Advances in Hematology and Oncology Research最新文献

{"title":"A Rare Case of Primary Cutaneous Apocrine Carcinoma","authors":"","doi":"10.33140/ahor.03.01.14","DOIUrl":"https://doi.org/10.33140/ahor.03.01.14","url":null,"abstract":"Primary cutaneous apocrine carcinoma is a rare malignant tumor that originates from apocrine sweat glands. Apocrine sweat gland tumor is infrequent: the first case was published by Horn in 1944 and less than 50 cases are described in literature worldwide. For this reason, there are no clear guidelines for the management and treatment of this uncommon cancer. We report a clinical case of primary cutaneous apocrine carcinoma in a 86 year-old female patient.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"334 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116463804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Spare a Life at a Time, Being Mindful of the Red Flags","authors":"","doi":"10.33140/ahor.03.01.01","DOIUrl":"https://doi.org/10.33140/ahor.03.01.01","url":null,"abstract":"In an era dominated by high-yield technology and novel therapies, a clinician’s insight and mindful reasoning remain more powerful than fine point instruments. During the course of our medical training, we are taught to consider the most prevalent aetiologies upfront, since « frequent conditions are widespread ». Moreover, we are trained to develop a unicist vision in front of a clinical scenario, especially when young patients are concerned. However, we shall never forget that the exceptional case will eventually present to clinic. It is our responsibility to recognize the Red Flags. Every patient has only one life, and good clinical awareness protects those lives. The case discussed in this review is highly pertinent for numerous medical fields, mentioning: Neurology, Neurosurgery, Internal Medicine, Psychiatry, Emergency Medicine, Family Medicine, General Surgery and Endocrinology. Numerous specialists are involved in a single case. A gentleman in his early 30s presents is diagnosed with a low-grade oligodendroglioma involving unilaterally the basal ganglia, documented clinically and radiologically to be stable for years. While he recited his story, we listened carefully. This young man mentioned one sentence, which retrospectively saved his life.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"171 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133656568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we Measure a Woman’s Cancer Risk When Breast Implants are Present? – YES!!!","authors":"","doi":"10.33140/ahor.03.01.06","DOIUrl":"https://doi.org/10.33140/ahor.03.01.06","url":null,"abstract":"Background: Breast implants are now recognized to be associated with a variety of potential problems, including inflammatory changes – both locally and systemically – precancerous and cancerous changes. Monitoring these changes are particularly problematic in the face of breast implants. Molecular breast imaging (MBI) using FMTVDM* provides a unique method for measuring changes in breast tissue in these individuals. This study examines that potential. Methods: Eighteen breast implants were evaluated in women who had undergone implantation for a variety of reasons. These women underwent measurement of regional blood flow (RBF) and metabolism differences to determine the extent of inflammation, precancerous and cancerous changes. Results: Measured changes in RBF and metabolism were not influenced by breast implants. Among the 18 breast implant studies; there were 4 instances of inflammation (22%), 5 (28%) instances of precancerous changes and 1 (5%) instance of breast cancer. Conclusions: MBI using FMTVDM provides a non-invasive ability to measure changes in breast tissue in women who have undergone breast implantation. The measured monitoring of these changes allows clinicians a tool to make clinical decisions regarding either the need to remove the breast implant or provide alternative treatment options.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129910355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Resection with Boyd Technique for Metastatic Ewing Sarcoma of the Bone Plus Docetaxel/Gemcitabine, Associated with Improved Outcomes in Tumor Activity","authors":"","doi":"10.33140/ahor.03.01.12","DOIUrl":"https://doi.org/10.33140/ahor.03.01.12","url":null,"abstract":"Ewing sarcoma is a malignant bone tumor that mainly affects children, adolescents and young adults with more than 1.5 cases per million worldwide. Approximately 20-25% of patients present metastatic disease at the diagnosis, that is often resistant to intensive therapy.We present the case of a 19-year-old male with history of epilepsy who started his condition with weight loss, increased volume, pain, swelling after receiving surgical treatment due to a left distal femur fracture, showing tomographic evidence of a 50-cm tumor with multiple lung lesions, so disarticulation was performed with the Boyd technique, obtaining histopathological result of Ewing’s Sarcoma, and was subsequently sent to the medical oncology service for follow-up and adjuvant treatment with significant clinical and radiological improvement in pulmonary metastatic activity.