ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS最新文献

{"title":"Systemic and cerebral hemodynamic changes in patients undergoing shoulder arthroscopy in the beach chair position","authors":"K. Lyzohub, M. Lyzohub","doi":"10.15674/0030-59872024138-42","DOIUrl":"https://doi.org/10.15674/0030-59872024138-42","url":null,"abstract":"Поєднання таких факторів як загальна анестезія та зміна положення тіла після індукції мають вплив на системну та церебральну гемодинаміку. Мета. Bиявити вплив зміни положення тіла та загальної анестезії на пікову систолічну швидкість внутрішньої сонної артерії (ПСШВСА) у пацієнтів під час проведення артроскопії. Методи. 85 пацієнтів із фізичним статусом за ASA I–II, середнього віку (33,0 ± 11,3) років, проведено артроскопію плечового суглоба під загальним наркозом. Основними вимірюваннями були систолічний артеріальний тиск (САТ), діастолічний артеріальний тиск (ДАТ), середній артеріальний тиск та ПСШВСА. Основні вимірювання: в положенні лежачи на столі перед індукцією, через 3 хв після введення в наркоз в положенні лежачи та в положенні пляжного крісла (ППК). Індукцію та забезпечення загальною анестезію проводили сибазоном, пропофолом і фентанілом. Дані проаналізовано статистично. Методи описової статистики використовували для розрахунку середнього, стандартного відхилення, мінімального і максимального значень вибірки. Порівняння проводили за допомогою Т-тесту для повторних порівнянь з розрахунком різниці середніх зі стандартним відхиленням (M ± SD), критичного значення критерію (t) та його статистичної значущості (p). Для порівняння динаміки зміни параметрів було проведено загальний лінійний аналіз з визначенням значення критерію Піллаї та його значення. Аналіз проводився в пакеті IBM SPSS Statistics 20.0. Результати. Початкові дані САТ, ДАТ та середнього артеріального тиску достовірно знижувались після індукції та після позиціонування, але індукція не вплинула на показник ПСШВСА. Після позиціювання до ППК було констатовано значне зниження показників ПСШВСА. Висновки. Констатовано достовірне зниження САТ, ДАТ, середнього артеріального тиску після индукції та подальшого позиціювання хворих у ППК. Постіндукційна гіпотензія не впливає на динаміку ПСШВСА, але виявлено достовірне її зниження після позиціювання.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"171 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140706427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE USE OF LABORATORY CRITERIA IN THE RISK ASSESSMENT OF POSTOPERATIVE COMPLICATIONS AFTER TRANSPEDICULAR FIXATION OF THE LUMBAR SPINE","authors":"O. Barkov, V. Tuliakov, Valerija Aplevich","doi":"10.15674/0030-59872024119-26","DOIUrl":"https://doi.org/10.15674/0030-59872024119-26","url":null,"abstract":"Objective. To investigate the peculiarities of the development of postoperative complications after surgical treatment of degenerative diseases of the lumbar spine with transpedicular fixation of the vertebrae and their relationship with changes in preoperative laboratory parameters. Methods. A retrospective analysis of the biochemical examination data of 35 patients with degenerative diseases of the lumbar spine who underwent discectomy with transpedicular fixation was performed. In four groups of patients with postoperative complications: 10 patients — inflammation of the what fabrics around metal structures and 5 patients — instability of the metal structure. The results of the examination of 20 people without specified complications served as a comparison group. Comparison was made with a control group (20 practically healthy people). Results. Patients have a significant increase in serum ALT activity by 42.29 and AST by 63.55 %, by 38.37 % of the level of CS content, by 37.21 % of total glycoproteins compared to those in the control group. In patients with soft tissue inflammation around the serum instrument zone, the content of LDLP was recorded by 29.27 %, by 23.53 % of the UA, by 12.34 % of TP results higher by 32.01 % ALT activity and 83 %, 49 % AST, 54.96 % AlP activity, 31.40 % — AlP/AcP, 60.47 % — concentration of CS, 95.57 % — total glycoproteins than in persons in the control group. In the serum of patients with the development of instability of metal structures, 28.55 % was observed by activity of the ALT, AlP — by 38.47 %, AcP — by 48.84 %, less by 58.35 % of AlP/AcP, the CHOL content of 13 88 %, higher by 25.43 % of the LDLP content than such persons in the control group. Content of the P was lower by 31.51 % and the Ca/P ratio was higher by 38.95 %, the content of CS by 83.72 %, total glycoproteins — by 48.83 %. Conclusions. Comparative analysis of the results of preoperative clinical and laboratory examination of patients with degenerative spinal diseases with transpedicular fixation which is reflected in the deviations of their preoperative laboratory parameters from such persons with uncomplicated course of the postoperative period after similar surgery.