-sectional one based on standard questionnaire of International Study of Asthma and Allergies in Childhood (ISAAC). For conducting this study, 1621 students of first grade in some primary schools and junior high schools of khomein were selected through nonrandom sampling and census and were evaluated during 2015-2016. Both groups were studied and evaluated in terms of being affected by asthma and its severity (current and previous wheezing ,night-time cough, talking limitation due to coughing or wheezing, exercise-induced wheezing, nocturnal awaking due to cough). Results were analyzed through the chi-square test. The asthma diagnosed in Khomein students by the physician during the study was 3.5% while 73.2% of the children under study had at least one asthma symptom. One eighth of the students under study had severe asthma. Comparing with polluted Tehran and northern cities of Iran, Asthma symptoms incidence was higher in khomein where the humidity and industrial pollution is less than in those cities and the asthma cases diagnosed by physicians were much fewer than expected asthma incidence.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75373201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compare Modeling the effect of Flow Parameters on the Efficiency of Membrane Clarification of Pomegranate Juice Regression Method with Artificial Intelligence Methods 比较模拟流动参数对石榴汁膜澄清效率的影响回归法与人工智能方法

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-03-01 DOI: 10.26655/IJABBR.2019.3.3

M. Poudineh

{"title":"Compare Modeling the effect of Flow Parameters on the Efficiency of Membrane Clarification of Pomegranate Juice Regression Method with Artificial Intelligence Methods","authors":"M. Poudineh","doi":"10.26655/IJABBR.2019.3.3","DOIUrl":"https://doi.org/10.26655/IJABBR.2019.3.3","url":null,"abstract":"Objective: Pomegranate juice is a fruit native to Iran because of attractive color, smell and value of mineral water is popular fruits in the world. Pomegranate juice has more nutritional value is due to a combination of anthocyanins that reduce the risk of diseases such as cancer. Processes Feta membrane such as microfiltration 1 and 2 are used to clarify beer industry. Methods: The advantage of this method compared to traditional methods require less labor, higher yields and the process is low. Making a mathematical model or artificial intelligence to predict the juice clarification process in membrane systems is a valuable tool in the field of membrane science and technology. Results: These models play an important role in the simulation and optimization of transparency in membrane systems in order to achieve an economic and efficient design Play. Many of the older models Polar models, the osmotic pressure and boundary layer model have been used to simulate the performance tuning 1 fruit juices. Conclusion: In this study, we tried to take advantage of four regression system, fuzzy inference, neural networks, and fuzzy-neural adaptive method for predicting the flow of water permeate the membrane pomegranate transparency in the system assessed","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"12 Neurol Sect 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82689654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional quality in rice grain and their relations to grain morphological traits 稻米营养品质及其与稻米形态性状的关系

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-01-01 DOI: 10.26655/IJABBR.2019.1.1

R. Heydari, N. Bagheri, N. B. Jelodar, H. N. Zarrini

引用次数: 0

Analysis of factors affecting the development of an entrepreneurial student 影响创业型学生发展的因素分析

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-01-01 DOI: 10.26655/IJABBR.2019.1.5

Feizollah Monavari Fard, Seyed Alireza Dehghan, Amine Lotfian, L. Salehi

{"title":"Analysis of factors affecting the development of an entrepreneurial student","authors":"Feizollah Monavari Fard, Seyed Alireza Dehghan, Amine Lotfian, L. Salehi","doi":"10.26655/IJABBR.2019.1.5","DOIUrl":"https://doi.org/10.26655/IJABBR.2019.1.5","url":null,"abstract":"The purpose of this paper is to explore the influential factors on entrepreneurial spirit of wood and paper industries students in two universities, namely Agriculture and natural resources faculty of Tehran University and Shahid Rajaiee teacher training University. A sample of 100 students were selected from a target population of 572 students using the Cochran formula. The respondents were asked to provide their answers to a standardized questionnaire. Results indicated that from the students’ perspective such factors as motivation, providence and achievement propensity had the greatest impact on entrepreneurial spirit of the respondents whilst factors like internal control, exception ability and having systematic attitude had the least influence. Moreover concerning the effect of educational and academic factors on entrepreneurial spirit, the most effective items were respectively favorable access to computer and internet and learned and efficient instructors whereas the least effective items considered were degree orientation, students’ apprenticeships in executive environments and education at the university. The findings showed a significant positive relation at the significance level of 0.05 between the level of education and age with the creation of entrepreneurial spirit amongst students. Furthermore a significant positive relation was observed between educational and academic factors, propensity to achievement, risk taking and ambiguity toleration, control source and family with entrepreneurial spirit at the significance level of 0.01. Also the results of multiple regression analysis showed that 79.7%of entrepreneurial spirit (the dependent variable) variance was explained by such independent variables as educational and academic factors, achievement propensity, being innovative, risk taking and ambiguity toleration, control source and family.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91412187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of using radiation processing in nutrition science and their restriction: a review 辐射加工在营养科学中的应用及其限制

International journal of Advanced Biological and Biomedical Research Pub Date : 2019-01-01 DOI: 10.26655/IJABBR.2019.1.3

M. Zarei

引用次数: 3

The Investigation Relation Between Inefficient Attitude and Social Undermining of the Employees of Football Clubs in Kerman 科尔曼足球俱乐部员工工作态度低下与社会破坏关系的调查

International journal of Advanced Biological and Biomedical Research Pub Date : 2018-06-01 DOI: 10.18869/IJABBR.2018.76

Maryam Kafinejad

{"title":"The Investigation Relation Between Inefficient Attitude and Social Undermining of the Employees of Football Clubs in Kerman","authors":"Maryam Kafinejad","doi":"10.18869/IJABBR.2018.76","DOIUrl":"https://doi.org/10.18869/IJABBR.2018.76","url":null,"abstract":"This research has been conducted by the aim of analysis of the relation of inefficient Attitude and social undermining of the employees of football clubs in Kerman. The research method is descriptive-correlative. The statistical population of this research includes all employees of teenage, youth and adult employees of Kerman city in 2017 with the total number of 192 from which 153 replied to the questionnaire. Collecting data from questionnaires, the inefficient Attitude with validity of 0.82 and stability of 0.93 and the social undermining questionnaire with the validity of 0.81 and stability of 0.87 were employed. The analysis of data was done by SPSS20 software, and some descriptive and inferential statics were used such as mean, variance, Pearson and Spearman correlative, and multi-variance linear regression. The result of the research illustrated that there is a direct and significant elation between inefficient Attitude and social undermining of the employees of football clubs in Kerman. Also, there is a direct and significant relation between inefficient Attitude about the performance and inefficient Attitude about social confirmation and social undermining of the employees of football clubs in Kerman. The best predicator of social undermining of employees can be the inefficient Attitude about social confirmation.","PeriodicalId":13887,"journal":{"name":"International journal of Advanced Biological and Biomedical Research","volume":"31 1","pages":"76-86"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74842047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0