International Cancer Conference Journal最新文献

{"title":"Successful management of a rare case of gallbladder neuroendocrine carcinoma with tumor thrombi.","authors":"Bishal Pal, Souradeep Dutta, Debasis Naik, Sundaramoorthy Sudharsanan, Rajesh Nachiappa Ganesh, Vishnu Prasad Nelamangala Ramakrishnaiah","doi":"10.1007/s13691-023-00617-7","DOIUrl":"10.1007/s13691-023-00617-7","url":null,"abstract":"<p><p>A gallbladder neuroendocrine neoplasm (GB‑NEN) is a bizarre heterogeneous neoplasm arising from neuroendocrine cells, which are present in minimal amounts on the GB mucosa either due to conversion of undifferentiated stem cells, chronic inflammation and resulting in pathological metaplasia or switching of GB adenocarcinoma to neuroendocrine one. Among all the GB malignancies, GB-NEN accounts for approximately 2.1%. A 41-year-old lady presented with right upper abdomen pain and distension for 2 weeks. Contrast CT showed heterogeneously enhancing wall thickening involving fundus-body of the GB with large exophytic component involving segments IV/V of liver, peripheral enhancement and central low attenuating necrotic areas. Middle hepatic and left branch of portal vein was filled with enhancing lesion, tumor thrombi. She underwent left trisectionectomy followed by adjuvant chemotherapy. Postoperative biopsy reported as poorly differentiated unifocal small cell GB-neuroendocrine carcinomas (GB-NEC). Resected margins were free of tumor with periportal lymph nodes negative for tumor. Follow-up PET-CT after six months of treatment completion shows no tumor recurrence or metastases. She has completed 12 months following the surgery and is asymptomatic. As the occurrence of GB-NEC is rare, there are little data regarding etiology, pathogenesis, treatment and prognosis of it. Even though metastasis is early and most frequent to lymph nodes, liver, lung and peritoneum, the presence of tumor thrombus in GB-NEC is rarely reported. Though most reports suggest very poor outcomes, radical surgery followed by adjuvant chemotherapy can yield good short-term results as seen in this case.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 4","pages":"248-254"},"PeriodicalIF":0.7,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who benefits from the abscopal effect?","authors":"Noriomi Matsumura","doi":"10.1007/s13691-023-00616-8","DOIUrl":"10.1007/s13691-023-00616-8","url":null,"abstract":"","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 3","pages":"167"},"PeriodicalIF":0.5,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9917014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of testicular seminoma with testicular abscess caused by <i>Salmonella saintpaul</i>.","authors":"Yoshitsugu Nasu, Yuya Kawago","doi":"10.1007/s13691-023-00609-7","DOIUrl":"10.1007/s13691-023-00609-7","url":null,"abstract":"<p><p>Testicular abscesses are rarer than epididymitis and orchitis. Here, we report a case of testicular seminoma with testicular abscess caused by <i>Salmonella saintpaul</i>. A 41-year-old male was referred for painful enlargement of the right scrotal content and fever for 1 week. With the diagnosis of epididymitis, he was administered levofloxacin (LVFX) but the fever and painful enlargement persisted. Because of the poor response to antimicrobial agents and the undeniable complications of testicular malignancy, radical orchiectomy was performed. The testis was enlarged to 7 cm, weighed approximately 100 g, and was filled with pus. A substantial portion of the tumor was seminoma, and pus culture revealed <i>Salmonella saintpaul</i>. Although testicular tumors are the most common differential diseases for testicular abscess, there are few reports of testicular abscess accompanying testicular tumors. Here, we report a case of testicular seminoma with testicular abscess caused by <i>Salmonella saintpaul</i>.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 4","pages":"291-293"},"PeriodicalIF":0.7,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case series title: femoral nerve injury with an episode of motor neuropathy caused by gynecological surgery: a case series.","authors":"Moyu Narita, Kazuhiro Suzuki, Keisuke Ogimoto, Keisuke Ichida, Junichi Aratake, Hiroshi Nakazawa, Takashi Shibutani, Miho Kitai, Takaya Shiozaki, Senn Wakahashi, Satoshi Yamaguchi","doi":"10.1007/s13691-023-00612-y","DOIUrl":"10.1007/s13691-023-00612-y","url":null,"abstract":"<p><strong>Background: </strong>Although iatrogenic nerve injury is sometimes diagnosed after gynecological surgery, its incidence is underestimated because most cases are self-limiting and underreported. Herein, we report on six cases of femoral nerve injury after gynecological surgery with both sensory and motor neuropathy.</p><p><strong>Methods: </strong>We retrospectively analyzed 785 patients with gynecological cancer requiring surgery, including lymph node dissection, between 2012 and 2016 at our center. The functional damage due to femoral nerve injury was postoperatively assessed and classified according to the Medical Research Council (MRC) scale by an orthopedist and a physiatrist. The eligibility criteria were grade 3 or less hip joint bending and muscular weakness due to nerve injury. Patients were excluded if they had been diagnosed with an isolated sensory disorder.