International Blood Research & Reviews最新文献

{"title":"Kell Blood Group Antigens Not Found in Indigenes of Ogoni Ethnic Group of Rivers State, Nigeria","authors":"S. Christian, E. Eze, A. C. Ezimah, F. Buseri","doi":"10.9734/ibrr/2020/v11i130119","DOIUrl":"https://doi.org/10.9734/ibrr/2020/v11i130119","url":null,"abstract":"Aim: The aim of the study was to determine the frequency of occurrence and percentage distribution of Kell blood group antigens in indigenes of Ogoni ethnic group of Rivers State, Nigeria. Study Design: This was a cross-sectional study carried out among indigenes of Ogoni whose first generational parental origin is Ogoni. A total of 101 subjects (49 females and 52 males), within the age of 30–60 years were recruited for the study and they were apparently healthy and free from transfusion transmissible infections upon serological screening. Place and Duration of Study: Ogoniland is located in an area along the Niger Delta Eastern edge, Original Research Article Christian et al.; IBRR, 11(1): 1-5, 2020; Article no.IBRR.54577 2 and to the north-east of the Imo River and Port Harcourt city. Ogoniland covers about 1036 Sq Km and borders the Bay of Guinea. All participants were recruited in Bori. Bori is the traditional headquarter of Ogoni. Bori is located on latitude: 4 0 40ʹ34.64ʺ N and longitude: 7 0 21ʹ54.68ʺ E. The analysis was carried out at the Post Graduate Laboratory of Rivers State University, NkpoluOroworukwo, Port Harcourt, Rivers State, Nigeria. Port Harcourt, the capital of Rivers State, is located on latitude 4.75N and longitude 7.00E and lies along Bonny River in the Niger Delta. All subjects were recruited the same day and their blood samples collected on 2 nd October, 2019, and analysis conducted on 3 October, 2019. Methodology: Identification of Kell blood group antigens was done using Anti-Kell monoclonal reagent, prepared by Lorne Laboratories Ltd, UK. Lot No: 76090-A5; Expiry Date: 2021/02/21. Phenotyping of red cells was done using tube method as described by Lorne Laboratory Ltd. Results: The result showed zero frequency of occurrence and percentage distribution of Kell blood group antigen in the studied population (49 males and 52 females). Conclusion: The presence of Kell blood group antigens in indigenes of Ogoni recruited for the study which serve as representative of the Ogonis was rare. It is therefore necessary to take into cognizance that haemolytic transfusion reactions due to Kell antigens and antibodies will rarely occur, and as such Kell blood group is not significant in blood transfusion and in antenatal and blood group serology amongst the Ogonis.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85827659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of ABO, Rhesus D and Subgroups of ABO among Blood Donors in Sokoto, North Western Nigeria","authors":"A. Ibrahim, H. Attahiru, O. Erhabor, P. F. Udomah, A. Yakubu, H. Buhari, H. M. Ahmed, F. Onuigwe, D. Isah, M. Kalgo, U. Abubakar","doi":"10.9734/ibrr/2020/v11i130120","DOIUrl":"https://doi.org/10.9734/ibrr/2020/v11i130120","url":null,"abstract":"ABO, Rhesus D and subgroups of ABO are highly immunogenic and are the common cause of antibody production in mismatched blood transfusions, haemolytic transfusion reaction and maternal alloimmunization. The aim of this study was to determine the occurrence of ABO, Rh D and subgroups of ABO among blood donors attending Specialist Hospital Sokoto, Nigeria. ABO, Rhesus D and subgroups of ABO antigen status of 176 blood donors with mean age of 30.44 ± 8.210 years Original Research Article Ibrahim et al.; IBRR, 11(1): 6-13, 2020; Article no.IBRR.54795 7 attending Specialist Hospital Sokoto were determined using tile method for ABO and Rh D and conventional tube method for antiA1, antiH reagents for ABO subgroups respectively. Among the 176 subjects tested, blood group O+ was the most frequent group with 93 (52.8%), 39 (22.2%) were blood group B+, 37(21.0%) were blood group A+, 5 (2.8%) were blood group AB+, 2 (1.1%) were blood group O-. No data was obtained for A-, Band ABblood groups. Out of 37 A blood groups obtained, 31 (83.8%) had A1 antigens and 6 (16.2%) had A2 antigens. Out of the 5 AB blood groups, all had A1B antigens. The study also shows that there was statistically significant difference between blood group A and ethnic groups (Hausa, Fulani and Yoruba) (p<0.05). Blood group O was found to be the most frequent followed by B, A and AB except among Hausa which revealed a pattern of O> A> B> AB. ABO, subgroups shows majority had A1 followed by A2 and A1B respectively.