International immunology最新文献_第8页

Follicular regulatory T cell subsets in mice and humans: origins, antigen specificity and function. 小鼠和人类的滤泡调节性 T 细胞亚群：起源、抗原特异性和功能。

IF 4.4 4区医学

International immunology Pub Date : 2023-12-23 DOI: 10.1093/intimm/dxad031

Sophia Sokolova, Irina L Grigorova

引用次数: 0

Memory B cell differentiation from germinal centers. 从生殖中心分化出记忆 B 细胞。

IF 4.4 4区医学

International immunology Pub Date : 2023-12-23 DOI: 10.1093/intimm/dxad017

Takeshi Inoue

引用次数: 0

Introduction: Synthetic Biology for Cancer Immunology Special Issue 导言：癌症免疫学合成生物学特刊

IF 4.4 4区医学

International immunology Pub Date : 2023-12-22 DOI: 10.1093/intimm/dxad052

Yuki Kagoya

引用次数: 0

Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation. 肺2组先天性淋巴细胞在先天和适应性免疫介导的气道炎症中不同地依赖于局部IL-7的分布、激活和维持。

IF 4.4 4区医学

International immunology Pub Date : 2023-11-07 DOI: 10.1093/intimm/dxad029

Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Guangwei Cui, Shizue Tani-Ichi, Takahiro Hara, Keishi Miyata, Masashi Ikutani, Kiyoshi Takatsu, Yuichi Oike, Koichi Ikuta

{"title":"Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation.","authors":"Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Guangwei Cui, Shizue Tani-Ichi, Takahiro Hara, Keishi Miyata, Masashi Ikutani, Kiyoshi Takatsu, Yuichi Oike, Koichi Ikuta","doi":"10.1093/intimm/dxad029","DOIUrl":"10.1093/intimm/dxad029","url":null,"abstract":"Interleukin-7 (IL-7) is a cytokine critical for the development and maintenance of group 2 innate lymphoid cells (ILC2s). ILC2s are resident in peripheral tissues such as the intestine and lung. However, whether IL-7 produced in the lung plays a role in the maintenance and function of lung ILC2s during airway inflammation remains unknown. IL-7 was expressed in bronchoalveolar epithelial cells and lymphatic endothelial cells (LECs). To investigate the role of local IL-7 in lung ILC2s, we generated two types of IL-7 conditional knockout (IL-7cKO) mice: Sftpc-Cre (SPC-Cre) IL-7cKO mice specific for bronchial epithelial cells and type 2 alveolar epithelial cells and Lyve1-Cre IL-7cKO mice specific for LECs. In steady state, ILC2s were located near airway epithelia, although lung ILC2s were unchanged in the two lines of IL-7cKO mice. In papain-induced airway inflammation dependent on innate immunity, lung ILC2s localized near bronchia via CCR4 expression, and eosinophil infiltration and type 2 cytokine production were reduced in SPC-Cre IL-7cKO mice. In contrast, in house dust mite (HDM)-induced airway inflammation dependent on adaptive immunity, lung ILC2s localized near lymphatic vessels via their CCR2 expression 2 weeks after the last challenge. Furthermore, lung ILC2s were decreased in Lyve1-Cre IL-7cKO mice in the HDM-induced inflammation because of decreased cell survival and proliferation. Finally, administration of anti-IL-7 antibody attenuated papain-induced inflammation by suppressing the activation of ILC2s. Thus, this study demonstrates that IL-7 produced by bronchoalveolar epithelial cells and LECs differentially controls the activation and maintenance of lung ILC2s, where they are localized in airway inflammation.","PeriodicalId":13743,"journal":{"name":"International immunology","volume":" ","pages":"513-530"},"PeriodicalIF":4.4,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9925211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjögren's syndrome. IL-27调节实验性干燥综合征中MDSCs的NLRP3炎症小体激活。

IF 4.4 4区医学

International immunology Pub Date : 2023-11-07 DOI: 10.1093/intimm/dxad037

Xiaoyu Xia, Qiqiang Long, Jie Zha, Tingting Jiang, Junqiao Guo, Bo Jiang, Xiaojing Li, Genhong Yao

