Indo Global Journal of Pharmaceutical Sciences最新文献

{"title":"Natural Gums and Carbohydrate-Based Polymers: Potential Encapsulants","authors":"Z. Ansari, S. Goomer","doi":"10.35652/igjps.2022.12001","DOIUrl":"https://doi.org/10.35652/igjps.2022.12001","url":null,"abstract":"Plants possess a wide range of bioactive compounds with established health benefits which are highly susceptible to degradation. The environmental dynamics such as high temperature, light, oxygen limits the shelf life and bioavailability of these compounds in food and drug formulations. Encapsulation serves as an effective way of preserving these sensitive compounds by enclosing them within a coating/wall material and hence improves their bioavailability and functional properties.Scope and Approach: The wall materials used for encapsulation also known as encapsulants act as physical barriers between core compound and external stimuli. There are different edible protein, lipid and carbohydrate based encapsulants used for coating of bioactive compounds. However, this review gives a detailed insight on composition, functional properties, and applications of carbohydrate based polymers in food, and pharmaceutical industries while emphasizing on the advantages and limitations of these polymers in encapsulation process. So, we explored recent expansion in the area of natural polysaccharides and their derivatives as carriers for the targeted and sustained delivery of active compounds. Key Findings and Conclusions:Polysaccharides, natural gums (Carrageenan, Alginate, Gum arabic, Guar gum, Gellan gum, Xanthan gum) and their derivatives are biodegradable polymers being used as sustained release carriers. They are more advantageous over lipid based and protein based carriers by virtue of their unique features such as thermo stability and versatility of interacting with a range of hydrophilic and hydrophobic compounds. Tailor-made carriers made by structural modifications of the polysaccharides using physical, chemical and enzymatic reactions result in improved functional properties and hence widen their area of applications.©2022iGlobal Research and PublishingFoundation. All rights reserved.Cite this article as:Ansari, Z.; Goomer, S.Natural gums and carbohydrate-based polymers: Potential encapsulants. Indo Global J. Pharm. Sci., 2022; 12:1-20. DOI:http://doi.org/10.35652/IGJPS.2022.12001.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78640685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FTIR and GCMS analysis of Euphorbia hirtaL. and its In-vitroAntibacterial and Antioxidant Activities","authors":"D. Kain, Suresh Kumar, Vandana, Amrita Suryavanshi, Atul Arya","doi":"10.35652/igjps.2022.12009","DOIUrl":"https://doi.org/10.35652/igjps.2022.12009","url":null,"abstract":"Introduction: Euphorbia hirtaL. is a common weed plant belongs to family Euphorbiaceae. Thepresent study brings out the importance of weed plants like E. hirtain medicine and health thecare system. Material and Methods:Plant E. hirtahas been collected from thegarden of Department of Botany, University of Delhi and plant leaves were extractedin ethanol by thesoxhlet method. Antibacterial screening has been done by disc-diffusion method. Theantioxidant potential has been determined by TPC, TFC, FRAP, Total antioxidants through phosphomolybdate assay and by DPPH radical scavenging activity. FTIR and GCMS analysis havebeen done for characterization.Result and Discussions:Plant E. hirtashowed significant antibacterial activity against Escherichia coli,Staphylococcus aureus, Bacilus subtilisand Pseudomonas aeruginosawith maximum ZOI diameter 19±0.5mmagainst S.aureusandP.aeruginosaboth. Plant E. hirtaL. showedsignificant antioxidant potential with 196.32 mg/g, 39.7133 mg/g, 595.99 mg/g, 525.84 mg/g values for TPC, TFC, FRAP activity and total antioxidants through phosphomolybdate assay respectively. Plant E. hirtaalso showedsignificant radical scavenging activity against DPPH free radical with amaximum % inhibition 68.505% at 1000μg/ml concentration. FTIR and GCMS of plant E. hirtahave confirmed the presence of various active functional groups and compounds.Conclusion:The current study justifies the importance of E. hirta L. a common weed asasource of natural antioxidants having antibacterial potential and its role in herbal medicines.