Scandinavian cardiovascular journal : SCJ最新文献_第6页

Response of growth differentiation factor-15 to percutaneous coronary intervention and regular exercise training. 生长分化因子-15对经皮冠状动脉介入治疗及常规运动训练的影响。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2011-02-01 Epub Date: 2010-09-13 DOI: 10.3109/14017431.2010.516368

Peter Scott Munk, Torstein Valborgland, Noreen Butt, Alf Inge Larsen

{"title":"Response of growth differentiation factor-15 to percutaneous coronary intervention and regular exercise training.","authors":"Peter Scott Munk, Torstein Valborgland, Noreen Butt, Alf Inge Larsen","doi":"10.3109/14017431.2010.516368","DOIUrl":"https://doi.org/10.3109/14017431.2010.516368","url":null,"abstract":"Background: Growth differentiation factor-15 (GDF-15) is considered to be a cardioprotective cytokine possessing antiapoptotic and antiproliferative properties. If GDF-15 plasma levels are influenced by percutanenous coronary intervention (PCI) or regular exercise training is currently not known.Methods: After successful revascularization by PCI with stent implantation 36 consecutive patients with stable angina pectoris were randomized to an exercise training program or to a control group. Patients were followed by serial measurements of GDF-15, high-sensitivity Troponin T (hsTNT) and N-terminal pro brain natriuretic peptide (NT-proBNP) levels in peripheral blood after PCI and during six months follow-up.Results: Plasma levels of GDF-15 showed an early response to PCI with a modest, but significant increase after 30 minutes (p = 0.007) peaking three hours after PCI. Levels of hsTNT rose 5-fold from baseline to 24 hours (p < 0.001) with a normalization at seven days post PCI. Changes in plasma levels of GDF-15, hsTNT and NT-proBNP were not significantly different between the training and control group during follow-up.Conclusions: GDF-15 levels show a modest transient increase in response to coronary intervention with stent implantation. Exercise training over six months does not affect plasma levels of GDF-15, hsTNT or NT-proBNP in patients with stable coronary artery disease.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"27-32"},"PeriodicalIF":2.2,"publicationDate":"2011-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/14017431.2010.516368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40063605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Interaction between inflammation and blood viscosity predicts cardiovascular mortality. 炎症和血液黏稠度之间的相互作用预测心血管死亡率。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2010-04-01 DOI: 10.1080/14017430903171248

Per Torger Skretteberg, Johan Bodegård, Sverre E Kjeldsen, Gunnar Erikssen, Erik Thaulow, Leif Sandvik, Jan E Erikssen

{"title":"Interaction between inflammation and blood viscosity predicts cardiovascular mortality.","authors":"Per Torger Skretteberg, Johan Bodegård, Sverre E Kjeldsen, Gunnar Erikssen, Erik Thaulow, Leif Sandvik, Jan E Erikssen","doi":"10.1080/14017430903171248","DOIUrl":"https://doi.org/10.1080/14017430903171248","url":null,"abstract":"Objectives: Inflammation and increased blood viscosity are associated with increased risk of cardiovascular mortality. Erythrocyte sedimentation rate (ESR) and hematocrit both influence blood viscosity whereas the first also is a marker of inflammation. We aimed to investigate ESR, hematocrit and the interaction between them as predictors of cardiovascular mortality during 26 years follow-up among healthy middle aged men.Design: Four hundred and eighty eight men aged 40-59 were extensively examined in 1972-1975 and followed over a period of 26 years. Risk estimation was made in Cox proportional hazards and adjusted for age, smoking, systolic blood pressure, total serum cholesterol, and physical fitness.Results: A 2.44-fold (95% CI 1.37-4.35) adjusted risk of cardiovascular mortality was found in the highest quartile of hematocrit compared to the lowest. Among the 265 men who had an ESR <6 mm/h (median), the adjusted risk of cardiovascular mortality was 3.05-fold (95% CI 1.49-6.23) in the highest quartile of hematocrit compared to the lowest. This association was not observed among the 223 men with ESR <6 mm/h.Conclusion: Elevated hematocrit is independently associated with increased long-term risk of cardiovascular mortality in men with high ESR. Our data suggest that the combination of inflammation and blood viscosity may improve the prediction of cardiovascular risk.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"107-12"},"PeriodicalIF":2.2,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40025656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Elevated CK-MB values after routine angioplasty predicts worse long-term prognosis in low-risk patients. 常规血管成形术后CK-MB值升高预示低危患者较差的长期预后。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2010-04-01 DOI: 10.1080/14017430903171230

