International Journal of Angiology最新文献_第7页

Postoperative Intimal Hyperplasia: Review from My Research. 术后内膜增生：我的研究回顾

IF 0.5

International Journal of Angiology Pub Date : 2024-02-05 eCollection Date: 2024-09-01 DOI: 10.1055/s-0044-1779300

Mitsuhiro Yamamura

{"title":"Postoperative Intimal Hyperplasia: Review from My Research.","authors":"Mitsuhiro Yamamura","doi":"10.1055/s-0044-1779300","DOIUrl":"10.1055/s-0044-1779300","url":null,"abstract":"Postoperative intimal hyperplasia is the major cause of the vein graft occlusion. It is very important to establish an animal model for the start of research. After my vascular surgery residency in Japan, I started my research work on postoperative intimal hyperplasia at the University of Wisconsin-Madison. My research showed that endothelial injury and monocyte infiltration is the key for postoperative intimal hyperplasia, which is very similar to Ross' pathogenesis of atherosclerosis as an inflammatory disease. Focusing on postoperative intimal hyperplasia as an inflammatory disease, especially on tumor necrosis factor-α, FR-167653 (tumor necrosis factor-α suppressive agent, inhibitor of p 38 mitogen-activated protein kinase; Fujisawa Pharmaceutical Co., Ltd., Japan) is found to suppress postoperative intimal hyperplasia in a rat model by reducing serum monocyte chemoattractant protein-1 levels. However, FR-167653 is not commercially available today. Because endothelial injury is the first step of postoperative intimal hyperplasia, I investigated whether the free radical scavenger, edaravone (Radicut, Mitsubishi Tanabe Pharma Co., Japan), which alleviates the endothelial injury in vitro , can also suppress postoperative intimal hyperplasia. Moreover, the free radical scavenger edaravone (Radicut®, Mitsubishi Tanabe Pharma Co.) is also found to suppress postoperative intimal hyperplasia, by alleviating endothelial injury. In clinical settings, it is very important to detect postoperative intimal hyperplasia before its establishment. Hepatocyte growth factor is not only a hepatic growth factor but also a vascular endothelial growth factor. Recently, serum hepatocyte growth factor level was found to be a candidate biomarker for postoperative intimal hyperplasia in our rat model.","PeriodicalId":13798,"journal":{"name":"International Journal of Angiology","volume":"33 3","pages":"135-138"},"PeriodicalIF":0.5,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic 1D Search and Processive Nucleosome Translocations by RSC and ISW2 Chromatin Remodelers. RSC 和 ISW2 染色质重塑器的动态一维搜索和过程性核糖体转移

International Journal of Angiology Pub Date : 2024-01-15 DOI: 10.1101/2023.06.13.544671

Jee Min Kim, Claudia C Carcamo, Sina Jazani, Zepei Xie, Xinyu A Feng, Maryam Yamadi, Matthew Poyton, Katie L Holland, Jonathan B Grimm, Luke D Lavis, Taekjip Ha, Carl Wu

{"title":"Dynamic 1D Search and Processive Nucleosome Translocations by RSC and ISW2 Chromatin Remodelers.","authors":"Jee Min Kim, Claudia C Carcamo, Sina Jazani, Zepei Xie, Xinyu A Feng, Maryam Yamadi, Matthew Poyton, Katie L Holland, Jonathan B Grimm, Luke D Lavis, Taekjip Ha, Carl Wu","doi":"10.1101/2023.06.13.544671","DOIUrl":"10.1101/2023.06.13.544671","url":null,"abstract":"Eukaryotic gene expression is linked to chromatin structure and nucleosome positioning by ATP-dependent chromatin remodelers that establish and maintain nucleosome-depleted regions (NDRs) near transcription start-sites. Conserved yeast RSC and ISW2 remodelers exert antagonistic effects on nucleosomes flanking NDRs, but the temporal dynamics of remodeler search, engagement and directional nucleosome mobilization for promoter accessibility are unknown. Using optical tweezers and 2-color single-particle imaging, we investigated the Brownian diffusion of RSC and ISW2 on free DNA and sparse nucleosome arrays. RSC and ISW2 rapidly scan DNA by one-dimensional hopping and sliding respectively, with dynamic collisions between remodelers followed by recoil or apparent co-diffusion. Static nucleosomes block remodeler diffusion resulting in remodeler recoil or sequestration. Remarkably, both RSC and ISW2 use ATP hydrolysis to translocate mono-nucleosomes processively at ~30 bp/sec on extended linear DNA under tension. Processivity and opposing push-pull directionalities of nucleosome translocation shown by RSC and ISW2 shape the distinctive landscape of promoter chromatin.","PeriodicalId":13798,"journal":{"name":"International Journal of Angiology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79996848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic Limb-Threatening Ischemia does not Enclose a Homogenous Population: Time for a More Detailed Classification 危及肢体的慢性缺血并不包括同质人群：是时候进行更详细的分类了

