A case of gastritis caused by immune checkpoint inhibitor treated with infliximab.

IF 0.5 Q4 ONCOLOGY

International Cancer Conference Journal Pub Date : 2024-09-18 eCollection Date: 2024-10-01 DOI:10.1007/s13691-024-00709-y

Shizu Itsukage, Noriko Kume, Aki Tajima, Takashi Okazaki, Koji Tsuta, Hideaki Tanizaki

引用次数: 0

Abstract

Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in various organs. Herein, we present a rare case involving a patient with immunotherapy-related gastritis who developed refractory vomiting and anorexia after treatment with nivolumab for cutaneous malignant melanoma. The patient was treated with oral corticosteroids, but the efficacy was limited. The symptoms improved markedly after treatment with infliximab. With the increasing use of ICIs, the number of reports of gastritis due to irAEs has also increased. Health care providers treating malignancies should be aware of this side effect and know how to diagnose and treat it.

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用英夫利昔单抗治疗免疫检查点抑制剂引起的胃炎病例。

免疫检查点抑制剂（ICIs）可在多个器官引起免疫相关不良事件（irAEs）。在此，我们介绍了一例罕见病例，患者在接受尼妥珠单抗治疗皮肤恶性黑色素瘤后出现难治性呕吐和厌食，并引发免疫疗法相关性胃炎。患者接受了口服皮质类固醇治疗，但疗效有限。使用英夫利西单抗治疗后，症状明显改善。随着 ICIs 的使用日益增多，由虹膜不良反应引起胃炎的报告也在增加。治疗恶性肿瘤的医护人员应了解这种副作用，并知道如何诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Cancer Conference Journal ONCOLOGY-

自引率

14.30%

发文量

期刊介绍： This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)