International Archives of Allergy and Immunology最新文献

{"title":"Possible Association of CD3+CD4-CD8- Phenotype of T-Cell Lymphoma with Peripheral Blood Eosinophilia.","authors":"Rie Tabata, Chiharu Tabata","doi":"10.1159/000541097","DOIUrl":"10.1159/000541097","url":null,"abstract":"<p><strong>Introduction: </strong>Because the prognosis of patients with peripheral T-cell lymphoma is poor compared to that of patients with B-cell lymphoma, we want to avoid further organ damage by eosinophilia. Moreover, in patients with some types of lymphoma, blood eosinophilia is implicated in a worse prognosis. To study the risk factors of eosinophilia, the association between lymphoma type, immunophenotypic features, and peripheral blood eosinophil counts were examined in the patients with mature T-cell lymphoma.</p><p><strong>Methods: </strong>We retrospectively examined 28 patients with mature T-cell lymphoma who were admitted to our hospital and whose immunophenotypic features were confirmed using flow cytometric, immunohistochemical analysis, or both between December 2012 and November 2023.</p><p><strong>Results: </strong>We report a possible association between peripheral eosinophilia and peripheral T-cell lymphoma - not otherwise specified and CD3+CD4-D8- (double-negative) phenotypes. Mild eosinophilia was observed in various types, but moderate and severe eosinophilia were observed in patients with peripheral T-cell lymphoma - not otherwise specified. Double-negative phenotype was rarely observed; however, all patients with double-negative phenotype exhibited peripheral blood eosinophilia. In addition, four of the five cases of the double-negative type were peripheral T-cell lymphoma - not otherwise specified.</p><p><strong>Conclusion: </strong>Here, we retrospectively examined patients with peripheral T-cell lymphoma whose immunophenotypic features were confirmed and report a possible association between peripheral eosinophilia and peripheral T-cell lymphoma - not otherwise specified and CD3+CD4-CD8- (double-negative) phenotypes. In addition, clinicians should be aware of the possible risk that patients with lymphocytic hypereosinophilic syndrome of the double-negative phenotype may develop peripheral T-cell lymphoma.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"184-188"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Allergies in Older Adults: A Major Problem in a Specific Population.","authors":"Mehmet Kılınç, Fatih Çölkesen, Filiz Sadi Aykan, Recep Evcen, Eray Yıldız, Tuğba Önalan, Ümmügülsüm Yılmaz Ergün, Fatma Arzu Akkuş, Mehmet Emin Gerek, Selim Kahraman, Şevket Arslan","doi":"10.1159/000540374","DOIUrl":"10.1159/000540374","url":null,"abstract":"<p><strong>Introduction: </strong>The use of medications in older adults is increasing due to the prevalence of chronic diseases. Data on the characteristics of drug allergies (DAs) in older adults are limited. This study investigated the prevalence and clinical characteristics of DAs in patients aged 65 years and older.</p><p><strong>Methods: </strong>Patient records were examined retrospectively between January 2018 and December 2022. The study included 200 patients aged ≥18 years who met the criteria for diagnosis of type B drug reactions. The patients were divided into two groups: the adult group (18-64 years) and the older adult group (≥65 years).</p><p><strong>Results: </strong>Advanced age was an independent risk factor for the development of anaphylaxis and immediate and delayed hypersensitivity reactions (odds ratio [OR] = 4.296; 95% confidence interval [CI] = 1.700-10.855; p = 0.002, OR = 3.800; 95% CI = 1.247-11.579; p = 0.019, OR = 3.028; 95% CI = 1.248-7.343; p = 0.014, respectively). Older adults had higher rates of comorbidities and polypharmacy (p < 0.001, p = 0.016, respectively), beta-lactam antibiotic allergy (p < 0.001), and hospitalization and intensive care unit (ICU) admission for DAs (p = 0.024, p = 0.045, respectively).</p><p><strong>Conclusion: </strong>Older age was an independent risk factor for anaphylaxis and both immediate and delayed reactions. Older adults had higher rates of comorbidities, polypharmacy, beta-lactam antibiotic triggers, and hospitalization and ICU admission.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"59-66"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific and Long-Term Trends of Asthma, Allergic Rhinitis, and Atopic Dermatitis in South Korea, 2007-2022: A Nationwide Representative Study.","authors":"Yesol Yim, Hyesu Jo, Seoyoung Park, Yejun Son, Jaeyu Park, Hyeon Jin Kim, Sooji Lee, Hayeon Lee, Damiano Pizzol, Lee Smith, Saiah Kim, Jiseung Kang, Selin Woo, Dong Keon Yon","doi":"10.1159/000540928","DOIUrl":"10.1159/000540928","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Although sex differences in allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), and asthma are considered important, a limited number of studies during the COVID-19 pandemic investigated this aspect. Therefore, this study aimed to analyze sex-specific and long-term trends and risk factors for allergic diseases before and during the pandemic.