</p><p><strong>Results: </strong>We found six cases (0.76%) of femoral motor neuropathy resulting from gynecological surgery. All six patients underwent laparotomy using energy devices under general anesthesia with epidural anesthesia in the lithotomy position. Four of them recovered fully within 8 months from surgery with either physical therapy or no treatment, while the other two died within a year post-treatment; thus, recovery evaluation could not be accurately performed.</p><p><strong>Conclusion: </strong>Postoperative femoral nerve injury can be diagnosed based on gait disturbances and difficulties climbing stairs. It is difficult to identify risk factors for femoral nerve injury as they may involve a combination of features, such as intraoperative compression with self-retaining retractors, the lithotomy position, and the use of energy devices. The surgeon should be familiar with the nature of energy devices, make every effort to understand the necessary anatomy, and make every effort to avoid femoral nerve injury. Iatrogenic femoral nerve injury caused by gynecological surgery should be further investigated regarding the patients' quality of life postoperatively.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 4","pages":"294-298"},"PeriodicalIF":0.7,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric neuroendocrine carcinoma presenting complete durable response by nivolumab treatment for multiple metastases and radiotherapy to oligoprogressive metastasis.","authors":"Yusuke Seyama, Takeshi Yamada, Hirosumi Suzuki, Satoshi Fukuda, Miki Tsuji, Yusuke Niisato, Suguru Hirose, Yoshiyuki Yamamoto, Toshikazu Moriwaki, Ichinosuke Hyodo","doi":"10.1007/s13691-023-00611-z","DOIUrl":"10.1007/s13691-023-00611-z","url":null,"abstract":"<p><p>Gastric neuroendocrine carcinomas (NEC) are highly aggressive cancer with dismal prognosis. Platinum-based chemotherapy is used as the first-line treatment for this entity. However, there are no established therapeutic guidelines for platinum-resistant gastric NEC. We herein report a patient with metastatic gastric NEC who achieved durable and complete response to nivolumab with radiotherapy for oligoprogressive metastasis. A 70-year-old male patient had recurrences of resected gastric NEC, involving the liver and lymph nodes. His disease became refractory to cisplatin and etoposide combination therapy, after which he was treated with nivolumab. All the tumors showed marked shrinkage. However, 1 year after starting nivolumab, one metastatic lesion of the liver began to enlarge, and radiotherapy was performed to the lesion. Thereafter, a complete response was obtained, which has been maintained without any treatment for the past 2 years.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 4","pages":"268-273"},"PeriodicalIF":0.7,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myxoid liposarcoma in an 11-year-old patient.","authors":"Tomoya Matsunobu, Akira Maekawa, Yuna Inaba, Kosuke Makihara, Masanori Hisaoka, Yukihide Iwamoto","doi":"10.1007/s13691-023-00615-9","DOIUrl":"10.1007/s13691-023-00615-9","url":null,"abstract":"<p><p>Myxoid liposarcoma is a mesenchymal malignancy that most commonly presents in young adults, with peak incidence between the ages of 30-50 years. The clinical behavior of myxoid liposarcoma has been well characterized in adults. However, little is known about the clinical features and treatment outcomes of myxoid liposarcoma in child, owing to its rarity. This case report describes an 11-year-old previously healthy female who presented with a painless mass in her right thigh. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a soft tissue mass with clear margins in the subfascial plane superficial to the gracilis and sartorius muscles. She was diagnosed with myxoid liposarcoma based on histological and molecular cytogenetic examinations of the core-needle biopsy specimen. The patient subsequently underwent wide resection without any adjuvant treatment. The patient has not experienced any symptoms of local recurrence and metastases as of 2.5 years after surgery.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 4","pages":"233-240"},"PeriodicalIF":0.7,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary management for primary uterine osteosarcoma, including gene panel testing: case report and literature review.","authors":"Takako Kusanishi, Naotake Tanaka, Mizue Itoi, Miwa Ijiri, Keiko Ebisawa, Kiyomi Suzuka, Youko Hagiwara, Tukasa Yonemoto, Akinobu Araki, Makiko Itami","doi":"10.1007/s13691-023-00613-x","DOIUrl":"10.1007/s13691-023-00613-x","url":null,"abstract":"<p><p>Primary osteosarcoma of the uterus (uOS) is rare, and its standard treatment has not yet been established. Herein, we present the case of a 50-year-old woman with uOS who demonstrated an improved prognosis after multiple surgeries to the metastatic sites. After the initial diagnosis of uOS, the patient showed recurrence and distant metastasis and hence expected to exhibit a poor prognosis. The patient underwent multiple surgical resections of the metastatic as well as primary tumors, which enabled the patient to survive for 24 months after the initial surgery. Considering that the median survival time of patients with uOS is approximately 6 months, the survival rate of our patient is noteworthy. Based on our observations, it is suggested that the resection of the primary and metastatic tumors might contribute to the extension of the survival period of the patient with chemo-resistant uOS.