IF 0.6

International Journal of Angiology Pub Date : 2023-12-15 DOI: 10.1055/s-0043-1777414

Schraepen Cédric, van der Laan Lijckle, Smet Nick, Meulenbroek Anne, Fourneau Inge

{"title":"Chronic Limb-Threatening Ischemia does not Enclose a Homogenous Population: Time for a More Detailed Classification","authors":"Schraepen Cédric, van der Laan Lijckle, Smet Nick, Meulenbroek Anne, Fourneau Inge","doi":"10.1055/s-0043-1777414","DOIUrl":"https://doi.org/10.1055/s-0043-1777414","url":null,"abstract":"Abstract Objective Chronic limb-threatening ischemia (CLTI) is associated with high morbidity and mortality. Classification methods differentiate into patients with rest pain or with ischemic ulcers. No distinction is made between the presence or absence of rest pain in patients with ischemic ulcers. Our aim is to determine any differences in outcome between these subdivisions so we can improve preoperative counseling and risk assessment. Methods This multicenter retrospective cohort study included all patients revascularized for a first episode of CLTI between 2013 and 2018. The cohort was divided in three groups: patients with solely rest pain (RP), solely ischemic ulcers (IU), and patients with both rest pain and ischemic ulcers (RP + IU). Baseline characteristics, morbidity, and mortality were analyzed. Results A total of 624 limbs in 599 patients were included: 225 (36.1%) in the rest pain group, 169 (27.1%) in the ischemic ulcers group, and 230 (36.2%) in combined group. Amputation rates were higher in the combined group at 6 months. Mortality rates were significantly higher in the ischemic ulcers group and the combined group at 6 months and 1 year. Conclusions Patients with solely rest pain have significantly lower mortality rates in comparison to patients with ischemic ulcers. Rest pain did not affect mortality rates in patients with ulcers. There was a higher amputation rate in patients with combined rest pain and ischemic ulcers because the presence of rest pain CLTI patients had a significant negative effect on amputation risk. A separate subdivision for patients with combined ulcers and rest pain is indicated.","PeriodicalId":13798,"journal":{"name":"International Journal of Angiology","volume":"33 3","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139000700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Atypical Presentation of Decubitis Angina in a Patient with Coronary Artery Disease and Aortic Regurgitation: Case Report 冠状动脉疾病和主动脉瓣反流患者褥疮性心绞痛的非典型表现：病例报告

IF 0.6

International Journal of Angiology Pub Date : 2023-12-12 DOI: 10.1055/s-0043-1777343

E. Yetkın, Hasan Atmaca, K. Yalta

引用次数: 0

A Simple, Low-Cost and Effective Technique for Percutaneous Closure of a Coronary Artery Fistula: A Closed-Loop Balloon–Stent System 经皮闭合冠状动脉瘘的简单、低成本和有效技术：闭环球囊支架系统

IF 0.6

International Journal of Angiology Pub Date : 2023-12-11 DOI: 10.1055/s-0043-1777670

