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Microbiome Therapeutics for Clostridioides difficile Infection. 艰难梭菌感染的微生物组治疗。
IF 4.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-08-11 DOI: 10.1016/j.idc.2025.07.007
Christine W Lucky, Brendan J Kelly, Jennie H Kwon, Michael H Woodworth, Rachel L Medernach
{"title":"Microbiome Therapeutics for Clostridioides difficile Infection.","authors":"Christine W Lucky, Brendan J Kelly, Jennie H Kwon, Michael H Woodworth, Rachel L Medernach","doi":"10.1016/j.idc.2025.07.007","DOIUrl":"10.1016/j.idc.2025.07.007","url":null,"abstract":"<p><p>Microbiota-based therapies are used increasingly for the treatment and prevention of Clostridioides difficile infection (CDI), particularly in cases of recurrent CDI (rCDI). This review discusses the different types of microbiota-based therapies, including fecal microbiota transplant, fecal microbiota products, and live biotherapeutic products. The authors present efficacy data regarding clinical use in rCDI and highlight the unique aspects of each product.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Making Sense of Differing Guidelines for Clostridioides difficile Infection. 难辨梭状芽胞杆菌感染不同指南的意义。
IF 4.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-08-11 DOI: 10.1016/j.idc.2025.07.010
Kanika Sehgal, Paul Feuerstadt, Mark H Wilcox
{"title":"Making Sense of Differing Guidelines for Clostridioides difficile Infection.","authors":"Kanika Sehgal, Paul Feuerstadt, Mark H Wilcox","doi":"10.1016/j.idc.2025.07.010","DOIUrl":"https://doi.org/10.1016/j.idc.2025.07.010","url":null,"abstract":"<p><p>The Clostridioides difficile infection (CDI) epidemic has been impacting the world for years. Understanding accurate diagnostics is imperative to allow the appropriate patients to be treated and improve outcomes. This article leverages multiple global societal guidelines to focus on the evolving diagnostic tests available summarizing best diagnostic practices including 2-step diagnostic testing. Therapeutically, guideline recommendations more recently have favored fidaxomicin and incorporated immune-based therapies and microbial restoration therapies. As treatment options and guideline recommendations change, it is imperative to understand why these recommendations have evolved and understand current best diagnostic and therapeutic practices in managing CDI.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infection Prevention Approaches for Clostridioides difficile. 艰难梭菌感染预防方法。
IF 4.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-08-08 DOI: 10.1016/j.idc.2025.07.004
Jesse Vance, Nicholas A Turner
{"title":"Infection Prevention Approaches for Clostridioides difficile.","authors":"Jesse Vance, Nicholas A Turner","doi":"10.1016/j.idc.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.idc.2025.07.004","url":null,"abstract":"<p><p>Clostridioides difficile prevention is challenging as spores are highly resilient and transmission sources diverse. Hand hygiene, contact precautions, and environmental decontamination are fundamental infection prevention strategies. Antimicrobial stewardship is highly effective at reducing C difficile risk at both the individual and institutional level. Supplemental control measures such as no-touch disinfection technologies and screening/isolation of carriers are generally reserved for situations in which fundamental control measures prove insufficient. Reducing host vulnerability through immunization, prophylactic antibiotics directed against C difficile, or products that protect/augment the microbiome may offer promise in the future.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clostridioides difficile in Children. 儿童难辨梭状芽孢杆菌。
IF 4.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-08-07 DOI: 10.1016/j.idc.2025.07.011
Larry K Kociolek, Thomas J Sandora, Preeti Mehrotra
{"title":"Clostridioides difficile in Children.","authors":"Larry K Kociolek, Thomas J Sandora, Preeti Mehrotra","doi":"10.1016/j.idc.2025.07.011","DOIUrl":"https://doi.org/10.1016/j.idc.2025.07.011","url":null,"abstract":"<p><p>After a significant increase in pediatric Clostridioides difficile infection (CDI) in the United States over the past 2 decades, incidence has declined over the past 5 y. Community-associated CDI incidence is 3 times higher than healthcare facility-associated CDI in children, but sources of community acquisition are poorly defined. Diagnosis of CDI is challenging because of high frequency of colonization in infants and some groups of older children. Recent data suggest that vancomycin should be considered a first-line treatment for CDI in children and that fidaxomicin and fecal microbiota transplantation are safe and effective therapies for recurrent CDI.</p>","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clostridioides difficile Infection: Advances and New Challenges. 艰难梭菌感染：进展与新挑战。
IF 4.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-08-02 DOI: 10.1016/j.idc.2025.07.012
Vincent B Young
{"title":"Clostridioides difficile Infection: Advances and New Challenges.","authors":"Vincent B Young","doi":"10.1016/j.idc.2025.07.012","DOIUrl":"https://doi.org/10.1016/j.idc.2025.07.012","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Musculoskeletal Infections 肌肉骨骼感染
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-07-25 DOI: 10.1016/S0891-5520(25)00056-X
Laura K. Certain (Editor)
{"title":"Musculoskeletal Infections","authors":"Laura K. Certain (Editor)","doi":"10.1016/S0891-5520(25)00056-X","DOIUrl":"10.1016/S0891-5520(25)00056-X","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 3","pages":"Page i"},"PeriodicalIF":6.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copyright 版权
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-07-25 DOI: 10.1016/S0891-5520(25)00057-1
{"title":"Copyright","authors":"","doi":"10.1016/S0891-5520(25)00057-1","DOIUrl":"10.1016/S0891-5520(25)00057-1","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 3","pages":"Page ii"},"PeriodicalIF":6.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forthcoming Issues 即将到来的问题
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-07-25 DOI: 10.1016/S0891-5520(25)00060-1
{"title":"Forthcoming Issues","authors":"","doi":"10.1016/S0891-5520(25)00060-1","DOIUrl":"10.1016/S0891-5520(25)00060-1","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 3","pages":"Page xi"},"PeriodicalIF":6.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors 贡献者
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-07-25 DOI: 10.1016/S0891-5520(25)00058-3
{"title":"Contributors","authors":"","doi":"10.1016/S0891-5520(25)00058-3","DOIUrl":"10.1016/S0891-5520(25)00058-3","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 3","pages":"Pages iii-vi"},"PeriodicalIF":6.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Native Joint Septic Arthritis 原生关节感染性关节炎。
IF 6.1 3区 医学
Infectious disease clinics of North America Pub Date : 2025-06-30 DOI: 10.1016/j.idc.2025.05.001
Benzi Estipona MD , Grant Logan Collins MD , Sai Sivapalan MD , Scott Montgomery MD , Talha Riaz MD
{"title":"Native Joint Septic Arthritis","authors":"Benzi Estipona MD ,&nbsp;Grant Logan Collins MD ,&nbsp;Sai Sivapalan MD ,&nbsp;Scott Montgomery MD ,&nbsp;Talha Riaz MD","doi":"10.1016/j.idc.2025.05.001","DOIUrl":"10.1016/j.idc.2025.05.001","url":null,"abstract":"","PeriodicalId":13562,"journal":{"name":"Infectious disease clinics of North America","volume":"39 3","pages":"Pages 449-463"},"PeriodicalIF":6.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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