{"title":"IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjögren's syndrome.","authors":"Xiaoyu Xia, Qiqiang Long, Jie Zha, Tingting Jiang, Junqiao Guo, Bo Jiang, Xiaojing Li, Genhong Yao","doi":"10.1093/intimm/dxad037","DOIUrl":"10.1093/intimm/dxad037","url":null,"abstract":"Excessive NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation has an important function in the pathogenesis of Sjögren's syndrome (SS). Increased and dysfunctional myeloid-derived suppressor cells (MDSCs) promoted SS. However, NLRP3 inflammasome activation of MDSCs in SS and its regulated components are unclear. Splenic MDSCs were purified by immunomagnetic beads and cultured. Western blot was used to assess NLRP3 inflammasomes. Interleukin-1β (IL-1β) and IL-18 were measured using enzyme-linked immunosorbent assay. Here we showed that the NLRP3 inflammasome was activated in non-obese diabetic (NOD) mice with SS-like manifestations. We found that NLRP3 inflammasome activation was augmented in MDSCs of SS mice and NLRP3 inflammasome activation was suppressed in IL-27-deficient NOD mice. Consistent with findings of SS mice in vivo, we observed that NLRP3 inflammasome activation by adenosine triphosphate and lipopolysaccharide was remarkably intensified in MDSCs with IL-27 treatment in vitro. Collectively, our data highlighted that IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental SS.","PeriodicalId":13743,"journal":{"name":"International immunology","volume":" ","pages":"531-542"},"PeriodicalIF":4.4,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41127017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Immunogenicity evaluation of viral peptides via nonspecific interactions between anti-peptide IgYs and non-cognate peptides. 修正:通过抗肽IgYs和非同源肽之间的非特异性相互作用来评估病毒肽的免疫原性。

IF 4.4 4区医学

International immunology Pub Date : 2023-11-07 DOI: 10.1093/intimm/dxad023

引用次数: 0

Correction to: Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation. 更正：肺2组先天性淋巴细胞在先天和适应性免疫介导的气道炎症中不同地依赖于局部IL-7的分布、激活和维持。

IF 4.4 4区医学

International immunology Pub Date : 2023-11-07 DOI: 10.1093/intimm/dxad036

引用次数: 0

Mucosal-associated invariant T cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity. 来自艰难梭菌感染患者的粘膜相关不变T细胞表现出明显的促炎表型和增强的细胞毒性活性。

IF 4.4 4区医学

International immunology Pub Date : 2023-11-07 DOI: 10.1093/intimm/dxad032

Steffen Brauns, Isabel Marquardt, Cosima Thon, Sarah Frentzel, Josefine Jakob, Jacqueline Färber, Lars Philipsen, Lothar Jänsch, Alexander Link, Dunja Bruder

{"title":"Mucosal-associated invariant T cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity.","authors":"Steffen Brauns, Isabel Marquardt, Cosima Thon, Sarah Frentzel, Josefine Jakob, Jacqueline Färber, Lars Philipsen, Lothar Jänsch, Alexander Link, Dunja Bruder","doi":"10.1093/intimm/dxad032","DOIUrl":"10.1093/intimm/dxad032","url":null,"abstract":"Mucosal-associated invariant T (MAIT) cells are innate-like T cells mainly found in the mucosa and peripheral blood. We have recently demonstrated that Clostridioides difficile activates MAIT cells in vitro. However, their role in the pathogenesis of C. difficile infection (CDI) in human patients remains elusive to date. In this study, we performed comprehensive immunophenotyping of MAIT cells derived from CDI patients and compared their phenotype to that of patients with inflammatory bowel diseases (IBD) and healthy controls. Our study revealed that blood MAIT cells from CDI patients exhibit an interleukin 17a (IL-17a)-dominated proinflammatory phenotype and an increased readiness to synthesize the proinflammatory cytokine interferon γ (IFN-γ) following in vitro re-stimulation. Moreover, the cytotoxic activity of MAIT cells, as measured by surface CD107a and intracellular granzyme B expression, was strongly increased in CDI. Multi epitope ligand cartography (MELC) analysis of intestinal biopsies from CDI patients revealed that MAIT cells exhibit an increased production of granzyme B and increased cytotoxicity compared to the control group. Together with previously published in vitro data from our group, our findings suggest that MAIT cells are functionally involved in the immune response against C. difficile and contribute to the pathogenesis of CDI.","PeriodicalId":13743,"journal":{"name":"International immunology","volume":" ","pages":"543-554"},"PeriodicalIF":4.4,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outstanding Merit Award 2023 2023年杰出优异奖

4区医学

International immunology Pub Date : 2023-10-31 DOI: 10.1093/intimm/dxad039

引用次数: 0

Introduction: Novel Aspects of the Germinal Center Reaction Special Issue 导言:生发中心反应的新方面特刊

4区医学

International immunology Pub Date : 2023-10-20 DOI: 10.1093/intimm/dxad040

Tomohiro Kurosaki

引用次数: 0