International Journal of Alzheimer's Disease最新文献_第6页

The Acceptability and Usefulness of Cognitive Stimulation Therapy for Older Adults with Dementia: A Narrative Review. 认知刺激疗法对老年痴呆患者的可接受性和有效性:一项叙述性回顾。

International Journal of Alzheimer's Disease Pub Date : 2016-01-01 Epub Date: 2016-07-11 DOI: 10.1155/2016/5131570

Hui Moon Toh, Shazli Ezzat Ghazali, Ponnusamy Subramaniam

{"title":"The Acceptability and Usefulness of Cognitive Stimulation Therapy for Older Adults with Dementia: A Narrative Review.","authors":"Hui Moon Toh, Shazli Ezzat Ghazali, Ponnusamy Subramaniam","doi":"10.1155/2016/5131570","DOIUrl":"https://doi.org/10.1155/2016/5131570","url":null,"abstract":"Cognitive stimulation therapy (CST) is an evidence-based therapy for individuals with mild-to-moderate dementia. Past reviews have only synthesized outcomes obtained through quantitative study which does not fully represent the understanding on the acceptability and usefulness of CST. Therefore, the present review aims to integrate outcomes obtained from both quantitative and qualitative studies to provide a deeper understanding on the acceptability and usefulness of CST for older adults with dementia. Findings of literature were retrieved from searches of computerized databases in relation to CST for people with dementia. Literatures were selected according to selection criteria outlined. Results obtained in previous studies pertaining to the effects of CST were discussed in relation to variables such as cognitive function, quality of life, and family caregivers' wellbeing. The review also explores the use of CST in different cultural context, the perception on its effectiveness, and individualized CST (iCST). There is considerable evidence obtained through quantitative and qualitative studies on the usefulness and acceptability of CST for older adults with dementia. Recommendations for future research are provided to strengthen the evidence of CST's effectiveness. ","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2016 ","pages":"5131570"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5131570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34722353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Family Dynamics and Personal Strengths among Dementia Caregivers in Argentina. 阿根廷痴呆症照护者的家庭动态和个人优势。

International Journal of Alzheimer's Disease Pub Date : 2016-01-01 Epub Date: 2016-06-20 DOI: 10.1155/2016/2386728

Aaliah G Elnasseh, Michael A Trujillo, Silvina Victoria Peralta, Miriam E Stolfi, Eliana Morelli, Paul B Perrin, Juan Carlos Arango-Lasprilla

{"title":"Family Dynamics and Personal Strengths among Dementia Caregivers in Argentina.","authors":"Aaliah G Elnasseh, Michael A Trujillo, Silvina Victoria Peralta, Miriam E Stolfi, Eliana Morelli, Paul B Perrin, Juan Carlos Arango-Lasprilla","doi":"10.1155/2016/2386728","DOIUrl":"10.1155/2016/2386728","url":null,"abstract":"This study examined whether healthier family dynamics were associated with higher personal strengths of resilience, sense of coherence, and optimism among dementia caregivers in Argentina. Caregivers are usually required to assist individuals with dementia, and family members have typically fulfilled that role. Personal strengths such as resilience, sense of coherence, and optimism have been shown to protect caregivers from some of the negative experiences of providing care, though the family-related variables associated with these personal strengths are largely unknown. Hierarchical multiple regressions investigated the extent to which family dynamics variables are associated with each of the caregiver personal strengths after controlling for demographic and caregiver characteristics. A sample of 105 caregivers from Argentina completed a set of questionnaires during a neurologist visit. Family dynamics explained 32% of the variance in resilience and 39% of the variance in sense of coherence. Greater family empathy and decreased family problems were uniquely associated with higher resilience. Greater communication and decreased family problems were uniquely associated with higher sense of coherence. Optimism was not found to be significantly associated with family dynamics. These results suggest that caregiver intervention research focused on the family may help improve caregiver personal strengths in Argentina and other Latin American countries. ","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2016 ","pages":"2386728"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34668131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Driving Competence in Mild Dementia with Lewy Bodies: In Search of Cognitive Predictors Using Driving Simulation 轻度路易体痴呆患者的驾驶能力:利用驾驶模拟寻找认知预测因子

International Journal of Alzheimer's Disease Pub Date : 2015-12-02 DOI: 10.1155/2015/806024

Stephanie Yamin, A. Stinchcombe, S. Gagnon

引用次数: 24

PET Imaging of Epigenetic Influences on Alzheimer's Disease 表观遗传学对阿尔茨海默病影响的PET成像

International Journal of Alzheimer's Disease Pub Date : 2015-10-22 DOI: 10.1155/2015/575078

P. J. Couto, R. Millis

引用次数: 15

Evaluating Adult's Competency: Application of the Competency Assessment Process. 成人胜任力之评估:胜任力评估程序之应用。