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 4","pages":"241-247"},"PeriodicalIF":0.7,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10002506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristic imaging findings in a patient with chronic expanding hematoma on the floor of the mouth.","authors":"Yusuke Miyasaka, Takashi Hiyama, Hirofumi Kuno, Takeshi Shinozaki, Shingo Sakashita, Tatsushi Kobayashi","doi":"10.1007/s13691-023-00610-0","DOIUrl":"10.1007/s13691-023-00610-0","url":null,"abstract":"<p><p>Chronic expanding hematoma (CEH) is defined as chronic hematoma enlargement for more than 1 month. Although CEH rarely occurs on the floor of the mouth, the need to distinguish these cases from malignant disease is critical, given the need for potentially extensive resection in patients with malignancy. We report a case of CEH on the floor of the mouth, which required differentiation from malignant tumor. A 42-year-old woman was referred to our hospital for a submucosal mass on the right floor of the mouth, with a diagnosis of class 3 on aspiration cytology. Computed tomography revealed a submucosal mass with peripheral calcification on the floor of the mouth, which exhibited a hypointense rim on T2-weighted imaging and gradual nodular-like enhancement in the periphery on contrast-enhanced magnetic resonance imaging. Enucleation was performed to reach a definitive diagnosis, and CEH was confirmed pathologically. Well-defined morphology, presence of calcification, a hypointense rim on T2-weighted imaging, and weak peripheral nodular-like enhancement may be characteristic findings of CEH on the floor of the mouth. Accordingly, these imaging features may aid in differentiating CEH from low-grade malignancies and in determining the optimal management strategy.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 3","pages":"185-189"},"PeriodicalIF":0.7,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9901270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surgical resection of hepatic granuloma mimicking intrahepatic cholangiocarcinoma: a case report.","authors":"Kazuki Omachi, Katsunori Imai, Yosuke Nakao, Hiro Nakamura, Takayoshi Kaida, Yuta Shiraishi, Rumi Itoyama, Hidetoshi Nitta, Hiromitsu Hayashi, Tsuguharu Asato, Yoshiki Mikami, Hideo Baba","doi":"10.1007/s13691-023-00607-9","DOIUrl":"10.1007/s13691-023-00607-9","url":null,"abstract":"<p><p>Hepatic granuloma is relatively rare, and benign tumor of the liver. Herein, we report an unusual case of hepatic granuloma mimicking intrahepatic cholangiocarcinoma (ICC). An 82-year-old woman with a history of viral hepatitis B was admitted for investigation of liver mass in the left lobe. Dynamic computed tomography revealed a mostly hypo-enhancing main tumor with a peripheral ring enhancement, and positron emission tomography demonstrated localized an abnormal accumulation of fludeoxyglucose. Considering the possibility of malignant disease, extended left hepatectomy was performed. The resected tumor was macroscopically a periductal infiltrating nodular type, 4.5 × 3.6 cm in diameter. The pathological findings showed that granuloma and coagulative necrosis were present, and diagnosis of hepatic granuloma was confirmed. Pathological studies demonstrated that periodic acid-Schiff stain, Grocott-Gomori stain and Ziehl-Neelsen stain were all negative in the lesion.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 3","pages":"195-199"},"PeriodicalIF":0.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9917009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual case of a tibial metastasis as the first clinical presentation of a serous papillary carcinoma of the ovarian epithelial type of the testis.","authors":"Maria Napoletano, Margherita Bartocci, Carlo Perna, Emanuele Vocino, Antonella Segoni","doi":"10.1007/s13691-023-00608-8","DOIUrl":"10.1007/s13691-023-00608-8","url":null,"abstract":"<p><p>Among testicular neoplasms, ovarian-type epithelial tumors constitute an exceedingly rare group, with only a few cases reported in the literature. We describe the case of an 82-year-old man, presented with complaints of right leg pain and difficulty walking, who was found to have a large right tibial metastasis of unknown primary origin. Whole body CT scan did not reveal any cranial, thoracic or abdominal tumor masses, but it showed abnormal para-aortic lymph nodes and right spermatic cord swelling. An extemporary ultrasound examination found a right testicular mass. The patient underwent radical orchiectomy, and the diagnosis of a serous papillary carcinoma of the ovarian epithelial type of the testis was made. To the best of our knowledge, this is the first case in the literature of isolated bone metastasis from ovarian-type epithelial tumor of testis.</p>","PeriodicalId":13703,"journal":{"name":"International Cancer Conference Journal","volume":"12 3","pages":"177-184"},"PeriodicalIF":0.7,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9599057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}