Integrative Cancer Therapies最新文献

{"title":"Effectiveness of Exercise-Based Interventions on Molecular Biomarkers in Head and Neck Cancer (HNC) Survivors: A Systematic Review.","authors":"Hritika D Pai, K Vijaya Kumar, Prasanna Mithra, Shruti D'Souza, Poornima Ajay Manjrekar, Stephen Rajan Samuel, Justin W L Keogh","doi":"10.1177/15347354251361463","DOIUrl":"https://doi.org/10.1177/15347354251361463","url":null,"abstract":"<p><strong>Purpose: </strong>HNC poses significant health challenges globally with over 650 000 new cases annually. Studies have demonstrated the benefits of exercise for many cancer types, with several exploring the effects of exercise on various molecular biomarkers. However, no study has systematically explored these effects among HNC survivors.</p><p><strong>Methods: </strong>Studies published up to February 2024 were screened on PubMed, SCOPUS and Web of Science using relevant keywords yielding 838 results. Studies that explored the effect of exercise-based interventions on molecular biomarkers among HNC survivors were eligible for inclusion. Risk of bias was assessed using the Joanna Briggs Institute quality assessment tool.</p><p><strong>Results: </strong>Three studies were included in the review. Primary biomarkers assessed were inflammatory (eg, IL-6, TNF-α), oxidative stress (eg, 8-OHdG, MDA), and collagen fragment markers (eg, IC6, ProC3). Significant changes were observed in collagen fragment markers, specifically Pro C3, IC6 and IC6/C6M over time, although no correlation with lean body mass was found. Oxidative stress markers improved following exercise, with increases in total antioxidant capacity, decreases in 8-OHdG and carbonyl content. However, no significant changes were found in inflammatory markers or DNA methylation patterns post-intervention.</p><p><strong>Conclusion: </strong>Our review suggests that exercise shows potential in modulating physiological and molecular pathways' among HNC survivors. Although only 3 studies were eligible for inclusion, these benefits might potentially translate into improvements in health-related outcomes amongst HNC survivors. Future large-scale trials with standardized exercise protocols and extended follow-up periods might improve our understanding of the long-term effects of exercise on biomarkers and survivorship outcomes in HNC.<b>PROSPERO Registration Number:</b> CRD42024508084.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251361463"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Clinical Usage of Phellinus Linteus as a Nutraceutical for Non-FOLFIRINOX-Based Postoperative Adjuvant Chemotherapy for Resected Pancreatic Cancer: A Retrospective Cohort Study.","authors":"Juwan Kim, Seung Soo Hong, Sung Hyun Kim, Ho Kyoung Hwang, Chang Moo Kang","doi":"10.1177/15347354251353499","DOIUrl":"10.1177/15347354251353499","url":null,"abstract":"<p><strong>Introduction: </strong>Most patients with pancreatic cancer experience systemic recurrence within 1 to 2 years after radical pancreatectomy. Phellinus linteus (PL) has demonstrated anti-inflammatory, antioxidant, and anti-cancer properties, suggesting potential as an adjunct to cancer therapy. This study aimed to evaluate the long-term oncological impact of perioperative PL in resected pancreatic cancer.</p><p><strong>Method: </strong>This retrospective cohort study included 407 patients who underwent curative resection and adjuvant chemotherapy for pancreatic cancer at Severance Hospital (2012-2022). Among them, 103 patients who began PL postoperatively and continued throughout treatment were assigned to the PL group; 304 patients without PL intake comprised the control group.</p><p><strong>Results: </strong>The mean overall survival (OS) was significantly longer in the PL group (47.0 months; 95% CI: 42.8-51.1) than in the control group (35.0 months; 95% CI: 30.3-39.7; <i>P</i> < .001). Recurrence-free survival (RFS) showed a borderline improvement (<i>P</i> = .053). PL use was marginally associated with improved OS in multivariate analysis (HR: 0.614; 95% CI: 0.376-1.002; <i>P</i> = .051). Subgroup analysis showed no significant OS or RFS benefit with PL in patients receiving FOLFIRINOX. However, among patients treated with non-FOLFIRINOX regimens, PL use led to significantly better OS (43.9 months vs 35.0 months; <i>P</i> = .021), though RFS remained similar. Notably, the OS of the non-FOLFIRINOX + PL group was comparable to that of the FOLFIRINOX group (<i>P</i> = .332) and superior to the non-FOLFIRINOX control group (<i>P</i> = .021).