Integrative Food, Nutrition and Metabolism最新文献

{"title":"Zinc may have a potential role in taste malfunctions treatment for COVID-19 patients. Journal Review article","authors":"Jumanah S. Al-Awfi","doi":"10.15761/IFNM.1000296","DOIUrl":"https://doi.org/10.15761/IFNM.1000296","url":null,"abstract":"The novel COVID-19 virus has ongoing signs and symptoms, one of the signs and symptoms that is discovered recently is loss of taste, some pieces of research suggested that COVID-19 patients may have zinc deficiency however the main undiscovered concern is whether the virus is a causative or those patients had deficiency pre COVID-19, approximately they found 57.4% COVID-19 patients have low zinc serum levels which may indicate an advantage to administer a therapeutic approach for zinc deficiency for those patients. Pervious research experienced with common cold symptoms and zinc administration and resulted in conflicting data. More recently, Cochran review indicates zinc may be useful for common cold patients only if administered within 24 hours onset of symptoms. It was known previously for upper respiratory tract infections to cause loss of taste; this concern might be","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89322426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted nutrigenomics as a means of breast cancer management: from DNA methylation to microRNAs","authors":"R. Hashemi, S. Arefhosseini, G. Folkerts, S. Varasteh, M. Morshedi","doi":"10.15761/IFNM.1000288","DOIUrl":"https://doi.org/10.15761/IFNM.1000288","url":null,"abstract":"Breast Cancer (BC) is the most prevalent cancer affecting females and the leading cause of death around the world. The World Health Organization (WHO) has announced that the incidence of BC increases approximately 1.8-2 % annually. Hence, it is important that new prevention and treatment strategies involving epigenetics and nutrigenomics are explored. Epigenetics refers to potential changes in gene expression and chromatin structure without alteration of DNA sequence, but still modulates the expression of a particular phenotype. Nutrigenomics determines the effect of dietary habits on cancer risk and tumor behavior, both in progression and inhibition of cancer. The modulation of chromatin structure is an essential component in the regulation of transcriptional activation and repression. Therefore, identifying the regulators of gene expression changes during cancer progression is essential for early diagnosis and inhibition of this malignancy. The methylation of promoter genes, as well as the interplay between microRNAs (miRNAs) and messenger RNAs (mRNAs) of target genes, is the primary component of epigenetics. Any defect in these processes is considered a crucial mechanism for gene and pathway dysregulation in all human cancers, including BC. Nutritional genomic and epigenetic mechanisms may play a pivotal role in prevention as well as early diagnosis of BC, especially for closely related female family members of BC patients. It seems cytosine methylation in Cytosine-phosphate-Guanine dinucleotide (CpG) Islands reflects changes in balance tissues rigidity. Hypo- and hypermethylation of CpG Islands (CGIs) play a crucial role in development of BC via up-regulation of oncogenes and down-regulation of tumor suppressor genes (TSGs). These could be the most effective mechanisms to distinguish BC from other types of cancer. beneficial effects of some nutritional components on the function and structure of non-coding RNA and DNA methylation. We also discuss the role of nutrigenomics as a non-invasive method to explore the epigenetic mechanisms involved in BC and also in the prevention, treatment, early diagnosis, and distinguishing a variety of cancers from each other. In addition, the importance of non-coding RNAs, including miRNAs in body fluids, also need to be further clarified.","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"-1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91101598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dietary phytoestrogens on the developmental reprogramming of steroid-hormone influenced traits: Medicinal and evolutionary aspects","authors":"G. Csaba","doi":"10.15761/IFNM.1000275","DOIUrl":"https://doi.org/10.15761/IFNM.1000275","url":null,"abstract":"Nutritional phytoestrogens are weak estrogens, which entering into the human organism are able to reprogram the developmental program in sensitive periods of life (perinatally, at weaning, at puberty and in certain systems (e.g. immune system) during the whole life. Consequently they could cause (by faulty hormonal imprinting) lifelong alterations in the binding capacity of hormone receptors, inclination to diseases, manifestation of diseases etc. At the same time by adult age employment they can help healing of certain diseases. In some human cultures the consumption of phytoestrogens (isoflavones, as soy genistein or daidzein) is regular (in Asian countries) for thousand years, and this could contribute to the differences between the physiology of races. At present the consumption of soy (and isoflavones=phytoestrogens in them) is exponentially growing in European and American countries, what could influence the future (evolutionary) development (and uniformization) of endocrine (and endocrine-directed) systems of man. Some transformations of life-periods are observed (e.g. early menarche) and more are expected, however without serious attention. Considering this, phytoestrogens are the Troian horse of endocrine disruptors. Studying from medicinal aspect, the irregular (undosed) eating of phytoestrogens especially which does not attend the sensitive life-periods, can influence the endocrine system as well, as the strongly endocrine-regulated systems, which can be manifested in lower risk of later manifested diseases, as tumors or geriatric alterations however, it can cause reproductive and immune-deficiencies. The positive and mainly negative character of phytoestrogens have to be propagated for doctors and laymen alike. As phytoestrogens could cause different durable pathological alterations, the label on their presence (and effects?) in commercial foods, would be advisable.","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76216072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nutrition behaviour change intervention on improving micronutrients concentration and linear growth of children age 6 to 59 months in central highland of Ethiopia: Cluster randomized control trial","authors":"Abebe Ferede, T. Belachew, M. Abera","doi":"10.15761/IFNM.1000287","DOIUrl":"https://doi.org/10.15761/IFNM.1000287","url":null,"abstract":"","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87653925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological and histopathological