East European Journal of Parkinson`s Disease and Movement Disorders最新文献

{"title":"PHYSICAL AND MENTAL FUNCTIONING OF PEOPLE WITH DIABETIC POLYNEUROPATHY ON THE BACKGROUND OF MULTIMORBIDITY","authors":"N. Svyrydova, G. Chupryna, V.M. Dubуnetska, Z.L. Tyzhuk","doi":"10.33444/2414-0007.6.3-4.8-18","DOIUrl":"https://doi.org/10.33444/2414-0007.6.3-4.8-18","url":null,"abstract":"The article analyzes the physical and psychological components of the quality of life (QOL) in patients with diabetic polyneuropathy (DP) on the background of type I and II diabetes mellitus (DM) with comorbidity. Has been demonstrated the prevalence of more frequent multimorbidity in this nosology and its effect on patients’ QOL. \u0000QOL is recognized as an integral part of a comprehensive analysis of new methods of diagnosis, treatment, prevention, quality of treatment and medical assistance [2].\u0000With the highest frequency in DM detect sensory or sensorimotor forms of distal symmetrical DP. However, there are motor symptoms in DM, including cranial neuropathy and Bruns-Garland syndrome (diabetic amyotrophy) [3], which interfere with the satisfactory functioning of patients.\u0000The purpose of our work was to assess the extent of physical and mental functioning of people with DP on the background of multimorbidity. \u0000Materials and methods. We examined 92 patients with DP on the background of type I and II DM, aged from 19 to 69 years, which were divided into 2 groups: from DP on the background of type 1 DM (group I) and type II (group II). We distinguished such subgroups: DP on the background of type I DM and concomitant cardiovascular pathology (CVP) (group A), DP on the background of type II DM and concomitant CVP (group B), DP on the background of type I DM and gastroenterological pathology (GEP) (group C), DP on the background of type II DM and GEP (group D), DP on the background of type I DM and pathology of the thyroid gland (thyroid) (group E), DP on the background of type II DM and thyroid pathology (group F). Patients underwent clinical and neurological examination, laboratory tests and ultrasound examination of the abdominal cavity and thyroid gland, electromyography (EMG). Static calculation was done in MS Excel 2003. \u0000Results and discussion. In groups A and B with the highest frequency among CVP was arterial hypertension - 91% vs 97% and coronary heart disease - 27% vs 41%. In group C - chronic hepatitis (40%), chronic cholecystitis (40%), chronic pancreatitis (40%), chronic gastroduodenitis (40%). In people of group D, gallstone disease was diagnosed more often than in other pathologies (43%). The leading place in group E was occupied by autoimmune thyroiditis (29%), idiopathic hypothyroidism (29%), thyrotoxicosis (29%), in group F - nodular goiter (57%). The longest duration of DM was observed in group A - 24.54 ± 2.46 years, the smallest in group D - 7.14 ± 1.01 years. Diabetic foot syndrome was diagnosed in patients of groups A and B in 14%, group C - in 2%. In patients of group I, the indicators of QOL were higher than in group II. The highest indicators were of groups I and II in the domains social (SF) and physical functioning (PF) - 66.75 ± 2.41; 65.5 ± 3.23 and 63.39 ± 3.54; 61.42 ± 3.88. In group A, the level of QOL was slightly higher than in group B, in particular in the domains of mental health (MH) - 53.09 ± 3.12, bodily pain (","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126371739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POST-STROKE DEPRESSION (MODERN LOOK AT THE PROBLEM AND OWN RESEARCH)","authors":"O. Onopriyenko","doi":"10.33444/2414-0007.6.1-2.10-19","DOIUrl":"https://doi.org/10.33444/2414-0007.6.1-2.10-19","url":null,"abstract":"The high incidence and increase in disability among the population after a stroke is a topical problem worldwide in the second decade of the 21st century. Brain strokes, their complications (dementias, depression), place a heavy burden on the society of the country, the families of patients. \u0000Objective: To investigate the impact of psychogenic factors on the epidemiology of stroke in Brоvаry district of Kyiv region for the last 10 years, to compile statistics and to compare them with world and regional data of Kyiv region and Ukraine. \u0000Methods. The resources of PubMed (1990-2016) and UpToDate (2016) were used to write the review article. To