International Archives of Allergy and Immunology最新文献

{"title":"Pollen food allergy syndrome in China：current knowledge and future research needs.","authors":"Nannan Jiang, Shan Deng, Kai Guan, Li Xiang","doi":"10.1159/000547646","DOIUrl":"https://doi.org/10.1159/000547646","url":null,"abstract":"<p><strong>Background: </strong>Pollen-food allergy syndrome (PFAS) is a distinct form of IgE mediated food allergy that occurs in individuals sensitized to pollen. The characteristics of PFAS vary across regions and exhibit significant heterogeneity due to differing pollen sensitization profiles.</p><p><strong>Summary: </strong>Research on PFAS in China has primarily focused on Northern regions, where weed and tree pollen allergy, particularly to Artemisia, are prevalent. PFAS is more commonly observed in China among patients allergic to Artemisia pollen, nsLTPs (e.g., Art v 3) derived from Artemisia pollen is regarded as a biomarker for severe food-pollen allergies in China. Other cross-reactive components, including PR-10, profilins, and recently identified GRP, also contribute to PFAS. Diagnosis mainly relies on clinical history, supported by specific IgE, skin prick testing and component resolved diagnostics (CRD), while management includes dietary modifications, allergen avoidance, and epinephrine for anaphylaxis. Although allergen immunotherapy (AIT) and biologics have been explored, their efficacy remains limited, highlighting unmet needs for further research. Critical knowledge gaps persist in understanding PFAS epidemiology, risk factors, and regional variations in China. Future priorities include large-scale epidemiological studies, validation of diagnostic tools, and the development of tailored management guidelines for China's diverse population.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-19"},"PeriodicalIF":1.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Triad of Pathogenesis in Allergic Bronchopulmonary Aspergillosis: Interactions Among Aspergillus fumigatus, Epithelium, and Immunity.","authors":"Yu Wang, Ling Zhang, Yuqing Sun, Yulin Zhang","doi":"10.1159/000547550","DOIUrl":"https://doi.org/10.1159/000547550","url":null,"abstract":"<p><strong>Background: </strong>Aspergillus fumigatus is a common airborne fungal pathogen responsible for a range of pulmonary diseases, particularly in individuals with pre-existing respiratory conditions. Among these, allergic bronchopulmonary aspergillosis (ABPA) represents the most severe allergic manifestation. It arises from persistent airway colonization by A. fumigatus and repeated immune activation, often leading to uncontrolled respiratory symptoms and progressive lung damage. Despite its clinical relevance, the pathogenesis of ABPA remains poorly understood.</p><p><strong>Summary: </strong>This review examines the pathogenesis of ABPA, focusing on three major aspects: host genetic susceptibility, persistent airway colonization by A. fumigatus, and an exaggerated type 2 immune response. We discuss how genetic variants affecting immune signaling and epithelial barrier function contribute to fungal persistence, how fungal components disrupt host defenses, and how chronic exposure promotes a Th2-skewed immune profile. These interactions between the fungus, airway epithelium, and immune cells drive chronic inflammation, airway remodeling, and irreversible structural damage.</p><p><strong>Key messages: </strong>ABPA arises from a complex interplay among genetic susceptibility, persistent colonization by A. fumigatus, and immune dysregulation. The sustained presence of the fungus is central to both the initiation and progression of disease, while an exaggerated Th2 immune response drives chronic inflammation and airway damage. A deeper understanding of these pathogenic mechanisms is essential to guide the development of more accurate diagnostic tools, effective therapies, and preventive strategies.