Kjell Vikenes, Tor Melberg, Mikael Farstad, Jan Erik Nordrehaug

{"title":"Elevated CK-MB values after routine angioplasty predicts worse long-term prognosis in low-risk patients.","authors":"Kjell Vikenes, Tor Melberg, Mikael Farstad, Jan Erik Nordrehaug","doi":"10.1080/14017430903171230","DOIUrl":"https://doi.org/10.1080/14017430903171230","url":null,"abstract":"Objectives: The long-term prognostic value (>5 years) of elevated cardiac biomarkers after elective coronary angioplasty is yet not clear. Most previous studies have included high risk, unstable patients. The aim of this study was to determine the prognostic value of CK-MB mass > or = three times the reference after elective angioplasty in low-risk patients with stable angina.Methods: A total of 278 consecutive patients were included in the final analysis. Patients with elevated CK-MB values at baseline, and those suffering an acute coronary syndrome <1 month before the time of inclusion, were excluded. Blood samples were drawn just before and 1-3 hours, 4-8 hours after the procedure and the next morning. Nineteen patients (6.8%) had peak CK-MB mass values > or =15 microg/L (three times the reference), and 259 patients had values <15 microg/L (defined as controls). No patient developed new Q-waves on ECG. The median follow-up time was 80.5 months.Results: None of the patients died during the procedure or within the first 30 days after angioplasty, confirming a low risk cohort. All cause mortality, readmission for acute coronary syndromes and target lesion revascularisation (TLR) were more frequent in patients with high CK-MB, 42.1% vs. 22.8%, p=0.034 (log rank). In a multivariate logistic regression analysis, high CK-MB and former angioplasty were the only variables independently related to a reduced event-free survival.Conclusions: CK-MB mass values > or = three times the reference after elective angioplasty predicts reduced long-term event-free survival.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"69-75"},"PeriodicalIF":2.2,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40025657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cardiac and systemic haemodynamic complications of liver cirrhosis. 肝硬化的心脏和全身血流动力学并发症。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2009-08-01 DOI: 10.1080/14017430802691528

Jens H Henriksen, Søren Møller

{"title":"Cardiac and systemic haemodynamic complications of liver cirrhosis.","authors":"Jens H Henriksen, Søren Møller","doi":"10.1080/14017430802691528","DOIUrl":"https://doi.org/10.1080/14017430802691528","url":null,"abstract":"Cardiovascular complications of liver cirrhosis include cardiac dysfunction and abnormalities in the central-, splanchnic,- and peripheral circulation. Vasodilatation prevails, but vascular beds with various degrees of reduced and increased haemodynamic resistance are the results of massive activation of powerful homeostatic, regulatory systems. Cirrhotic cardiomyopathy implies systolic and diastolic dysfunction and electrophysiological abnormalities, an entity that is different from alcoholic heart muscle disease. Being often clinical latent, cirrhotic cardiomyopathy can be unmasked by physical and pharmacological strain. Cardiac failure is an important cause of mortality after liver transplantation and stressful procedures as insertions of transjugular intrahepatic portal systemic shunt (TIPS), peritoneal venous shunting, and other types of surgery. Improvement of liver function has been shown to reverse the cardiovascular complications. The clinical significance is an important topic for future research. At present, no specific treatment can be recommended, and the cardiac failure in cirrhosis should be treated as in non-cirrhotic patients with sodium restriction, diuretics, and beta-adrenergic blocking agents. Special care should be taken with the use of ACE-inhibitors and angiotensin antagonist in these patients.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"218-25"},"PeriodicalIF":2.2,"publicationDate":"2009-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430802691528","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39993348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

Paediatric cardiac surgery. 儿科心脏外科。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2009-02-01 DOI: 10.1080/14017430802422387

Victor T Tsang, Marc De Leval, Martin Utley

引用次数: 9

Statement of retraction. WITHDRAWN: The effect of leg lifting on tissue Doppler parameters in severe coronary artery disease. 撤回声明。撤下:抬腿对重症冠状动脉病患者组织多普勒参数的影响。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2009-02-01 DOI: 10.1080/14017430801932840

引用次数: 0

Mitral regurgitation--evaluation of a multidimensional echocardiographic grading system. A study on 177 patients with chronic primary and secondary mitral regurgitation. 二尖瓣返流——多维超声心动图分级系统的评价。177例慢性原发性和继发性二尖瓣反流的研究。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2009-01-01 DOI: 10.1080/14017430802651811