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82192718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beta Thalassemia Major: Overview of Molecular Etiology, Pathophysiology, Current and Novel Therapeutic Approaches","authors":"S. E. Kababi, B. E. Khalfi, K. Maani, A. Soukri","doi":"10.9734/ibrr/2019/v10i230118","DOIUrl":"https://doi.org/10.9734/ibrr/2019/v10i230118","url":null,"abstract":"Major beta thalassemia is a severe form of thalassemia caused by the alteration of two beta globin genes resulting in a defective synthesis of hemoglobin. \u0000It is characterized by chronic severe anemia, ineffective erythropoiesis (IE) and iron overload. However although the thransfusion and chelation assosciated constitute the basis of the traitement curently recommended, they do not allow always to control the iron overload induced by pathology and repeated transfusions. \u0000Hematopoietic stem cell transplantation (HSCT) has proven to be a definitive treatment for beta thalassemia. However, this procedure is confronted to immunological complications and the small nomber of histocompatible donors. In the face of these therapeutic blocks, much research has been undertaken in recent years leading to the development of a number of promising therapeutic strategies in order to reduce the constraints linked to current chronic treatments, and to move towards an access to healing for all patients. Among other three approaches are envisaged and are in the experimental phase: Gene therapy to restore globin chain imbalance, Improve ineffective erythropoiesis and Improve iron dysregulation. In this article we give a view on the pathophysiology, clinical manifestations, genetic origin of beta-thalassaemia major. The second part presents the therapeutic arsenal currently used, and its limits leading to therapeutic impasse. The last part explores the scientific tracks that present a real therapeutic potential in β-Thalassemia.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89807983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-PRF Membrane (Fibrin Rich in Platelets and Leukocytes) and Its Derivatives (A-PRF, i-PRF) are Helpful as a Basis of Stem Cells in Regenerative Injury Treatment: Trial Work on the Horse","authors":"A. Crisci, Maria Chiara Barillaro, G. Lepore, Federica Cardillo","doi":"10.9734/ibrr/2019/v10i230117","DOIUrl":"https://doi.org/10.9734/ibrr/2019/v10i230117","url":null,"abstract":"Developing a multidisciplinary field of tissue engineering aims to recover, improve or supplant typically damaged or missing tissues for a collection of conditions brought about by trauma, malady and old age. To guarantee that tissue engineering techniques are generally relevant in the clinical setting, it is important to adjust them so that they are promptly accessible and moderately simple to use in the everyday clinical schedule. Consequently, the steps between preparation and application Review Article Crisci et al.; IBRR, 10(2): 1-14, 2019; Article no.IBRR.54363 2 must be limited and improved to make them practical in application. The general objective of creating platelet concentrates of natural origin can be delivered near the patient to quicken the implantation procedure, being monetarily practical for the patient and the health framework. Fibrin rich in platelets and leukocytes (PRF) and its derivatives (L-PRF, A-PRF, i-PRF) has been utilized in a wide collection of medical fields for delicate tissue restoration. Practically all platelets (> 97%) are missing within test-tubes in groups tested after PRF membrane extraction. Growth Factors liberated by platelets contained in derivatives of L-PRF induce and control the proliferation and migration of other cell types, associated with tissue repair, similar to smooth cell muscles (SMCs) and mesenchymal stem cells (MSCs). Conclusively, the outcomes of this work feature the positive effects of PRF on wound healing after regenerative treatment for the administration of different delicate tissue defects found in wound care.