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"69 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140704770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"META-ANALYSIS OF RAVITCH AND NUSS PROCEDURES FOR THE TREATMENT OF FUNNEL-SHAPED CHEST DEFORMITY IN CHILDREN AND ADOLESCENTS","authors":"Olena Karpinska, A. Levytskyi, V. Pylypko","doi":"10.15674/0030-59872024170-78","DOIUrl":"https://doi.org/10.15674/0030-59872024170-78","url":null,"abstract":"Funnel-shaped chest deformity is the most common anomaly of the chest wall development, occurring in 8 out of every 1 000 children. The defect is noticeable at birth in approximately 86 % of patients with chest deformity. Objective. To conduct a systematic review comparing the treatment of funnel-shaped chest deformity in children and young people under 20 years of age by surgical methods according to Ravitch and Nuss by the number of complications that occur in the short (up to 30 days) and long-term periods (2–3 years). Methods. A search of scientometric databases revealed 1 734 sources, of which 8 papers were selected for further analysis. Results. We evaluated systematic reviews and meta-analyses comparing methods of treatment of lumbar deformity in children and adolescents. It was determined that there are currently no randomized trials comparing these procedures in children and adolescents. A comparative analysis of the risk of complications in the surgical treatment of the funnel-shaped sternum in children and young adults using the Ravitch and Nuss methods determined that there is no difference in the overall incidence of complications between the Nuss and Ravitch procedures when considering the pediatric population in terms of overall, early, and late complications. With the development of the Nuss technology, complications associated with plate mixing are practically non-existent, and the development of new methods of controlling operations, anesthesia and further patient management has reduced the development of both postoperative and long-term complications. Conclusions. According to the results of the meta-analysis of the risk of early and late complications, it is impossible to definitively determine the advantage of any surgical method for the correction of lumbar deformity of the chest. The number of Nuss surgeries has been increasing over the years, which means that the minimally invasive approach is the method of choice for patients and surgeons, although questions remain about achieving structural stability and the method of Nuss correction in severe deformities. The lack of definitive conclusions is more related to the methodological problems of the analyzed data, including a limited number of observations and a large age difference in the observation groups, the lack of a standard for presenting data to describe the patient's condition (magnitude and type of deformity, primary complications of the cardiac and respiratory systems, the presence of complicating factors).","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140706584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotechnological aspects of the working-out and manufacturing of living bone equivalent","authors":"Dmytro Zubov, Iurii Poliachenko, Oleksandr Kostrub, R. Blonskyi, O.M. Magomedov, Oleksii Dolgopolov, I. Zasadnyuk","doi":"10.15674/0030-59872023487-92","DOIUrl":"https://doi.org/10.15674/0030-59872023487-92","url":null,"abstract":"Objective. To handle biotechnological aspects in manufacturing processes of three-dimensional living bone equivalent for restoration of critical sized bone defects for innovative treatment of combat-related casualties. Methods. To fabricate living bone equivalent we used devitalized xenogeneic bone scaffolds (DBM chips) and autologous fibrin hydrogel seeded with autologous cultured bone marrow-derived multipotent mesenchymal stem/stromal cells (BM-MSCs). Quality/identity control of cell cultures was assured by donor and cell culture infection screening (IFA, PCR), flow cytometry (cell phenotype), karyotyping (GTG banding), functional assays (CFU assay, multilineage differentiation assay). Results. The BM-MSC cultures had a normal karyotype and appropriate phenotype, multilinear differentiation potential and functional properties, appropriate CFU frequency and hadn’t any signs of cell senescence. The FDA/PI combined staining showed the demineralized bone chips’ regular seeding with viable cells. Conclusions. An actual regenerative medicine approach to organ-saving transplantation of the three-dimensional living bone equivalent for combat-related casualties requires further preclinical and clinical approbation for thorough studies on the bone integrity restoration, forming new bone tissue in a site of bone defect, and duration of rehabilitation period compared to the gold standard of the conventional bone defect cure.