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"374 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132809538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Lymphovascular Invasion in Colorectal Adenocarcinoma at Dr. Cipto Mangunkusumo General Hospital, Jakarta: A Preliminary Report","authors":"","doi":"10.33140/ahor.03.01.11","DOIUrl":"https://doi.org/10.33140/ahor.03.01.11","url":null,"abstract":"Background: Lymph node metastasis is a prognostic factor in colorectal adenocarcinoma. Besides, lymphovascular invasion is one of the factors to indicate the lymph node metastasis. This study aimed to investigate factors associated with lymphovascular invasion in our hospital. Methods: This preliminary report was a cross−sectional study of patients with colorectal adenocarcinoma in Cipto Manungkusumo General Hospital, Jakarta, Indonesia between 2012 and 2016. Our focus of interest was the association between lymphovascular invasion and variables of patient’s characteristics, including age, gender, location of the tumor, tumor differentiation, pathological stage of tumor infiltration, and lymph node metastasis. Results: We found 70% of the 68 subjects had lymphovascular invasions. Among all the variables analyzed for association with lymphovascular invasion, there is no factor with significant association. However, lymph node metastasis was found to have significant association with lymphovascular invasion (odd ratio [OR] = 6.69, 95% confidence interval [CI] = 2.09–21.38, p−value =0.001). Conclusion: Although lymphovascular invasion was significantly associated with lymph node metastasis in colorectal adenocarcinoma, there is no factor significantly associated with lymphovascular invasion in this study.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129128635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude of Virological Treatment Failure and Its Determinate Factors Among Adults on First Line Antiretroviral Treatment at Defence Main Health Department - Level II & Level III Hospitals In Ethiopia","authors":"","doi":"10.33140/ahor.02.02.01","DOIUrl":"https://doi.org/10.33140/ahor.02.02.01","url":null,"abstract":"Introduction: Highly active antiretroviral therapy (HAART) played a critical role in the medical management of HIV infected individuals by restoring the immune function and minimizes HIV related outcomes. But treatment failure minimized these advantages and leads to an increment of morbidity and mortality with poor quality of life in all HIV patients. Objective: The aim of this study was to assess the virological treatment failure and its determinant factors of patients on first line HAART at five commandant Hospitals, Ethiopia. Methods: A Retrospective hospital based study design was used to determine magnitude of treatment/virology failure and its determinant factors, among HIV positive adults enrolled to HAART program at five commandant Hospitals from February 1 to May 30, 2018. Data abstracted from patient charts or electronic data base was cleaned, coded, entered and analyzed using EPI data version 3.1 and SPSS version 23 statistical software package. Descriptive statistics, proportion of treatment failure cases among those diagnosed to have treatment failure was calculated. Bi-variate and multiple logistic regressions were used to analysis association between the outcome and the independent variables were taken as significant at P<0.05 (2 tail test) and 95% confidence intervals (CIs). Result: Among the 326 participants enrolled, 229(70.2%) were males. The mean ages were 36.84 years (SD+7.716) years and the median months on HAART from initiation were 81.50 months. A total of 75(23%) participants were found to have treatment failure among those 50(15.3%) immunological failure, 7(2.1%) virological failure and 16(4.9%) all Treatment failure (VF, IF&CF in one). The mean CD4 T-cells at base line and at study time were 213.3 cells/ µl. Long duration on treatment (AOR= 4.231, 95% CI: 1.453-12.320) , IPT cycle (AOR = 3.060, 95% CI: 1.388-6.746), Type of drug AZT based therapy (AOR= 2.572, 95% CI: 1.357-4.875), experience of PEP (AOR=7.950, 95% CI: 1.945-66.915) and lost to follow up (AOR= 9.104, 95% CI: 2.973-27.873) were found to be significant predictors of treatment/virologic failure and showed positive odds ratio. Conclusion: This study demonstrates high treatment /virologic failure and the determinant factors of treatment/virologic failures among HAART first line adult are still changing. Therefore, evidence-based intervention and early detection of treatment failure must be made to further identify the potential causes and set standardized protective mechanisms of treatment/virologic failures.