International Journal of Alzheimer's Disease Pub Date : 2015-01-01 Epub Date: 2015-07-15 DOI: 10.1155/2015/753873

Dominique Giroux, Sylvie Tétreault, Marie-Pier Landry

{"title":"Evaluating Adult's Competency: Application of the Competency Assessment Process.","authors":"Dominique Giroux, Sylvie Tétreault, Marie-Pier Landry","doi":"10.1155/2015/753873","DOIUrl":"https://doi.org/10.1155/2015/753873","url":null,"abstract":"Competency assessment of adults with cognitive impairment or mental illness is a complex process that can have significant consequences for their rights. Some models put forth in the scientific literature have been proposed to guide health and social service professionals with this assessment process, but none of these appear to be complete. A new model, the Competency Assessment Process (CAP), was presented and validated in other studies. This paper adds to this corpus by presenting both the CAP model and the results of a survey given to health and social service professionals on its practical application in their clinical practice. The survey was administered to 35 participants trained in assessing competency following the CAP model. The results show that 40% of participants use the CAP to guide their assessment and the majority of those who do not yet use it plan to do so in the future. A large majority of participants consider this to be a relevant model and believe that all interdisciplinary teams should use it. These results support the relevance of the CAP model. Further research is planned to continue the study of the application of CAP in healthcare facilities. ","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2015 ","pages":"753873"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/753873","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33908720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Auditory and Visual Cues for Topic Maintenance with Persons Who Exhibit Dementia of Alzheimer's Type. 阿尔茨海默氏型痴呆患者话题维持的听觉和视觉提示。

International Journal of Alzheimer's Disease Pub Date : 2015-01-01 Epub Date: 2015-06-10 DOI: 10.1155/2015/126064

Amy F Teten, Paul A Dagenais, Mary J Friehe

引用次数: 0

Inhibitory effects of sodium arsenite and acacia honey on acetylcholinesterase in rats. 亚砷酸钠和金合欢蜂蜜对大鼠乙酰胆碱酯酶的抑制作用。

International Journal of Alzheimer's Disease Pub Date : 2015-01-01 Epub Date: 2015-03-02 DOI: 10.1155/2015/903603

Aliyu Muhammad, Oyeronke A Odunola, Michael A Gbadegesin, Abdullahi B Sallau, Uche S Ndidi, Mohammed A Ibrahim

{"title":"Inhibitory effects of sodium arsenite and acacia honey on acetylcholinesterase in rats.","authors":"Aliyu Muhammad, Oyeronke A Odunola, Michael A Gbadegesin, Abdullahi B Sallau, Uche S Ndidi, Mohammed A Ibrahim","doi":"10.1155/2015/903603","DOIUrl":"https://doi.org/10.1155/2015/903603","url":null,"abstract":"This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats. Male Wistar albino rats in four groups of five rats each were treated with distilled water, sodium arsenite (5 mg/kg body weight), Acacia honey (20% v/v), and sodium arsenite and Acacia honey, daily for one week. The sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the brain with the combined treatment being more potent. Furthermore, sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the serum. Strong correlation was observed between the sodium and calcium ion levels with acetylcholinesterase activity in the brain and serum. The gas chromatography mass spectrometry analysis of Acacia honey revealed the presence of a number of bioactive compounds such as phenolics, sugar derivatives, and fatty acids. These findings suggest that sodium arsenite and/or Acacia honey modulates acetylcholinesterase activities which may be explored in the management of Alzheimer's diseases but this might be counteracted by the hepatotoxicity induced by arsenics. ","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2015 ","pages":"903603"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/903603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33172085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats. 二甲双胍对糖尿病大鼠记忆损伤和脑组织氧化损伤的有益作用。

International Journal of Alzheimer's Disease Pub Date : 2015-01-01 Epub Date: 2015-02-24 DOI: 10.1155/2015/493729

S Mojtaba Mousavi, Saeed Niazmand, Mahmoud Hosseini, Zarha Hassanzadeh, Hamid Reza Sadeghnia, Farzaneh Vafaee, Zakieh Keshavarzi

