Indonesian Journal of Pharmaceutical and Clinical Research最新文献_第6页

Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats Pirdot叶乙醇提取物对大鼠急性毒性的评价

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2020-12-31 DOI: 10.32734/IDJPCR.V3I2.4303

N. Simanjuntak, Rosidah, Yuandani

{"title":"Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats","authors":"N. Simanjuntak, Rosidah, Yuandani","doi":"10.32734/IDJPCR.V3I2.4303","DOIUrl":"https://doi.org/10.32734/IDJPCR.V3I2.4303","url":null,"abstract":"Traditionally pirdot leaves are used to treat various diseases. The purpose of this study was to determine determine the potential for acute toxicity of ethanolic extract of pirdot leaf (Saurauia vulcani Korth.) with value LD50 and hematological Parameters in rats. The acute toxicity of ethanolic extract of pirdot leaf was evaluated by OECD guidelines. The number of animals used in this research were 15 female rats. The control group was given Na CMC 0.5%, the treatment groups were given ethanolic extract of pirdot leaves with doses 2000 and 5000 mg/kg bw. The results showed that ethanolic extract of pirdot leaves with doses of 2000 and 5000 mg/kg bw did not show any toxicity signs. There was no mortality was observe. The ethanolic extract of pirdot leaves did not cause any changes in hematological parameters, these include red blood cells (RBC), hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet, white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, and basophils levels as compared to normal control (P>0.05). It was estimated that LD50 of ethanolic extract of pirdot leaves was higher than 5000 mg/kg bw and the extract were practically non-toxic. The ethanolic extract of pirdot leaves did not cause any toxic effect on hematological parameters.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88812484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Evaluation of Supplement Consumption on North Sumatera Regional Police Headquarters Personnel 北苏门答腊地区警察总部人员补给品消费评价

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2020-12-31 DOI: 10.32734/idjpcr.v3i2.4333

Munazar, Wiryanto, Khairunnisa

{"title":"Evaluation of Supplement Consumption on North Sumatera Regional Police Headquarters Personnel","authors":"Munazar, Wiryanto, Khairunnisa","doi":"10.32734/idjpcr.v3i2.4333","DOIUrl":"https://doi.org/10.32734/idjpcr.v3i2.4333","url":null,"abstract":"The purpose of his study was to determine the factors that influence the consumption pattern of supplements, and to prove the potential interactions of anti-cholesterol, antihypertensive, anti-uric acid, and antidiabetic drugs with supplements. This research is a descriptive research with a survey method. Data collection was carried out on 373 North Sumatera Regional Police Headquarters Personnel. This study used the dependent variable, namely the pattern of supplement consumption, while the independent variables were age, gender, health status, perception, information sources and physical activity. The results of the study using descriptive statistical tests presented using tables and percentages. The results showed that the factors that influenced the pattern of supplement consumption were male (57.1%); 30-49 years old (62.5%); healthy condition (63%); perception as a stamina enhancer (61.7%); sources of information (62.2%) and strenuous physical activity (49.9%). There are synergistic interactions of anti-cholesterol drugs with supplements and antagonistic interactions of antihypertensive, anti-diabetic, anti-gout drugs with supplements.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86147724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-effectiveness of Antipsychotics in Treatment of Schizophrenia Patients admitted to a secondary Hospital 抗精神病药物治疗二级医院精神分裂症患者的成本-效果

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2019-12-31 DOI: 10.32734/IDJPCR.V2I2.454