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139619245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPERIENCE OF THE SEGMENTAL BONE DEFECTS' TREATMENT FOR PATIENTS WITH COMBAT TRAUMA USING THE METHOD OF DISTRACTION OSTEOGENESIS","authors":"Serhiy Hariyan, Oleksandr Tsybulskyi, Vasyl Makhovskyi, Zoia Salii","doi":"10.15674/0030-59872023471-78","DOIUrl":"https://doi.org/10.15674/0030-59872023471-78","url":null,"abstract":"Upper and lower limb injuries resulting from battlefield trauma is a complex multidisciplinary problem. Efficacy of the treatment of segmental bone defects in patients with combat trauma is a subject of analysis for improving its results. Purpose. An analysis of the modern treatment strategies of the segmental bone defects in patients with battlefield trauma under conditions of distraction osteogenesis (based on data available in the literature and own clinical experience). Methods. Analytical review of scientific works and analysis of treatment results of 39 patients with segmental bone defects associated with battlefield trauma and treated using distraction osteogenesis were conducted. Results. Patients with segmental limbs defects require special attention of a multidisciplinary team of specialists to identify reconstructive opportunities to save the limb. Distraction osteogenesis — is an effective method of treating of segmental fractures and shortening of the limbs, infectious complications that led to bone defect formation. Bone transport with ring external fixator (ExFix) is considered as a classical method. Authors analyzed and illustrated with three clinical cases their own results of application of different distraction osteogenesis technique. Conclusions. Different types of ExFix can be applied independently or in combination with internal fixators. The use of an intramedullar nail along which distraction osteogenesis is carried out allows to provide better control of the axis of the limb and transported fragment, reduce the residence time in the ExFix, and, moreover, external fixation devices with a simpler configuration can be used. Transport along the plate allows to maintain proper axial relationships in the presence of short periarticular fragments and improve the quality of fixation but it also increases the risks of FRI and re-operations.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139618917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MULTICENTRIC OSTEOSARCOMA AS A RARE TYPE OF OSTEOSARCOMA (CASE REPORT)","authors":"Yanina Golovina, O. Vyrva","doi":"10.15674/0030-598720234103-108","DOIUrl":"https://doi.org/10.15674/0030-598720234103-108","url":null,"abstract":"Multicentric osteosarcoma (M-OGS) is classified as a special type of osteosarcoma, which is characterized by multicentric bone lesions without visceral organs involvement in the tumor process. Synchronous type of the lesion is noted when several  foci of osteosarcoma are diagnosed at the same time, whereas metachronous type may develop additional foci 6 months after the primary tumor diagnosis. This type of osteosarcoma is very rare with only a few articles describing this pathology. Objective. Present a clinical case of rare pathology — multicentric osteosarcoma. Materials and methods. Clinical, radiological, pathomorphological data of a patient with multicentric osteosarcoma. Data on the results of treatment of the patient. Results. Multicentric osteosarcoma It accounts for about 1.5 % of all cases reported worldwide. Fuchs et al described a multifactorial etiology of this pathology, considering it a part of hereditary diseases, such as Rothmund-Thomson, Li-Fraumani, Bloom syndromes. Patients with Pagetʼs disease or McCuneAlbright syndrome have also been diagnosed with multicentric M-OGS. Tumor genetic predisposition has been described as one of the etiology factors, where a genetic mutation is detected. While studying the nature of multicentric M-OGS, various scientists have created classifications of this lesion. Taking to account all clinical and radiological data, a differential diagnosis comes to multiple metastatic lesions of carcinoma, chronic recurrent osteomyelitis and hyperphosphatasia. Conclusions.  Multicentric osteosarcoma is a highly malignant and aggressive tumor that has a characteristic clinical presentation in the form of multiple bone lesions without visceral organs involvement. Mandatory patient monitoring after a comprehensive treatment allows to detect a spread of tumor process, as well as verify this rare pathology and choose the best treatment course. ","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"37 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139528585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RECOVERY OF STABILIZING MUSCLES THAT PROVIDE A VERTICAL POSITION OF THE TRUNK IN PATIENTS WITH POST-TRAUMATIC DEFORMITIES OF THE LONG BONES OF THE LOWER LIMBS IN THE DISTANT PERIOD","authors":"V. Staude, Konstantyn Romanenko, Anna Staude","doi":"10.15674/0030-59872023479-86","DOIUrl":"https://doi.org/10.15674/0030-59872023479-86","url":null,"abstract":"Rehabilitation treatment in the case of posttraumatic deformities of long bones of lower extremities (PDLBLE) in the distant period after trauma is aimed at the restoration of support ability of lower extremity while walking and