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study utilized data from the Korea National Health and Nutrition Examination Survey, 2007-2022, including 92,135 participants aged 19 years and older. This study used weighted multivariate regression analysis to examine the estimates of related factors and assessed weighted odds ratios or β-coefficients for these factors across multiple categories.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;During the study period (2007-2022), the prevalence of AR was more common in females than in males. Particularly in 2022, the prevalence among females was 19.3% (95% confidence interval, 17.3-21.3), while among males, it was 15.6% (13.8-17.4). The prevalence of AD and asthma showed a slight disparity between males and females. Before and during the pandemic, the prevalence of AD and AR showed a continuous increase (AD: from 2.8% [2.5-3.2] in 2007-2009 to 4.7% [3.9-5.4] in 2022; AR: from 11.7% [11.1-12.4] in 2007-2009 to 17.4% [16.0-18.9] in 2022), while asthma maintained a relatively stable trend. Moreover, this study identified several sex-specific factors that seem to be associated with a higher prevalence of allergic diseases in females, such as high household income, smoking, and being overweight or obese.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Throughout all the periods examined, females consistently exhibited a higher prevalence of AR compared to males. Moreover, the risk factors for males and females varied depending on the disease, with females generally facing a greater number of risk factors. Consequently, this study highlights the necessity for sex-specific health interventions and further research to comprehend the complex influence of socioeconomic factors and lifestyle choices on the prevalence and risk of AD, AR, and asthma.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Although sex differences in allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), and asthma are considered important, a limited number of studies during the COVID-19 pandemic investigated this aspect. Therefore, this study aimed to analyze sex-specific and long-term trends and risk factors for allergic diseases before and during the pandemic.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study utilized data from the Korea National Health and Nutrition Examination Survey, 2007-2022, including 92,135 participants aged 19 years and older. This study used weighted multivariate regression analysis to examine the estimates of related factors and assessed weighted odds ratios or β-coefficients for these factors across multiple categories.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/stron","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"166-183"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Yellow Fever Vaccine Reactions in IgE-Mediated Egg Allergic Patients.","authors":"Ruth-Helena Ramírez-Giraldo, Paola-Andrea Giraldo-Avila, Ana-Maria Calle, Luis-Carlos Santamaria, Jorge Sánchez","doi":"10.1159/000539505","DOIUrl":"10.1159/000539505","url":null,"abstract":"<p><strong>Introduction: </strong>Egg allergy usually manifests during the initial 2 years of life, a period in which most vaccinations are administered. This often leads to delays in the application of some vaccines in patients with egg allergies, exposing them to a risk of contracting preventable infections. The aim of the study was to describe the frequency of reactions after applying the yellow fever vaccine (YFV) within a population with egg allergy.</p><p><strong>Methods: </strong>This was a cohort study with retrospective, multicenter data (2014-2023). Patient records diagnosed with egg allergy were gathered from their initial egg-related reactions until their YFV administration. Information was also collected about hypersensitivity tests conducted for egg and YFV such as the skin prick test (SPT) and intradermal test (IDT).</p><p><strong>Results: </strong>Among the 171 records analyzed, 23.9% of patients had a history of egg anaphylaxis. Out of these, 5 patients had a positive SPT and 21 IDT with the YFV. All patients tolerated the application of YFV without developing hypersensitivity reactions, regardless of the results of the YFV tests, the severity of egg reactions, the number of egg reactions, or the time since the last egg reaction. Out of the total patient cohort, 46.1% (79 individuals) encountered delays in receiving the YFV, and in this subset, 14% faced delays lasting longer than 12 months.