Yunita Andriani, Frisca Nindy Septiani, Defirson Defirson

{"title":"Cost-effectiveness of Antipsychotics in Treatment of Schizophrenia Patients admitted to a secondary Hospital","authors":"Yunita Andriani, Frisca Nindy Septiani, Defirson Defirson","doi":"10.32734/IDJPCR.V2I2.454","DOIUrl":"https://doi.org/10.32734/IDJPCR.V2I2.454","url":null,"abstract":"Abstract. Schizophrenia is a chronic disease that requires relatively high treatment costs [1]. Several studies have found that atypical antipsychotics are more effective compared to typical antipsychotics. As a result, the duration of treatment and the patients’ length of hospital stay will be shorter which ultimately reduce the overall treatment costs. Therefore, it is necessary to conduct a cost-effectiveness analysis (CEA) of the two classes of antipsychotic drugs in the treatment of schizophrenia inpatients admitted to Jambi Province Hospital period 2013-2016. Method: This descriptive retrospective cohort study was undertaken to analyze cost-effectiveness of the antipsychotic drugs provided to patients with schizophrenia (n=910) admitted to Jambi Province Hospital from the perspective of a healthcare provider. using purposive sampling technique. Characteristics of the patients, antipsychotic drugs usage, costs consumed, and treatment outcome were extracted from the hospital databases. Results: It was found that the total ACER value of the typical antipsychotic group was Rp. 142,789.25 and atypical antipsychotics is IDR 163,045.50 which indicates that the typical ACER antipsychotic value is smaller than those of atypical antipsychotics based on the length of stay of patients in the Psychiatric Intensive Care Unit (PICU) room. Whereas based on the PANSS-EC score of the patient, the total ACER value of the typical antipsychotic group was IDR1,189,910.42 and in atypical antipsychotics was IDR. 572,089.47. Conclusion: Atypical antipsychotics are more cost-effective than typical antipsychotics.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77409543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cytotoxicity Activity of Ethanol Extract of Andaliman Fruits (Zanthoxylum acanthopodium DC.) towards 4T1 Breast Cancer Cells 安达利曼果实乙醇提取物对4T1乳腺癌细胞的细胞毒性活性

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2019-12-30 DOI: 10.32734/IDJPCR.V2I2.3220

R. Rosidah, P. Hasibuan, G. Haro, D. Satria

{"title":"Cytotoxicity Activity of Ethanol Extract of Andaliman Fruits (Zanthoxylum acanthopodium DC.) towards 4T1 Breast Cancer Cells","authors":"R. Rosidah, P. Hasibuan, G. Haro, D. Satria","doi":"10.32734/IDJPCR.V2I2.3220","DOIUrl":"https://doi.org/10.32734/IDJPCR.V2I2.3220","url":null,"abstract":"Breast cancer is one of the world's leading cause of death in women. Due to the resistance of chemotherapeutic agents, there is a continuous need to search of natural products with anticancer activity. The use of natural products is expected to increase the effectiveness and decrease side effect. The purpose of this study was to investigate the anticancer activity of ethanol extract of andaliman fruits (EEAF) towards 4T1 cells. Extracts were prepared by maceration using solvent ethanol 96%. 4T1 cells were grown in culture medium DMEM then given by EEAF and doxorubicin. Cytotoxic test in vitro was done by MTT method [3-(4,5-dimetiltiazol-2-il) -2.5 difeniltetrazolium bromide] which is then analyzed using SPSS 21. The results from this study showed that the cytotoxic results (IC50) after treatment with EEAF and doxorubicin were 54.48 ± 0.22 µg/mL dan 0.80 ± 0.02 µg/mL.Based on the result above, we conclude that EEAF has cytotoxic activity towards 4T1 cancer cells. Key words: andaliman fruits, Zanthoxylum acanthopodium DC., ethanol extract, breast cancer, 4T1 cell line.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"163 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86661663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Formulation and Characterization of Nanoemulsion of Tread leave Ethanol Extract (Catharanthus roseus (L.) G. Don) as Antihyperglycemic 花楸叶乙醇提取物纳米乳的制备及表征G. Don)作为抗高血糖药

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2019-12-30 DOI: 10.32734/IDJPCR.V2I2.3204