</p><p><strong>Conclusion: </strong>PL may enhance survival in resected pancreatic cancer, particularly in patients receiving non-FOLFIRINOX chemotherapy, supporting its role as a potential adjunct when FOLFIRINOX is not feasible.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251353499"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Possible Role of Melatonin in Balancing Reactive Oxygen Species (ROS) in Cancer Biology.","authors":"Farzaneh Shomoossi, Shayan Sheikhmiri, Reza Chaman, Sara Shenavaei Zare, James S Welsh, Seyed Alireza Javadinia","doi":"10.1177/15347354251372078","DOIUrl":"https://doi.org/10.1177/15347354251372078","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251372078"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of Constitutional Bias and Associated Factors in Patients with Recurrent and Metastatic Gastric Cancer, and the Therapeutic Effect of <i>Yiqi Wenyang Jiedu</i> Prescription: A one-arm study.","authors":"Luchang Cao, Xinmiao Wang, Xinyi Ma, Guanghui Zhu, Jie Li","doi":"10.1177/15347354251331100","DOIUrl":"https://doi.org/10.1177/15347354251331100","url":null,"abstract":"<p><strong>Objective: </strong>This study was conducted to elucidate the distribution characteristics of predominant unbalanced constitutions and TCM syndrome elements in patients with recurrent and metastatic gastric cancer. This study was also undertaken to analyze the potential relationship between the body constitutions of patients, syndrome elements, and biological indicators, as well as to investigate the effect of <i>Yiqi Wenyang Jiedu</i> prescription (YWJP) on symptoms and biological indicators before and after treatment.</p><p><strong>Result: </strong><i>Yang</i>-deficiency and <i>Qi</i>-deficiency were identified as prevalent imbalanced constitutions among patients with recurrent and metastatic gastric cancer. The primary syndrome factors associated with disease localization included the spleen-stomach and liver, with the main syndrome elements being <i>Qi</i>-deficiency, <i>Yang</i>-deficiency, and <i>Qi</i>-stagnation. Patients with <i>Qi</i>-deficiency and <i>Yang</i>-deficiency constitutions exhibited lower BMI and higher monocyte-to-lymphocyte ratio (MLR). A notable positive correlation was observed between cold (<i>Yang</i>-deficiency) and BMI, as well as between <i>Qi</i>-deficiency constitution and neutrophil-to-lymphocyte ratio (NLR). Furthermore, YWJP demonstrated efficacy in alleviating symptoms associated with <i>Qi</i>-deficiency and <i>Yang</i>-deficiency in patients with recurrent and metastatic gastric cancer, including dyspnea, fatigue, diaphoresis, cold intolerance, abdominal sounds, postural changes, and abdominal distension.</p><p><strong>Discussion: </strong><i>Yang</i>-deficiency and <i>Qi</i>-deficiency emerged as prevalent constitutional patterns in patients with recurrent and metastatic gastric cancer. Notably, BMI, MLR, and NLR may serve as physiological indicators of these conditions. Furthermore, YWJP treatment demonstrated potential efficacy in alleviating symptoms associated with <i>Qi</i>-deficiency and <i>Yang</i>-deficiency in this patient population.</p><p><strong>Clinical trial registration: </strong>Chinese Clinical Trial Registry: ChiCTR2200055826.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251331100"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Potential and Metabolomic Profiling of <i>Solanum lycopersicum</i> Roots Extract and Their Nanocrystals: An <i>In Silico</i> Approach.","authors":"Marwa A M Abdel-Razek, Miada F Abdelwahab, Soad A Mohamad, Hesham A Abou-Zied, Usama R Abdelmohsen, Ashraf N E Hamed","doi":"10.1177/15347354251335599","DOIUrl":"10.1177/15347354251335599","url":null,"abstract":"<p><p><i>Solanum lycopersicum</i> L. Moench (Tomato) is a rich source of bioactive compounds. This study investigated the anticancer potential of <i>S. lycopersicum</i> roots methanol extract (TMESLR) and their nanocrystals (TMESLR-NCs) against breast (MCF-7), hepatocellular (HepG2), and colon (Caco-2) cancer cell lines, for the first time. TMESLR exhibited significant cytotoxicity against all 3 cell lines, with the nanocrystals demonstrating enhanced activity, Caco-2, MCF-7, and HepG2 cells with IC₅₀ values of 9.69 ± 0.6, 12.52 ± 0.58, and 14.34 ± 0.62 µg/mL, respectively. Whereas, the prepared TMESLR-NCs displayed significantly the highest cytostatic potential against Caco-2 with IC₅₀ value of 5.733 ± 0.29 µg/mL. Metabolomic profiling revealed <b>17</b> secondary metabolites, including