Integrative Cancer Therapies最新文献

{"title":"Biobran/MGN-3, Arabinoxylan Rice Bran, Ameliorates the Liver Architecture in Ehrlich Ascites Tumor-Bearing Mice as a Cotreatment with Chemotherapy.","authors":"Mai Alaa El-Dein, Doaa A Ali, Mamdooh H Ghoneum","doi":"10.1177/15347354261430853","DOIUrl":"10.1177/15347354261430853","url":null,"abstract":"<p><strong>Background: </strong>Hepatic metastases are a leading cause of mortality in gastrointestinal cancers, often exacerbated by the limited efficacy of conventional chemotherapeutics. Biobran/MGN-3, a rice bran-derived arabinoxylan, has shown promise in sensitizing cancer cells to paclitaxel.</p><p><strong>Objective: </strong>This study evaluates the hepatoprotective potential of Biobran/MGN-3 in a murine model of Ehrlich ascites carcinoma (EAC).</p><p><strong>Methods: </strong>Female Swiss mice inoculated with EAC were treated with paclitaxel (10 mg/kg) and Biobran (40 mg/kg) concomitantly for 30 days. Tumor volume along with liver function enzymes were quantified, and hepatic tissue was examined using Masson's trichrome staining, histopathology, and transmission electron microscopy.</p><p><strong>Results: </strong>Biobran administration significantly reduced tumor volume and liver enzyme levels, indicating improved hepatic function. Collagen deposition around hepatic capillaries was markedly diminished. Histological analysis revealed restoration of normal lobular architecture, while ultrastructural examination showed enhanced nuclear integrity, bile duct morphology, and cytoplasmic organelle preservation. Notably, Biobran activated Kupffer cells to target neoplastic cells infiltrating hepatic parenchyma.</p><p><strong>Conclusion: </strong>Biobran/MGN-3, in combination with paclitaxel, confers substantial hepatoprotective effects in EAC-bearing mice, supporting its potential as a nutraceutical adjunct in cancer therapy.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261430853"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13039626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an Assessment Tool for YouTube Videos With Medical Content: A Focus on Nutrition and Cancer.","authors":"Alina Grumt, Sophia Huchel, Christian Keinki, Viktoria Mathies, Lukas Käsmann, Jutta Huebner","doi":"10.1177/15347354261422762","DOIUrl":"10.1177/15347354261422762","url":null,"abstract":"<p><strong>Background: </strong>Cancer patients increasingly use YouTube for nutritional guidance, yet information quality varies substantially. Existing text-based assessment tools fail to capture audiovisual content characteristics. This study aimed to (1) develop a video-specific assessment tool, (2) evaluate German-language YouTube videos on cancer nutrition, and (3) identify quality indicators for laypersons.</p><p><strong>Methods: </strong>A 20-criteria assessment tool integrating established instruments and video-specific elements was developed. The first 30 YouTube videos on cancer nutrition were systematically evaluated. Spearman correlation and Kruskal-Wallis tests identified associations between video characteristics and quality scores. Interrater reliability was assessed.</p><p><strong>Results: </strong>Intraclass correlation coefficient indicated good to very good interrater reliability (95% CI: 0.87-0.96). Overall video quality was poor (mean: 38.6/60, SD: 5.3). Videos from hospitals (<i>P</i> = .002) and healthcare organizations (<i>P</i> = .006) scored significantly higher than those from independent persons. Videos with clearly formulated goals (<i>r_s</i> = 0.71, <i>P</i> < .001) and cited references (<i>r_s</i> = 0.43, <i>P</i> = .019) demonstrated stronger evidence-based content. High-quality videos more frequently addressed missing evidence (<i>r_s</i> = 0.51, <i>P</i> = .004). Quality scores inversely correlated with likes (<i>r_s</i> = -0.55, <i>P</i> = .002) and views (<i>r_s</i> = -0.46, <i>P</i> = .01).</p><p><strong>Conclusion: </strong>YouTube videos on cancer nutrition exhibit substantial quality deficits, even from institutional providers. The validated assessment tool identifies observable quality indicators including clear objectives, scientific citations, transparent discussion of evidence gaps, and institutional authorship. However, no single feature reliably predicts quality. Strengthening digital health literacy and improving evidence-based content production and visibility remain essential priorities.