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-22"},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Component-Resolved Diagnostics for House Dust Mite Allergy: Enhancing Diagnostic Precision and Guiding Subcutaneous Immunotherapy in Children.","authors":"Yifan Li, Changshan Liu, Xueyan Wang, Chunquan Cai","doi":"10.1159/000547445","DOIUrl":"https://doi.org/10.1159/000547445","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate sIgE and sIgG4 profiles against house dust mite (HDM) components to distinguish HDM-induced allergic rhinitis (AR) from asymptomatic sensitization, and to evaluate the longitudinal changes following allergen immunotherapy (AIT) in symptomatic patients, exploring their potential as biomarkers for selecting candidates for subcutaneous immunotherapy (SCIT).</p><p><strong>Methods: </strong>A total of 72 HDM-sensitized participants were included: 46 symptomatic AR patients (with/without allergic asthma) and 26 asymptomatic individuals. Eight healthy children served as the controls. In the symptomatic group, 32 patients received SCIT. Blood samples were analyzed for sIgE and sIgG4 levels to HDM components and the basophil activation test (BAT) was performed at baseline and after 18 months of SCIT. Clinical assessments were performed using the children's Asthma Control Test (C-ACT) and visual analog scale (VAS).</p><p><strong>Results: </strong>sIgE levels to Der p 1, Der p 2, Der f 1 and Der f 2 were significantly elevated in symptomatic patients. Higher sensitization to Der p 2 and Der f 2 was observed in patients with AR and allergic asthma. SCIT significantly reduced sIgE and increased sIgG4 levels for specific components, particularly Der p 1, Der p 2, Der f 1, Der f 2, and Der p 23. BAT results support these findings. No significant changes were observed in the non-SCIT group.</p><p><strong>Conclusion: </strong>Component-resolved diagnostics (CRD) and BAT are valuable tools for distinguishing between asymptomatic and symptomatic HDM-sensitized individuals. The longitudinal monitoring of sIgE, sIgG4, and BAT levels may enhance SCIT outcomes and guide treatment decisions.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-26"},"PeriodicalIF":1.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic relevance of MDK and TIMP1 with immune infiltration in lung adenocarcinoma.","authors":"Qinghua Zhu, Qingqing Huang, Xiaohua He, Miaomiao Jiang, Junkai Fu, Chenyuan Ding","doi":"10.1159/000547102","DOIUrl":"https://doi.org/10.1159/000547102","url":null,"abstract":"<p><strong>Background: </strong>LUAD is a common and fatal form of lung cancer, with varying expressions of MDK and TIMP1 across different cancers. However, their specific roles in LUAD progression and tumor immunity remain unclear.</p><p><strong>Methods: </strong>We analyzed RNA-seq data from TCGA using the ggpubr R package to compare MDK and TIMP1 expression in normal versus LUAD tissues. This was validated through qRT-PCR and western blot. LUAD patients were categorized into high and low expression groups for MDK and TIMP1, and their impacts on overall survival (OS), disease-free interval (DFI), progression-free interval (PFI), and disease-specific survival (DSS) were assessed using Kaplan-Meier curves and ROC curves. KEGG and GO enrichment analyses were performed for 50 genes similar to MDK and TIMP1, and a gene-gene interaction network was created with GeneMANIA, examining DEGs across both expression groups. We also evaluated the mutational landscape and immune cell infiltration correlations. Finally, the relationship between MDK, TIMP1 and immune cells was explored by immunohistochemical (IHC) experiments.</p><p><strong>Results: </strong>MDK and TIMP1 were significantly overexpressed in LUAD. Patients with low MDK and TIMP1 expressions had better OS, DFI, DSS, and PFI. The AUC values for MDK and TIMP1 were 0.943 and 0.875, respectively, with TIMP1 identified as a risk factor for OS. Genes similar to MDK were enriched in the Proteasome pathway, while those akin to TIMP1 were linked to endopeptidase activity. No survival impact was noted from mutations in these genes. Higher expression of MDK and TIMP1 correlated with reduced tumor purity and altered immune scores, suggesting increased immune dysfunction in the high TIMP1 group. IHC results showed that when MDK and TIMP1 expression levels were higher, B cell and TREG cell infiltration was stronger, but macrophage infiltration was weaker.</p><p><strong>Conclusion: </strong>MDK and TIMP1 significantly influence the prognosis and progression of LUAD and immune cell infiltration, highlighting their potential as targets for immunotherapy.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-28"},"PeriodicalIF":1.