address these issues and to improve the quality of care provided to patients in the Kyiv region, Brovary and Brovary district, an epidemiological study of stroke patients and its risk factors has been continued. We screened 771 patients with stroke in the angioneurology department of the Brоvаry Multidisciplinary Clinical Hospital of the Kyiv region for psycho-emotional depressive disorders in the acute and late recovery period of ischemic stroke using NIHSS scales, Bartel index, modified Rankin scale, RASS scale. Statistical analysis of the obtained data was performed using the Spearman correlation coefficient, multiple regression analysis, descriptive statistics methods. \u0000Results. The risk factors for depression in the early recovery period after ischemic stroke and the association of post-stroke depression (PSD) with the risk of recurrence have been identified. 771 stroke patients (13%) had anxiety-depressive syndrome: 436 (56%) man, 335 (44%) women. PSD has been found to be more pronounced in old people, female, single patients. The development of PSD is influenced by many factors, including severity of stroke, disease course, significant functional impairment and degree of disability, reduced cognitive, language functions, and dependence on outsiders. The more pronounced severity of PSD is related to the degree of functional dependence and language-cognitive status. \u0000Conclusions. The presence of PSD results in worst prognosis of stroke of functional and cognetiv renewal of patients, increases their dependence on an extraneous help, considerably worsens quality of life. The origin of PSD has multifactorial genesis, mostly psychogenicsocial factor, influences on the degree of functional dependence of patients, especially aphasia. Influence on risk factors will give an opportunity to prevent development of PSD will promote it to effective rehabilitation and prevantion of repeated ischemic stroke. \u0000Keywords: ischemic stroke, psychogenic factors, post-stroke depression, principles of rehabilitation, treatment, prevention.","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131273364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STIFF PERSON SYNDROME (SPS) THE IMPORTANCE OF EXTENSIVE PHYSICAL EXAMINATION","authors":"C. Canepa-Raggio, M. Choudhury","doi":"10.33444/2414-0007.6.1-2.20-23","DOIUrl":"https://doi.org/10.33444/2414-0007.6.1-2.20-23","url":null,"abstract":"Stiff Person Syndrome (SPS) is a rare condition with a prevalence of one to two cases per million and an incidence of one case per year. Characterized by progressive muscle stiffening, rigidity and spasm, mainly involve the axial muscles, resulting in severely impaired ambulation. The pathogenesis is not that clear. \u0000Classic SPS presents with extreme and persistent rigidity and stiffness of truncal and proximal limb muscles, significant lumber/cervical lordosis resulting from simultaneous actions of opposing paraspinous muscles are the hallmark. Wide and unsteady gait (Frankenstein’s gait) resulting from stiff muscles increases the risk of fall and fracture. Patient’s ADLs get severely restricted progressively. Startle reflex which is a superimposed episodic muscle spasm precipitated by sudden movement, noise, or emotional upset is a sensitive and specific feature of SPS and can be visible and palpable. Autonomic dysfunctions are common and are common cause of death in patients with SPS. In cases of partial SPS, we can find that truncal muscles are spared and limb muscles are affected, hence the term stiff-limb syndrome is used sometimes. Can involve a limb or focal part of a limb. \u0000As for treatment, symptom control and improving mobility and overall functionality is the primary target. High dose benzodiazepine is the best initial treatment. Those who are refractory can be benefit from Baclofen, IVIG, Plasma exchange, biological agent, e.g. Rituximab. Treatment of primary malignancies in paraneoplastic SPS can achieve remission.