Büşra Güvendi Şengör, Cemalettin Yılmaz, R. Zehir

{"title":"A Simple, Low-Cost and Effective Technique for Percutaneous Closure of a Coronary Artery Fistula: A Closed-Loop Balloon–Stent System","authors":"Büşra Güvendi Şengör, Cemalettin Yılmaz, R. Zehir","doi":"10.1055/s-0043-1777670","DOIUrl":"https://doi.org/10.1055/s-0043-1777670","url":null,"abstract":"Abstract Coronary artery fistulas (CAFs), rare anomalies of coronary vasculature, often remain asymptomatic but can lead to complications necessitating intervention. We report a case of a 79-year-old man presenting with chest pain and dyspnea. Diagnostic workup revealed atrial fibrillation, severe mitral regurgitation, and a CAF connecting the circumflex artery to the left atrium. Given high surgical risk, percutaneous closure was chosen. Utilizing a closed-loop balloon–stent technique, a stent was positioned at the fistula's ostium, effectively ceasing flow. The patient was discharged after 5 days, reporting symptom relief at 3-month follow-up. Our experience demonstrates the feasibility and cost-effectiveness of this technique, which can be readily implemented using standard materials available in catheterization laboratories. The closed-loop balloon–stent method offers a compelling alternative to surgical closure, particularly in patients with elevated surgical risks. This technique holds advantages over other percutaneous methods, such as coil embolization or vascular plug, due to its simplicity, affordability, and lower risk of coronary thrombosis. In conclusion, percutaneous closure with the closed-loop balloon–stent technique presents a viable approach for managing symptomatic CAFs, offering an attractive option for patients with limited surgical options. This method's practicality and affordability render it an appealing alternative in appropriate cases, highlighting its potential to improve patient outcomes and enhance overall management strategies.","PeriodicalId":13798,"journal":{"name":"International Journal of Angiology","volume":"11 12","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supervised Exercise Training May Improve Postural Control in Patients with Symptomatic Lower Extremity Peripheral Artery Disease 有指导的运动训练可改善有症状的下肢外周动脉疾病患者的姿势控制能力

IF 0.6

International Journal of Angiology Pub Date : 2023-11-27 DOI: 10.1055/s-0043-1777257

Francis Degache, Willy Mak, L. Calanca, Lucia Mazzolai, S. Lanzi

{"title":"Supervised Exercise Training May Improve Postural Control in Patients with Symptomatic Lower Extremity Peripheral Artery Disease","authors":"Francis Degache, Willy Mak, L. Calanca, Lucia Mazzolai, S. Lanzi","doi":"10.1055/s-0043-1777257","DOIUrl":"https://doi.org/10.1055/s-0043-1777257","url":null,"abstract":"Abstract Patients with symptomatic peripheral artery disease (PAD) have been shown to present balance disorders and a history of falling, which are associated with functional and daily life impairments. Although postural control improvement is an important outcome, the benefits of supervised exercise training (SET) on postural control have been seldom investigated in these patients. This article investigates the effects of SET on traditional measures of postural control and on stabilogram-diffusion analysis (SDA) parameters in patients with symptomatic PAD. Patients with symptomatic chronic lower limb claudication were investigated. All subjects who completed the 3-month multimodal SET program and postural control assessment before and after SET were included. Center of pressure trajectory analysis and SDA parameters were investigated using a posturographic platform. Patients were instructed to stand on the platform and maintain balance to their best ability. Treadmill pain-free (PFWD) and maximal (MWD) walking distances were also assessed prior and following SET. Forty-four patients with PAD (65.2 ± 9.8 years, 34% women) were investigated. All postural control parameters were unchanged following SET, except the length of center of pressure displacement as a function of the surface of center of pressure trajectory (LFS), which was significantly increased (before SET: 1.4 ± 0.4; after SET: 1.5 ± 0.5; p = 0.042). PFWD (before SET: 103.5 ± 77.9 m; after SET: 176.8 ± 130.6 m; p ≤ 0.001) and MWD (before SET: 383.6 ± 272.0 m; after SET: 686.4 ± 509.0 m; p ≤ 0.001) significantly improved following SET. The increased LFS suggests a better postural control accuracy following SET in patients with symptomatic PAD.","PeriodicalId":13798,"journal":{"name":"International Journal of Angiology","volume":"8 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139232983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Endovascular Treatment of Postbiopsy AVF in Transplanted Kidneys: Lessons Learned from Two Cases in Multiorgan Transplant Recipients 移植肾活检后动静脉瘘的成功血管内治疗：从两例多器官移植受者中汲取的经验教训

