Indian Journal of Health Sciences and Biomedical Research (KLEU)最新文献

Salivary growth differentiation factor-15 levels in oral leukoplakia and oral squamous cell carcinoma 口腔白斑和口腔鳞状细胞癌中的唾液生长分化因子-15水平

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_364_23

Ramyani Sinha, P. Angadi

{"title":"Salivary growth differentiation factor-15 levels in oral leukoplakia and oral squamous cell carcinoma","authors":"Ramyani Sinha, P. Angadi","doi":"10.4103/kleuhsj.kleuhsj_364_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_364_23","url":null,"abstract":"OBJECTIVES: About 90% of oral cancers are oral squamous cell carcinomas (OSCC) whose appropriate treatment requires early diagnosis, based on knowledge about biomarkers which are expressed during the complex process of carcinogenesis. Growth differentiation factor-15 (GDF-15) has been considered an important serum and immunohistochemical marker in several cancers. Saliva has several advantages as a diagnostic biofluid. This research intends to evaluate the salivary GDF-15 levels in oral leukoplakia (OL) and in OSCC. MATERIALS AND METHODS: We estimated and compared levels of salivary GDF-15 in cases of OL, OSCC, and healthy controls. Study groups comprised 30 cases each of OL and OSCC. Control group comprised 30 healthy individuals. Saliva samples were assessed using the enzyme-Linked immunosorbent assay for GDF-15 levels. RESULTS: Salivary GDF-15 levels showed a gradual increase from healthy volunteers to cases of OL and highest GDF-15 levels were noted in OSCC group. Increase in concentration of GDF-15 was also noted with increasing grades of OSCC. CONCLUSION: Increased level of GDF-15 in premalignant cases reflects its antitumorigenic role, whereas its expression in later stages of OSCC demonstrates its protumorigenic role. The regulatory mechanism associated with GDF-15 may help in developing some novel therapeutic strategies based on its expression.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular authentication of Thevetia peruviana (pers.) roxb plant by random amplified polymorphic deoxyribonucleic acid – Barcoding technique 通过随机扩增多态脱氧核糖核酸--条形码技术对 Thevetia peruviana (pers.) roxb 植物进行分子鉴定

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_158_23

R. Kore, Shrishail M. Ghurghure, Manish Kondawar

{"title":"Molecular authentication of Thevetia peruviana (pers.) roxb plant by random amplified polymorphic deoxyribonucleic acid – Barcoding technique","authors":"R. Kore, Shrishail M. Ghurghure, Manish Kondawar","doi":"10.4103/kleuhsj.kleuhsj_158_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_158_23","url":null,"abstract":"BACKGROUND: DNA fingerprinting is a Special technique used to determine the probable identity of a person based on the nucleotide sequences of certain regions of Plant DNA that are unique to individuals. AIMS AND OBJECTIVES: In this study, the random amplified polymorphic deoxyribonucleic acid (RAPD) technique was employed for the determination of the components in Ayurvedic herbal medicine. The RAPD approach is appealing to a large number of scientists since it may be implemented in a variety of settings with little effort. Most importantly, RAPD analysis does not require any cloning, sequencing, or other molecular characterization of the genome to extract a large number of genetic markers from a small amount of deoxyribonucleic acid (DNA). MATERIALS AND METHODS: Fresh leaves of the Thevetia peruviana (Pers.) Roxb plants were gathered in the month of June in the surroundings of Solapur. RESULTS: We used OPAB11, OPT12, OPQ15, and OPC104 decamer primers to conduct an RAPD study that measures genetic variation at random. Pure and RNA free high molecular weight DNA was extracted from the leaves. CONCLUSION: The DNA was amplified with repeat primers and 4 polymerase chain reaction primers, and then analyzed on agarose gels. Other wild T. peruviana species might be easier to track down with this method.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical education and Humanitarian emergencies: Necessity to strengthen 医学教育与人道主义紧急情况：必须加强

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_295_23

Saurabh Ram Bihari Shrivastava, P. Shrivastava

引用次数: 0

Morphometric analysis of palatal vault for sex determination in Central Indian population 对中印度人口腭穹进行形态计量分析以确定性别