Mariadi, B. Prasetyo, H. Adela, Winda Wiladatika

{"title":"Formulation and Characterization of Nanoemulsion of Tread leave Ethanol Extract (Catharanthus roseus (L.) G. Don) as Antihyperglycemic","authors":"Mariadi, B. Prasetyo, H. Adela, Winda Wiladatika","doi":"10.32734/IDJPCR.V2I2.3204","DOIUrl":"https://doi.org/10.32734/IDJPCR.V2I2.3204","url":null,"abstract":"Nanoemulsion technology has been widely developed and applied on natural extract to enhance bioavailability and drug effects. The tread plant (Catharanthus roseus (L.) G. Don) is commonly known in traditional medicine for lowering blood sugar levels. This study aimed to make and characterize nanoemulsion of tread leaf extract as antihyperglycemic using sesame oil and olive oil as carriers. Nanoemulsion formulations were made using ethanol extract of tread leaves, and additives such as Tween 80, isopropyl myristate in varying ratios and some of vegetable oils. The nanoemulsion was physically evaluated tests including the pH, the type of emulsion, homogeneity and size distribution which measured by the Particle Size Analyzer (PSA). Antihyperglycemic testing was carried out on 4 groups of male mice (5 mice/ group) induced with glucose and treated with extract, nanoemulsion, and distilled water. The results showed that the nanoemulsion preparation had a pH of 6.4 to 6.5; o/w type of emulsion and it was stable on storage for 1 month. The particle size distribution of the nanoemulsion was 85.8% with size <500 nm. Nanoemulsion could reduce the blood glucose levels in mice to normal level after 60 minutes. It also showed the decreae for 43-46% of the blood glucose level after 2 hours. The Nanoemulsion of tread leaf extract has a faster ability and a greater percentage in reducing blood glucose levels compared to extract and control. \u0000Keywords: Nanoemulsion, Catharanthus roseus, sesame oil, olive oil, Antihyperglikemic","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80167882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Potential Medication Errors in Electronic Prescribing in A Primary Health Care 初级卫生保健电子处方中潜在的用药错误

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2019-08-09 DOI: 10.32734/idjpcr.v2i1.1166

R. Nurfitria, Rima Nur Adillah Effendi, Deni Iskandar

{"title":"Potential Medication Errors in Electronic Prescribing in A Primary Health Care","authors":"R. Nurfitria, Rima Nur Adillah Effendi, Deni Iskandar","doi":"10.32734/idjpcr.v2i1.1166","DOIUrl":"https://doi.org/10.32734/idjpcr.v2i1.1166","url":null,"abstract":"An effort to reduce medication errors is to use drugs prescription electronically[1,2,4]. However, there needs to be an evaluation of this system, because this system is not free from errors in medication. This study aimed to find out the description of prescribing flow, to examine electronic prescription completeness, and find out the potential medication errors that occur in the prescribing phase of electronic prescription using prescribing indicators[1,5,9,10]. This study used observational method by taking general practice outpatient prescription data of March 2018 in a company health service located in Bandung and analyzed descriptively[6,7,8]. Electronic prescription of medicines at this health care was made and inputted by doctors. When an error occured on a computer system, the doctor would prescribe it manually so that the patient can still be served. Incompleteness of the most common recipe was on administrative requirements where all prescriptions did not listed the doctor's practice permit, patient's gender, patient's weight, telephone number of the place of practice, and patient's contact number. Medication errors had the most potential for the occurrence of prescription writing with two or more drugs interacting and this error was classified as category D according to The National Coordinating Council for Medication Error Reporting and Prevention (NCC-MERP). \u0000 ","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76733112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Appropriateness of Antibiotic Utilization in Hospitalized Post-Surgery Patients 住院术后患者抗生素使用的适宜性

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2019-06-28 DOI: 10.32734/IDJPCR.V2I1.1103

A. Nasution, Noor Fashilah, S. E. Nugraha

{"title":"Appropriateness of Antibiotic Utilization in Hospitalized Post-Surgery Patients","authors":"A. Nasution, Noor Fashilah, S. E. Nugraha","doi":"10.32734/IDJPCR.V2I1.1103","DOIUrl":"https://doi.org/10.32734/IDJPCR.V2I1.1103","url":null,"abstract":"Abstract. One of the most common health problems related to surgery is infection which needs treatment with antibiotics. Inappropriate use of antibiotics results in many problems including microbial resistance, interference of the required clinical outcomes, increasing side effects of the provided antibiotics and health resources utilization, causing toxic effects to the body organs, and even death. This study aimed to evaluate the appropriateness of antibiotic utilization on post-surgery patients admitted to Haji Adam Malik (HAM) Hospital, Medan, Indonesia. This three-month prospective descriptive study was conducted to evaluate the appropriateness of antibiotic utilization based on Gyssens method categorized into appropriate and inappropriate (in terms of dose, interval, route, too long provision, too short provision, less effective, toxicity, price, and the spectrum), and trustable literatures on post-surgery patients assessed from their medical records (n=31) in HAM Hospital Medan. Most (54.8%) of the patients were females. The study proved that 23 (74.2%) of the patients received appropriate/rational antibiotic therapy and 8 (25.8%) of them received inappropriate antibiotic therapy consisted of problems with: inappropriate dose, 13%; too long duration, 3.2%); too short duration, 29%. More than a quarter of the patients received inappropriate dosages of antibiotics.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87649080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Turmeric Extract (Curcuma Domestica Val) Against the Durability of Yellow Rice Storage 姜黄提取物(Curcuma Domestica Val)对黄米贮藏耐久性的影响

