International journal of cancer and clinical research最新文献_第2页

Comparative Analysis of Primary Tumour and Matched Metastases in Colorectal Cancer Patients: An Investigation of the Genomic, Proteomic and Post-Transcriptional Regulation Profiles 结直肠癌患者原发肿瘤和匹配转移瘤的比较分析:基因组、蛋白质组学和转录后调控谱的研究

International journal of cancer and clinical research Pub Date : 2022-06-30 DOI: 10.23937/2378-3419/1410180

Karim Hersh Ham, Negm Ola, Ahmad Narmeen, Ilyas Mohammad

{"title":"Comparative Analysis of Primary Tumour and Matched Metastases in Colorectal Cancer Patients: An Investigation of the Genomic, Proteomic and Post-Transcriptional Regulation Profiles","authors":"Karim Hersh Ham, Negm Ola, Ahmad Narmeen, Ilyas Mohammad","doi":"10.23937/2378-3419/1410180","DOIUrl":"https://doi.org/10.23937/2378-3419/1410180","url":null,"abstract":"Introduction: Approximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the possible molecular discrepancies between primary colorectal cancer (pCRC) and their respective metastases. Methods: A total of 22 pairs of pCRC and metastases were tested. Mutation profiling of 26 cancer-associated genes was undertaken in 22/22primary-metastasis tumour pairs using next-generation sequencing, whilst the expression of a panel of six microRNAs (miRNAs) was investigated using qPCR in 21/22 pairs and 22 protein biomarkers was tested using Reverse Phase Protein Array (RPPA) in 20/22 patients’ tumour pairs. Results: Among the primary and metastatic tumours, the mutation rates for the individual genes are as follows: TP53 (86%), APC (44%), KRAS (36%), PIK3CA (9%), SMAD4 (9%), NRAS (9%) and 4% for FBXW7 , BRAF , GNAS and CDH1 . The primary-metastasis tumour mutation status was identical in 54/60 (90%) loci. However, there was discordance in heterogeneity status in 40/58 genetic loci (z-score = 6.246, difference = 0.3793, P < 0.0001). Furthermore, there was loss of concordance in miRNA","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77591355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncology and Reproductive Outcomes Over Sixteen Years of Malignant Ovarian Germ Cell Tumors Treated with Fertility Sparing Surgery 保留生育能力手术治疗恶性卵巢生殖细胞肿瘤16年的肿瘤和生殖预后

International journal of cancer and clinical research Pub Date : 2022-06-30 DOI: 10.23937/2378-3419/1410170

Rungoutok Muangloei, Suprasert Prapaporn

{"title":"Oncology and Reproductive Outcomes Over Sixteen Years of Malignant Ovarian Germ Cell Tumors Treated with Fertility Sparing Surgery","authors":"Rungoutok Muangloei, Suprasert Prapaporn","doi":"10.23937/2378-3419/1410170","DOIUrl":"https://doi.org/10.23937/2378-3419/1410170","url":null,"abstract":"Background: Malignant Ovarian Germ Cell Tumors (MOGCT) are rare and frequently occur in the young reproductive age and the oncologic and reproductive outcome after Fertility-Sparing Surgery (FSS) this disease is still limited. Objective: To evaluate the oncology and reproductive outcome of MOGCT who underwent FSS. Method: All MOGCT who underwent FSS defined as the operation with a preserved uterus and at least one side of the ovary at our institute between January 2005 and December 2020 were retrospective reviews. Results: Sixty-two patients were recruited in this study. The median age was 22-year-old and over 77% were nulliparity. The three most common histology findings were immature teratoma (32.2%), dysgerminoma (24.2%), and yolk sac tumor (24.2%). The distribution of stage was as follows; stage I = 74.8%, stage II = 9.7%, stage III = 11.3% and stage IV = 4.8%. Forty-three (67.7%) patients received adjuvant chemotherapy. With a median follow-up time of 96.3 months, the ten-year progression-free survival and overall survival were 82.4% and 91%, respectively. For reproductive outcomes, 43 patients who received adjuvant chemotherapy, 18 (41.9%) had normal menstruation, and 17 cases (39.5%) resumed menstruation with a median time of four months. About 14 patients who desired to conceive, four cases were pregnant and delivered good outcomes. Only one case was aborted. Therefore, the successful pregnancy rate was 28.6%. Conclusion: The oncology and reproductive outcome of MOGCT treated with FSS were excellent. Many patients showed a long survival time with normal menstruation. However, the obstetric outcome was not quite high.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86041249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoprevention of 1,2 Dimethyl Hydrazine-Induced Colon Tumor in Albino Rat by Meloxicam and its Correlation with Immunoassay of Serum CEA 美洛昔康对1,2 -二甲基肼诱导的白化大鼠结肠肿瘤的化学预防作用及其与血清CEA免疫测定的相关性

International journal of cancer and clinical research Pub Date : 2022-06-30 DOI: 10.23937/2378-3419/1410166