flavonoids, phenolic acids, and terpenoids. <i>In silico</i> analyses, including PPI network construction, GO enrichment, and KEGG pathway analysis, highlighted the involvement of apoptotic pathways, p53 signaling, and TNF signaling in the anticancer effects of TMESLR. Molecular docking studies identified chlorogenic acid and inosine as potential inhibitors of Histone Deacetylase 2 (HDAC2). Inosine (<b>6</b>) displayed a superior docking score of -7.86 kcal/mol, interacting with critical residues GLY154, ASP269, and HIS146. On the other hand, chlorogenic acid (<b>12</b>) achieved a docking score of -7.32 kcal/mol, forming stable interactions with TYR308, PHE210, and LEU276 residues. These findings suggest that TMESLR and TMESLR-NCs possess promising anticancer activity and warrant further investigation as potential therapeutic agents.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251335599"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition Assessment and Counseling in Integrative Cancer Care: Effects on Patient Self-Reported Symptoms.","authors":"Meroë Morse, Aimee J Christie, Andrew Cusimano, Chandler Nguyen, Richard Wagner, Santhosshi Narayanan, Gabriel Lopez","doi":"10.1177/15347354251342756","DOIUrl":"10.1177/15347354251342756","url":null,"abstract":"<p><strong>Background: </strong>Nutrition guidance can affect treatment and survival outcomes for patients with cancer. The effect of a single nutrition consult on patient-reported outcomes is not well known. This study describes characteristics of patients referred for a single outpatient nutrition consult in an integrative oncology center at a cancer hospital, examining effects on self-reported symptoms.</p><p><strong>Methods: </strong>We completed a retrospective chart review of 1517 adult oncology patients who completed a single nutrition consult. Demographics, clinical characteristics, and reasons for referral were extracted. Modified Edmonton Symptom Assessment System (mESAS) and Patient-Reported Outcomes Measurement Information System (PROMIS10) scores were collected. Standard descriptive statistics and the Wilcoxon signed-rank test were used.</p><p><strong>Results: </strong>Most patients were white, women, overweight/obese with breast cancer and non-advanced disease, mean age 55.3 years. Primary reasons for referral were \"lifestyle change,\" \"overweight weight-related,\" and \"nutrition knowledge deficit.\" PROMIS10 results were average. Other than sleep and hot flashes, mESAS symptom scores at baseline were in the mild range. All change scores after nutrition consult were statistically but not clinically significant.</p><p><strong>Conclusion: </strong>Patients presenting for nutrition counseling had a mild symptom burden at baseline and experienced statistically, not clinically, significant improvement in self-reported symptoms following a single visit. Additional research is needed to explore strategies to enhance the intervention and understand the effects of multiple follow-up sessions.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251342756"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Modified Tongyou Decoction and Its Separated Formulas Inhibiting Vasculogenic Mimicry in Esophageal Cancer TE-1 Cells via NF-κB/HIF-1α Axis.","authors":"Qian Wang, Yingying Tian, Lingyu Kong, Zeyi Chen, Xin Yan, Chenxi Wu, Huijuan Cao, Fanwu Wu, Yongsen Jia","doi":"10.1177/15347354251332590","DOIUrl":"https://doi.org/10.1177/15347354251332590","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore mechanisms of Modified Tongyou Decoction (MTD) and its separated formulas inhibiting vasculogenic mimicry (VM) in esophageal cancer (EC) TE-1 cells and improving the hypoxic environment via NF-κB/HIF-1α axis on the basis of the hypoxia stimulating the cells' VM formation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The extract of MTD was prepared by water extraction and alcohol precipitation-whirl evaporation, and amygdalin, the content of the antitumor active component, was determined by chromatography. TE-1 cells were divided into normoxia control (NC) group, hypoxia control (HC) group, MTD group, activating blood (AB), promoting Qi (PQ) and removing toxin (RT) separated formula groups. The optimal concentration and time dependent manner of MTD and the 3 separated formulas were screened by CCK-8 assay. Migration and invasion ability was detected by wound healing and invasion assay. Vasculogenesis experiment was performed to investigate TE-1 cells' vasculogenic capacity. Protein expression of NF-κB/HIF-1α axis and VM related molecules were detected by Western blot. Interaction between HIF-1α and NF-κB was detected by double immunofluorescence labeling assay. mRNA expression of HIF-1α and NF-κB was detected by qRT-PCR. Protein secretion of HIF-1α and E-cadherin in supernatant of culture media was determined by ELISA assay.