Integrative Cancer Therapies最新文献

{"title":"Efficacy of Rikkunshito on Chemotherapy-Induced Nausea and Vomiting in Patients With Uterine Corpus or Cervical Cancer Treated With Cisplatin-Based Regimen-Placebo-controlled, Double-Blind, Randomized Confirmatory Study (JORTC-KMP03).","authors":"Yosuke Konno, Shunsuke Ohnishi, Shinichiro Minobe, Eiji Nomura, Takayuki Nagasawa, Etsuko Fujimoto, Tatsuru Ohara, Shin Nishio, Hisamori Kato, Yoshihito Yokoyama, Etsuko Miyagi, Hideki Tokunaga, Koji Nishino, Akira Kikuchi, Yoshio Yoshida, Takashi Iwata, Daito Noguchi, Wataru Kudaka, Shunsuke Oyamada, Keisuke Ariyoshi, Kota Kihara, Hidemichi Watari","doi":"10.1177/15347354251329346","DOIUrl":"https://doi.org/10.1177/15347354251329346","url":null,"abstract":"<p><strong>Background: </strong>The current standard treatment for chemotherapy-induced nausea and vomiting (CINV) with standard antiemetics is insufficient. Rikkunshito, a Japanese traditional herbal medicine, has been shown to improve cisplatin-induced anorexia and functional dyspepsia, and our exploratory study found that rikkunshito has an additive beneficial effect on CINV in patients with uterine corpus and cervical cancer receiving cisplatin containing chemotherapy (JORTC KMP-02).</p><p><strong>Methods: </strong>One hundred eighty patients with uterine corpus or cervical cancer who were scheduled to receive treatment with a cisplatin based regimen as initial chemotherapy were enrolled across 17 Japanese institutions. Patients were randomized with a 1:1 equal allocation ratio to the rikkunshito group or placebo groups and given oral administration on days 1 to 5 with standard antiemetics (granisetron, aprepitant, and dexamethasone). The primary endpoint was complete response (CR; no vomiting or rescue medication) during the delayed phase (24-120 hours after cisplatin treatment). The secondary endpoints were complete control (CC; CR without significant nausea) and total control (TC; CR without nausea) rates during the overall (0-120 hours), acute (0-24 hours), and delayed phases, as well as the CR rate during the overall and acute phases, time to treatment failure, degree of nausea and appetite during the overall phase, and adherence to the intervention.</p><p><strong>Results: </strong>The CR rate in the delayed phase was similar between the rikkunshito group and control groups (50.6% vs 58.9%, <i>P</i> = .2631), as were the secondary endpoints: CR rates in the overall and acute phases, CC and TC rates in the overall, acute, and delayed phases, degrees of nausea and appetite, and time to treatment failure.</p><p><strong>Conclusion: </strong>Rikkunshito had no additive effect on CINV prevention in patients with uterine corpus or cervical cancer who were treated with a cisplatin based regimen and standard antiemetics.</p><p><strong>Clinical trial registration: </strong>https://jrct.mhlw.go.jp/re/reports/detail/66957, identifier jRCT1011190007.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251329346"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subject: Letter to the Editor regarding \"Translation, Cross-cultural Adaptation, and Validation of the Kannada Version of the Exercise Adherence Rating Scale (EARS-Kn) Among Head and Neck Cancer (HNC) Survivors in a Tertiary Care Setup in India\" in Integrative Cancer Therapies.","authors":"Chindhu Shunmuga Sundaram","doi":"10.1177/15347354251331102","DOIUrl":"https://doi.org/10.1177/15347354251331102","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251331102"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Measuring Context Specific Sedentary Behavior and Pulse Wave Velocity in Endometrial Cancer Survivors.","authors":"Lauren C Bates-Fraser, Jake C Diana, Aiden J Chauntry, Victoria L Bae-Jump, Michelle L Meyer, Justin B Moore, Hyman B Muss, Claudio L Battaglini, Lee Stoner, Erik D Hanson","doi":"10.1177/15347354251324912","DOIUrl":"10.1177/15347354251324912","url":null,"abstract":"<p><strong>Purpose: </strong>Sedentary behavior (SB) contributes to the heightened risk of cardiovascular disease (CVD) in endometrial cancer survivors (ECS). This feasibility study aimed to evaluate key outcomes to assess the practicality of SB reduction interventions for ECS. Secondary aims included SB domain assessment and preliminary efficacy testing of the relationship between SB and arterial stiffness.