Inflammation & allergy drug targets最新文献_第5页

Acne vulgaris: an inflammatory disease even before the onset of clinical lesions. 寻常痤疮:一种炎症性疾病，甚至在发病前就有临床病变。

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140606110024

Marco Alexandre Rocha, Caroline Sousa Costa, Edileia Bagatin

引用次数: 44

Dengue fever: theories of immunopathogenesis and challenges for vaccination. 登革热:免疫发病机制理论和疫苗接种的挑战。

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140828113158

Melissa M Remy

{"title":"Dengue fever: theories of immunopathogenesis and challenges for vaccination.","authors":"Melissa M Remy","doi":"10.2174/1871528113666140828113158","DOIUrl":"https://doi.org/10.2174/1871528113666140828113158","url":null,"abstract":"Dengue fever is a mosquito-borne viral disease infecting several hundred million people in tropical and subtropical areas every year. Its clinical manifestations range from mild fever to severe life-threatening shock syndrom. No therapeutics or licensed vaccines are available yet and with half of the world's population already at risk, it represents a major public health concern. The co-existence of four different Dengue virus serotypes renders difficult the obtaining of full protective immunity against each one of them. On the contrary, these serotypes trigger significant cross-reactivities of antibodies and T cells, both of which may lead to disease enhancement when reactivated in the context of reinfection with a heterologous serotype. Several immunological concepts have been developed to explain disease enhancement, and the uncertainty around the topic has consequently slowed down the development of Dengue vaccines. Recent advances however have shed light on key aspects of both the immunoprotective and immunopathological mechanisms. In particular the responses of specific antibodies and T cells have been a focus of many studies. These immunological players are thought to directly influence a cytokine dysbalance that eventually leads to severe disease and vascular leakage. In this review I outline current concepts and ongoing debates on the above topics. A better understanding of Dengue virus immunopathogenesis is critically needed to optimize candidate vaccines including those currently under development. In particular, the results from large-scale human efficacy trials will offer outstanding opportunities to refine correlates of protection and design even more effective vaccines. ","PeriodicalId":13680,"journal":{"name":"Inflammation & allergy drug targets","volume":"13 4","pages":"262-74"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32619985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

R848, a Toll-like receptors 7 and 8 agonist, a potential therapy for allergic rhinitis patients. R848, toll样受体7和8激动剂，变应性鼻炎患者的潜在治疗方法。

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140429111658

Ghada Boghdadi, Noha Hammad, Ahmed Amer, Somaya Sammour, Samir Sorour

{"title":"R848, a Toll-like receptors 7 and 8 agonist, a potential therapy for allergic rhinitis patients.","authors":"Ghada Boghdadi, Noha Hammad, Ahmed Amer, Somaya Sammour, Samir Sorour","doi":"10.2174/1871528113666140429111658","DOIUrl":"https://doi.org/10.2174/1871528113666140429111658","url":null,"abstract":"Background/purpose(s): There is a growing interest in the targeting of Toll-like receptors (TLRs) for the treatment of allergic diseases. TLRs7/8 ligands are future candidates of therapeutic value in allergic rhinitis (AR). This study focus on TLRs7/8 ligand; resiquimod (R848) as an adjuvant to immunotherapy (IT) in AR patient.Methods: Peripheral blood mononuclear cells (PBMCs) were obtained from atopic donors and non atopic donors. PBMCs were cultured in the absence and presence of date palm pollen allergen (Phoenix dactylifera; Pho d) and/or R848. Interleukin-4 (IL-4), IL-10, IL-13 and interferon gamma (IFN-γ) were measured in the culture supernatants.Results: R848 was able to significantly increase the anti-inflammatory response in atopic donors more than non atopic donors. Nevertheless, the combination of both; R848 and Pho d provides inferior stimulus as compared to R848 alone in both atopic and non atopic donors.Conclusion: Invitro treatment of PBMCs with R484 hijacks the pro inflammatory immune process triggered by TLRs7/8 to mediate anti-inflammatory response. This may provide a conception about the activity and efficacy of TLRs7/8 ligands in AR and open the gate for them to be applied in clinically in humans.","PeriodicalId":13680,"journal":{"name":"Inflammation & allergy drug targets","volume":"13 2","pages":"144-9"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32296152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Chronic pain: cytokines, lymphocytes and chemokines. 慢性疼痛:细胞因子、淋巴细胞和趋化因子。

