Scandinavian cardiovascular journal : SCJ最新文献_第7页

Alpha-2 adrenergic antagonism enhances risk of ventricular tachycardia during acute ischemia. α -2肾上腺素能拮抗剂增加急性缺血时室性心动过速的风险。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2007-12-01 DOI: 10.1080/14017430701487713

David O Arnar, Dezhi Xing, James B Martins

{"title":"Alpha-2 adrenergic antagonism enhances risk of ventricular tachycardia during acute ischemia.","authors":"David O Arnar, Dezhi Xing, James B Martins","doi":"10.1080/14017430701487713","DOIUrl":"https://doi.org/10.1080/14017430701487713","url":null,"abstract":"Objective. In this study we tested the hypothesis that α-2 adrenergic antagonism could facilitate induction of previously non-inducible ventricular tachycardia (VT) during acute ischemia. Previous reports suggest that VT during ischemia may be modulated by α-2 adrenergic agonists. Design. The left anterior descending artery was occluded after instrumentation of the ischemic risk zone with 21 multipolar plunge needles, each recording 6 bipolar electrograms. Three dimensional mapping characterized the mechanism of VT induced with extrastimuli. Results. Of 16 non-inducible dogs included, eight which were given the α-2 adrenergic antagonist yohimbine all had inducible VT, while all eight in the control group remained non-inducible (p <0.05). Six of the VTs were of focal Purkinje origin. The cycle length of the VT was 119±4 ms. Mean arterial pressure (81±8 to 82±8 mmHg, p =ns), ventricular effective refractory period (146±6 to 144±5 ms, p =ns) and ischemic zone size (55±6% vs. 61±4%, p =0.45) were not altered by yohimbine indicating minimal central or pre-junctional effects of the drug. Conclusions. Yohimbine facilitates induction of VT, especially those with focal Purkinje fiber origin, suggestive of an effect mediated through antagonism of post-junctional α-2 adrenoceptors on Purkinje fibers.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"378-85"},"PeriodicalIF":2.2,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430701487713","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40960795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X. 心脏综合征X患者PBMC中激肽受体B1和B2的基因表达

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2007-12-01 DOI: 10.1080/14017430701499379

Jozefa Dabek, Tadeusz Wilczok, Zbigniew Gasior, Sylwia Kucia-Kuzma, Romuald Twardowski, Andrzej Kulach

{"title":"Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X.","authors":"Jozefa Dabek, Tadeusz Wilczok, Zbigniew Gasior, Sylwia Kucia-Kuzma, Romuald Twardowski, Andrzej Kulach","doi":"10.1080/14017430701499379","DOIUrl":"https://doi.org/10.1080/14017430701499379","url":null,"abstract":"Introduction. Cardiac syndrome X (CSX) is defined by typical chest pain, ST segment depression on ECG and normal coronary angiography. Pathology of CSX may involve microvascular dysfunction related to inflammation and abnormal pain sensitivity. Kinins are labile peptides participating in vasodilation, inflammation and pain. Their effects are mediated by two receptors: B1 and B2. The aim of the study was to assess gene expression of kinin receptors in peripheral blood mononuclear cells (PBMC) from patients with CSX. Methods. The study was carried out in 34 patients with cardiac syndrome X, 13 with unstable angina and ten healthy subjects. Total mRNA was extracted from PBMC and the number of mRNA copies was assessed by quantitive reverse transcriptase polymerase chain reaction. Results and Conclusion. The study showed 7-fold higher transcriptional activity of B1R in CSX vs. control and 3.5 higher vs. UA. B2R expression was 2.5-fold higher in CSX group vs. control and UA, while in the letter two groups it was similar. Such disturbance in kinin signaling may participate in local vasoconstriction and may reflect disturbances in kinin signaling leading to nociceptive disturbances in these patients.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"391-6"},"PeriodicalIF":2.2,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430701499379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41034528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Left ventricular hypertrophy persists after successful treatment for coarctation of the aorta. 在主动脉缩窄成功治疗后，左心室肥厚仍然存在。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2007-12-01 DOI: 10.1080/14017430701397839