characteristics of heat and biochemical processed Kariya (Hildegardia bateri) seedsBiological and histopathological characteristics of heat and biochemical processed Kariya (Hildegardia bateri) seeds","authors":"A. V. Ikujenlola, Olamide Esther Aluko, S. Gbadamosi, D. Adeyemi","doi":"10.15761/IFNM.1000290","DOIUrl":"https://doi.org/10.15761/IFNM.1000290","url":null,"abstract":"","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88226569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of plasma and urine metabolome in colorectal cancer survivors consuming rice bran.","authors":"Iman Zarei, Renee C Oppel, Erica C Borresen, Regina J. Brown, E. Ryan","doi":"10.15761/IFNM.1000252","DOIUrl":"https://doi.org/10.15761/IFNM.1000252","url":null,"abstract":"Rice bran has bioactive phytochemicals with cancer protective actions that involve metabolism by the host and the gut microbiome. Globally, colorectal cancer (CRC) is the third leading cause of cancer-related death and the increased incidence is largely attributed to poor dietary patterns, including low daily fiber intake. A dietary intervention trial was performed to investigate the impact of rice bran consumption on the plasma and urine metabolome of CRC survivors. Nineteen CRC survivors participated in a randomized-controlled trial that included consumption of heat-stabilized rice bran (30 g/day) or a control diet without rice bran for 4 weeks. A fasting plasma and first void of the morning urine sample were analyzed by non-targeted metabolomics using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). After 4 weeks of either rice bran or control diets, 12 plasma and 16 urine metabolites were significantly different between the groups (p≤0.05). Rice bran intake increased relative abundance of plasma mannose (1.373-fold) and beta-citrylglutamate (BCG) (1.593-fold), as well as increased urine N-formylphenylalanine (2.191-fold) and dehydroisoandrosterone sulfate (DHEA-S) (4.488-fold). Diet affected metabolites, such as benzoate, mannose, eicosapentaenoate (20:5n3) (EPA), and N-formylphenylalanine have been previously reported for cancer protection and were identified from the rice bran food metabolome. Nutritional metabolome changes following increased consumption of whole grains such as rice bran warrants continued investigation for colon cancer control and prevention attributes as dietary biomarkers for positive effects are needed to reduce high risk for colorectal cancer recurrence.","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84299122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of bergamot (<i>Citrus bergamia</i>) for reducing high cholesterol and cardiovascular disease markers.","authors":"Mirielle C Nauman,&nbsp;Jeremy J Johnson","doi":"10.15761/IFNM.1000249","DOIUrl":"https://doi.org/10.15761/IFNM.1000249","url":null,"abstract":"<p><p>The bergamot is a citrus fruit native to southern Italy with traditional uses that include improving immune response and cardiovascular function. There are a variety of phytochemicals that have been found in the bergamot including brutieridin and melitidin as well as other flavonoids, flavones O-glucosides and C-glucosides. Multiple clinical trials have provided evidence that different forms of orally administered bergamot can reduce total cholesterol and low-density lipoprotein cholesterol. In vitro mechanistic studies have provided evidence that polyphenols from the bergamot can alter the function of AMPK and pancreatic cholesterol ester hydrolase (pCEH). The use of bergamot in multiple clinical trials has consistently shown that it is well tolerated in studies ranging from 30 days to 12 weeks. This mini-review reports on the clinical studies performed with different forms of bergamot along with their effectiveness in reducing total cholesterol and LDL cholesterol in patients with hypercholesterolemia.</p>","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15761/IFNM.1000249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37377119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrate supplementation in thoroughbred racehorses: Addition of beetroot juice to the equine diet and effects on the gut metabolome","authors":"R. Waring, J. Hunter, C. Turner, C. Batty, P. Ramzan","doi":"10.15761/IFNM.1000246","DOIUrl":"https://doi.org/10.15761/IFNM.1000246","url":null,"abstract":"Beetroot juice (BJ), a source of nitrate, was added to the diet of thoroughbred racehorses for a four-week period. Analysis of nitrate/nitrite in plasma showed no significant differences between control and dosed groups. SIFT/MS (selected ion-flow tube/mass spectrometry) was used to analyse the faecal metabolome. The levels and types of volatile organic compounds (VOCs) were compared using headspace sampling of faeces from control and beetroot-supplemented equines, However, there were no significant differences apart from raised levels of acetonitrile in samples from the animals dosed with BJ. The conclusion was that racehorses appear not to have nitrate transporters and that addition of BJ to equine diets would not improve performance","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86551735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes peer-education on food choices part I: Development of framework","authors":"Nwose Eu, Onokade M, A. O, Igumbor Eo","doi":"10.15761/IFNM.1000240","DOIUrl":"https://doi.org/10.15761/IFNM.1000240","url":null,"abstract":"Medical nutrition therapy (MNT) for diabetes has paved its way through many randomized trials, meta-analysis and observational studies [1]. There is now the established concept of nutrition counseling in MNT, which is focused on supporting clients to set priorities, establish goals, and create their individual food menu plans [2]. Indeed, it is also speculated that lifestyle including dietary habit vis-à-vis MNT interventions work better than metformin in reducing the incidence of type 2 diabetes [3]. It has been proposed that peer-support education is probably a better option than general public health lectures that is provided by the healthcare professional [4-6], especially for selfmanagement that considers cultural and geographical factors [7].","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72681856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting African indigenous vegetables and its medical nutrition properties: A mini-narrative review based on Ukwani communities of Delta State Nigeria","authors":"Ishiekwene Ic, D. Te, J. Odoko, Nwose Eu","doi":"10.15761/ifnm.1000256","DOIUrl":"https://doi.org/10.15761/ifnm.1000256","url":null,"abstract":"","PeriodicalId":13631,"journal":{"name":"Integrative Food, Nutrition and Metabolism","volume":"101 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76874982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}