Christoph Langer, Thomas Butz, Barbara Lamp, Armin Zittermann, Hermann Storm, Nikola Bogunovic, Olaf Oldenburg, Thomas Bitter, Dieter Fassbender, Young Za Kim, Dieter Horstkotte, Lothar Faber

{"title":"Mitral regurgitation--evaluation of a multidimensional echocardiographic grading system. A study on 177 patients with chronic primary and secondary mitral regurgitation.","authors":"Christoph Langer, Thomas Butz, Barbara Lamp, Armin Zittermann, Hermann Storm, Nikola Bogunovic, Olaf Oldenburg, Thomas Bitter, Dieter Fassbender, Young Za Kim, Dieter Horstkotte, Lothar Faber","doi":"10.1080/14017430802651811","DOIUrl":"https://doi.org/10.1080/14017430802651811","url":null,"abstract":"Introduction: In grading mitral regurgitation (MR) magnetic resonance imaging is the gold standard but 2D echo is mostly used in clinical practice. However, each single echo parameter is prone to confounding influences. With regard to chronic primary and secondary MR the purpose of this study was to compare a new multi-dimensional echo-based grading system with an independent pre-operatively used invasive standard.Methods: In a retrospective study we analyzed 177 patients with different degrees of MR severity, who were examined both by echocardiography and by cardiac catheterization. For MR grading a combination of four echocardiographic parameters was used: density of the regurgitation velocity profile, peak mitral inflow velocity (Vmax E-wave), radius of the proximal flow convergence zone (PISA), and vena contracta (Vc) width. Invasive grading was based on left ventriculography (Seller's method), V wave hight, and regurgitation fraction. Both methods resulted in an integrative score on an eight point scale (<I-IV in half-steps). Echocardiographic and invasive data were correlated.Results: There was a reasonable overall correlation of r = 0.72 (p = 0.001) between both grading systems. Echo tended to slightly overestimate MR severity. In patients with secondary MR, agreement was worse (p = 0.01) than in primary MR. The most powerful single echo parameter was Vc r = 0.71 (p = 0.001). Presence or absence of sinus rhythm had no significant influence on echo grading.Conclusions: The proposed echocardiographic multidimensional MR grading system is feasable and shows good correlation with invasive grading.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"311-7"},"PeriodicalIF":2.2,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430802651811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39988306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fluid overload during cardiopulmonary bypass is effectively reduced by a continuous infusion of hypertonic saline/dextran (HSD). 体外循环期间液体负荷可通过持续输注高渗盐水/葡聚糖(HSD)有效降低。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2008-02-01 DOI: 10.1080/14017430701635147

Venny L Kvalheim, Stein E Rynning, Marit Farstad, Oddbjørn Haugen, Else Nygreen, Arve Mongstad, Paul Husby

{"title":"Fluid overload during cardiopulmonary bypass is effectively reduced by a continuous infusion of hypertonic saline/dextran (HSD).","authors":"Venny L Kvalheim, Stein E Rynning, Marit Farstad, Oddbjørn Haugen, Else Nygreen, Arve Mongstad, Paul Husby","doi":"10.1080/14017430701635147","DOIUrl":"https://doi.org/10.1080/14017430701635147","url":null,"abstract":"Objective: Cardiopulmonary bypass (CPB) is associated with fluid overload. We examined how a continuous infusion of hypertonic saline/dextran (HSD) influenced fluid shifts during CPB.Materials and methods: Fourteen animals were randomized to a control-group (CT-group) or a hypertonic saline/dextran-group (HSD-group). Ringer's solution was used as CPB-prime and as maintenance fluid at a rate of 5 ml/kg/h. In the HSD group, 1 ml/kg/h of the maintenance fluid was substituted with HSD. After 60 min of normothermic CPB, hypothermic CPB was initiated and continued for 90 min. Fluid was added to the CPB-circuit as needed to maintain a constant level in the venous reservoir. Fluid balance, plasma volume, total tissue water (TTW), intracranial pressure (ICP) and fluid extravasation rates (FER) were measured/calculated.Results: In the HSD-group the fluid need was reduced with 60% during CPB compared with the CT-group. FER was 0.38(0.06) ml/kg/min in the HSD-group and 0.74 (0.16) ml/kg/min in the CT-group. TTW was significantly lower in the heart and some of the visceral organs in the HSD-group. In this group ICP remained stable during CPB, whereas an increase was observed in the CT-group (p<0.01).Conclusions: A continuous infusion of HSD reduced the fluid extravasation rate and total fluid gain during CPB. TTW was reduced in the heart and some visceral organs. During CPB ICP remained normal in the HSD-group, whereas an increase was present in the CT-group. No adverse effects were observed.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"63-70"},"PeriodicalIF":2.2,"publicationDate":"2008-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430701635147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40995213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