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between allergic rhinitis and oral disease: a meta-analysis.","authors":"Xuelian Yi, Zili Wen, Wei Deng, Danyan Mao, Qingsong Huang","doi":"10.1159/000547503","DOIUrl":"https://doi.org/10.1159/000547503","url":null,"abstract":"<p><strong>Introduction: </strong>The bidirectional relationship between allergic rhinitis (AR) and oral disease remains controversial. Therefore, this study aimed to amalgamate the current body of scientific literature to summarize and elucidate the association between AR and oral disease.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science identified observational studies exploring AR and oral diseases. The study results, complete with their respective 95% confidence intervals (CIs), were aggregated by employing a random-effects model for data synthesis. Supplementary subgroup and sensitivity analyses were conducted to evaluate the stability and reliability of the study outcomes.</p><p><strong>Results: </strong>Nine studies were included. When examining oral health status as the exposure, the pooled results showed no significant associated with the odds of AR (OR=1.01, 95%CI:0.84-1.22, p=0.884; I²=95%). Similarly, when evaluating AR as the exposure, no overall association was observed between AR and the odds of oral diseases (OR=0.97, 95%CI:0.76-1.23, p=0.798; I²=100%). However, in subgroup analyses limited to cross-sectional studies examining the association between AR and oral diseases, a reduced odds was observed (OR=0.77, 95%CI:0.67-0.89, p<0.001; I²=0%), suggesting a possible inverse correlation in these specific study designs.</p><p><strong>Conclusion: </strong>This meta-analysis found no significant overall association between oral health and allergic rhinitis in either direction of exposure. Considerable heterogeneity was present among studies, particularly in analyses of AR as an exposure. Subgroup findings from cross-sectional studies suggest a potential inverse relationship between allergic rhinitis and oral diseases; however, these results should be interpreted cautiously due to study design limitations and require validation in future prospective studies.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of natural composed and size excluded Hymenoptera venom preparations on the safety and efficacy of venom immunotherapy: A monocentric experience.","authors":"Jörg Fischer, Lena Löffelad, Paula Kranert, Manfred Kneilling, Sebastian Volc","doi":"10.1159/000547194","DOIUrl":"https://doi.org/10.1159/000547194","url":null,"abstract":"<p><strong>Background: </strong>The first-line treatment for patients with Hymenoptera venom allergy, a potentially life-threatening condition, is venom immunotherapy (VIT). However, for reasons still unclear, honeybee VIT (HBV-IT) is less effective than yellow jacket VIT (YJV-IT).</p><p><strong>Objective: </strong>To investigate the safety and efficacy of natural composed Hymenoptera venom (NC-HV) in a rush protocol with a high total venom dose and compare them with previously acquired data on size excluded Hymenoptera venom (SE-HV).</p><p><strong>Methods: </strong>In this retrospective monocentric study, data regarding the number of build-up cycles and maintenance of VIT with NC-HV were retrieved from institutional records. The VIT protection rate was determined by the results of the sting challenge test (SCT).</p><p><strong>Results: </strong>We evaluated 648 individuals treated with NC-HV and compared their results with data from 1,258 individuals treated with SE-HV. The frequency of systemic reactions (SRs) with NC-HV in HBV-IT was 25.6% and YJV-IT 10.1%, respectively. The use of NC-HV was associated with an elevated frequency of SR when compared to previous experience with SE-HV (SR rate HBV-IT 10.4 and YJV-IT 6.3%). The protection rate in HBV-IT, as determined by SCT, was found to be 100% with NC-HV, which is notably higher than the 95.4% previous observed with SE-HV. The efficacy of YJV-IT was equivalent to 99.0% for NC-HV and 99.6% for SE-HV.</p><p><strong>Conclusions: </strong>Nearly complete protection was achieved with the NC-HV. The efficacy gap between HBV-IT and YJV-IT, which has limited VIT for decades, can be overcome with NC-HV in combination with a high total venom dose rush protocol.