</p><p><strong>Conclusion: </strong>The risk of allergic reactions with the YFV remains low. YFV tests generate delays in the vaccine application without providing high diagnostic accuracy. YFV should not be deferred even in patients with a history of severe egg reactions.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"52-58"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Genetic Analysis Exploring Sedentary Lifestyle, Physical Activity, and Respiratory Diseases: A Bidirectional Mendelian Randomization with over 500,000 Participants.","authors":"Wei Wan, Junhao Tu, Xinyi Huang, Yingxiang Ren, Zhiqiang Zhang, Xinyu Huang, Mengyuan Liu, Yi Qiu, Chunping Yang","doi":"10.1159/000543150","DOIUrl":"10.1159/000543150","url":null,"abstract":"<p><strong>Introduction: </strong>The association between sedentary lifestyle, physical activity, and risk of respiratory diseases is a crucial area of medical and health research. Despite numerous studies, uncertainties and controversies regarding the causal relationships persist. We utilized Mendelian randomization (MR) analysis, an advanced statistical tool, to further investigate causal links.</p><p><strong>Methods: </strong>In this study, bidirectional MR analysis was performed to determine the potential causal relationships between leisure screen time (LST), moderate-to-vigorous intensity physical activity during leisure time (MVPA), sedentary behavior at work (SBW), and 10 common respiratory diseases.</p><p><strong>Results: </strong>Aggregating outcomes from analytical assessments showed that LST was positively correlated with the risk of asthma (odds ratio [OR] = 1.22, 95% confidence interval [CI] = 1.10-1.34, p = 9.36E-5), chronic obstructive pulmonary disease (COPD) (OR = 1.31, 95% CI = 1.16-1.49, p = 2.45E-5), lung cancer (OR = 1.18, 95% CI = 1.05-1.32, p = 0.005), and obstructive sleep apnea (OR = 1.12, 95% CI = 1.04-1.22, p = 0.003). MVPA was correlated with a reduced risk of developing asthma (OR = 0.68, 95% CI = 0.53-0.88, p = 0.004) and COPD (OR = 0.62, 95% CI = 0.47-0.83, p = 0.001). A genetic predisposition to SBW was associated with a decreased risk of nasal polyps (OR = 0.60, 95% CI = 0.423-0.86, p = 0.005).</p><p><strong>Conclusion: </strong>Our findings demonstrate complex causal relationships among sedentary lifestyle, physical activity, and various respiratory system diseases. These discoveries hold significant value in devising precision-oriented approaches for the prevention and treatment of respiratory diseases.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Biologic Therapies in the Management of Asthma in Children and Adolescents: A Comprehensive Network Meta-Analysis.","authors":"Jinting Lin, Kexin Yang, Qilin Zhou, Qiqing Ye, Zhuanggui Chen, Pingping Zhang, Min Zhou, Li Pan","doi":"10.1159/000542797","DOIUrl":"10.1159/000542797","url":null,"abstract":"<p><strong>Introduction: </strong>Emerging evidence has underscored the positive impact of biologics on asthmatic patients. However, there is a pressing need to verify their therapeutic efficacy in children and adolescents with asthma. To address this, we conducted a network meta-analysis (NMA) to evaluate the efficacy and safety of biologics in the asthma management of this demographic.</p><p><strong>Methods: </strong>The databases of PubMed, Embase, Web of Science, and Cochrane Library were comprehensively searched in our study until May 29, 2024. Only randomized controlled trials were included to estimate the value of biologics on asthmatic children and adolescents. Data extraction and risk of bias assessment were independently performed by two researchers. Outcomes were analyzed by a fixed effects model, and the surface under the cumulative ranking (SUCRA) scores were calculated to determine the likelihood of each biologic being the most effective intervention.</p><p><strong>Results: </strong>2,672 patients were included for comparing four different biologics (dupilumab, omalizumab, lebrikizumab, and mepolizumab) with a placebo. Dupilumab has been demonstrated to have the highest efficacy in reducing asthmatic exacerbations, improving lung function, and improving patients' quality of life, with the SUCRA values of 0.956, 0.999, and 0.897, respectively. Omalizumab showed the best safety potential by reducing the risk of adverse and severe events, with the SUCRA values of 0.876 and 0.930.</p><p><strong>Conclusions: </strong>In this NMA, focusing on biologics that target type 2 inflammation in childhood and adolescent asthma, four biologics demonstrated a favorable safety profile. Notably, dupilumab emerged as the most effective, while omalizumab was identified as the safest therapy. Further studies must be conducted in order to confirm these findings.