International Journal of Alzheimer's Disease最新文献_第5页

Corrigendum to "Alzheimer's Disease Dementia as the Diagnosis Best Supported by the Cerebrospinal Fluid Biomarkers: Difference in Cut-Off Levels from Thai Experience". 对“阿尔茨海默病痴呆症作为脑脊液生物标志物最支持的诊断:泰国经验的截止水平差异”的更正。

International Journal of Alzheimer's Disease Pub Date : 2017-01-01 Epub Date: 2017-04-02 DOI: 10.1155/2017/2647086

Vorapun Senanarong, Nobdham Sivasariyanonda, Leatchai Wachirutmanggur, Niphon Poungvarin, Chatchawan Rattanabannakit, Nuttapol Aoonkaew, Suthipol Udompunthurak

引用次数: 0

Diagnostic Accuracy of the Overlapping Infinity Loops, Wire Cube, and Clock Drawing Tests for Cognitive Impairment in Mild Cognitive Impairment and Dementia. 重叠无限循环、线立方体和时钟绘制测试对轻度认知障碍和痴呆症认知障碍的诊断准确性。

International Journal of Alzheimer's Disease Pub Date : 2017-01-01 Epub Date: 2017-01-31 DOI: 10.1155/2017/5289239

Thammanard Charernboon

引用次数: 0

Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia. 重度抑郁症状增加轻度痴呆患者3年死亡率

International Journal of Alzheimer's Disease Pub Date : 2017-01-01 Epub Date: 2017-04-06 DOI: 10.1155/2017/7482094

Jindong Ding Petersen, Frans Boch Waldorff, Volkert Dirk Siersma, Thien Kieu Thi Phung, Anna Carina Klara Magdalena Bebe, Gunhild Waldemar

{"title":"Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia.","authors":"Jindong Ding Petersen, Frans Boch Waldorff, Volkert Dirk Siersma, Thien Kieu Thi Phung, Anna Carina Klara Magdalena Bebe, Gunhild Waldemar","doi":"10.1155/2017/7482094","DOIUrl":"https://doi.org/10.1155/2017/7482094","url":null,"abstract":"Depression and dementia are commonly concurrent and are both associated with increased mortality among older people. However, little is known about whether home-dwelling patients newly diagnosed with mild dementia coexisting with depressive symptoms have excess mortality. We conducted a post hoc analysis based on data from the Danish Alzheimer's Intervention Study of 330 individuals who were diagnosed with mild dementia within the past 12 months. Thirty-four patients were identified with major depressive symptoms (MD-S) at baseline. During the 3-year follow-up period, 56 patients died, and, among them, 12 were with MD-S at baseline. Multivariable analysis adjusting for the potential confounders (age, sex, smoking status, alcohol consumption, education, BMI, household status, MMSE, CCI, QoL-AD, NPIQ, ADSC-ADL, medication, and RCT allocation) showed that patients with MD-S had a 2.5-fold higher mortality as compared to the patients without or with only few depressive symptoms. Our result revealed that depression is possibly associated with increased mortality in patients with mild dementia. Given that depression is treatable, screening for depression and treatment of depression can be important already in the earliest stage of dementia to reduce mortality.","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2017 ","pages":"7482094"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7482094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34979181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease. 双转基因淀粉样蛋白-β前体蛋白/早老素2小鼠阿尔茨海默病模型的早期情境恐惧记忆缺陷

International Journal of Alzheimer's Disease Pub Date : 2017-01-01 Epub Date: 2017-11-27 DOI: 10.1155/2017/8584205