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261422762"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Efficacy of Herbal Medicine Therapy Combined with Palliative Chemotherapy in Unresectable Advanced NSCLC: A Systematic Review and Meta-Analysis\".","authors":"Rui Wang, Xingzhen Li, Yi Liang","doi":"10.1177/15347354261439133","DOIUrl":"10.1177/15347354261439133","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261439133"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hydrogen Water Gargling on Oral Mucositis and Pain in Head and Neck Cancer Patients: A Randomized Controlled Pilot Study.","authors":"Hui-Ting Tsai, Chih-Jen Huang, Hui-Ching Wang, Sheng-Dean Luo, Kun-Ming Rau, Pi-Ling Chou","doi":"10.1177/15347354261463550","DOIUrl":"10.1177/15347354261463550","url":null,"abstract":"<p><p>BackgroundTraditional, complementary, and integrative medicine (TCIM) is an evolving field in oncology focused on managing cancer symptoms. Hydrogen water (HW) has gained attention for its antioxidant and anti-inflammatory properties, yet its clinical effectiveness needs further exploration. This randomized controlled trial aimed to assess the impact of gargling with HW on oral mucositis severity, pain levels, oral frailty, and quality of life in head and neck cancer patients undergoing radiotherapy or concurrent chemo-radiotherapy.MethodsIn this single-center, single-blind, parallel-group randomized controlled trial, patients were randomly assigned to receive either HW or distilled water (DW) for gargling. Oral mucositis (OM) severity, pain, oral frailty, and quality of life (QoL) were assessed using the World Health Organization Oral Mucositis Grading Criteria (WHO-OMGC), the Brief Pain Inventory-Taiwan (BPI-T), the Oral Frailty Checklist (OFC), and the EORTC QLQ-H&N35 questionnaire. Assessments were conducted at baseline (T0) and on Days 1 (T1), 3 (T2), 7 (T3), and 14 (T4) post-treatment.ResultsThe HW group showed significant OM improvement at Day 7 (p = 0.04) and Day 14 (p = 0.002). Pain decreased significantly in the HW group at Day 14 (p = 0.02). QoL improved in the HW group (p = 0.03), while OFC scores showed no significant difference between groups (p = 0.74).ConclusionHW gargling significantly alleviated OM severity and pain and improved QoL in head and neck cancer (HNC) patients undergoing radiotherapy or CCRT. HW gargling may serve as a simple, well-tolerated, and effective complementary and integrative therapy during cancer treatment.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261463550"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Growth Arrest and Protective Effects of <i>Myrianthus arboreus</i> P. Beauv. (Cecropiaceae) Methanolic Extract on benzo(a)pyrene-Induced Prostate Cancer in Adult Wistar Rats.","authors":"Florette Tedjo Motoum, Sefirin Djiogue, Charline Florence Awounfack, Kevine Silihe Kamga, Stéphane Zingue, Derek Tantoh Ndinteh, Dieudonné Njamen","doi":"10.1177/15347354261492307","DOIUrl":"https://doi.org/10.1177/15347354261492307","url":null,"abstract":"<p><p>Prostate cancer is the second most frequently diagnosed malignancy in men globally, with over 1.4 million new cases and approximately 397,430 deaths in 2022. Despite available treatments, incidence and mortality remain high, underscoring the need for novel, cost-effective therapeutic options. <i>Myrianthus arboreus</i> P. Beauv. (Cecropiaceae) is traditionally employed in Cameroonian herbal medicine for cancer-related conditions. This study assessed the anti-prostate cancer activity of aqueous and methanolic bark extracts of M. arboreus on LNCaP, DU145, and PC3 human prostate cancer cell lines and in a benzo(a)pyrene (B[a]P)-induced prostate cancer rat model. <i>In vivo</i>, 48 male Wistar rats were randomized into six groups (n = 8) receiving distilled water, casodex (13.5 mg/kg), or <i>M. arboreus</i> methanolic extracts (50, 100, or 200 mg/kg) orally for 196 days following B[a]P-induced carcinogenesis. <i>In vitro</i>, both extracts inhibited cancer cell growth in time- and concentration-dependent manner, with <i>M. arboreus</i> methanolic extracts showing greater potency. <i>M. arboreus</i> methanolic extracts promoted apoptosis in LNCaP and DU145 cells, suppressed clonogenicity, migration, and invasion in DU145 cells, and enhanced adhesion to collagen and fibronectin matrices. <i>M. arboreus</i> methanolic extracts significantly reduced tumor incidence, mass, volume, and PSA levels, and reversed B[a]P-induced oxidative stress, inflammation, dyslipidemia, and hepatorenal dysfunction. These findings indicate that <i>M. arboreus</i> methanolic extracts exerts potent chemopreventive and anti-proliferative effects in prostate cancer models, supporting its development as a plant-based therapeutic candidate against prostate cancer.