</p><p><strong>Methods: </strong>Forty stage-1 ECS (BMI ≥ 25.0 kg/m², aged 50-80, <12 months post-treatment) participated in the study, which measured total and domain-specific SB using accelerometry and ecological momentary assessment (EMA). Aortic pulse wave velocity (PWV) was estimated via Mobil-O-Graph, and linear regression models examined the association between SB and PWV.</p><p><strong>Results: </strong>The study achieved 4 of 5 assessed outcomes, with a 63% consent rate in 10 months. Retention was high, with 90% of participants completing all aspects. Fidelity was strong, though EMA compliance was 69%, slightly below the 70% target. Self-reported SB was 71.4% lower than accelerometer-measured SB [MD: -5.00 hours/day (95% CI: -6.57 to -3.43), <i>P</i> < .001]. ECS exhibited a PWV of 9.04 ± 1.80 m/s, 13.4% higher than normative values, with occupational SB significantly associated with PWV.</p><p><strong>Conclusions: </strong>This study highlights high SB and PWV levels in ECS, indicating the need for interventions, particularly for occupational SB. The high retention and consent rates suggest ECS are willing to engage in behavior change, pointing to future research focusing on strategies to reduce SB and improve cardiovascular health.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251324912"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effect of HAD-B1 and Osimertinib Against Gefitinib Resistant HCC827 Non-Small Cell Lung Cancer Cells.","authors":"Eun-Ju Ko, Eun-Bin Kwag, Ji-Hye Park, Sung-Hyuk Cho, So-Jung Park, Mi-Kyung Jung, In-Cheol Kang, Hwa-Seung Yoo","doi":"10.1177/15347354241307006","DOIUrl":"10.1177/15347354241307006","url":null,"abstract":"<p><p>In this study, we investigated the synergistic effect of co-administration of osimertinib and HAD-B1 using gefitinib-resistant non-small cell lung cancer cells, HCC827-GR. HAD-B1 is composed of 4 natural drugs, Panax Notoginseng Radix, Panax ginseng C. A. Meyer, Cordyceps militaris, and Boswellia carterii Birdwood, and has been reported to have therapeutic effects on patients with advanced non-small cell lung cancer in several studies. Resistance to gefitinib in HCC827 cells was acquired through MET activity. Co-treatment with osimertinib and HAD-B1 reduced the cell viability of HCC827-GR cells. In addition, phosphorylation of MET and ERK were effectively suppressed for HCC827-GR cells. And, compared to when osimertinib and HAD-B1 were administered alone, cell proliferation was significantly inhibited and apoptosis was effectively induced when osimertinib and HAD-B1 were co-administered to HCC827-GR cells. We found that the synergistic effect of osimertinib and HAD-B1 combination therapy resulted in cancer cell death and cell cycle arrest by targeting the ERK and mTOR signaling pathways. In conclusion, this study confirmed that the combination of osimertinib, a third-generation anticancer drug, and HAD-B1, a natural anticancer drug, had a potentially synergistic effect on non-small cell lung cancer resistant to EGFR-targeted anticancer drugs.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354241307006"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143055935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Cohort Study on the Preliminary Efficacy of Massage Therapy for Chemotherapy-Induced Peripheral Neuropathy Among Cancer Patients.","authors":"Mingxiao Yang, Cassie Shao, Carrie Shao, Kirin Saint, Mira Gupta, Rocco Caputo, Mary Lou Galantino, Steven Harte, Ting Bao","doi":"10.1177/15347354251323258","DOIUrl":"10.1177/15347354251323258","url":null,"abstract":"<p><strong>Purpose: </strong>Chemotherapy-induced peripheral neuropathy (CIPN) worsens the quality of life for people with cancer. Massage therapy involves neuromuscular modulations and can potentially reduce CIPN symptoms. We examined the immediate improvements in CIPN-related pain and neuropathy following massage therapy among patients with CIPN.