standing. Objective. To work out the set of the exercises targeted on the restoration of muscle-stabilizer function in patients with (PDLBLE) Methods. Research group — 40 patients who received closed injuries of the long bones of the lower limbs, initial trauma occured 6–12 months ago. Among them were 21 women. (52.5 % of persons; age 27–73 years) and 19 men (47.5 % of people, age 29–77 years). The comparison group included 40 healthy volunteers, among which there were 12 women (30 % of persons; age 24–50 years) and 28 men (70 % of people, age 31–49 years). The assessment was carried out before and after rehabilitation for 2 weeks. Parameters evaluated: pain scores on VAS, the results of restoring the support ability using the scale of Tyazhelov O. A. Results. The results of observations are given, where in addition to descriptive statistics (minimum, maximum, average meanings), parameters of support ability and VAS, in patients and volunteers before and after treatment, cumulative group indicators (CG) were calculated for each group at the beginning (CG0) and 2 weeks after rehabilitation (CG1); the «rehabilitation» coefficient as a ratio of group indicators before and after treatment was calculated as well. Cumulative group indicator after rehabilitation (CG1) increased to 2 995 points, which indicates an increase in support ability. Cumulative group VAS score after rehabilitation (CG1) decreased to 116 points from 200 points before rehabilitation — reduction of pain in patients. After rehabilitation, volunteers showed a slight increase in the cumulatory group indicator (CG1) to 3 917 points. Conclusions. The system of rehabilitation of patients with PDLBLE in the remote period after injuries proved its effectiveness in restoring muscle-stabilizers vertical position of the trunk, pelvis, lower limbs and pain reduction.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"30 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139528685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Сompletely slipped capital femoral epiphysis in an 11 year old girl successfully treated bu DUNN’s open reduction through GANZ’ surgical dislocation of the hip (clinical case)","authors":"Bohdan Romanyshyn, Alexander Schchurovsky, G. Ulrich Exner","doi":"10.15674/0030-59872023498-102","DOIUrl":"https://doi.org/10.15674/0030-59872023498-102","url":null,"abstract":"Slipped capital femoral epiphysis (SCFE) is a hip condition that occurs in teens and preteens who are still growing. Treatment for SCFE involves surgery to stop the head of the femur from slipping any further. Without early detection and proper treatment, SCFE can lead to potentially serious complications, including rapid degeneration of the femoral head and/or painful arthritis in the hip joint. Objective. Our case is presented to familiarize with the technique of safe surgical hip dislocation for the treatment of intraarticular hip pathologies. Case report and Methods. After collision while playing the 11 year old girl developed left hippain still allowing to walk. Imaging documented an acute slipped femoral capital epiphysis with the metaphysis articulating against the acetabulum. The patient was underwent open reduction could be performed using the DUNN procedure modified by GANZ. 6 weeks later prophylactic screw stabilization of the healthy right hip followed. Results. At 9 months follow-up the patient walks painfree with symmetric range of motion. Conclusion. The goal of treatment is to prevent the mildly displaced femoral head from slipping any further. This is always accomplished through surgery. Early diagnosis of SCFE provides the best chance of stabilizing the hip and avoiding complications. When treated early and appropriately, long-term hip function can be expected to be very good. Once SCFE is confirmed, the child will not be allowed to put weight on their hip and will be admitted to the hospital. In most cases, surgery is performed within 24 to 48 hours. In patients with unstable SCFE, the surgeon may first make an open incision in the hip, then gently manipulate (reduce) the head of the femur back into its normal anatomic position. The surgeon will then insert one or two metal screws to hold the bone in place until the growth plate closes. Sometimes surgeon may recommend inserting a screw into the unaffected hip at the same time to reduce the risk of SCFE. Our case demonstrates the value of open reduction of a severely dislocated femoral capital epiphysis in a case otherwise probably needing endoprosthetic hip replacement for restitution of hip function or hip arthrodesis at short-term follow-up","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139618726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of magnesium deficiency on bone health","authors":"N. Diedukh, N. Grygorieva, A. Musiienko","doi":"10.15674/0030-598720234121-127","DOIUrl":"https://doi.org/10.15674/0030-598720234121-127","url":null,"abstract":"Objective. To assess the impact of magnesium deficiency on bone metabolism based on an analytical