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Pyogenic Vertebral Osteomyelitis. 化脓性椎体骨髓炎。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-04-08 DOI: 10.1016/j.idc.2025.02.011
Michael W Henry, James E Dowdell, Andy O Miller
{"title":"Pyogenic Vertebral Osteomyelitis.","authors":"Michael W Henry, James E Dowdell, Andy O Miller","doi":"10.1016/j.idc.2025.02.011","DOIUrl":"https://doi.org/10.1016/j.idc.2025.02.011","url":null,"abstract":"<p><p>Vertebral osteomyelitis is a general term for a heterogenous group of spine infections involving the vertebral bone, intervertebral discs, and facet joints. These infections can often spread contiguously to adjacent paraspinal structures, including paravertebral muscles and the epidural space and frequently presents with nonspecific and indolent symptoms, which can delay diagnosis. Treatment can be arduous, requiring prolonged courses of antibiotics often combined with surgical debridement. This review focuses primarily on pyogenic vertebral osteomyelitis in adults, reviewing the pathophysiology, epidemiology, microbiology, diagnosis, and treatment of this infection.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetic Foot Infections. 糖尿病足感染。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-04-08 DOI: 10.1016/j.idc.2025.02.014
Laila M Castellino, Peter A Crisologo, Avneesh Chhabra, Orhan K Öz
{"title":"Diabetic Foot Infections.","authors":"Laila M Castellino, Peter A Crisologo, Avneesh Chhabra, Orhan K Öz","doi":"10.1016/j.idc.2025.02.014","DOIUrl":"https://doi.org/10.1016/j.idc.2025.02.014","url":null,"abstract":"<p><p>Diabetes is a growing public health concern, with diabetic foot infections (DFI) being one of the leading causes of lower extremity limb amputation in the United States. Accurate diagnosis of DFI requires a combination of clinical, laboratory, and radiologic tests to determine the extent and depth of infection, including the presence of osteomyelitis. Treatment often includes a combination of antibiotics and surgical debridement. Addressing comorbidities such as peripheral vascular disease, glycemic control, and offloading pressure from ulcers and bony prominences is paramount to achieving a successful outcome, and patients should ideally be managed by dedicated interdisciplinary teams.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Manifestations and Outcomes of SARS-CoV-2 Infection in Children and Adolescents 儿童青少年SARS-CoV-2感染的临床表现及转归
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-04-04 DOI: 10.1016/j.idc.2025.02.018
Andrew T. Pavia MD
{"title":"Clinical Manifestations and Outcomes of SARS-CoV-2 Infection in Children and Adolescents","authors":"Andrew T. Pavia MD","doi":"10.1016/j.idc.2025.02.018","DOIUrl":"10.1016/j.idc.2025.02.018","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 2","pages":"Pages 293-308"},"PeriodicalIF":6.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preventing Orthopedic Infections. 预防骨科感染。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-04-04 DOI: 10.1016/j.idc.2025.02.016
Alaina S Ritter, Simon Mears
{"title":"Preventing Orthopedic Infections.","authors":"Alaina S Ritter, Simon Mears","doi":"10.1016/j.idc.2025.02.016","DOIUrl":"https://doi.org/10.1016/j.idc.2025.02.016","url":null,"abstract":"<p><p>The prevention of orthopedic infections is of critical importance to improve patient outcomes and reduce health care costs. Preventative strategies can be employed preoperatively, including mitigation of medical risk factors, methicillin-resistant Staphylococcus aureus decolonization, appropriate skin preparation, and optimizing perioperative antimicrobial prophylaxis; intraoperatively, including utilizing irrigation, topical antibiotics, infection control measures, and timely debridement/optimal surgical techniques; and postoperatively, including consideration of antibiotic duration after primary arthroplasty and reimplantation. This article provides an evidence-based discussion of these strategies while also highlighting areas where ongoing research may be beneficial.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19: How Far We’ve Come and Where We Need to Go Next COVID-19：我们已经走了多远，下一步需要走到哪里。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-04-03 DOI: 10.1016/j.idc.2025.03.001
Rajesh T. Gandhi MD, Michael R. Jordan MD, MPH
{"title":"COVID-19: How Far We’ve Come and Where We Need to Go Next","authors":"Rajesh T. Gandhi MD,&nbsp;Michael R. Jordan MD, MPH","doi":"10.1016/j.idc.2025.03.001","DOIUrl":"10.1016/j.idc.2025.03.001","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 2","pages":"Pages ix-xi"},"PeriodicalIF":6.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Models of Musculoskeletal Infection Care: The Importance of Multidisciplinary Collaboration. 肌肉骨骼感染护理模式：多学科合作的重要性。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-04-02 DOI: 10.1016/j.idc.2025.02.017