Anneli Eerola, Eero Jokinen, Talvikki Boldt, Ilkka P Mattila, Jaana I Pihkala

{"title":"Left ventricular hypertrophy persists after successful treatment for coarctation of the aorta.","authors":"Anneli Eerola, Eero Jokinen, Talvikki Boldt, Ilkka P Mattila, Jaana I Pihkala","doi":"10.1080/14017430701397839","DOIUrl":"https://doi.org/10.1080/14017430701397839","url":null,"abstract":"Objectives: To evaluate cardiac size and function in patients with coarctation of the aorta (CoA) before and after treatment.Design: Ventricular size and function were examined by 2- and 3-dimensional echocardiography, and concentrations of natriuretic peptides measured in 15 paediatric patients before repair, and one, 6, and 12 months thereafter. Controls comprised 15 children.Results: Before repair, mitral inflow velocities and left ventricular (LV) size and wall thickness were higher in patients. Thicknesses of interventricular septum and LV posterior wall decreased after repair but increased to initial level one year thereafter. The LV end-diastolic diameter remained larger than in controls despite successful repair. The size of right ventricle increased and levels of natriuretic peptides decreased during follow-up. Levels of natriuretic peptides correlated with the smallest diameter of CoA segment and diastolic indices of LV function.Conclusion: LV hypertrophy persists and LV size remains larger than in controls after successful repair even in normotensive patients with normal growth of CoA segment. This may be due to remodelling of ventricles and the aorta caused by CoA.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"370-7"},"PeriodicalIF":2.2,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430701397839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41034526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The relationship between ASAT, CKMB, troponin-T and mortality after cardiac surgery. 心脏手术后ASAT、CKMB、肌钙蛋白- t与死亡率的关系。

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2007-12-01 DOI: 10.1080/14017430701400104

Anna Sellgren, Folke Nilsson, Anders Jeppsson

{"title":"The relationship between ASAT, CKMB, troponin-T and mortality after cardiac surgery.","authors":"Anna Sellgren, Folke Nilsson, Anders Jeppsson","doi":"10.1080/14017430701400104","DOIUrl":"https://doi.org/10.1080/14017430701400104","url":null,"abstract":"Objective: To investigate the relationship between ASAT, CKMB, troponin-T and mortality after cardiac surgery.Design: ASAT, CKMB and TnT were analysed in 116 patients. Correlation, sensitivity, specificity and predictive values for permanent myocardial injury (defined as TnT > or = 2.0 microg/l postoperative day four) were calculated. In the second part our clinical protocol (ASAT on postoperative day 1 and TnT on day 3-4 in patients with ASAT above 2.5 microkat/l) was evaluated. Mortality was compared between patients with ASAT < 2.5 microkat/l (ASAT-), 2. ASAT > or = 2.5 microkat/l and TnT < 2.0 microg/l (ASAT+/TnT-) and 3. ASAT > or = 2.5 microkat/l and TnT > or = 2.0 microg/l (ASAT+/TnT+).Results: Both ASAT and CKMB had irrespectively of cut-off level, low positive and high negative predictive value of permanent myocardial injury. Early and mid-term mortality did not differ significantly between ASAT- and ASAT+/TnT- patients.Conclusions: ASAT and CKMB can be used to exclude but not to diagnose permanent myocardial injury after cardiac surgery. Increased postoperative ASAT in the absence of increased TnT is not associated with worse clinical outcome than after normal postoperative ASAT.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"386-90"},"PeriodicalIF":2.2,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430701400104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41034525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Coronary heart disease in diabetics: prognostic implications and results of interventions. 糖尿病患者的冠心病:干预的预后意义和结果

IF 2.2

Scandinavian cardiovascular journal : SCJ Pub Date : 2007-12-01 DOI: 10.1080/14017430701504244

Per Mølstad

{"title":"Coronary heart disease in diabetics: prognostic implications and results of interventions.","authors":"Per Mølstad","doi":"10.1080/14017430701504244","DOIUrl":"https://doi.org/10.1080/14017430701504244","url":null,"abstract":"Objectives: The aim of the present study was to compare the extent of coronary disease and subsequent survival in diabetics and non-diabetics.Design: From the database at Feiring Heart Clinic 13511 patients were identified with no previous revascularization and were examined with coronary angiography in the period from March 1999 to December 31, 2005. In the cohort 1,475 patients were diabetics. Their survival status of May 31, 2006 was ascertained through the Norwegian National Registry.Results: Diabetics were more symptomatic and had a more severe coronary artery disease at the time of referral with more than 40% having three vessel disease. The unadjusted survival was lower in the diabetics. After adjustment through Cox regression, diabetes mellitus remained a risk factor for subsequent death (overall hazard ratio 1.33), with the excess mortality mainly residing in smoking diabetics.Conclusions: Diabetics were more severely diseased at the time of referral. In Cox regression diabetes mellitus remained a significant risk factor for death in smokers except in the cohort treated with CABG.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":" ","pages":"357-62"},"PeriodicalIF":2.2,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14017430701504244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41036080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Laser Doppler flowmetry detects early risk of tracheal anastomotic complications after lung transplantation. 激光多普勒血流检测肺移植术后气管吻合口并发症的早期危险。

Scandinavian cardiovascular journal : SCJ Pub Date : 1999-04-01 DOI: 10.1097/00007890-199904150-00444

T. Hyytinen, M. Halme

引用次数: 4

Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production. 血管平滑肌收缩是内皮细胞一氧化氮生成的独立调节因子。

Scandinavian cardiovascular journal : SCJ Pub Date : 1900-01-01 DOI: 10.1080/14017439950141876