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Extract of MTD contained amygdalin, an active anti-cancer component, the concentration of it being 104.397 μg/mL. Effect-time dependent manner was achieved when cells were treated with MTD and the 3 separated formulas for 24 hours with IC50 concentration, MTD, 2550 μg/mL; PQ, 3384 μg/mL; AB, 3979 μg/mL; RT, 3832 μg/mL. Cell migration area rate of NC group was 43% while that of HC group was 56% after 12 hours; the rate of the 4 medications decreased differently, showing statistical significance with that of NC group (&lt;i&gt;P&lt;/i&gt; &lt; .05). Cell invasion area in HC group was 80% within invasion field while it was 55% in NC group after 48 hours; Cell invasion ability was inhibited differently by the 4 medications, invasion area showing statistical significance with that of NC group (&lt;i&gt;P&lt;/i&gt; &lt; .05). Hypoxia stimulation promoted formation of reticular structure of cells after 6 hours. The structure disappeared after the 4 medications' activity. Fluorescent signals of HIF-1α and NF-κB were enhanced in the hypoxia, compared with those in the normoxia, showing statistical significance (&lt;i&gt;P&lt;/i&gt; &lt; .05). The 2 fluorescent signals were notably inhibited by the medications, among which MTD and the AB formula were much stronger. Proteins of the NF-κB/HIF-1α axis and VM related molecules were over-expressed in the hypoxia except E-cadherin was down-regulated. After intervention with the medications, the protein expression was remarkably inhibited, while E-cadherin was over-expressed. HIF-1α mRNA expression significantly increased after hypoxia stimulation, however, the expression in AB","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251332590"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a Randomized Sham-Controlled Trial: Strengthening Positive Treatment Expectations Using a Communication Model for Maximized Antiemetic Effects of Acupuncture and Antiemetics During Emetogenic Neo-/Adjuvant Chemotherapy.","authors":"Widgren Ylva, Fransson Per, Englund Erling, Efverman Anna","doi":"10.1177/15347354251361464","DOIUrl":"https://doi.org/10.1177/15347354251361464","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy-induced nausea and vomiting is a common problem in patients undergoing chemotherapy, influencing quality of life (QoL) and daily activities. This study will investigate whether therapists' positive communication may strengthen positive treatment expectations and induce antiemetic effects during antiemetic treatment using standard care, sham acupuncture, or verum acupuncture, compared to neutral communication. It will also investigate whether a variety of patient, therapist and treatment components modify the treatment outcomes.</p><p><strong>Methods: </strong>This is a trial protocol for a randomized, sham-controlled, patient- and evaluator-blinded clinical trial. Patients (n = 198 patients according to a sample size calculation) with breast, colorectal, or bladder cancer undergoing neo-/adjuvant moderately to highly emetogenic chemotherapy are being randomized in 2 × 3 factorial design to the following conditions: 1. neutral or 2. positive communication style regarding expected treatment effects, during the antiemetic treatment types: A) standard care only (including antiemetics, no acupuncture), or, in addition to standard care, B) sham acupuncture with telescopic non-penetrating needles, or C) verum, penetrating acupuncture. The 2 communication styles 1 and 2 are carried out during the antiemetic treatments given by an intervention therapist immediately pre and post (20 minutes × 2) an intravenous chemotherapy session. Data are being collected at baseline on the day before the chemotherapy session, daily for 10 days, at a 10-day follow-up, and at a follow-up after completing the entire chemotherapy period, lasting about 6 months. Primary outcome is mean score Visual Analog Scale nausea grading for the first 5 days of the chemotherapy session period. Secondary outcomes are for example, vomiting, treatment expectations, QoL, daily and physical activity, and physiological measures. Treatment effect modifiers will be analyzed, for example, blinding success, treatment expectations, and previous nausea experiences.