</p><p><strong>Methods: </strong>In a retrospective cohort, we assessed patients who received 1 massage therapy session for CIPN symptom relief during or after chemotherapy at a National Cancer Institute-Designated Comprehensive Cancer Center from October 2017 to September 2022. We measured the severity of pain and neuropathy before and after massage therapy with a 4-item verbal rating scale (VRS) or a 0 to 10 numerical rating scale (NRS). We converted NRS to VRS scores and examined the pre-post differences in symptom severity using the Wilcoxon rank test.</p><p><strong>Results: </strong>Among 23 patients (median [range] age 64 [4-85] years, female 74%, White 70%), one session of massage therapy decreased the percentage of patients reporting moderate-to-severe pain from 81% at baseline to 0% (none) post-massage; percentage of patients reporting neuropathy also reduced from 77% at baseline to 12% following treatment. The pre-post differences were statistically significant for both pain (mean: -1.6, 95% confidence interval [CI] -1.9 to -1.2; <i>P</i> = .001) and neuropathy scores (mean: -1.2, 95%CI -1.4 to -0.9; <i>P</i> < .0001).</p><p><strong>Conclusion: </strong>Among cancer patients with CIPN, one session of massage therapy was associated with immediate neuropathy and CIPN pain relief reported by patients following treatment. However, this preliminary finding requires further rigorous verifications in future randomized controlled clinical trials.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251323258"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises\".","authors":"","doi":"10.1177/15347354251321239","DOIUrl":"10.1177/15347354251321239","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251321239"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Note: Inhibition of Glutamine Uptake Improves the Efficacy of Cetuximab on Gastric Cancer.","authors":"","doi":"10.1177/15347354241312737","DOIUrl":"10.1177/15347354241312737","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354241312737"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, Cross-Cultural Adaptation, and Validation of the Kannada Version of the Exercise Adherence Rating Scale (EARS-Kn) Among Head and Neck Cancer (HNC) Survivors in a Tertiary Care Setup in India.","authors":"Hritika D Pai, K Vijaya Kumar, Prasanna Mithra, Stephen Rajan Samuel, Mariappan Senthiappan Athiyamaan, Emma Louise Godfrey","doi":"10.1177/15347354251313534","DOIUrl":"10.1177/15347354251313534","url":null,"abstract":"<p><strong>Background: </strong>Adherence in rehabilitation services includes attending appointments, regularly performing prescribed exercises, and correct exercise execution. The Exercise Adherence Rating Scale (EARS) has been adapted into several languages, but there is lack of a standardized tool for various Indian languages and cultural contexts, particularly for use with cancer survivors. With the anticipated 57.7% rise in cancer cases by 2040, this study aims to address this gap.</p><p><strong>Aims and objectives: </strong>To cross-culturally adapt EARS to Kannada (EARS-Kn) and evaluate its validity and reliability amongst HNC survivors enrolled in the Multimodal Oncology Rehabilitation Exercise-MORE^© Program.</p><p><strong>Methodology: </strong>Following Beaton guidelines, the EARS tool was adapted to Kannada. 34 HNC survivors engaged in the MORE^© program. Internal consistency (Cronbach's ⍺) and construct validity (Exploratory Factor Analysis, EFA) were assessed. The Receiver Operating Curve (ROC) determined cut-off scores, sensitivity and specificity of the EARS-Kn.</p><p><strong>Results: </strong>The EARS-Kn demonstrated a Cronbach's-⍺ value of .93. The EFA revealed a one-factor solution with eigenvalues exceeding one and 70.1% loading. The area under the curve (AUC) was 0.908. A cut-off score of 17 was established, with 95.83% sensitivity and 80% specificity.</p><p><strong>Conclusion: </strong>The EARS-Kn version showed strong validity and reliability among Kannada-speaking HNC survivors, indicating its potential to enhance the understanding of exercise adherence among them. Future studies could explore the EARS-Kn version among diverse populations prescribed various rehabilitation regimes. Studies could also further investigate psychometric properties of the EARS in different Indian languages among cancer survivors, which would help improve survivorship outcomes.