IF 0.6

International Journal of Angiology Pub Date : 2023-11-27 DOI: 10.1055/s-0043-1777256

Sven Želalić, B. Šimunov, Bojana Maksimović, Rea Mužar, Mario Laganović, V. Vidjak

引用次数: 0

Current Evidence and Future Directions of Omega-3 Supplementation and Cardiovascular Disease Risk 补充欧米茄-3 和心血管疾病风险的当前证据和未来方向

IF 0.6

International Journal of Angiology Pub Date : 2023-11-24 DOI: 10.1055/s-0043-1777258

B. Dwiputra, Anwar Santoso, Budhi Setianto Purwowiyoto, B. Radi, B. Pandhita, Serlie Fatrin, A. M. Ambari

引用次数: 0

A Lethal Late Complication: Aortoesophageal Fistula after TEVAR 一种致命的晚期并发症:TEVAR术后主动脉食管瘘

International Journal of Angiology Pub Date : 2023-10-19 DOI: 10.1055/s-0043-1776144

Sedat Karaca, İslam Yalic, Barkın Bulut, Yaprak Engin, Hakan Posacıoğlu

引用次数: 0

ASVAL with Phlebectomy/Sclerofoam Technique: Preliminary Results ASVAL与静脉切除术/硬化泡沫技术:初步结果

International Journal of Angiology Pub Date : 2023-10-18 DOI: 10.1055/s-0043-1776145

Alberto Garavello, Paola Fiamma, Enrico Oliva

{"title":"ASVAL with Phlebectomy/Sclerofoam Technique: Preliminary Results","authors":"Alberto Garavello, Paola Fiamma, Enrico Oliva","doi":"10.1055/s-0043-1776145","DOIUrl":"https://doi.org/10.1055/s-0043-1776145","url":null,"abstract":"Abstract The ambulatory selective varicose vein ablation under local anesthesia (ASVAL) method recommends preserving the great saphenous vein (GSV), unless there is a serious terminal valve insufficiency, and suggests phlebectomy of superficial varicose reservoir as a primary treatment. To increase patient comfort, foam safety and cosmetic results, we used ASVAL with a mixed phlebectomy/foam technique on local anesthesia. Thirty consecutive patients treated with ASVAL phlebectomy-sclerofoam technique were reviewed retrospectively between December 2022 and April 2023. All patients were evaluated by clinical examination and duplex ultrasound (DUS); the main selection criteria were a minimal GSV insufficiency (main GSV < or = to 1 cm). Muller phlebectomy of tributaries at entry point in the saphenous trunk was performed; after 1 week, patients were checked for foam sclerotherapy of residual trunk. Under visual control, 0.5% polidocanol foam (from 5 to 10 cc. “Tessari Technique”) was injected in visible veins and elastic compression with pad was applied for 1 week. Compression with Class I elastic stockings was prescribed, and patients were reviewed after 1 month. Postoperative complications included thigh hematoma in two patients, three thrombosis of injected trunk, and hyperpigmentation in three patients. No GSV thrombosis at DUS was recorded. In 27 patients, a satisfying cosmetic result was achieved, and in 3 patients a new foam session was needed. Phlebectomy/foam ASVAL technique is a safe, low-traumatic technique with no need of US guidance, with less risk of foam migrating in GSV, simple and inexpensive, for patients with less advanced GSV insufficiency.","PeriodicalId":13798,"journal":{"name":"International Journal of Angiology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135825493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0