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79738631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Donation Practices of Tertiary Level Students in South Eastern Nigeria: Prevalence and Determinants","authors":"C. Duru, Uche R. Oluoha, A. Iwu, C. Aguocha, I. Ohale, Emmanuel N. Ndukwu, E. Nwaigbo, Nnamdi P. Okafor","doi":"10.9734/ibrr/2019/v10i230116","DOIUrl":"https://doi.org/10.9734/ibrr/2019/v10i230116","url":null,"abstract":"Introduction: Safe and adequate blood donation is critical in saving millions of lives annually. In many developing including Nigeria, there is paucity of blood donors. Aim: In this study, we assessed the blood donation practices of tertiary level students in Imo State, South East Nigeria as well as its prevalence and determinants. Methodology: Multistage sampling technique was used. Stage one involved the stratification of the institutions into universities and non-universities. In stage two, one university and one non university was selected using simple random method. Stage three involved the selection of study participants from the student registry using systematic sampling method. Self-administered Original Research Article Duru et al.; IBRR, 10(2): 1-12, 2019; Article no.IBRR.53461 2 questionnaire was the study instrument. Data analysis was with Statistical Package for Social Sciences (IBM – SPSS) version 20. Results: Six hundred (600) undergraduates participated in the study. The mean age of the respondents was 21.3 ± 5.0 years. The one year prevalence of blood donation in this study was 13.8% and 63.1% of the non-donors were willing to donate. Respondents aged 15 – 29 years more willing to donate blood compared to those aged 30 – 44 years (OR = 3.03, p = 0.0003), those that were single were 4 times more willing to donate in comparison to those that were married/divorced (OR = 4.02, p < 0.0001). Respondents that were of Catholic faith were also more willing to donate compared to those that were of Pentecostal/Orthodox denomination (OR = 2.72, p = <0.0001). Class distribution and residence were not independent predictors of willingness to donate blood. Conclusion: From the findings in this study, it was obvious that the willingness to donate blood is far greater than the actual act of donating blood. There is need to continue to reach out to those willing to donate but do not know how to go about it.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72828512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutathione and Bilirubin Concentrations as Markers of Oxidative Stress Measured among Sickle Cell Anaemia Subjects Attending University of Calabar Teaching Hospital, Calabar Nigeria","authors":"E. E. Onukak, E. Akwiwu, J. Akpotuzor, A. Okafor, A. Onukak","doi":"10.9734/ibrr/2019/v10i230114","DOIUrl":"https://doi.org/10.9734/ibrr/2019/v10i230114","url":null,"abstract":"Aims: This study aimed at examining the oxidative stress level of sickle cell anaemia subjects using glutathione and bilirubin levels as markers as well as the red cell parameters. Study Design: Case-control study. Place and Duration of Study: University of Calabar Teaching Hospital, Calabar-Nigeria, between August 2018 and July 2019. Methodology: Subjects comprised 45 SCA patients (27 females, 18 males; age range 10-45 years) attending clinic at University of Calabar Teaching Hospital Calabar, Nigeria and equal number of age and sex-matched control subjects with Hb AA. Blood samples were collected and analyzed by Original Research Article Onukak et al.; IBRR, 10(2): 1-6, 2019; Article no.IBRR.52192 2 standard methods. The red cell parameters were analysed by automation using FY-Smart-1 auto haematology analyzer. Bilirubin assay was performed using the colorimetric method, while glutathione was performed by enzyme-linked immunosorbent assay technique. Results: The red blood cell count, haemoglobin concentration, and haematocrit values of SCA subjects were significantly lower (p=0.001) compared to values from control subjects, while the red cell indices and red cell distribution width values were increased in SCA subjects (p=0.001). The Total bilirubin, conjugated bilirubin and unconjugated bilirubin were significantly increased (p=0.001) among SCA subjects, while the glutathione concentration values were reduced (p=0.001) when compared to values obtained from control subjects. Conclusion: SCA subjects have marked red cell size variation, lymphocytosis and thrombocytosis. The haemolytic events that occur in sickle cell anaemia results in glutathione depletion.