TNFR gene-modified mesenchymal stem cells attenuate inflammation and cardiac dysfunction following MI. TNFR基因修饰的间充质干细胞减轻心肌梗死后的炎症和心功能障碍。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2008-02-01 DOI: 10.1080/14017430701543556

Cuiyu Bao, Jun Guo, Guosheng Lin, Mingyan Hu, Zhimin Hu

{"title":"TNFR gene-modified mesenchymal stem cells attenuate inflammation and cardiac dysfunction following MI.","authors":"Cuiyu Bao, Jun Guo, Guosheng Lin, Mingyan Hu, Zhimin Hu","doi":"10.1080/14017430701543556","DOIUrl":"https://doi.org/10.1080/14017430701543556","url":null,"abstract":"Objectives: To investigate the protective effect of tumor necrosis factor receptor (TNFR) gene modified mesenchymal stem cells (MSCs) transplantation against inflammation and cardiac dysfunction following acute myocardial infarction (AMI).Design: MSCs were extracted from the tibias and femurs of rats and transfected with recombinant adeno-associated viral (rAAV) expressing EGFP (enhanced green fluorescent protein) or p75 (human 75 kilodalton) TNFR at multiplicity of infection of 10(5) particles/cell. Rats with AMI induced by occlusion of the left coronary artery were randomized to MSCs-TNFR transplantation group, MSCs-EGFP transplantation group and MI control group.Results: The effects of MSCs-TNFR transplantation on cardiac inflammation and left ventricular dysfunction were observed after 2 weeks of MI. We found that: 1) MSCs-TNFR transplantation attenuated protein production and gene expression of inflammatory cytokines TNF-, IL-1beta and IL-6; 2) MSCs-TNFR transplantation inhibited cardiomyocytes apoptosis and 3) MSCs-TNFR transplantation improved left ventricular function.Conclusions: The experimental data show that transplantation with rAAV-TNFR transfected MSCs improves left ventricular function following MI through anti-apoptotic and anti-inflammatory mechanisms.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"56-62"},"PeriodicalIF":2.2,"publicationDate":"2008-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430701543556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41034527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Effect of acute changes in oxygen tension on flow-mediated dilation. Relation to cardivascular risk. 急性氧张力变化对血流介导的舒张的影响。与心血管风险有关。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2008-02-01 DOI: 10.1080/14017430701466402

Ole Frøbert, Pernille Holmager, Ken Michael Jensen, Erik Berg Schmidt, Ulf Simonsen

{"title":"Effect of acute changes in oxygen tension on flow-mediated dilation. Relation to cardivascular risk.","authors":"Ole Frøbert, Pernille Holmager, Ken Michael Jensen, Erik Berg Schmidt, Ulf Simonsen","doi":"10.1080/14017430701466402","DOIUrl":"https://doi.org/10.1080/14017430701466402","url":null,"abstract":"Objective: Oxygen-dependent changes in vascular diameters may be detrimental when the endothelium is dysfunctional.Design: Endothelial responsiveness was evaluated by brachial ultrasound and flow-mediated/nitroglycerin-mediated dilation (FMD/NMD). FMD/NMD was investigated in males with increased risk of cardiovascular disease (mean age 44+/-2 years, n=10) and matched controls without risk factors (44+/-2 years, n=10). FMD/NMD was assessed during normoxia (21% O2, 79% N2), while inhaling hypoxic gas (12.5% O2, FMDHyp/NMD), and 100% O2 supplementation (FMDO2/NMD). In a second study we addressed the effect of lipid lowering. Twenty persons with cardiovascular risk (mean age 50+/-2 years) were treated with atorvastatin (80 mg/day) and FMD/NMD was measured during normoxia, hypoxia and oxygen supplementation before, after 1 day and 3 months.Results: Oxygen supplementation evoked vasoconstriction, while FMDHyp/NMD was reduced compared to FMD/NMD. Atorvastatin significantly lowered total cholesterol, LDL cholesterol, and ADMA after 1 day of treatment, while triglycerides, ApoB and hsCRP were lowered after 3 months. Atorvastatin did not change FMD/NMD irrespective of oxygen tension.Conclusion: Irrespective of risk factors or atorvastatin, hypoxia reduced endothelial vasodilation while oxygen supplementation evoked vasoconstriction.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"38-47"},"PeriodicalIF":2.2,"publicationDate":"2008-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430701466402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40960797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19