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132771370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian Metastasis from Breast Cancer over the Last Decade: a Breast Clinical Center Report","authors":"","doi":"10.33140/ahor.02.01.03","DOIUrl":"https://doi.org/10.33140/ahor.02.01.03","url":null,"abstract":"Background: A decline in mortality rates in breast cancer patients and an increased probability of developing secondary cancers, namely ovarian metastases, has been widely observed due to diagnostic improvement and treatment advances. The aim of this report is to evaluate the impact of ovarian metastases from breast cancer patients. Material and Methods: A retrospective and descriptive study was performed based on data collected through medical records. Breast cancer patients with ovarian metastases histologically confirmed after surgery in the last decade were included. Statistical analysis was performed using SPSS version 22. Results: Fourteen patients were analyzed, being 71% premenopausal. Primary breast cancer were associated with poor prognostic factors, namely large tumor size (100% >2cm), positive lymph nodes (79%) and differentiation grade 2/3 (50%). Mortality rate was 64%, and a 5-year survival rate after breast cancer diagnosis of 64% while after ovarian metastases diagnosis it was 29%, with a mean survival time of 95 and 38 months, respectively. Conclusion: Screening for distant metastases should become the focus of increased concern in breast cancer patients, mostly premenopausal, and ovarian metastases should stand a warning sign since they rarely occur as an isolated event.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115557764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theranostic Information Provided by FMTVDM ©ⓟ; B.E.S.T ©ⓟ. Imaging","authors":"","doi":"10.33140/ahor.02.01.01","DOIUrl":"https://doi.org/10.33140/ahor.02.01.01","url":null,"abstract":"Until quite recently, diagnostic imaging has relied upon “qualitative” imaging limited by the ability to define disease as either present or absent. The first marker that you are using a “qualitative” test is a discussion of sensitivity, the ability to find disease when present and specificity, the ability to exclude disease when absent [1-9]. This yes/no approach to medicine reflects the limitations qualitatively imposed upon us despite the understanding that tissues don’t simply exist in either a “normal” or “diseased” state but rather a transition occurs as the genetic and environmental factors influencing tissues results in transitional changes, transitional changes which can now be fully appreciated and measured [1-9].","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127601128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dose per Fraction May be correlated with Late Kidney Toxicity after Total Body Irradiation: a Single Institution Experience","authors":"","doi":"10.33140/ahor.02.01.02","DOIUrl":"https://doi.org/10.33140/ahor.02.01.02","url":null,"abstract":"Background: The purpose of the present study was to retrospectively evaluate the subacute or late toxicities in the kidney, lung, and liver after two total body irradiation regimens, 12 Gy in 6 fractions (group A) and 12 Gy in 4 fractions (group B). Methods: Forty-two patients who underwent total body irradiation (group A, n=32; group B, n=10) between June 1997 and June 2013 were included in the present study. The median follow up period was 60 months (range: 3–219 months) for the patients in group A and 143 months (range: 5–220 months) for the patients in group B. We evaluated the renal, pulmonary, and hepatic toxicities using the Common Terminology Criteria for Adverse Events version 4.0. Results: There were 4 cases of chronic kidney disease (group A, n=1; group B, n=3). Although the cumulative incidence of chronic kidney disease differed significantly between the two total body irradiation regimens (p=0.014), the pulmonary and hepatic toxicities did not differ to a statistically significant extent. Conclusion: The present study suggests that a higher dose per fraction caused a higher incidence of chronic kidney disease.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133660536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Storage on Osmotic Fragility in CPDA-1 Stored Blood in Sokoto, Northwestern Nigeria","authors":"","doi":"10.33140/ahor.01.01.02","DOIUrl":"https://doi.org/10.33140/ahor.01.01.02","url":null,"abstract":"The aim of this study was to investigate the effects of storage on the in vitro osmotic fragility of erythrocytes of humans in a single unit of whole blood. Blood was collected by venepunture from a healthy adult male (70-75 kg) into CPDA-1(450ml) blood bag containing citrate phosphate dextrose as anticoagulant (63ml) and stored in a blood bank maintained at 4°c ± 2°c. The osmotic fragility of the erythrocytes was determined by measuring the release of haemoglobin from blood added to tubes containing serially diluted phosphate buffered saline (pH 7.4). The Blood samples were analyzed on day 1 to day 35 after collection (5 weeks). Increased erythrocyte osmotic fragility was observed at week 3 (p=0.010). The initial haemolysis (>5%) occurred between 0.50% and 0.55% PBS. The mean corpuscular fragility was between 0.35 and 0.45% PBS. Maximum haemolysis occurred in 0.35% PBS. Osmotic fragility was significantly affected by storage (p<0.05). In conclusion, this research showed that there is an increase in the osmotic fragility as donor blood is stored and that the effect is more pronounced from week 3. There is need to maintain the cold chain management of stored donor blood to ensure that the aim of red cell transfusion which is to manage anaemia and increase the oxygen carrying capacity is not compromised.","PeriodicalId":134553,"journal":{"name":"Advances in Hematology and Oncology Research","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124811572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}