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75016347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Impact of Some Selected Plants on Haematological Parameters of Testosterone and Estradiol Induced Benign Prostatic Hyperplasia Adult Male Rats","authors":"M. Ugwu, A. Asuk, M. Eteng, Edward Odey Emuru","doi":"10.9734/ibrr/2019/v10i130113","DOIUrl":"https://doi.org/10.9734/ibrr/2019/v10i130113","url":null,"abstract":"Background: Benign prostate hyperplasia (BPH) is an age-related disease of unknown etiology, characterized by prostate enlargement. The effect of Prosopis africana (PA), Vernonia amydalina (VA) and Ocimum gratissmum (OG), plant extracts on haematological parameters of BPH animal model was investigated. Methods: BPH was induced in 45 male Wistar rats (250-350 g) by exogenous injection of testosterone and estradiol in staggered doses for 3 weeks. To confirm BPH induction, some animals Original Research Article Ugwu et al.; IBRR, 10(1): 1-15, 2019; Article no.IBRR.53052 2 were sacrificed; histological inspection of prostate gland and PSA was carried out. Forty BPH induced rats were divided into 8 groups. Group 1 and 2, 3 and 4, 5 and 6 were treated with 50 mg/kg bw and 100 mg/kg bw doses of PA, VA and OG extracts respectively. Group 7 received finasteride (0.1 mg/kg bw). Group 8 BPH control and five rats without induction constitute group 9, the normal control and both received distilled water. After 45 days, the rats were anaesthetised by a brief exposure to trichloromethane vapour and 5 ml of blood was collected from the rats through cardiac puncture and dispensed into well-labelled EDTA containers to avoid coagulation. All analyses were completed within 24 h of sample collection. Results: Results showed that induction of BPH caused a significant (P< 0.05) enlargement of prostate gland when compared to normal control. All extracts produced significant (P<0.05) reduction in the weight of the enlarged prostate when compared to the BPH control. There were significant (P ˂0.05) decline in RBC, PCV and Hb of BPH control when compared to the normal control and treated groups. In the treated groups the administration of the extracts and standard drug exhibited an increase in RBC, PCV and Hb concentration when compared with the BPH control. Also there was significant (P < 0.05) increase in the WBC, neutrophils, platelets, monocytes, lymphocytes and eosinophils levels in BPH control when compared to normal control and treated groups. In all treated groups there was significant decrease in WBC, neutrophils, platelets, monocytes, lymphocytes and eosinophils concentration levels when compared with the BPH control group. Conclusion: The result of this study indicates that the extracts have the potential to reverse the inflammation caused by BPH and also have the capacity to boost the numbers of red blood cells probably by inhibiting the hemolysis caused by inflammatory factors or by enhancing the production of red blood cell from the bone marrow.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76051821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting Ferritin Level in Children of 6 to 59 Months in the Eastern Region of Cameroon","authors":"S. D. Agokeng, C. Tayou, J. Assob, A. Njunda","doi":"10.9734/ibrr/2019/v10i130112","DOIUrl":"https://doi.org/10.9734/ibrr/2019/v10i130112","url":null,"abstract":"Aim: Ferritin reflects total iron storage and is also the first laboratory index to decline with iron deficiency. It may be less accurate in children with infectious or inflammatory conditions as an acute phase reactant. Considering the fact that Cameroonian children live in malaria endemic and high risk hookworm infection area, our objective was to study factors affecting Ferritin level including socio-demographic data, child nutrition, anaemia and inflammatory status. \u0000Study Design: A case control study was carried out with anaemic children as cases