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-18"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Chronic Spontaneous Urticaria Clinical Characteristics and Management between Canadian and Israeli Adults.","authors":"Katya Peri, Roy Khalaf, Alona Baum, Aviv Barzilai, Elena Netchiporouk, Michael Nathan Fein, Moshe Ben-Shoshan","doi":"10.1159/000547551","DOIUrl":"https://doi.org/10.1159/000547551","url":null,"abstract":"<p><strong>Background: </strong>Chronic spontaneous urticaria (CSU), is increasingly recognized as a significant health issue with significant impacts on quality of life in adult populations. Data are sparse regarding differences in clinical characteristics and management of CU in different countries.</p><p><strong>Objective: </strong>We aimed to compare adult CU populations in Canada and Israel to identify demographic, clinical, and management differences.</p><p><strong>Results: </strong>From 2013 to 2024, 71 adults at the Montreal General Hospital (MGH) and adjutant clinic were diagnosed with spontaneous urticaria, with a median age of 45.8 years (35.2-59.3) and 22.5% male. Between 2009 and 2022, 151 adults at Sheba Hospital were diagnosed with CSU, with a median age of 48.5 years (32.3-60.0) and 32% male. The male prevalence was significantly higher in Israeli CU patients (P<0.01). Israeli adults had lower reports of comorbidities, including atopic dermatitis (5.3% vs. 19.7%, P<0.01) and asthma (7.9% vs. 25.4%, P=0.04). Antihistamine use was higher in Israel (99.3% vs. 85.9%, P<0.01), along with steroids (72.8% vs. 14.1%, P<0.01).</p><p><strong>Conclusion: </strong>Differences in the demographics, comorbidities, and treatment of chronic spontaneous urticaria may be related to differences between populations and management practices in different countries.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Ferroptosis in chronic inflammatory diseases of the upper and lower airways.","authors":"Jiaying Li, Jingyun Li, Yunbo Gao, Luo Zhang, Yuan Zhang","doi":"10.1159/000547363","DOIUrl":"https://doi.org/10.1159/000547363","url":null,"abstract":"<p><p>Background：The pathogenesis of chronic inflammatory diseases in the upper and lower airways is common and mutually influential, and should be managed systematically. Disorders of iron metabolism and redox homeostasis imbalance, which lead to the accumulation of reactive oxygen species (ROS) and lipid peroxidation, are considered key common characteristics linking ferroptosis to chronic inflammatory diseases of the upper and lower airways. Recognizing the mechanism of ferroptosis and how it contributes to chronic inflammatory diseases of the upper and lower airways enables a more comprehensive understanding of the pathogenesis of these conditions and offers novel avenues for therapeutic intervention. Summary：Ferroptosis is a novel form of iron-dependent, regulated cell death that is regulated by integrated oxidative and antioxidant systems and is typified by the accumulation of ROS. The Excessive iron can induce the Fenton reaction, leading to the generation of large amounts of ROS. Under the catalytic action of iron-containing enzymes, ROS promote the formation of lipid hydroperoxides, which is a key mechanism underlying ferroptosis. In contrast, the antioxidant system centered on glutathione peroxidase 4 (GPX4) serves as the primary regulatory pathway for inhibiting ferroptosis. Inflammation promotes the excessive production of ROS and Fe2+ within cells, thereby inducing ferroptosis in airway epithelial cells and inflammatory cells. This, in turn, triggers the release of damage-associated molecular patterns (DAMPs), further amplifying the inflammatory response. Key Messages：In this review, we explore the bidirectional interactions between ferroptosis and chronic inflammatory diseases of the upper and lower airways, as well as the potential role and complex effects of ferroptosis in the pathological processes of these diseases.