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251313534"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of <i>Astragalus membranaceus</i> (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (huang qi) and <i>Angelica sinensis</i> (Oliv.) Diels (dang gui) in Ameliorating Hypoxia and Angiogenesis to Delay Pulmonary Nodule Malignant Transformation.","authors":"Ying Guo, Peng Yang, Zihong Wu, Sanyin Zhang, Fengming You","doi":"10.1177/15347354241311917","DOIUrl":"10.1177/15347354241311917","url":null,"abstract":"<p><p>Screening for pulmonary nodules (PN) using low-dose CT has proven effective in reducing lung cancer (LC) mortality. However, current treatments relying on follow-up and surgical excision fail to fully address clinical needs. Pathological angiogenesis plays a pivotal role in supplying oxygen necessary for the progression of PN to LC. The interplay between hypoxia and angiogenesis establishes a vicious cycle, rendering anti-angiogenesis therapy alone insufficient to prevent PN to LC transformation. In traditional Chinese medicine (TCM), PN is referred to as \"Feiji,\" which is mainly attributed to Qi and blood deficiency, correspondingly, the most commonly prescribed medicines are <i>Astragalus membranaceus</i> (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (huang qi) (AR) and <i>Angelica sinensis</i> (Oliv.) Diels (dang gui) (ARS). Modern pharmacological studies have demonstrated that AR and ARS possess immune-enhancing, anti-tumor, anti-inflammatory, and anti-angiogenic properties. However, the precise mechanisms through which AR and ARS exert anti-angiogenic effects to delay PN progression to LC remain inadequately understood. This review explores the critical roles of hypoxia and angiogenesis in the transition from PN to LC. It emphasizes that, compared to therapies targeting angiogenic growth factors alone, AR, ARS, and their compound-based prescriptions offer additional benefits. These include ameliorating hypoxia by restoring blood composition, enhancing vascular structure, accelerating circulation, promoting vascular normalization, and blocking or inhibiting various pro-angiogenic expressions and receptor interactions. Collectively, these actions inhibit angiogenesis and delay the PN-to-LC transformation. Finally, this review summarizes recent advancements in related research, identifies existing limitations and gaps in knowledge, and proposes potential strategies and recommendations to address these challenges.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354241311917"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism Study of Bufalin Reversal of Drug Resistance by Inhibiting Hypoxic Colon Cancer Cell-Induced Polarization of M2 Macrophages.","authors":"Haijing Wang, Linlin Jia, Hongjie Yu, Hui Tang, Huabowen Chi, Wei Zhang, Jinbao Chen","doi":"10.1177/15347354251325806","DOIUrl":"10.1177/15347354251325806","url":null,"abstract":"<p><p>Chemoresistance is still an important factor affecting the efficacy of treatment in colorectal cancer (CRC) patients. Hypoxia is related to poor prognosis and treatment resistance in cancer. Relevant studies have shown that a hypoxic microenvironment can promote the polarization of M2 macrophages and thus promote tumor development. Previous research has found that bufalin has a wide range of antitumor effects, but whether bufalin can reverse tumor resistance by improving the hypoxic tumor microenvironment is still unclear. In present research, it was found that high expression of SRC-3 in CRC cells under hypoxic conditions promoted the polarization of M2 and caused chemotherapy resistance, while bufalin, a monomeric drug used in Chinese medicine, reduced the level of SRC-3 and HIF-1α, thereby reversing chemoresistance. In addition, overexpression of SRC-3 reduced the hypoxia-mitigating effect of bufalin on CRC cells to promote the polarization of M2. Bufalin also inhibits the polarization of M2 caused by hypoxic CRC cells. Therefore, bufalin has the potential to become a new adjuvant therapy that can be further explored in future studies on its treatment of CRC.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"24 ","pages":"15347354251325806"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}