Yasushi Kishimoto, Kai Fukumoto, Mika Nagai, Ayaka Mizuguchi, Yuiko Kobashi

{"title":"Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease.","authors":"Yasushi Kishimoto, Kai Fukumoto, Mika Nagai, Ayaka Mizuguchi, Yuiko Kobashi","doi":"10.1155/2017/8584205","DOIUrl":"https://doi.org/10.1155/2017/8584205","url":null,"abstract":"Presenilin 1 and presenilin 2 (PS1 and PS2) play a critical role in γ-secretase-mediated cleavage of amyloid-β precursor protein (APP) and the subsequent generation of β-amyloid peptides. The purpose of the present study was to test whether PS2 mutation accelerates the onset of contextual fear memory deficits in a mouse model of AD that expresses a mutation (K670N/M671L) of the human APP with the Swedish mutation (Tg2576 mice). In the present study, an APP/PS2 double-transgenic mouse model (PS2Tg2576) was generated by crossbreeding transgenic mice carrying the human mutant PS2 (N141I) with Tg2576 mice. Contextual fear conditioning was tested in PS2Tg2576 mice aged 3, 4, 6, and 10-12 months. PS2Tg2576 mice showed a tendency of lower freezing behavior as early as 3 months of age, but significant memory impairment was observed from the age of 4 months. The cognitive impairment was more prominent at ages of 6 and 10-12 months. In contrast, Tg2576 mice aged 3 and 4 months exhibited successful acquisition of contextual fear learning, but Tg2576 mice aged 6 months or older showed significantly impaired fear memory. These results show that PS2 mutation significantly accelerates the onset of fear memory deficits in the APP AD model mice.","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2017 ","pages":"8584205"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8584205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35736521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Association between the APOE ε4 Allele and Late-Onset Alzheimer's Disease in an Ecuadorian Mestizo Population. 厄瓜多尔混血人群APOE ε4等位基因与晚发性阿尔茨海默病的关系

International Journal of Alzheimer's Disease Pub Date : 2017-01-01 Epub Date: 2017-12-04 DOI: 10.1155/2017/1059678

Stefany Montufar, Cristian Calero, Rodrigo Vinueza, Patricio Correa, Andrea Carrera-Gonzalez, Franklin Villegas, Germania Moreta, Rosario Paredes

{"title":"Association between the APOE ε4 Allele and Late-Onset Alzheimer's Disease in an Ecuadorian Mestizo Population.","authors":"Stefany Montufar, Cristian Calero, Rodrigo Vinueza, Patricio Correa, Andrea Carrera-Gonzalez, Franklin Villegas, Germania Moreta, Rosario Paredes","doi":"10.1155/2017/1059678","DOIUrl":"https://doi.org/10.1155/2017/1059678","url":null,"abstract":"Alzheimer's disease (AD) is the most common neurodegenerative disease. It has two main pathological hallmarks: amyloid plaques and neurofibrillary tangles. The APOE ε4 allele has been recognized as the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD) in several populations worldwide, yet the risk varies by region and ethnicity. The aims of this study were to describe APOE allele and genotype frequencies and examine the relationship between the APOE ε4 allele and LOAD risk in an Ecuadorian Mestizo population. We carried out a case-control study comprising 56 individuals clinically diagnosed with probable AD (≥65 years of age) and 58 unrelated healthy control subjects (≥65 years of age). Genotyping was performed using the real-time PCR method. Our data showed that allelic and genotypic frequencies follow the trends observed in most worldwide populations. We also found a high-risk association between APOE ε4 allele carriers and LOAD (OR = 7.286; 95% CI = 2.824-18.799; p < 0.001). Therefore, we concluded that APOE ε4 must be considered an important genetic risk factor for LOAD in the Ecuadorian Mestizo population. Additionally, we suggest that in mixed populations the effects of admixture and ethnic identity should be differentiated when evaluating genetic contributions to Alzheimer's disease risk.","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2017 ","pages":"1059678"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1059678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35750318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42. 膳食姜黄素和固体脂质姜黄素颗粒暴露于Aβ42后对培养小鼠神经母细胞瘤细胞的神经保护作用比较。

International Journal of Alzheimer's Disease Pub Date : 2017-01-01 Epub Date: 2017-04-16 DOI: 10.1155/2017/4164872

