ImmunologyPub Date : 2024-12-12DOI: 10.1111/imm.13882
Xin-hua Yu, Xin-ning Guo, Kui Li, Jia-wei Li, Kaijin Wang, Dan Wang, Bi-cui Liu
{"title":"The Role of Wnt5a in Inflammatory Diseases","authors":"Xin-hua Yu, Xin-ning Guo, Kui Li, Jia-wei Li, Kaijin Wang, Dan Wang, Bi-cui Liu","doi":"10.1111/imm.13882","DOIUrl":"10.1111/imm.13882","url":null,"abstract":"<p>Wnt5a plays an important role in cell development and maturation and is closely associated with various diseases, such as malignant tumours, metabolic disorders, fibrosis, growth and development. Recent studies have shown that Wnt5a expression and signal transduction are strongly involved in the inflammatory response. This study comprehensively reviewed the latest research progress on the association between Wnt5a and several inflammatory diseases, such as sepsis, asthma, chronic obstructive pulmonary disease, tuberculosis, rheumatoid arthritis, atherosclerosis and psoriasis vulgare. We elucidated the mechanism by which the Wnt5a protein is involved in the pathogenesis of these diseases, providing a basis for the prevention and treatment of inflammatory diseases.</p>","PeriodicalId":13508,"journal":{"name":"Immunology","volume":"174 2","pages":"203-212"},"PeriodicalIF":4.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/imm.13882","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transient Anti-TCRβ mAb Treatment Induces CD4\u0000 + T Cell Exhaustion and Prolongs Survival in a Mouse Model of Systemic Lupus Erythematosus","authors":"Nancy Mize Gonzalez, Dawei Zou, Zihua Zeng, Frances Xiuyan Feng, Xiaolong Zhang, Caitlin Sannes, Andy Gu, Youli Zu, Wenhao Chen","doi":"10.1111/imm.13881","DOIUrl":"10.1111/imm.13881","url":null,"abstract":"<div>\u0000 \u0000 <p>T cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). Chronic T cell receptor (TCR) signalling induces T cell exhaustion, characterised by reduced capacity to induce tissue damage. Here, we investigated the therapeutic potential of the anti-TCRβ (H57-597) monoclonal antibody (mAb) in a mouse model of SLE. Four-month-old MRL/<i>lpr</i> mice exhibiting SLE phenotypes received 5 weekly doses of anti-TCRβ mAb or phosphate-buffered saline (PBS) vehicle control. Subsequently, mouse survival was monitored daily. On day 1 post the final dose of treatment, SLE pathogenesis was determined using histological staining and spot urine test. T and B cell states in the brain, kidney, and secondary lymphoid organs were determined by flow cytometry. Transient treatment of anti-TCRβ mAb significantly prolonged the survival of MRL/<i>lpr</i> mice. Accordingly, MRL/<i>lpr</i> mice in the anti-TCRβ mAb group exhibited decreased proteinuria scores and minimal renal pathological damage compared to the PBS control group. Flow cytometric analysis revealed that anti-TCRβ mAb treatment resulted in a reduction in the frequencies of CD4<sup>+</sup> T cells and CD138<sup>+</sup>B220<sup>lo/−</sup> plasma cells, plus an increase in Foxp3<sup>+</sup> regulatory T cell frequency. Furthermore, CD4<sup>+</sup> T cells from anti-TCRβ mAb treated mice exhibited elevated expression levels of PD-1 and TIM-3, with reduced IFN-γ production, indicative of an exhaustion-like phenotype. Therefore, transient administration of anti-TCRβ mAb treatment induces an exhaustion-like phenotype in CD4<sup>+</sup> T cells, resulting in prolonged survival of MRL/<i>lpr</i> mice. Inducing autoreactive T-cell exhaustion holds promise as an attractive therapeutic approach for SLE.</p>\u0000 </div>","PeriodicalId":13508,"journal":{"name":"Immunology","volume":"174 2","pages":"239-246"},"PeriodicalIF":4.9,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}