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528114666150114170004

Marcia de Miguel, Durval Campos Kraychete, Roberto Jose Meyer Nascimento

引用次数: 23

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140908113841

Sara Mariotto, Sergio Ferrari, Salvatore Monaco

{"title":"HCV-related central and peripheral nervous system demyelinating disorders.","authors":"Sara Mariotto, Sergio Ferrari, Salvatore Monaco","doi":"10.2174/1871528113666140908113841","DOIUrl":"https://doi.org/10.2174/1871528113666140908113841","url":null,"abstract":"Chronic infection with hepatitis C virus (HCV) is associated with a large spectrum of extrahepatic manifestations (EHMs), mostly immunologic/rheumatologic in nature owing to B-cell proliferation and clonal expansion. Neurological complications are thought to be immune-mediated or secondary to invasion of neural tissues by HCV, as postulated in transverse myelitis and encephalopathic forms. Primarily axonal neuropathies, including sensorimotor polyneuropathy, large or small fiber sensory neuropathy, motor polyneuropathy, mononeuritis, mononeuritis multiplex, or overlapping syndrome, represent the most common neurological complications of chronic HCV infection. In addition, a number of peripheral demyelinating disorders are encountered, such as chronic inflammatory demyelinating polyneuropathy, the Lewis-Sumner syndrome, and cryoglobulin-associated polyneuropathy with demyelinating features. The spectrum of demyelinating forms also includes rare cases of iatrogenic central and peripheral nervous system disorders, occurring during treatment with pegylated interferon. Herein, we review HCV-related demyelinating conditions, and disclose the novel observation on the significantly increased frequency of chronic demyelinating neuropathy with anti-myelin-associated glycoprotein antibodies in a cohort of 59 consecutive patients recruited at our institution. We also report a second case of neuromyelitis optica with serum IgG autoantibody against the water channel aquaporin-4. The prompt recognition of these atypical and underestimated complications of HCV infection is of crucial importance in deciding which treatment option a patient should be offered. ","PeriodicalId":13680,"journal":{"name":"Inflammation & allergy drug targets","volume":"13 5","pages":"299-304"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1871528113666140908113841","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32649083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Increased expression of forkhead box protein 3 gene of regulatory T cells in patients with active tuberculosis. 调节性T细胞叉头盒蛋白3基因在活动性肺结核患者中的表达升高。

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140908112939

Elham Beiranvand, Saeid Abediankenari, Mohammad Sadegh Rezaei, Soghra Khani, Soroush Sardari, Behnoush Beiranvand

{"title":"Increased expression of forkhead box protein 3 gene of regulatory T cells in patients with active tuberculosis.","authors":"Elham Beiranvand, Saeid Abediankenari, Mohammad Sadegh Rezaei, Soghra Khani, Soroush Sardari, Behnoush Beiranvand","doi":"10.2174/1871528113666140908112939","DOIUrl":"https://doi.org/10.2174/1871528113666140908112939","url":null,"abstract":"Cell mediated immunity is the most important response against Mycobacterium tuberculosis (MTB). Regulatory T cells (Treg) play a vital role in suppressing the effector T cell response in tuberculosis (TB) patients. Forkhead box protein 3 (Foxp3) is an important regulator of Treg cells development and function. In this study, we showed that the expression of Foxp3 gene in Treg cells is increased in patients with active tuberculosis. In a case-control study, 183 TB patients and 183 controls were recruited according to ethnicity, gender and living area. Then, after isolation of peripheral blood mononuclear cells (PBMCs), FoxP3 gene expression was studied by real-time PCR. The expression of this gene in patients with pulmonary and extra-pulmonary tuberculosis was 2.8 fold higher than normal subjects (CI=1.29±2.37, P≤0.001). Also comparing the patients with pulmonary tuberculosis and the control group, a significant difference was observed (CI=1.81±2.96, P≤0.001). FoxP3 gene expression was 1.5 fold higher in women with pulmonary and extrapulmonary tuberculosis than in men with tuberculosis (CI=0.12±2.01, P=0.02). According to this study, the increased Foxp3 gene expression in patients with TB was observed and this may play as a contributing factor to suppression of Th1-type immune responses. ","PeriodicalId":13680,"journal":{"name":"Inflammation & allergy drug targets","volume":"13 5","pages":"330-4"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32649084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