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2019-06-14 DOI: 10.32734/IDJPCR.V2I1.950

H. Maha, E. Sitompul, J. Silalahi

{"title":"The Effect of Turmeric Extract (Curcuma Domestica Val) Against the Durability of Yellow Rice Storage","authors":"H. Maha, E. Sitompul, J. Silalahi","doi":"10.32734/IDJPCR.V2I1.950","DOIUrl":"https://doi.org/10.32734/IDJPCR.V2I1.950","url":null,"abstract":"Yellow cooked rice is a traditional food in some regions in Indonesia. Yellow cooked rice with the addition of turmeric and flavoring which can longer shelf life of savings because it has antibacterial activity and flavor. The purpose of this study was to determine the effect of turmeric extract (Curcuma domestica Val) to extend shelf life of yellow cooked rice. The samples used were made of yellow cooked rice with handmade and without any seasoning flavored with turmeric extract concentration of 1.8% and 2.4%. Organoleptic testing were conducted every 3 hours, test of microbial growth daily and inhibition of turmeric extract with a concentration of 1.8% and 2.4% of fungi isolated from yellow cooked rice with a total plate count method. Research showed that turmeric extract concentration and the addition of herbs affect the longer shelf life of yellow cooked rice store. High more and more concentration of the turmeric extract can made longer the shelf life of yellow cooked rice either through organoleptic and also total plate count. Yellow cooked rice without seasoning with turmeric extract concentration of 1.8% and 2.4% were 30 and 33 hours respectively, while the yellow cooked rice was flavored with the same concentration of turmeric extract were 36 and 39 hours respectively.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84039511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mineral Analysis in Dioscorea hispida Dennst. Tuber by Atomic Absorption Spectrophotometry 薯蓣矿物分析。块茎原子吸收分光光度法

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2019-05-27 DOI: 10.32734/IDJPCR.V2I1.858

Masfria, Rehulina Gultom, Tedy Prayoga

引用次数: 0

Antibacterial Activities of Perfume: Combination Flower Magnolia alba, Cananga odorata and Mimusops elengi L, Fixed with Pogostemon cablin Oil 用广藿香油固定的白玉兰、加南加和蜜草复合花香水的抑菌活性研究

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2019-05-08 DOI: 10.32734/IDJPCR.V2I1.814

R. Nasution, Azalia Izdhihar Azwar, H. Helwati, Marianne

{"title":"Antibacterial Activities of Perfume: Combination Flower Magnolia alba, Cananga odorata and Mimusops elengi L, Fixed with Pogostemon cablin Oil","authors":"R. Nasution, Azalia Izdhihar Azwar, H. Helwati, Marianne","doi":"10.32734/IDJPCR.V2I1.814","DOIUrl":"https://doi.org/10.32734/IDJPCR.V2I1.814","url":null,"abstract":"Abstract: The making of perfume from the combination Magnolia alba (M. alba) flower oil, Cananga odorata (C. odorata) and Mimusops elengi L (M. elengi) fixed with Pogostemon cablin oil (P. cablin) have been done. Essential oil of M. alba and C. odorata was distilled by water distillation and extraction essential oil of M. elengi flower using n-hexane evaporated solvent method. Composition perfume through organoleptic test obtained with a ratio of 4% v/v, 4% v/v, and 2% v/v for each essential oil M. alba, C. odorata and M. elengi. Antibacterial activity of the perfume and each of the volatile oil was performed by the disc diffusion method. Antibacterial activity test showed that perfumes were able to inhibit the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, but less active. Antibacterial activity of the perfume was more active against E. coli with an inhibitory zone of 8.3 mm and 39.81% inhibitory power than S. aureus bacterial 7.3 mm inhibition zone with 37.55% inhibitory power. Perfumes after storage for one, and two months had better antibacterial activity than before storage with an average inhibitory zone of 11-15 mm and inhibitory power of 50- 68,18%. \u0000 \u0000Keywords: Antibacterial, E. Coli, C. Odorata, M. alba, M. elengi, P. cablin, , S. aureus \u0000 ","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88075958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3