\u0000Keywords: Stiff Person Syndrome, clinical features, diagnosis and treatment.","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130704961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIVE CASES OF ACUTE HYPOACUSIA/DEAFNESS SECONDARY TO ARTERIAL AND VENOUS CEREBROVASCULAR DISEASE","authors":"C. Canepa-Raggio","doi":"10.33444/2414-0007.6.1-2.3-9","DOIUrl":"https://doi.org/10.33444/2414-0007.6.1-2.3-9","url":null,"abstract":"I present five cases of acute onset hypoacusia (four unilateral and one bilateral), all of different physiopathological mechanisms and vascular territories, secondary to either arterial or venous causes. First case is a 39-year-old male with Left Middle Inferior Pontine Syndrome (Foville Syndrome) with associated Vertebro-Basilar Insufficiency (VBI) secondary to Spontaneous Vertebral Artery Dissection (SVAD) and secondary hypoacusia. Case two, is a 76-year-old female with right Anterior Inferior Cerebellar Artery (AICA) Syndrome generating a lateral pontine infarct with hypoacusia as an initial presentation. Case three, is a 77-year-old male presenting a left Superior Cerebellar Artery (SCA) infarct with hypoacusia as an initial presentation. Case four, a 79-year-old female patient presenting sudden onset bilateral hypoacusia secondary to Basilar Artery (BA) thrombosis. Finally, case five, is a 23-year-old post-partum female presenting a right Transverse Venous Sinus Thrombosis (CVST) presenting with acute hypoacusia as only clinical manifestation. Keywords: hypoacusia, deafness, cerebrovascular disease.","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133571298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of vascular parkinsonism: a modern view on the problem (literature review and own observations)","authors":"O. Onopriyenko","doi":"10.33444/2414-0007.5.1-2.16-30","DOIUrl":"https://doi.org/10.33444/2414-0007.5.1-2.16-30","url":null,"abstract":"The aim of our research was to study modern ideas about the clinical course, diagnosis and differential diagnosis of vascular, post-stroke parkinsonism among the patients who suffered from the cerebral stroke during 10 years of the observation in Brovary. The resources PubMed (1990-2018) and UpToDate (2016) were used to write the review article. The vascular parkinsonism is a variant of secondary parkinsonism, caused by the ischemic or hemorrhagic lesions of the basal ganglia, the middle brain and/or their connections with the frontal lobes. The part of patients with the vascular parkinsonism (VP) makes up only 1.0-3.2% in the structure of all patients with parkinsonism [22, 37]. The vascular parkinsonism differs from Parkinson’s disease with more rapid disease progression and unfavorable course [3, 6, 9, 16, 22, 27, 37]. Taking into consideration the wide range of clinical manifestations, not clear criteria, the diagnosis of vascular parkinsonism is ambiguous, which makes relevant the problem of studying this pathology and modern concepts of diagnosis and therapy. Dopaminergic drugs are ineffective in most patients with vascular parkinsonism [26, 27, 28]. This article shows the analysis of the epidemiological parameters of cerebral strokes in Brovary, Kiev region. The total number of patients was 5818 (mean age 73.5 ± 10.2). Signs of vascular parkinsonism were detected in 73 patients (1.25%), including 44 (60%) women and 29 (39%) men. The lesions of subcortical structures were verified on CT and МRI. The dispensary group consisted of 312 patients with parkinsonism in 2016. The proportion of vascular parkinsonism was 23.3% of all patients with parkinsonism. Taking into consideration the progressive increase in stroke risk factors, the increase in stroke incidence among the population in Brovary (Kyiv region, Ukraine) has increased more than 4 times since 1991 (from 186 to 752 patients). The actual problem of the current time are cerebrovascular disease, strokes and their complications, which placed a heavy burden on the country’s society. Based on the aforementioned, further research would be required in this area, as well as the development of a new scientific concept regarding the prevention, early diagnosis and treatment of cerebral stroke, thus reducing disability and mortality, improving the quality of life of patients and their relatives. Keywords: vascular parkinsonism, clinical features, disease course, diagnostic criteria, differential diagnosis, risk factors.","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"349 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124307324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnosis and management of ocular myasthenia gravis","authors":"G. Plant","doi":"10.33444/2414-0007.5.1-2.3-8","DOIUrl":"https://doi.org/10.33444/2414-0007.5.1-2.3-8","url":null,"abstract":"Ocular