ACE and ACE2 in inflammation: a tale of two enzymes. 炎症中的ACE和ACE2:两种酶的故事。

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140713164506

Ravinder Reddy Gaddam, Stephen Chambers, Madhav Bhatia

{"title":"ACE and ACE2 in inflammation: a tale of two enzymes.","authors":"Ravinder Reddy Gaddam, Stephen Chambers, Madhav Bhatia","doi":"10.2174/1871528113666140713164506","DOIUrl":"https://doi.org/10.2174/1871528113666140713164506","url":null,"abstract":"The renin-angiotensin system (RAS) conceived as a coordinated hormonal cascade plays an important role in controlling multiple functions in many organs and is much more complex than previously thought. The RAS has continued to expand, with the identification of new components, functions and subsystems. Angiotensin-converting enzyme (ACE) and its novel homolog angiotensin converting enzyme 2 (ACE2) are two key enzymes involved in the synthesis of bioactive components of the RAS. The main active peptides of the RAS include angiotensin II (Ang II), Ang III, Ang IV, and angiotensin-(1-7) [Ang-(1-7)] among which Ang II and Ang-(1-7) are much more important in health and disease. The axis formed by ACE2 represents an endogenous counter-regulatory pathway within the RAS, and its actions are opposite to those of the ACE axis. Conventionally the RAS has been considered to be important in the cardiovascular system, metabolism, cell growth and homeostasis. In recent years, a key role of ACE and ACE2 and their peptides has been recognized in the inflammatory process in conditions such as cardiac hypertrophy, pulmonary hypertension, glomerulonephritis, lung injury, sepsis, and acute pancreatitis. Investigations are ongoing to better understand the role of the RAS in inflammation. A comprehensive understanding of the RAS components in inflammation can provide new possibilities for therapeutic approaches against inflammatory diseases. In this review, we discuss our current understanding of the subject, based on recent findings, on the role of ACE and ACE2 in inflammation. ","PeriodicalId":13680,"journal":{"name":"Inflammation & allergy drug targets","volume":"13 4","pages":"224-34"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32500337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 133

Reciprocity in microbiome and immune system interactions and its implications in disease and health. 微生物组和免疫系统相互作用中的互惠性及其对疾病和健康的影响。

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140330201056

Enayat Nikoopour, Bhagirath Singh

{"title":"Reciprocity in microbiome and immune system interactions and its implications in disease and health.","authors":"Enayat Nikoopour, Bhagirath Singh","doi":"10.2174/1871528113666140330201056","DOIUrl":"https://doi.org/10.2174/1871528113666140330201056","url":null,"abstract":"Adaptation of the whole microbial normal flora residing in a host to its natural habitat over an evolutionary peroid has resulted in peaceful coexistence with mutual benefits for both microbiota and host in steady state. This symbiotic relationship between host and microbiota has a significant impact on shaping the immune response in the host to achieve an immune tolerance to microbiota but retaining the ability to respond to invading pathogens. Perturbation of this balance by manipulation of microbial communities in the host can lead to immune dysregulation and susceptibility to diseases. By studying the host in the absence of microbiota or with alteration of microbiota the complexity of microbial impact on the immune system can be resolved. Conversely, the study of microbiota in the absence of immune system factors can show how the immune system contributes to preservation of the host-microbiota balance. The absence of molecules involved in innate or adaptive immunity in knockout models can perturb the balance between host and microbiota further adding to more immune dysregulation. A better understanding of Microbiome-immune system interaction provides a new opportunity to identify biomarkers and drug targets. This will allow the development of new therapeutic agents for modulating the immune system to improve health with little or no toxicity. The study of interplay between host and microbiota has a promising role in the design of therapeutic interventions for immunopathological diseases arising from imbalanced host and microbiota interactions. ","PeriodicalId":13680,"journal":{"name":"Inflammation & allergy drug targets","volume":"13 2","pages":"94-104"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32216196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Effect of botanicals on inflammation and skin aging: analyzing the evidence. 植物药对炎症和皮肤衰老的影响:证据分析。

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140526163052

Amanda Suggs, Patricia Oyetakin-White, Elma D Baron

引用次数: 21

Cardiovascular magnetic resonance for evaluation of heart involvement in ANCA-associated vasculitis. A luxury or a valuable diagnostic tool? 心血管磁共振评价anca相关性血管炎的心脏受累程度。是奢侈品还是有价值的诊断工具?

Inflammation & allergy drug targets Pub Date : 2014-01-01 DOI: 10.2174/1871528113666140924123717

Sophie Mavrogeni, George Markousis-Mavrogenis, Genovefa Kolovou

引用次数: 1