</p><p><strong>Conclusions: </strong>This trial will expand integrative cancer care's understanding of the effects of communication for strengthening treatment expectations and thus alleviating chemotherapy-induced nausea and vomiting. If proven effective, the communication model of strengthening positive treatment expectations in patients with risk for nausea and vomiting can be implemented in routine clinical care as part of side-effect management for patients with cancer.</p><p><strong>Trial registration: </strong>US National Institutes of Health, https://clinicaltrials.gov/study/NCT03232541?term=NCT03232541&rank=1), # NCT03232541.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251361464"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peach Gum Polysaccharide Prevents Chemotherapy-Induced Intestinal Injury and Degenerative Behavior.","authors":"Jiaqi Cui, Wuhong Wang, Zhongjia Yi, Huan Tian, Hui Wang, Chunyun Jiang, Yiliu Chen, Dajin Pi, Qianjun Chen, Yingchao Wu","doi":"10.1177/15347354251368410","DOIUrl":"https://doi.org/10.1177/15347354251368410","url":null,"abstract":"<p><p>This study investigated the effects of peach gum polysaccharide (PGP) on chemotherapy-induced intestinal injury and behavioral changes in mice. Female C57BL/6 mice were injected with E0771 breast cancer cells and divided into 3 groups: control, chemotherapy (pirarubicin), and PGP treatment (pirarubicin plus PGP). Behavioral tests, colon length measurement, tissue staining, 16S rDNA sequencing, and metabolomics were performed. Transcriptomic data of colon and hippocampal tissues were analyzed and validated by Western blotting. PGP significantly alleviated colon damage, reduced inflammation and apoptosis, and restored colon length. It mitigated depressive behaviors by suppressing inflammasome activation in the hippocampus, increased gut microbiota diversity, and improved depression-associated metabolites. After the depletion of the intestinal flora, the antidepressant effect of PGP is significantly weakened. These findings suggest that PGP protects against chemotherapy-induced intestinal and behavioral damage by modulating the gut microbiota and gut-brain axis.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251368410"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Effects of Healing Touch During Cervical Cancer Treatment: An Exploratory Analysis.","authors":"Herman A van Wietmarschen, Estela Area-Gomez, Martin Picard, Michael J Goodheart, Anil K Sood, Susan K Lutgendorf","doi":"10.1177/15347354251367793","DOIUrl":"10.1177/15347354251367793","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer treatment with chemotherapy frequently leads to side effects such as fatigue, pain, nausea, and anxiety. Healing Touch is a non-invasive complementary therapy often used by cancer patients to address side effects of treatment. To better inform the use of complementary therapies, there is a need to understand the biological mechanisms underlying the effects of such treatments.</p><p><strong>Methods: </strong>This study included 44 patients with cervical cancer undergoing chemoradiation randomized into a Healing Touch (HT), a relaxation training (RT) and a usual care (UC) group. An exploratory metabolomics analysis was conducted on plasma samples taken at baseline, 4, and 6 weeks of ongoing treatment (4 sessions per week).</p><p><strong>Results: </strong>A multivariate data analysis revealed no significant separation in metabolites between the 3 groups. Univariate data analysis revealed changes in metabolites between baseline and week 6 within each group. The main findings were lower levels of acylcarnitines, bile acids and proline in the HT group, higher levels of fatty acids in the HT and RT groups, and lower levels of kynurenine and quinolate in the UC group. The network of correlations between metabolites shows clear differences in correlations between steroids, fatty acids, sphyngomyelins, amino acids, and γ glutamyl peptides between the 3 groups, suggesting a more flexible and resilient metabolism in the HT and RT groups compared with UC.</p><p><strong>Conclusion: </strong>This first exploratory study investigating metabolic effects of Healing Touch in cancer patients indicated suggestive differences in metabolic signatures which need further investigation in a larger study.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251367793"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}