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261492307"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter Regarding \"Herbal Medicine Combined With Chemotherapy in Advanced NSCLC\".","authors":"Dong-Hyeon Kim, Keon-Jun Lee, So-Jung Park","doi":"10.1177/15347354251414642","DOIUrl":"10.1177/15347354251414642","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354251414642"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146062822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ze-qi Decoction Inhibits Neutrophil Extracellular Trap Formation to Suppress the Progression and Metastasis of Non-Small Cell Lung Cancer.","authors":"Yi-Yang Jiang, Bin-Bin Li, Qian Meng, Xiang-Yang Liu, Min-Min Yu, Xue Li, Fei Xu","doi":"10.1177/15347354261420750","DOIUrl":"10.1177/15347354261420750","url":null,"abstract":"<p><p>Non-small-cell lung cancer (NSCLC) research has focused on complementary and well-established treatments with clear mechanisms and less toxicity. Immune dysregulation is vital in NSCLC progression and metastasis. Ze-qi decoction (ZQD) exhibits therapeutic effects in patients with NSCLC; however, its pharmacodynamic material basis and specific mechanisms remain unclear. In this study, we integrated UPLC-HRMS, pharmacological analysis, and transcriptomic analysis to identify the potential effective components of ZQD and elucidate its intrinsic mechanisms. ZQD exhibited potent anti-NSCLC activity in the mouse subcutaneous tumor model. A total of 297 bioactive compounds were identified in mouse plasma following ZQD administration. Pharmacological analysis revealed liquiritigenin, vibsanin B, and 11-keto-beta-boswellic acid as the potential active ingredients of ZQD and suggested that ZQD exerted anti-NSCLC effects primarily via immunomodulatory and anti-inflammatory pathways. Integrative analysis of network pharmacology and transcriptomics indicated the neutrophil extracellular trap (NET) formation as a key pathway. Further analysis showed that ZQD disrupted the neutrophil recruitment environment by decreasing hypoxia-inducible factor-1α, CD18, and intercellular adhesion molecule-1 levels and downregulating NET-related markers (citrullinated histone H3, myeloperoxidase, and neutrophil elastase). Finally, these results were confirmed in a lung metastasis model. This is the first study designed to analyze the material basis of ZQD responsible for its effect on NSCLC. Our results indicate that the mechanisms of action of ZQD involve impeding neutrophil recruitment and activation, as well as reducing the levels of NETs-related markers. These suggest the potential of ZQD in suppressing NETs formation or release, inhibiting NSCLC progression and metastasis.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261420750"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12909755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: The Effect of a Ketogenic Diet on Cancer: Evidence From Systematic Reviews and Meta-Analyzes.","authors":"Guoping Xu","doi":"10.1177/15347354261493876","DOIUrl":"https://doi.org/10.1177/15347354261493876","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261493876"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture Versus Auricular Acupressure Versus WaitliSt Control for Endocrine Therapy-Related Joint Pain in Patients With Breast Cancer (EASE): Study Protocol for a Pragmatic Multicenter Randomised Controlled Trial.","authors":"Jing Xue, Lisen Lin, Bin Wang, Miaozhou Wang, Hailong Wang, Xiumei Feng, Mingxiao Yang, Shiyan Yan, Jiuda Zhao, Zhanyu Pan, Yue Pan, Qianqian Chen, Li Yang, Xiao Dong, Sihan Sun, Lin Cai, Yaoran Wang, Qiaorui Chen, Fanming Kong, Yunchao Zhang, Menghan Li, Chaoran Wang, Jiachang Wei, Zhanliang Ruan, Yiting Guo, Qiming Xing, Qian Song, Xiaonong Fan, Sha Yang, Guanran Wang, Fuxing Zhao, Fahe Pu, Qian Li, Ying Huang, Qi Li, Hongcheng Lv, Jianchu Dong, Shu Wang, Li Li","doi":"10.1177/15347354261484151","DOIUrl":"10.1177/15347354261484151","url":null,"abstract":"<p><p>BackgroundThe incidence of breast cancer has been steadily increasing in recent years. Endocrine therapy, as a first-line treatment, is typically required for 5 to 10 years. However, joint pain is one of the most common adverse effects, affecting 50%-70% of patients and significantly compromising treatment adherence and quality of life. Current management strategies have limited efficacy. Electroacupuncture has been shown to alleviate joint pain intensity and improve related symptoms, but the need for