myasthenia is not the most severe form of myasthenia but it might cause certain difficulties to diagnose. In this article, we shall discuss the clinical presentations of ocular myasthenia, its differential diagnostics, examinations and management. Keywords: ocular myasthenia gravis, diagnosis, examination, management.","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115476398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wilson’s Disease: diagnosis and treatment","authors":"Y. Trufanov","doi":"10.33444/2414-0007.5.1-2.9-15","DOIUrl":"https://doi.org/10.33444/2414-0007.5.1-2.9-15","url":null,"abstract":"Wilson’s Disease is a chronic hereditary, autosomal-recessive disorder associated with excessive deposition of copper in the liver, brain, and other tissues. Diagnosis delay and untimely initiation of treatment lead to a rapid progression of neurological symptoms, pathological changes in the liver and patient’s death for several years. Adequate, continuous treatment (diet, penicillamine) initiated in the early stages of the disease greatly improves clinical symptoms and the prognosis of Wilson’s Disease. The success of treatment and prognosis depends on early recognition of this disease. Keywords: Wilson’s Disease, clinical features, diagnostic, treatment.","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131946564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A – C.A.N.V.A.S (CEREBELLAR ATAXIA, NEURONOPATHY AND VESTIBULAR AREFLEXIA WITH AUTONOMIC DYSFUNCTION): A FASCINATING CLINICAL PORTRAIT","authors":"C. Canepa-Raggio","doi":"10.33444/2414-0007.4.3-4.3-8","DOIUrl":"https://doi.org/10.33444/2414-0007.4.3-4.3-8","url":null,"abstract":"57-year-old male patient with a 30-year history chronic cough, balance difficulties (most noticeable in the dark), ataxia and sensory neuropathy. There was also evidence of orthostatic hypotension and hypohydrosis. Examination revealed downbeat nystagmus, an abnormal visually-enhanced vestibulo-ocular reflex, length-dependent sensory neuropathy, high-stepping tandem ataxia and bilateral dysmetria. MRI brain shows marked vermian cerebellar atrophy (more noticeable in lobes VI and VIIa/b) and nerve conduction studies reveal absent sensory conductions (ganglionopathy). Genetic testing for Friedrich’s ataxia, spinocerebellar ataxia and hereditary motor sensory neuropathy (Charcot-Marie-Tooth disease) were all negative. Sural nerve biopsy showed pattern of severe loss of myelinated fibres. This patient was diagnosed with cerebellar ataxia, neuronopathy (ganglionopathy) and vestibular areflexia with autonomic dysfunction. Keywords: ataxia, neuronopathy, vestibular areflexia, autonomic dysfunction.","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125979044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The East European Journal of Parkinson’s Disease and Movement Disorders","authors":"","doi":"10.33444/2414-0007.4.1-2","DOIUrl":"https://doi.org/10.33444/2414-0007.4.1-2","url":null,"abstract":"","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"12 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113970797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALZHEIMER’S DISEASE: TYPICAL AND ATYPICAL. PART II","authors":"R. Camicioli","doi":"10.33444/2414-0007.4.3-4.9-16","DOIUrl":"https://doi.org/10.33444/2414-0007.4.3-4.9-16","url":null,"abstract":"The article describes typical and atypical forms of Alzheimer’s disease (AD), risk factors, clinical features, diagnosis and treatment. There are 35.6 million people worldwide with AD, and the number of patients will double in the next 30 years. AD is a common problem seen by neurologists, family physicians, geriatrics and psychiatrists who all should be familiar the diagnosis and course in order to best advise families. AD is the most common cause of dementia, in which memory is affected and at least one other cognitive domain. The disease has an insidious onset and gradual progression. Donepezil, rivastigmine, galantamine, and memantine are used to treat dementia in AD. Key words: Alzheimer’s disease, dementia, mild cognitive impairment, vascular dementia, dementia with Lewy bodies.","PeriodicalId":135229,"journal":{"name":"East European Journal of Parkinson`s Disease and Movement Disorders","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128698211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}