Mohamed Saeed Mahmoud Saeed, Amin Afaf Mosaad, Skander Suzanne William, Hewala Taha Ismail Mahmoud, Saleh Eithar Omer Mohamed, Salih Aisha Mohammed Osman, Al-Qadasi Sabah Ali Mugahed, Badawi Marwan Mustafa, Hamed Mahmoud Assem

{"title":"Chemoprevention of 1,2 Dimethyl Hydrazine-Induced Colon Tumor in Albino Rat by Meloxicam and its Correlation with Immunoassay of Serum CEA","authors":"Mohamed Saeed Mahmoud Saeed, Amin Afaf Mosaad, Skander Suzanne William, Hewala Taha Ismail Mahmoud, Saleh Eithar Omer Mohamed, Salih Aisha Mohammed Osman, Al-Qadasi Sabah Ali Mugahed, Badawi Marwan Mustafa, Hamed Mahmoud Assem","doi":"10.23937/2378-3419/1410166","DOIUrl":"https://doi.org/10.23937/2378-3419/1410166","url":null,"abstract":"Colorectal Cancer (CRC) is among the most common types of cancer in the world. Globally a steadily increasing proportion of elderly people in the world result in approximately 16 million new cases of cancer by the year 2021. Regarding treatment; Meloxicam was shown to prevent the initiation of chemical-induced tumors, and considered as anticancer agent by virtue of its anti-proliferative effect, capacity for cell cycle arrest, and pro-apoptotic effects, also acted as free radical scavenger, in particular superoxide anion oxidation scavenge. The aim of the current study was to clarify much important information on histopathology, histochemistry and immunoassay of CEA tumor marker characteristics of 1,2 DMH-induced colon tumor in albino rat and its relationship with the aberrant crypt mucosa as precursor in colon cancer progression. The study was carried out on 60 male albino rats, animals were divided into 5 groups; A: control group, B: animals received S.C. injections of 20 mg 1,2 DMH/Kg b.w, C: animals received 1,2 DMH with ad libitum access to water and high fat diet, D: animals fed high fat diet and water ad libitum. E: animals received S.C. injections of 1,2 DMH and oral 15 mg/Kg/day meloxicam/0.1 ml saline. Colon tissues from all studied groups were stained applying the following techniques: Hematoxylin & eosin, Alcian blue pH 2.5-acid mucopolysaccharide, Feulgen nuclear staining of DNA, Whole mount staining of colon and Immunoassay of serum CEA. The results confirmed the efficacy of meloxicam inhibiting or delaying growth of aberrant crypt foci in colon. Further research is needed to support presented findings.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86381631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamous Cell Carcinoma Arising from Inverted Papilloma 由内翻性乳头状瘤引起的鳞状细胞癌

International journal of cancer and clinical research Pub Date : 2022-05-28 DOI: 10.23937/2378-3419/1410168

Ruggeri Carlos Santiago, Aguirre Claudina, E. Claudia, Aragon Guillermo Sebastian

{"title":"Squamous Cell Carcinoma Arising from Inverted Papilloma","authors":"Ruggeri Carlos Santiago, Aguirre Claudina, E. Claudia, Aragon Guillermo Sebastian","doi":"10.23937/2378-3419/1410168","DOIUrl":"https://doi.org/10.23937/2378-3419/1410168","url":null,"abstract":"Introduction: Inverted papilloma (IP) may be associated with synchronously or metachronously rhinosinusal squamous cell carcinoma. Objectives: To determine the incidence of squamous cell carcinoma in patients with IP of the paranasal sinuses andlocal control in patients treated for cancer associated with IP. Methods: A descriptive and retrospective study was carried out. All patients who were treated in the rhinosinusology section of the otorhinolaryngology department of the Hospital Italiano de Buenos Aires with histopathology diagnosis of inverted papilloma between January 2005 and December 2021 were included. Those with associated malignant tumors were selected. Results: Sixty three patients with a histopathological diagnosis of inverted papiloma were treated. Five had a synchronous malignant tumors, 4 epidermoid carcinomas and one a verrucous carcinoma and two a metachronous cancer (11.11%). The treatment included surgery, radiotherapy and chemotherapy combined in different schemes according to the indication of the tumor committee. Conclusions: The incidence of malignant tumors associated with inverted papilloma found in our study was 11.11% (7 of 63 patients). Two patients had metachronous and 5 synchronous malignant tumors. In three patients local control of the disease was obtained. The prognosis of epidermoid and verrucous carcinoma associated with inverted papilloma is similar to rhinosinusal squamous carcinomas not associated with inverted papilloma.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79703652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proposed Immunology of the Spontaneous Remission of Acute Myleiod 急性粒细胞增多症自发性缓解的免疫学研究

International journal of cancer and clinical research Pub Date : 2022-04-29 DOI: 10.23937/2378-3419/1410167

Niakan Behzad

引用次数: 0

Treatment of Cancer Patients in the Era of the Covid-19 Pandemic 新冠肺炎大流行时代癌症患者的治疗

International journal of cancer and clinical research Pub Date : 2022-04-18 DOI: 10.23937/2378-3419/1410165

