The Effect of Melatonin on Increasing the Health Related Quality of Life in Non-Metastatic Breast Cancer Patients: Three-Year Follow up a Clinical Trial

IF 2.9 3区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Cancer Therapies Pub Date : 2024-04-16 DOI:10.1177/15347354241237520

Zahra Keshtpour Amlashi, Fatemeh Sheida, Robab Anbiaee, Leili Tapak, Seyed Rohallah Hosseini, Hossein Mosaedian, Nastaran Barati

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Abstract

Introduction:Although breast cancer is common worldwide, if diagnosed early and treated on time, the probability of recovery is high and patients often experience a long life. Reducing the quality of life is a common side effect in patients. Melatonin may have an important role in fatigue, sleep disorders and, as a result, the health-related quality of life (HRQoL) in people. About 184 patients with breast cancer were enrolled in 2 groups: intervention with daily melatonin intake of 18 mg for 3 years (93 patients) and the control group with placebo intake (91 patients). Health-related quality of life and the effect of melatonin on increasing that were evaluated with the EORTC QLQ-C30 questionnaire, third edition at the beginning, 2 months later and 3 years after the beginning of the study.Results:The general score of the HRQoL was significantly different both in the passage of time and in the comparative study of the 2 groups, and it was better in the melatonin group ( P < .05).Conclusion:Long-term use of 18 mg of melatonin for 3 years in patients with non-metastatic breast cancer can lead to an increase in the patients’ quality of life.

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褪黑素对提高非转移性乳腺癌患者健康相关生活质量的影响：临床试验的三年随访

导言：虽然乳腺癌在全世界都很常见，但如果早期诊断并及时治疗，痊愈的概率很高，患者通常都能长寿。降低生活质量是患者常见的副作用。褪黑素可能对疲劳、睡眠障碍，进而对人们的健康相关生活质量（HRQoL）有重要作用。约 184 名乳腺癌患者被分为两组：每天摄入 18 毫克褪黑素的干预组（93 名患者）和摄入安慰剂的对照组（91 名患者），干预组为期 3 年。在研究开始时、2个月后和3年后，使用第三版EORTC QLQ-C30问卷对健康相关生活质量和褪黑素对提高健康相关生活质量的影响进行评估。结果：两组患者的 HRQoL 总分在时间推移和对比研究中均存在显著差异，褪黑素组的 HRQoL 总分更高（P < .05）。结论：非转移性乳腺癌患者长期服用 18 毫克褪黑素 3 年，可提高患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Integrative Cancer Therapies 医学-全科医学与补充医学

CiteScore

4.80

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ICT is the first journal to spearhead and focus on a new and growing movement in cancer treatment. The journal emphasizes scientific understanding of alternative medicine and traditional medicine therapies, and their responsible integration with conventional health care. Integrative care includes therapeutic interventions in diet, lifestyle, exercise, stress care, and nutritional supplements, as well as experimental vaccines, chrono-chemotherapy, and other advanced treatments. Contributors are leading oncologists, researchers, nurses, and health-care professionals.