Squamous Cell Carcinoma Arising from Inverted Papilloma

Introduction: Inverted papilloma (IP) may be associated with synchronously or metachronously rhinosinusal squamous cell carcinoma. Objectives: To determine the incidence of squamous cell carcinoma in patients with IP of the paranasal sinuses andlocal control in patients treated for cancer associated with IP. Methods: A descriptive and retrospective study was carried out. All patients who were treated in the rhinosinusology section of the otorhinolaryngology department of the Hospital Italiano de Buenos Aires with histopathology diagnosis of inverted papilloma between January 2005 and December 2021 were included. Those with associated malignant tumors were selected. Results: Sixty three patients with a histopathological diagnosis of inverted papiloma were treated. Five had a synchronous malignant tumors, 4 epidermoid carcinomas and one a verrucous carcinoma and two a metachronous cancer (11.11%). The treatment included surgery, radiotherapy and chemotherapy combined in different schemes according to the indication of the tumor committee. Conclusions: The incidence of malignant tumors associated with inverted papilloma found in our study was 11.11% (7 of 63 patients). Two patients had metachronous and 5 synchronous malignant tumors. In three patients local control of the disease was obtained. The prognosis of epidermoid and verrucous carcinoma associated with inverted papilloma is similar to rhinosinusal squamous carcinomas not associated with inverted papilloma.