L. Bang, J. Nielsen-Kudsk, N. Gruhn, S. Theilgaard, S. Olesen, S. Boesgaard, J. Aldershvile

{"title":"Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production.","authors":"L. Bang, J. Nielsen-Kudsk, N. Gruhn, S. Theilgaard, S. Olesen, S. Boesgaard, J. Aldershvile","doi":"10.1080/14017439950141876","DOIUrl":"https://doi.org/10.1080/14017439950141876","url":null,"abstract":"This investigation was conducted to determine whether endothelial nitric oxide (NO) production is regulated by vascular smooth muscle contraction. Unperfused ring segments of rat aorta and mesenteric artery were studied using isometric tension recording (n = 6-8 in all experiments). Following a reference contraction to K+ 80 mM (100%), arteries were left either unstimulated or stimulated by different concentrations of K+ or prostaglandin F2alpha (PGF2alpha) to induce different levels of vascular precontraction. N(G)-nitro-L-arginine methyl ester (L-NAME 0.1-300 microM) or NS 2028 (0.03-3 microM), which is a new specific inhibitor of the NO-sensitive guanylate cyclase, was then added at increasing concentrations to evaluate endothelial NO production. L-NAME and NS 2028 produced a concentration-dependent vasoconstrictor response which was progressively enhanced with increasing levels of precontraction. For L-NAME, this amounted in aorta to (% of reference contraction): 35+/-1% and 105 +/- 4% (precontraction by K(+) 20 and 30 mM) and 22+/-1%, 89+/-1%, 138+/-1% and 146+/-2% (precontraction by PGF2alpha 0.5, 1, 2 and 3 microM). A similar coupling was found in the mesenteric artery. A precontraction as little as 2% was enough to trigger a vasoconstrictor response to L-NAME. In contrast, L-NAME and NS 2028 had no effect in non-contracted arteries, not even when passive mechanical stretch was increased by 100%. The results suggest (i) that endothelial NO formation is progressively increased with increasing vascular tone, and (ii) that vascular isometric contraction per se stimulates endothelial NO formation. It is concluded, that active vascular smooth muscle contraction is an independent regulator of endothelial NO production.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122009898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Haemostasis at low heparin dosage during cardiopulmonary bypass with heparin-coated circuits in pigs. 猪肝素包被循环体外循环期间低剂量肝素的止血作用。

Scandinavian cardiovascular journal : SCJ Pub Date : 1900-01-01 DOI: 10.3109/14017439709069548

L. Bagge, J. Borowiec, S. Thelin, J. Hultman

{"title":"Haemostasis at low heparin dosage during cardiopulmonary bypass with heparin-coated circuits in pigs.","authors":"L. Bagge, J. Borowiec, S. Thelin, J. Hultman","doi":"10.3109/14017439709069548","DOIUrl":"https://doi.org/10.3109/14017439709069548","url":null,"abstract":"Cardiopulmonary bypass (CPB) causes activation of cascade systems. Although heparin coating of CPB circuits improves biocompatibility, the effects on coagulation remain controversial. Theoretically, heparin coating should permit the reduction of systemic anticoagulation during CPB. We investigated influences on haemostatic variables in animal CPB, comparing heparin-coated circuits and reduced systemic heparinization (group HC) with uncoated circuits and full heparinization (group C). Twenty pigs underwent 2-h CPB. Seven (HC, n = 4; C, n = 3) were weaned from CPB and studied for up to 4 h. Total administered heparin was 470 +/- 6 IU/kg (mean +/- SEM) in group C and 100 +/- 0 IU/kg in group HC. Protamine dosage was significantly reduced in group HC. In group C, levels of prothrombin complex, factor VIII and adhesive platelets were reduced significantly during CPB, and postoperatively there were significantly lower values of prothrombin complex, fibrinogen antithrombin III, factor VIII and adhesive platelets but a significantly increased concentration of von Willebrand factor and cumulative bleeding after 4 h. In conclusion, heparin-coated CPB circuits combined with lowered heparin dosage reduced coagulation factor consumption and preserved platelet function, possibly contributing to improved postoperative haemostasis.","PeriodicalId":137876,"journal":{"name":"Scandinavian cardiovascular journal : SCJ","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116212988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Transdermal kinetics and nitrate tolerance. Measurements of vasodilation by photoplethysmography. 透皮动力学和硝酸盐耐受性。光容积脉搏图测量血管舒张。

Scandinavian cardiovascular journal : SCJ Pub Date : 1900-01-01 DOI: 10.3109/14017439709075956

T. Klemsdal

引用次数: 0

Circumflex artery motion; a new angiographic method for assessment of left ventricular function. 旋动脉运动;一种评价左心室功能的血管造影新方法。

Scandinavian cardiovascular journal : SCJ Pub Date : 1900-01-01 DOI: 10.1080/1401743031001195

A. Kähäri, K. Emilsson, Mikael Danielewicz, T. Andersson, B. Wandt

引用次数: 4