Alexander M Tatara, Antonia F Chen, F Joseph Simeone, Sandra B Nelson
{"title":"Models of Musculoskeletal Infection Care: The Importance of Multidisciplinary Collaboration.","authors":"Alexander M Tatara, Antonia F Chen, F Joseph Simeone, Sandra B Nelson","doi":"10.1016/j.idc.2025.02.017","DOIUrl":"https://doi.org/10.1016/j.idc.2025.02.017","url":null,"abstract":"<p><p>Musculoskeletal infections are increasing in incidence and complexity. There is mounting evidence that formal models of multidisciplinary care improve patient outcomes in severe infection. In this study, we review different published models of multidisciplinary care for patients with musculoskeletal infection. We then characterize the roles of different specialists and staff on multidisciplinary teams. Lastly, we discuss core themes in successful multidisciplinary care and the current gaps in the literature. This study also serves as a call to action for institutions to support the implementation and rigorous study of multidisciplinary care for patients with musculoskeletal infection.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pelvic Osteomyelitis. 盆腔骨髓炎。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-03-26 DOI: 10.1016/j.idc.2025.02.013
Jakrapun Pupaibool, Justin Haller
{"title":"Pelvic Osteomyelitis.","authors":"Jakrapun Pupaibool, Justin Haller","doi":"10.1016/j.idc.2025.02.013","DOIUrl":"https://doi.org/10.1016/j.idc.2025.02.013","url":null,"abstract":"<p><p>Pelvic osteomyelitis is a challenging infection often caused by contiguous spread, direct inoculation, or hematogenous dissemination, with key risk factors including trauma, surgery, radiation, and intra-abdominal or genitourinary infections. Diagnosis relies on bone biopsy with culture and histopathology, and MRI is the most sensitive imaging study. Treatment requires surgical debridement with extended antimicrobial therapy. Local antibiotic therapy can provide targeted antimicrobial treatment at the site of infection, enhancing the effectiveness of systemic antibiotics. Early recognition, thorough diagnostic workup, and individualized treatment strategies are crucial for improving outcomes in this complex condition.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fracture-Related Infections. Fracture-Related感染。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-03-25 DOI: 10.1016/j.idc.2025.02.012
Jessica Seidelman, Malcolm DeBaun
{"title":"Fracture-Related Infections.","authors":"Jessica Seidelman, Malcolm DeBaun","doi":"10.1016/j.idc.2025.02.012","DOIUrl":"https://doi.org/10.1016/j.idc.2025.02.012","url":null,"abstract":"<p><p>Fracture-related infections are challenging complications in orthopedic care, marked by infection at fracture or surgical sites, often involving biofilm-associated pathogens. They result in significant morbidity, prolonged hospitalizations, and high health care costs. Diagnosis integrates clinical, laboratory, and imaging findings, while treatment combines surgical debridement, implant management, and targeted antimicrobial therapy. Common pathogens include Staphylococcus aureus and Staphylococcus epidermidis, with culture-negative cases requiring advanced diagnostics. A multidisciplinary approach is critical to optimizing outcomes, addressing complications, and reducing the socioeconomic impact of these infections. Advances in treatment strategies continue to improve survival and quality of life for affected patients.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-Generation Coronavirus Disease 2019 Vaccines 新一代冠状病毒病2019疫苗：临床数据和未来方向。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-03-15 DOI: 10.1016/j.idc.2025.02.003
Kathryn E. Stephenson MD, MPH
{"title":"Next-Generation Coronavirus Disease 2019 Vaccines","authors":"Kathryn E. Stephenson MD, MPH","doi":"10.1016/j.idc.2025.02.003","DOIUrl":"10.1016/j.idc.2025.02.003","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 2","pages":"Pages 253-274"},"PeriodicalIF":6.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Acute Respiratory Syndrome Coronavirus 2 Immunology and Coronavirus Disease 2019 Clinical Outcomes 2019年严重急性呼吸综合征冠状病毒免疫学与冠状病毒病临床结果
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-03-14 DOI: 10.1016/j.idc.2025.02.001
Aljawharah Alrubayyi DPhil , Hsinyen Huang BS , Gaurav D. Gaiha MD, DPhil
{"title":"Severe Acute Respiratory Syndrome Coronavirus 2 Immunology and Coronavirus Disease 2019 Clinical Outcomes","authors":"Aljawharah Alrubayyi DPhil ,&nbsp;Hsinyen Huang BS ,&nbsp;Gaurav D. Gaiha MD, DPhil","doi":"10.1016/j.idc.2025.02.001","DOIUrl":"10.1016/j.idc.2025.02.001","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 2","pages":"Pages 221-232"},"PeriodicalIF":6.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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