Panchanan Maiti, Gary L Dunbar

{"title":"Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42.","authors":"Panchanan Maiti, Gary L Dunbar","doi":"10.1155/2017/4164872","DOIUrl":"https://doi.org/10.1155/2017/4164872","url":null,"abstract":"Aggregation of amyloid beta protein (Aβ) and phosphorylated tau (p-Tau) plays critical roles in pathogenesis of Alzheimer's disease (AD). As an antiamyloid natural polyphenol, curcumin (Cur) has a potential role in prevention of neurodegeneration in AD. However, due to limited absorption of the dietary Cur, the solid lipid Cur particles (SLCP) have been suggested as being more effective for AD therapy. In the present study, we compared the role of dietary Cur and SLCP on oxidative stress, neuronal death, p-Tau level, and certain cell survival markers in vitro, after exposure to Aβ42. Mouse neuroblastoma cells were exposed to Aβ42 for 24 h and incubated with or without dietary Cur and/or SLCP. Reactive oxygen species (ROS), apoptotic cell death, p-Tau, and tau kinase (including GSK-3β and cell survival markers, such as total Akt, phosphorylated Akt, and PSD95 levels) were investigated. SLCP showed greater permeability than dietary Cur in vitro, decreased ROS production, and prevented apoptotic death. In addition, SLCP also inhibited p-Tau formation and significantly decreased GSK-3β levels. Further, the cell survival markers, such as total Akt, p-Akt, and PSD95 levels, were more effectively maintained by SLCP than dietary Cur in Aβ42 exposed cells. Therefore, SLCP may provide greater neuroprotection than dietary Cur in Alzheimer's disease.","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2017 ","pages":"4164872"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/4164872","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35047972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Comparing Cognitive Profiles of Licensed Drivers with Mild Alzheimer's Disease and Mild Dementia with Lewy Bodies 轻度阿尔茨海默病和轻度痴呆伴路易体驾照驾驶员的认知特征比较

International Journal of Alzheimer's Disease Pub Date : 2016-09-27 DOI: 10.1155/2016/6542962

Stephanie Yamin, A. Stinchcombe, S. Gagnon

引用次数: 5

Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer's Disease versus Age-Matched Controls: A Presymptomatic Stage Study 与年龄匹配的对照组相比，阿尔茨海默病转基因小鼠模型中表型星形细胞标志物的表达增加:一项症状前阶段的研究

International Journal of Alzheimer's Disease Pub Date : 2016-09-08 DOI: 10.1155/2016/5696241

Aurélie Doméné, C. Cavanagh, G. Page, S. Bodard, C. Klein, C. Delarasse, S. Chalon, S. Krantic

{"title":"Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer's Disease versus Age-Matched Controls: A Presymptomatic Stage Study","authors":"Aurélie Doméné, C. Cavanagh, G. Page, S. Bodard, C. Klein, C. Delarasse, S. Chalon, S. Krantic","doi":"10.1155/2016/5696241","DOIUrl":"https://doi.org/10.1155/2016/5696241","url":null,"abstract":"Recent mouse studies of the presymptomatic stage of Alzheimer's disease (AD) have suggested that proinflammatory changes, such as glial activation and cytokine induction, may occur already at this early stage through unknown mechanisms. Because TNFα contributes to increased Aβ production from the Aβ precursor protein (APP), we assessed a putative correlation between APP/Aβ and TNFα during the presymptomatic stage as well as early astrocyte activation in the hippocampus of 3-month-old APPswe/PS1dE9 mice. While Western blots revealed significant APP expression, Aβ was not detectable by Western blot or ELISA attesting that 3-month-old, APPswe/PS1dE9 mice are at a presymptomatic stage of AD-like pathology. Western blots were also used to show increased GFAP expression in transgenic mice that positively correlated with both TNFα and APP, which were also mutually correlated. Subregional immunohistochemical quantification of phenotypic (GFAP) and functional (TSPO) markers of astrocyte activation indicated a selective and significant increase in GFAP-immunoreactive (IR) cells in the dentate gyrus of APPswe/PS1dE9 mice. Our data suggest that subtle morphological and phenotypic alterations, compatible with the engagement of astrocyte along the activation pathway, occur in the hippocampus already at the presymptomatic stage of AD.","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77682010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Medical Students' Perceptions of Dementia after Participation in Poetry Workshop with People with Dementia 与失智症患者参与诗歌工作坊后医学生对失智症的认知