frequent hospital visits imposes a logistical burden on patients and their families, which may reduce adherence and limit accessibility. Auricular acupressure offers a simple and safe alternative that provide sustained stimulation, and facilitates hospital-guided, home-based self-management between clinic visits. This trial aims to evaluate the effectiveness and safety of electroacupuncture and auricular acupressure versus waitlist control for endocrine therapy-related joint pain in patients with breast cancer.Methods and analysisThis multicentre, pragmatic, three-arm randomised controlled trial will enrol 200 eligible participants with breast cancer experiencing endocrine therapy-related joint pain. Participants will be randomised in a 2:2:1 ratio to receive electroacupuncture, auricular acupressure, or waitlist control. The primary outcome is the change from baseline to week 8 in the Brief Pain Inventory-Short Form (BPI-SF) worst pain score. Secondary outcomes include the BPI-SF pain severity and pain interference scores, the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health scale, the Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES), the EuroQol-5 Dimension 5-Level (EQ-5D-5L), the Quantitative Analgesic Questionnaire (QAQ), and the Credibility/Expectancy Questionnaire (CEQ). Intervention adherence, endocrine therapy usage, and adverse events will also be recorded. Analyses will follow the modified intention-to-treat principle. The trial will compare each active intervention with the waitlist control and assess whether auricular acupressure is non-inferior to electroacupuncture.Ethics and DisseminationThis study protocol has been approved by the ethics committees of the participating institutions. The trial results will be disseminated through peer-reviewed publications and conference presentations.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261484151"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Melatonin in Alleviating Radiotherapy-Induced Fatigue, Anxiety, and Depression in Breast Cancer Patients: A Systematic Review and Meta-Analysis.","authors":"Khadija Panhwar, Shiza Rizwan, Muhammad Bilal Khan, Diksha Ladhani, Rachna Katyara, Bibi Zarfeen Talpur, Nouraiz Abbas, Archita Archita, Fatima Laique, Bibek Giri","doi":"10.1177/15347354261490585","DOIUrl":"10.1177/15347354261490585","url":null,"abstract":"<p><p>BackgroundBreast cancer (BRCA) remains the most diagnosed malignancy among women globally and is predominantly managed through multimodal therapy. Radiotherapy, an essential component of BRCA management, often causes fatigue, anxiety, and depression that compromise the quality of life (QoL) of patients. Melatonin, an endogenous hormone with antioxidant, anti-inflammatory, and circadian rhythm-modulating properties, has shown potential for preventing radiotherapy-associated toxicities. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of melatonin in alleviating radiotherapy-induced fatigue, anxiety, and depression among breast cancer patients.MethodsFollowing PRISMA guidelines (PROSPERO: CRD420251144916), a comprehensive search was conducted across PubMed, Scopus, Cochrane Library, Embase, and Google Scholar up to August 2025. RCTSs comparing melatonin with placebo in adult female patients with non-metastatic breast cancer undergoing adjuvant radiotherapy were included. The Cochrane RoB-2 tool was employed for quality assessment. Pooled standardized mean differences (SMDs) and mean differences (MDs) were calculated using a random-effects model in RevMan 5.4 software.ResultsFive RCTs encompassing 561 patients were analyzed. Melatonin significantly reduced fatigue severity (SMD = -0.43; 95% CI -0.65 to -0.20; p = 0.0002) and improved cognitive functioning (MD = 1.16; 95% CI 0.95 to 1.36; p < 0.00001) and global health status (MD = 2.47; 95% CI 2.07 to 2.87; p < 0.00001). No significant effects were observed for emotional, social, or physical functioning, nor for gastrointestinal, pain, or sleep-related domains.ConclusionBased on limited number of studies, melatonin supplementation appears to be a safe, well-tolerated, and low-cost adjunct to radiotherapy, capable of improving fatigue, cognitive performance, and overall QoL in breast cancer patients. However, small sample sizes and heterogeneous dosing regimens require further large-scale RCTs to establish optimal dosing and long-term efficacy.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261490585"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13569999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}