and non-anaemic as controls. \u0000Place and Duration: Paediatric and laboratory units of the Bertoua regional Hospital, from November 2018 to January 2019. \u0000Methodology: A case control study was carried out in children of 6 to 59 months attending the Bertoua regional hospital. Data were collected and blood distributed in EDTA and dry tubes for full blood count, C - reactive protein (CRP) and Ferritin analysis. Obtained data were analysed with SPSS 21.0 using Pearson’s Chi Square test. \u0000Results: 126 children were included, 63 anaemic (Haemoglobin<11 g/dL) as cases and 63 non anaemic as controls. The Mean age of children was 27.3+/- 15.4 months, the mean haemoglobin was 10.4+/- 1.6 g/dL. Ferritin as state by WHO for the diagnosis of iron deficiency anaemia, was below 30 μg/L in 3.2% independently of anaemic status. Inflammation tested by CRP occurred in 37.3% of children. When the ferritin cut-off value was shifted to 50 μg/L, Ferritin was low in 9.5% thus approaching the stated frequency of iron deficiency obtained recentlyin Cameroon. Mean Ferritin level was 346.5 μg/L. \u0000Conclusion:  The relatively high level of Ferritin showed that iron storage seems to remain intact in most children despite anaemic or inflammatory status. The level of Ferritin in children is highly dependent on haem iron consumption and food diversification also has a role to play.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81037699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocardiosis Associated with Novel Agents at Relapsed Multiple Myeloma: Case Series","authors":"A. Turgutkaya, Z. Bolaman, E. Ceylan, M. Telli, B. Korkmazgil, C. Karaman, I. Yavaşoğlu","doi":"10.9734/ibrr/2019/v10i130111","DOIUrl":"https://doi.org/10.9734/ibrr/2019/v10i130111","url":null,"abstract":"Nocardiosis is a gram positive bacterial infection caused by aerobicactinomycetes. It’s nonspesific presentation and radiographic findings usually make it undiagnosed with highly fatal outcomes. The patients with intracelluler defects are prone to nocardiosis. Multiplemyelom(MM) itself is a mainly humoral deficiency disorder because of defective antibodies but recent drugs such as proteasome inhibitors and immuno modulatory drugs also cause cellular deficiency. Here we presented two definite and oneprobable pulmonary nocardiosis patients who have a diagnosis of MM, autologou shematopoetic stem cell transplant history in their past and anti myeloma therapy presently.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75810489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Electrolytes and Red Blood Cell Membrane Potential of Hypertensive Patients","authors":"N. Constance, Nosiri Chidi Ijeoma, Eze A. Adindu, Onyeabo Chimaraoke, Ezekwe Ahamefula Sunday, Onyejiekwe Catherine","doi":"10.9734/ibrr/2019/v10i130110","DOIUrl":"https://doi.org/10.9734/ibrr/2019/v10i130110","url":null,"abstract":"Serum electrolyte and red blood cell membrane potential of hypertensive patients in Owerri metropolis were investigated. A total of 50 volunteer subjects were used for the study.  Thirty (30) of the volunteer subjects were hypertensive subjects and were used as test subjects; while the remaining 20 subjects were healthy subjects with normal blood pressure used as normentensive subjects (control). Results observed showed increased red blood cell (RBC) K+ and Cl- in hypertension subjects against normentensive subjects. Apart from K+ which reduced significantly (p<0.05), other electrolyte ions of the serum increased significantly (p<0.05) in hypertensive subjects against normentensive subjects. However, Na+ and Cl- membrane potential was not significantly (p>0.05) altered in hypertensive subjects against normotensive subjects while K+ was significantly (p<0.05) altered. The observed alterations in the parameters investigated in hypertensive subjects in the present study could be as a result of a host of derangements involving electrolyte metabolism, altered membrane transport and a possible increase in membrane fragility. This study has shown the serum electrolyte and red blood cell membrane potential of hypertensive patients in Owerri metropolis.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78436760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}