{"title":"Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats.","authors":"S Mojtaba Mousavi, Saeed Niazmand, Mahmoud Hosseini, Zarha Hassanzadeh, Hamid Reza Sadeghnia, Farzaneh Vafaee, Zakieh Keshavarzi","doi":"10.1155/2015/493729","DOIUrl":"https://doi.org/10.1155/2015/493729","url":null,"abstract":"Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods. The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met). Groups 3-6 were treated by 100, 200, and 400 mg/kg of the extract or metformin, respectively, for 6 weeks (orally). Results. In passive avoidance test, the latency to enter the dark compartment in Diabetic group was lower than that of Control group (P < 0.01). In Dia-Ext 100, Dia-Ext 200, and Dia-Ext 400 and Metformin groups, the latencies were higher than those of Diabetic group (P < 0.01). Lipid peroxides levels (reported as malondialdehyde, MDA, concentration) in the brain of Diabetic group were higher than Control (P < 0.001). Treatment by all doses of the extract and metformin decreased the MDA concentration (P < 0.01). Conclusions. The results of present study showed that metformin and the hydroalcoholic extract of Teucrium polium prevent diabetes-induced memory deficits in rats. Protection against brain tissues oxidative damage might have a role in the beneficial effects of the extract and metformin. ","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2015 ","pages":"493729"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/493729","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33161885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics. 维生素D和阿尔茨海默病:从神经认知到治疗。

International Journal of Alzheimer's Disease Pub Date : 2015-01-01 Epub Date: 2015-08-17 DOI: 10.1155/2015/192747

Anindita Banerjee, Vineet Kumar Khemka, Anirban Ganguly, Debashree Roy, Upasana Ganguly, Sasanka Chakrabarti

{"title":"Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics.","authors":"Anindita Banerjee, Vineet Kumar Khemka, Anirban Ganguly, Debashree Roy, Upasana Ganguly, Sasanka Chakrabarti","doi":"10.1155/2015/192747","DOIUrl":"https://doi.org/10.1155/2015/192747","url":null,"abstract":"Alzheimer's disease (AD), the major cause of dementia worldwide, is characterized by progressive loss of memory and cognition. The sporadic form of AD accounts for nearly 90% of the patients developing this disease. The last century has witnessed significant research to identify various mechanisms and risk factors contributing to the complex etiopathogenesis of AD by analyzing postmortem AD brains and experimenting with animal and cell culture based models. However, the treatment strategies, as of now, are only symptomatic. Accumulating evidences suggested a significant association between vitamin D deficiency, dementia, and AD. This review encompasses the beneficial role of vitamin D in neurocognition and optimal brain health along with epidemiological evidence of the high prevalence of hypovitaminosis D among aged and AD population. Moreover, disrupted signaling, altered utilization of vitamin D, and polymorphisms of several related genes including vitamin D receptor (VDR) also predispose to AD or AD-like neurodegeneration. This review explores the relationship between this gene-environmental influence and long term vitamin D deficiency as a risk factor for development of sporadic AD along with the role and rationale of therapeutic trials with vitamin D. It is, therefore, urgently warranted to further establish the role of this potentially neuroprotective vitamin in preventing and halting progressive neurodegeneration in AD patients. ","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2015 ","pages":"192747"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/192747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33988453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 74

Neprilysin is poorly expressed in the prefrontal cortex of aged dogs with cognitive dysfunction syndrome. Neprilysin在患有认知功能障碍综合征的老年狗的前额皮质中表达不良。

International Journal of Alzheimer's Disease Pub Date : 2014-01-01 Epub Date: 2014-01-06 DOI: 10.1155/2014/483281

Jesús Canudas, Daniel Insua, Leticia Sarasa, Angela González-Martínez, María Luisa Suárez, Germán Santamarina, Pedro Pesini, Manuel Sarasa

{"title":"Neprilysin is poorly expressed in the prefrontal cortex of aged dogs with cognitive dysfunction syndrome.","authors":"Jesús Canudas, Daniel Insua, Leticia Sarasa, Angela González-Martínez, María Luisa Suárez, Germán Santamarina, Pedro Pesini, Manuel Sarasa","doi":"10.1155/2014/483281","DOIUrl":"https://doi.org/10.1155/2014/483281","url":null,"abstract":"Neprilysin (NEP) is the principal amyloid β (A β ) degrading peptidase; this activity may protect against Alzheimer's disease (AD), the most important age-related neurodegenerative process. The aim of this work was to analyze NEP mRNA expression in the frontal cortex of dogs with and without canine cognitive dysfunction syndrome (CDS), which is considered a natural model for AD. Expression of canine cerebral NEP mRNA was assessed by RT-PCR followed by qPCR in young, aged-cognitively unimpaired (CU), and aged-cognitively impaired (CI) dogs. On average, aged-CI dogs showed 80% (P < 0.01) lower expression levels of NEP mRNA than their aged-CU counterparts. Furthermore, the standard deviation of the qPCR measurements was more than 6 times higher in the cognitively healthy animals (young and aged-CU) than in the aged-CI group. Another interesting find is the determination of a positive correlation between NEP expression and the number of cholinergic neurons in basal telencephalon, indicating a probable connection between both events in these types of neurodegeneration processes. These results suggest that high expression levels of NEP might be a protective factor for canine CDS and, most likely, for other A β -associated neurodegenerative diseases, such as AD. ","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2014 ","pages":"483281"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/483281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32102290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7