International Journal of Alzheimer's Disease Pub Date : 2016-02-09 DOI: 10.1155/2016/2785105

Alaina J. Garrie, Shruti Goel, Martin Forsberg

{"title":"Medical Students' Perceptions of Dementia after Participation in Poetry Workshop with People with Dementia","authors":"Alaina J. Garrie, Shruti Goel, Martin Forsberg","doi":"10.1155/2016/2785105","DOIUrl":"https://doi.org/10.1155/2016/2785105","url":null,"abstract":"Purpose. Researchers assessed whether medical students' participation in a poetry workshop with people with Alzheimer's disease and related dementias (ADRD) affected their attitudes towards persons with ADRD. Objective. To add to the growing body of research summarizing the impact of nonclinical interventions on medical students' perspectives about people with ADRD. Design. Researchers used dementia attitudes scale (DAS) and interpretive phenomenological analysis (IPA) to analyze participants' attitudes. Setting. Osteopathic medical school and dementia care unit in the state of New Jersey. Participants. Eleven out of fourteen medical students completed the study. Measurements. Emerging themes were classified from the postintervention semistructured interviews and descriptive statistics were used to compare the preintervention to postintervention DAS. Results. Researchers found statistically significant differences between preintervention and postintervention DAS scores. Study participants scored a preintervention DAS mean, 107.09 (SD = 11.85), that changed positively and significantly to the postintervention DAS mean, 121.82 (SD = 10.38). DAS subdomains, “comfort” (P = 0.002) and “knowledge” (P = 0.01), and eleven of the twenty DAS items underwent a positive and statistically significant shift from preintervention to postintervention. IPA of the interviews yielded five primary and five secondary themes, supporting the measured statistical outcomes. Conclusion. Medical students' participation in a poetry workshop, with people with ADRD, positively impacts their attitudes.","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83759492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Nanoscale Extracellular Vesicle Analysis in Alzheimer's Disease Diagnosis and Therapy. 纳米尺度细胞外囊泡分析在阿尔茨海默病诊断和治疗中的应用。

International Journal of Alzheimer's Disease Pub Date : 2016-01-01 Epub Date: 2016-04-26 DOI: 10.1155/2016/8053139

Pete Heinzelman, Tina Bilousova, Jesus Campagna, Varghese John

{"title":"Nanoscale Extracellular Vesicle Analysis in Alzheimer's Disease Diagnosis and Therapy.","authors":"Pete Heinzelman, Tina Bilousova, Jesus Campagna, Varghese John","doi":"10.1155/2016/8053139","DOIUrl":"https://doi.org/10.1155/2016/8053139","url":null,"abstract":"Diagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as \"windows into the brain\" can predict incidence of Alzheimer's Disease (AD) many years prior to onset. Beyond diagnostics, bloodborne neuronal nsEVs analysis may have substantial translational impact by revealing mechanisms of AD pathology; such knowledge could enlighten new drug targets and lead to new therapeutic approaches. The potential to establish three-dimensional nsEV analysis methods that characterize highly purified bloodborne nsEV populations in method of enrichment, cell type origin, and protein or RNA abundance dimensions could bring this promise to bear by yielding nsEV \"omics\" datasets that uncover new AD biomarkers and enable AD therapeutic development. In this review we provide a survey of both the current status of and new developments on the horizon in the field of neuronal nsEV analysis. This survey is supplemented by a discussion of the potential to translate such neuronal nsEV analyses to AD clinical diagnostic applications and drug development. ","PeriodicalId":13802,"journal":{"name":"International Journal of Alzheimer's Disease","volume":"2016 ","pages":"8053139"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8053139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34572372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6