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_219_23

Saurabh Sharma, Paran Joshi, Raman Grover

{"title":"Morphometric analysis of palatal vault for sex determination in Central Indian population","authors":"Saurabh Sharma, Paran Joshi, Raman Grover","doi":"10.4103/kleuhsj.kleuhsj_219_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_219_23","url":null,"abstract":"BACKGROUND: Palate has been a topic of interest regarding sex determination from human skeletal remains in physical anthropology. Palatal index (PI) is an important parameter for the sex determination of deceased individuals with unknown identity. AIM: The study aimed to determine and compare PI, clinically and radiographically, and evaluate its role in sexual dimorphism in the Central Indian population. MATERIALS AND METHODS: This study was conducted on 392 participants, in the department of anatomy and dentistry of a premium medical college in India. Maxillary casts were used for clinical measurement. Posteroanterior and lateral cephalogram (Ceph) were used for the radiographic method. Palatal length (PL) and palatal breadth (PB) were measured. PI was calculated as PB/PL × 100. Data were analyzed using unpaired Student's t-test. RESULTS: Participants belonged to the age group of 41–50 years (31.63%), 51–60 years (27.04%), and 18–30 years (18.87%). Clinical and radiographic PB was found to be higher in males (37.94 ± 1.28 mm, 38.87 ± 3.11 mm) than females (35.44 ± 1.18 mm, 36.62 ± 2.75 mm). PL demonstrated almost similar clinical values in males (45.25 ± 1.65 mm) and females (45.21 ± 1.51 mm) with no statistical significance. Radiographic PL was significantly higher in males (48.28 ± 1.60 mm) than females (46.41 ± 1.69 mm). Males demonstrated higher PI, clinically and radiographically (83.84 ± 3.82 mm, 80.51 ± 5.32 mm), than females (78.38 ± 4.19 mm, 78.91 ± 5.06 mm). CONCLUSION: Palatal parameters showed significant differences suggesting sexual dimorphism. They serve as important anthropometric, clinical, and radiographic tools useful in the identification of deceased individuals as a part of forensic medicine and odontology.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracheal foreign body misdiagnosed as acute bronchial asthma in a toddler child 被误诊为急性支气管哮喘的幼儿气管异物

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_218_23

Bablu Gaur, Naadia Nazim, Sumanyu Ahuja, Anahita Fatma

引用次数: 0

Cluster of differentiation 44 and matrix metalloproteinase 2 markers: A prospective study and insight to their role in bladder cancer 分化群44和基质金属蛋白酶2标记物：前瞻性研究及其对膀胱癌作用的启示

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_582_22

Manoj Yadav, Poorvi Mathur, A. Singhai, Suresh Babu, Bhupendra Singh, Apul Goel, Ravi Lohani

{"title":"Cluster of differentiation 44 and matrix metalloproteinase 2 markers: A prospective study and insight to their role in bladder cancer","authors":"Manoj Yadav, Poorvi Mathur, A. Singhai, Suresh Babu, Bhupendra Singh, Apul Goel, Ravi Lohani","doi":"10.4103/kleuhsj.kleuhsj_582_22","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_582_22","url":null,"abstract":"INTRODUCTION: Cluster of differentiation 44 (CD44), a transmembrane glycoprotein and Matrix metalloproteinase 2 (MMP2), a gelatinase enzyme have been implicated in several malignancies for their role in prognostication and diagnosis. We, therefore, made an effort to use these markers in urothelial malignancies and discuss their importance along with review of the literature. METHODS: A prospective study conducted for 1 year using light microscopy and immunohistochemistry for CD44 and MMP2. RESULTS: CD44 showed concordance with low-grade tumors while MMP 2 was found to show positivity in high-grade tumors. Score 3 in CD44 expression was seen exclusively (100%) in low-grade tumors while similar score of MMP2 expression was seen in 90.9% of high-grade tumors. CONCLUSION: CD44 and MMP2 expression can, therefore, serve as an important tool to predict the clinical behavior and prognosis in patients of urothelial carcinoma of the bladder. The management and survival rate varies according to grade; hence, these markers can be used for prognostication of disease.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reading journals on phone 用手机阅读期刊

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_149_23

Harish Gupta

引用次数: 0

Celebrating World Hearing Day 庆祝世界听力日

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_240_23

S. Sahoo

引用次数: 0

Management of panfacial and complex facial fractures: A Belgaum perspective – Case series 全面部和复杂面部骨折的处理：贝尔高姆视角--病例系列

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_333_23

Vijaylaxmi Shettar, S. Baliga, Sanjay Rao, Prashasti Sharma, Kritika Pandey

引用次数: 0

Rare case presentation of parathyroid adenoma in a young female presenting as pathological fracture of long bones: A case study 年轻女性甲状旁腺腺瘤罕见病例，表现为长骨病理性骨折：病例研究

Indian Journal of Health Sciences and Biomedical Research (KLEU) Pub Date : 2023-09-01 DOI: 10.4103/kleuhsj.kleuhsj_170_23

Himanshi Vats, PAjay Kale

引用次数: 0