Budi Tulaka, H. Haroen, Linda Rotty, P. Lasut, C. Hendratta

引用次数: 0

Proposed Biology of the Spontaneous Remission of Merkel Cell Carcinoma after Biopsy 默克尔细胞癌活检后自发性缓解的生物学机制

International journal of cancer and clinical research Pub Date : 2022-01-01 DOI: 10.23937/2378-3419/1410172

Niakan Behzad

引用次数: 0

Awareness of Breast Cancer and Practice of Breast Self-Examination Amongst Female Students of a Tertiary Institution in South-South Nigeria 尼日利亚南南一所高等院校女学生对乳腺癌的认识和乳房自我检查的做法

International journal of cancer and clinical research Pub Date : 2022-01-01 DOI: 10.23937/2378-3419/1410175

PW Alabrah, A. Eguvbe, J. Agbo, D. Allagoa

{"title":"Awareness of Breast Cancer and Practice of Breast Self-Examination Amongst Female Students of a Tertiary Institution in South-South Nigeria","authors":"PW Alabrah, A. Eguvbe, J. Agbo, D. Allagoa","doi":"10.23937/2378-3419/1410175","DOIUrl":"https://doi.org/10.23937/2378-3419/1410175","url":null,"abstract":"Background: Breast cancer is the leading cause of cancer deaths presently, representing about 23% of all cancer cases and approximately 18% percent of deaths are attributed to it in Nigeria. It is presently the most prevalent kind of cancer worldwide, with 2.26 million cases reported in 2020. Breast Self-Examination (BSE) is a way to watch for signs of breast cancer. It is a step-by-step process women can use to examine their breasts. By looking at, and feeling their breasts regularly, they can observe abnormal changes. Aim: To assess the awareness of breast cancer and practice of breast self-examination amongst female students in a tertiary institution in South-South Nigeria. Methods: This was a cross-sectional descriptive study done amongst female students of the Federal University Otuoke from January to March 2018. Simple random sampling technique by simple balloting was used in the selection of the respondents until sample size was achieved. Data was collected using a semi-structured questionnaire and were analyzed using SPSS version 23. Results: Most, 406 (95.8%) of the respondents have heard about breast cancer. Just 52.1% of the respondents practice Breast Self-Examination (BSE) and 203 (47.9%) do not. Amongst those that practice BSE, majority 113 (54.1%) do it at least once a month. Amongst those that do not practice BSE, 48 (27.6%) do not consider it important. Age, ethnic group/tribe and the religion of respondents have a statistically significant association with been aware of breast cancer and also with practice of BSE (p > 0.05). Conclusion: Awareness about breast cancer was very high but practice of breast self-examination was on the average. There is need for more education on the risks of the disease in the general population and the need for early detection by practicing BSE and other screening measures.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76676934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant Neural Sheath Tumors of the Head and Neck 头颈部恶性神经鞘肿瘤

International journal of cancer and clinical research Pub Date : 2022-01-01 DOI: 10.23937/2378-3419/1410174

Ruggeri Carlos Santiago, Gonzalez Gabriel Rondón, Ragoni Ana Clara, Fagalde Inés

{"title":"Malignant Neural Sheath Tumors of the Head and Neck","authors":"Ruggeri Carlos Santiago, Gonzalez Gabriel Rondón, Ragoni Ana Clara, Fagalde Inés","doi":"10.23937/2378-3419/1410174","DOIUrl":"https://doi.org/10.23937/2378-3419/1410174","url":null,"abstract":"Introduction: Malignant neural sheath tumors located in the head and neck region are very rare. Surgical treatment if possible is the best option, trying to obtain wide resection margins free of tumor. Objects: To determine the incidence of malignant tumors of neural histology, in relation to nerve tumors originating in the head and neck and description of two clinical cases. Methods: A retrospective and descriptive study was carried out by reviewing the electronic medical records of all patients who were diagnosed and treated for neural histology tumors originating in the head and neck, between March 1998 and December 2021. Results: Eighteen patients were treated for nerve tumors originating in the head and neck. The benign tumors of neural origin were located in the nasal cavity and paranasal sinuses (6/18) and in the neck (10/18). Four originated from the facial nerve in the parotid, three from the cervical sympathetic nerve in the retro styloid carotid space, one in the submaxillary region, and two in the supraclavicular fossa. The incidence of malignant nerve tumors was 11.11% (2/18). Conclusions: The incidence of malignant neural sheath tumors in our study was 11.11%. Most neural sheath tumors are benign and can cause functional alterations due to compression of the nerve of origin or adjacent structures, but when the neoplasm grows rapidly malignancy should be suspected. The main treatment is surgery trying to obtain wide tumor-free margins.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75054946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucosal Reconstruction with Nasal Lateral Wall Flap after Rhinectomy: Two Case Reports 鼻切除术后鼻侧壁皮瓣重建粘膜2例报告

International journal of cancer and clinical research Pub Date : 2021-12-31 DOI: 10.23937/2378-3419/1410164

Zamar Claudia Esper, Pita Elián García, Cajelli Ana Laura, Ruggeri Carlos Santiago

引用次数: 0