analysis of current literature, as well as to systematize data on the impact of magnesium deficiency on the development of osteoporosis, bone regeneration, and to consider it as a risk factor for fracture. Methods. The review is based on the analysis of literature sources from PubMed, Scopus, Web of Science, Cochrane Library, Google, Google Scholar, and RLNS. The search was conducted by keywords: magnesium, deficiency, magnesium and bone tissue, magnesium and osteoporosis, magnesium and fractures, magnesium and bone regeneration. Results. Magnesium is a key element in the metabolic and regulatory processes of the body. Its effects on bone tissue are direct and indirect. The direct magnesium effect on genes involved in osteogenesis is accompanied by proliferation of mesenchymal stem cells and osteoblasts, but magnesium deficiency leads to their reduction and apoptosis. In case of magnesium deficiency, the number and activity of osteoclasts increases. Magnesium regulates bone mineralization in a concentration-dependent manner. Magnesium deficiency increases bone resorption and affects osteopenia and osteoporosis, which can occur indirectly through decreased vitamin D levels, increased biosynthesis of parathyroid hormone, increased oxidative stress and biosynthesis of proinflammatory cytokines. However, data on bone mineral density at different skeletal sites in magnesium deficiency are ambiguous. Magnesium deficiency is considered a risk factor for fracture. It is of great importance for bone regeneration, affecting in various ways: it stimulates the proliferation and differentiation of mesenchymal stem cells and osteoblasts, periosteum cells, increases the movement of osteoblasts to the area of traumatic bone injury, and activates signaling pathways. At the early stage of regeneration magnesium has a positive effect on macrophages, its specificity of action is inhibition of transformation of M2 macrophages into M1 at the tissue-specific stage of regeneration. One of the mechanisms stimulating regeneration may be the effect of magnesium on axons, release and increase of calcitonin-related polypeptide α. Conclusions. Since hypomagnesemia is a potentially modifiable factor, this opens up prospects for maintaining bone health and requires further research in this area.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139618927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN INDICATORS OF THE COAGULATION SYSTEM AND MARKERS OF INFLAMMATION IN THE BLOOD OF PATIENTS WITH DEGENERATIVE DISEASES OF LARGE JOINTS IN THE CASE OF TOTAL ARTHROPLASTY","authors":"V. Filipenko, Stanislav Bondarenko, F. Leontyeva, V. Tuliakov, O. Vysotskyi","doi":"10.15674/0030-59872023436-42","DOIUrl":"https://doi.org/10.15674/0030-59872023436-42","url":null,"abstract":"Predicting the risk of developing thrombotic complications is an extremely important task when planning total arthroplasty of large joints (TAJ). Objective. Based on the retrospective analysis of the results of the biochemical examination of patients with degenerative diseases of large joints before and after TAJ, determine the changes in the markers of the hemostasis system and inflammatory processes, which are the most informative for the preoperative prediction of the development of hypercoagulable conditions. Methods. In the blood serum of 39 patients with degenerative diseases of the hip and knee joints of III–IV stages according to Kellgren–Lawrence before and after TAJ, the following were investigated: prothrombin time, international normalized ratio (INR); the content of fibrinogen, soluble fibrin-monomeric complexes (SFMC), D-dimer, antithrombin III, glycoproteins (GP), sialic acids, C-reactive protein (SRP), seroglycoides, haptoglobin; activated partial thrombin time (APTT), fibrinolytic activity (FA). The control group consisted of 30 practically healthy donors. The results. Before TAJ, the serum content of GP patients was 28.80 % higher than the control indicators; haptoglobin — by 20.00; CRP — 82.88; SFMC — 33.60; fibrinogen — 60.32; D-dimer — 41.04 %. The INR was reduced by 25.40 %, the content of antithrombin III — by 21.90 %, FA slowed down by 63.00 %. After TAJ, the content of total HP in the blood serum ofpatients exceeded the indicator of the control group by 55.80 %, sialic acids by 35.60 %; seroglycoides — 55.26; haptoglobin — 61.42; CRP — 151.33 %. An additional reduction of 10.58 %, prothrombin time, APTT — by 15.40 %, antithrombin III activity — 19.10 %, increase in fibrinogen content — 34.90 % was observed; D-dimer — 25.10; SFMC — 36.18; prolongation of FA time — by 29.30 %. Conclusions. To prevent the development of thrombophilic conditions after TES, it is necessary to monitor the most informative markers: increase in FA time, content of fibrinogen, D-dimer, SFMC and haptoglobin.","PeriodicalId":137495,"journal":{"name":"ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS","volume":"52 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139527582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}