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-14"},"PeriodicalIF":2.5,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"α2-3 Sialic Acids-Decorated Allergens Exert a Tolerogenic Effect on CD4+ T Cells from Der p 2-Allergic Patients.","authors":"Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Evert E Peterse, Hakan Kalay, Serge A Versteeg, Ronald van Ree, Esther E C de Jong, Yvette van Kooyk","doi":"10.1159/000543157","DOIUrl":"10.1159/000543157","url":null,"abstract":"<p><strong>Introduction: </strong>Allergen-specific immunotherapy is so far the only disease-modifying therapy for allergy, resulting in a long-lasting tolerance. However, the existing safety concerns and the need for more efficacious alternatives that shorten the duration of treatment have stimulated research into the development of novel alternatives. Some of these novel alternatives involve modifying allergens with molecules that target innate immunomodulatory receptors to suppress the immune activity of immune cells.</p><p><strong>Methods: </strong>Freshly prepared monocyte-derived dendritic cells (moDCs) from mite-allergic and non-atopic volunteers were treated with α2-3 sialic acid-conjugated recombinant Der p 2 (sia-Der p 2) and unconjugated Der p 2 in culture and matured with toll-like receptor 1/2 (Pam3CSK4) (Pam3) and 2/4 (lipopolysaccharide [LPS]) agonists, followed by coculture with autologous CD4+ T cells. Secretion of cytokines in supernatants was measured by ELISA, and expression of cell surface and intracellular markers was measured by flow cytometry.</p><p><strong>Results: </strong>Sia-Der p 2 unlike Der p 2 modulated moDCs from mite-allergic volunteers by reducing expression of CD83 and CXCR5. We also observed that sia-Der p 2-treated moDCs in the presence of Pam3 and LPS significantly suppressed the proportion of CD25+, Ki67+, IL-13+, and IFNγ+ CD4+ T cells of mite-allergic volunteers, while Der p 2-treated moDCs did not. Sia-Der p 2-treated moDC did not alter these CD4+ T-cell populations in non-atopic volunteers.</p><p><strong>Conclusion: </strong>Our data suggest that Der p 2 conjugated with α2-3 sialic acids modifies moDCs and promotes the differentiation of allergen-specific CD4+ T cells toward a regulatory profile.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Fibroblast Growth Factor 2 Impact and Mechanism on Broncho-Pulmonary Dysplasia.","authors":"Ling Lu, Ye-Dan Liu, Dong-Yun Liu, Rong Jin, Zheng-Hai Qu","doi":"10.1159/000543105","DOIUrl":"10.1159/000543105","url":null,"abstract":"<p><strong>Objective: </strong>Epithelial-mesenchymal transition (EMT) of alveolar epithelial cells is an important mechanism for the onset and development of broncho-pulmonary dysplasia (BPD). Fibroblast growth factor 2 (FGF2) is involved in the development and repair of injury in many organs, particularly the lung. The role of FGF2 in BPD is currently unclear. The aim of our study was to investigate the expression of FGF2 in lung tissue of BPD mice, to further clarify the effect of FGF2 on EMT in alveolar epithelial cells and to actively search for possible signaling pathways.</p><p><strong>Methods: </strong>The BPD model was induced by exposure to hyperoxia. Lung tissue samples were collected and hematoxylin and eosin staining was used to determine the modeling effect. Quantitative real-time polymerase chain reaction (QRT-PCR), immunohistochemistry was used to detect FGF2 expression in BPD mice. To further investigate the effect of FGF2 supplementation and deficiency on EMT in alveolar epithelial cells, A549 cells were cryopreserved, resuspended, cultured, and passaged. Transforming growth factor-β1 (TGF-β1) was used to induce EMT. FGF2 small interfering RNA fragments were synthesized and screened. Fibroblast growth factor receptor 1 (FGFR1) expression was inhibited by BGJ398. (3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium) (MTS) assay was used to detect the effect of FGF2 and infigratinib (BGJ398) on cell proliferation. We used qRT-PCR and Western blot to detect the expression of epithelial cell markers, mesenchymal cell markers and EMT-related signaling pathway proteins.</p><p><strong>Results: </strong>Our results showed that the successful established hyperoxia mice model were characteristic by BPD. Hyperoxia decreased FGF2 on day 4, upregulated FGF2 on day 21, which resulted in EMT. In vitro, we found that FGF2 alone increased the expression of mesenchymal markers, decreased the expression of epithelial markers and activated phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), small mother against decapentaplegic (Smad), mitogen-activated protein kinase (P38), and extracellular signal-regulated kinase (ERK) signaling pathways. FGF2 could not reverse but synergistically promote Transforming growth factor-β1 (TGF-β1)-induced EMT of alveolar epithelial cells. Silencing FGF2 increased the expression of epithelial marker E-cadherin, inhibited the PI3K/AKT, Smad, and P38 signaling pathways activated by TGF-β1, but activated ERK signaling. FGF2 receptor inhibitor BGJ398 reversed TGF-β1-induced EMT, decreased the expression of FGFR1, and inhibited ERK signaling pathway activation.