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-17"},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking Beta-Lactam Allergies in Children: A Closer Look at Diagnosis and Risk Factors.","authors":"Zeynep Meric, Betul Gemici Karaaslan, Sezin Aydemir, Muhammed Aydin, Dilan Demir Gumus, Sevval Ozyildirim Demirel, Lida Bulbul, Ulviye Mustu, Haluk Cokugras, Mehmet Halil Celiksoy, Esra Yucel, Ayca Kiykim","doi":"10.1159/000547369","DOIUrl":"https://doi.org/10.1159/000547369","url":null,"abstract":"<p><strong>Background: </strong>Beta-lactam (BL) antibiotics are the most commonly implicated drugs in pediatric drug hypersensitivity reactions. However, most children with suspected BL allergy can safely tolerate these antibiotics after careful evaluation.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the clinical characteristics, diagnostic work-up results, and risk factors associated with confirmed BL allergy in children referred with suspected BL hypersensitivity.</p><p><strong>Methods: </strong>We retrospectively analyzed 158 children referred for suspected BL allergy between 2019 and 2025. Clinical and demographic data were collected from medical records. Diagnostic evaluation included skin testing and drug provocation testing. Patients were divided into two groups: those with confirmed BL allergy and those whose allergy label had been removed. Risk factors for BL allergy were compared between groups.</p><p><strong>Results: </strong>The cohort included 158 children (58% male; median age: 100.5 months [IQR: 75-150.75]). The median time from reaction to clinical evaluation was 7 months (IQR: 3-25). The most commonly implicated drug was amoxicillin/clavulanate (81.5%). Immediate reactions (IR) occurred in 47.8% of cases. BL allergy was confirmed in 36.7% of the cases. In the final logistic regression model, the type of hypersensitivity reaction (p=0.001), severity of reaction (p=0.001), and the presence of comorbidities (p=0.008) remained significant predictors of confirmed drug allergy.</p><p><strong>Conclusion: </strong>Given the low true allergy rate, accurate diagnosis and delabeling of suspected BL allergy in children is essential to avoid unnecessary antibiotic restriction.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Real-world Outcomes in Patients with Hereditary Angioedema Receiving Lanadelumab for 3 or More Years.","authors":"William R Lumry, Mark Davis-Lorton, Daniel Soteres, Lucy Earl, Kieran Wynne-Cattanach, Daniel Fox, Krystal Sing, Salomé Juethner, Bob G Schultz","doi":"10.1159/000546987","DOIUrl":"https://doi.org/10.1159/000546987","url":null,"abstract":"<p><strong>Introduction: </strong>Hereditary angioedema (HAE) is a rare genetic disorder characterized by unpredictable, painful swelling attacks that significantly impair patients' quality of life (QoL). Clinical trials of lanadelumab led to its approval for long-term prophylaxis in patients with HAE; however, real-world data on long-term lanadelumab use in patients with HAE are limited. This analysis describes real-world outcomes of patients with HAE who have received lanadelumab as long-term prophylaxis for ≥3 years.</p><p><strong>Methods: </strong>From January 2023 to January 2024, investigators collected data from the Adelphi Wave II Disease Specific Programme,™ a real-world, cross-sectional survey of physicians and their patients with HAE in the United States. Physicians retrospectively reported attack frequency, attack severity,, and QoL before lanadelumab initiation, at 12, 24, and 36 months post initiation, and at the time of the survey.</p><p><strong>Results: </strong>Physicians reported data on 51 patients who had received lanadelumab for ≥3 years. Before lanadelumab initiation, physicians reported attack severity as mild in 49.0% of patients and very severe in 8.2%; at 36 months post lanadelumab initiation, 62.5% of patients experienced mild attacks and none experienced very severe attacks in the preceding year. The proportion of patients experiencing ≥1 attack per month on average decreased from 54.0% before lanadelumab initiation to 9.8% at the time of the survey. The proportion of patients with good or excellent QoL increased from 68.6% before lanadelumab initiation to 88.2% at the time of the survey.</p><p><strong>Conclusion: </strong>In this real-world HAE study, patients treated with lanadelumab for ≥3 years experienced improvements in attack frequency, disease severity, and QoL.</p>","PeriodicalId":13652,"journal":{"name":"International Archives of Allergy and Immunology","volume":" ","pages":"1-18"},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}