</p><p><strong>Conclusions: </strong>FGF2 was closely associated with EMT in BPD mice. Both high and low levels of FGF2 promoted EMT in A549. The FGF2 receptor inhibitor BGJ398 reversed TGF-β1-induced EMT in A549 by inhibiting the FGFR1/P-ERK signaling pathway.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-15"},"PeriodicalIF":2.5,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergen Sensitization in Allergic Skin Diseases in Suzhou, East China: A Retrospective Study from 2021 to 2023.","authors":"Chunjiao Zheng, Jiacheng Dong, Peizhen Li, Yan Li, Miaomiao Wang, Yueqian Zhu, Tingting Wu, Naihui Zhou","doi":"10.1159/000543021","DOIUrl":"10.1159/000543021","url":null,"abstract":"<p><strong>Introduction: </strong>Allergen distribution varies geographically, and local epidemiological data can guide disease prevention and management. We investigated allergen sensitization among patients with three types of allergic skin disease in Suzhou, East China, from 2021 to 2023.</p><p><strong>Methods: </strong>Serum-specific immunoglobulin E levels were analyzed from 4,603 patients who visited the First Affiliated Hospital of Soochow University between January 2021 and December 2023. Sensitization prevalence of 20 allergen species was assessed, considering age, sex, year, and disease type.</p><p><strong>Results: </strong>Common aeroallergens included Dermatophagoides farinae, Dermatophagoides pteronyssinus, and house dust, while major food allergens were soybean, egg, and crab. Children exhibited higher sensitization rates, with males more sensitized to D. farinae, D. pteronyssinus, Alternaria, and milk, and females more sensitized to Blattella germanica and egg. Compared with previous years, sensitization rates for soybean and milk decreased in 2023, whereas those for D. farinae and crab increased. Patients with atopic dermatitis had the highest overall sensitization rates.</p><p><strong>Conclusion: </strong>Allergen sensitization patterns in Suzhou varied by age, sex, year, and disease type. Understanding these patterns can help improve the management of allergic skin diseases in this region.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes after Slow Low-Dose Oral Immunotherapy for Cow's Milk.","authors":"Yoshito Matsuo, Shiro Sugiura, Seiya Masukane, Fumi Tanaka, Atsushi Makino, Katsumasa Kitamura, Teruaki Matsui, Yoshihiro Takasato, Komei Ito","doi":"10.1159/000542796","DOIUrl":"10.1159/000542796","url":null,"abstract":"<p><strong>Introduction: </strong>We previously reported the result of slow low-dose oral immunotherapy (SLOIT), which is a 1-year severity-stratified low-dose OIT for severe cow's milk (CM) allergy (CMA) (threshold dose ≤287 mg of cumulative CM protein at the entry oral food challenge [OFC]). After completing the SLOIT protocol (exit OFC to cumulative 287 mg of CM protein), the participants were instructed to gradually increase the amount of CM, roughly doubling the increasing pace, if they could consume it symptom free for 2-3 months (SLOIT plus). This study evaluated the long-term outcomes of SLOIT and identified the factors associated with these outcomes.</p><p><strong>Methods: </strong>The subjects were 23 children who completed the SLOIT protocol and proceeded with the SLOIT-plus instructions. The proportion of subjects who were desensitized to the full dose (FD; 200 mL of CM) was evaluated. Additionally, factors associated with FD 3 years after SLOIT (FD group) were analyzed. The allergic symptoms provoked in the OFC were quantified using the total score (TS) of the Anaphylaxis Scoring Aichi (ASCA), and the overall severity was expressed as TS/Pro (TS/cumulative protein dosage).</p><p><strong>Results: </strong>The number of subjects who were desensitized to FD within 12, 24, and 36 months was 0 (0%), 3 (13%), and 8 (35%), respectively. The FD group exhibited a larger decrease in TS/Pro, IgE specific to CM, and casein after the SLOIT protocol.</p><p><strong>Conclusion: </strong>A third of the children with severe CMA were desensitized to FD within 36 months after SLOIT. A better response to the 1-year SLOIT protocol was associated with better long-term outcomes.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-8"},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}