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78382800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disporum Cantoniense(Lour.) Merr.: An Overview and Study of Traditional Use","authors":"S. Regmi, Kmensiful Binan, Himal Barakoti, Rajeev K. Singla","doi":"10.35652/igjps.2022.12034","DOIUrl":"https://doi.org/10.35652/igjps.2022.12034","url":null,"abstract":"Over the past two decades, there has been a tremendous increase in the use of indigenous herbal medicinal plants in modern medicine; however, there is still a significant lack of research data in this field. This incomprehensive information base shades thedevelopment of a comprehensive research agenda especially in the context of developing Asian countries like Nepal. This chapter gives an overview of traditional medicinal plant Disporum Cantoniense,which is called hadjora (bone-joining) in Nepaliandhasbeen used since time unmemorable in case of bone fracture. Apart from this, D. cantoniense has various other medicinal uses in other regions around the globe. This chapter deals with overall aspects of D. cantoniense with sequential demystification thus enabling a greater understanding of its use and possibility to be used as alternative medicine in the future.©2022Caproslaxy Media. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73767625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Cancer: How Well We Have Fared?","authors":"Pradeep S. Patil, Hitendra S. Mahajan","doi":"10.35652/igjps.2022.12007","DOIUrl":"https://doi.org/10.35652/igjps.2022.12007","url":null,"abstract":"Lung Cancer has been one of the most common causes of death worldwide. With the death toll increasing in millions every year globally it has become a global scourge. With poor prognosis and disappointing 5 years survival rate post diagnosis, treatment for this disease has been ambiguous. Various advances in treatment are being made but till date the 5 years survival for major patients remains a dream. This review encompasses different treatment options that are available, problems associated with treatment and future perspective for the treatment of lung cancer. ©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87497674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitroCytotoxic Activity of a Sulphated Polysaccharide Ulvan against Human Breast and Glioblastoma Cell line","authors":"K. Sonia, K. Meena, S. Bai","doi":"10.35652/igjps.2022.12012","DOIUrl":"https://doi.org/10.35652/igjps.2022.12012","url":null,"abstract":"This study was designed to evaluate the hemolysis, anti-inflammatoryand cytotoxicityactivity of sulphated polysaccharideulvan extracted from greenseaweed Ulvalactuca(UL).Ulvan was extracted and characterized with UV-Visible Spectroscopy, Fourier transform infraredspectroscopy (FTIR) and Scanning electron microscopy(SEM).Total uronic acid and sulphate content were found to be 19.38% w/w and 22.53% w/w.The biocompatibilityof the sulphated polysaccharide ulvan wasevaluatedviahemolysis, its interaction with erythrocyte structure and anti-inflammatory studies.Further,thepolysaccharide was treated for cellular toxicityagainsthuman breast cancer(MCF-7)and human glioblastoma cancer (U87) cell linesusing the 3-(4, 5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assaymethod.This study indicates that the sulphated polysaccharide ulvanwas more suitable for biomedical applications with promising chemo preventive and chemotherapeutic activity.©2022iGlobal Research and PublishingFoundation. All rights reserved.Cite this article as:Sonia, K.; Meena, K.S.; Alamelu Bai, S.In vitro Cytotoxic Activity of a Sulphated Polysaccharide Ulvan against Human Breast and Glioblastoma Cell line.Indo Global J. Pharm. Sci., 2022; 12:122-127. DOI:http://doi.org/10.35652/IGJPS.2022.12012.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79965415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Diet and Salvia miltiorrhiza to Manage Osteoporosis","authors":"Shelly Garg, L. Sharma, Hardik Dalal","doi":"10.35652/igjps.2021.111006","DOIUrl":"https://doi.org/10.35652/igjps.2021.111006","url":null,"abstract":": The main aim of this study is to get information about the effect of Salvia miltiorrhiza on the bone health of individuals affected from osteoporosis, and also the prevalence of osteoporosis in the different parts of the globe and also to find out its effects and the group of people affected. Different studies are being carried out to find the method of reduction of stiffness and pain in the joints. Osteoporosis is a silent disease and symptoms are not easily visible until complete development, but the major symptom is bone fracture even when a little force is exerted on the bone. It affects a total combined population of about 75 millions in Japan, Europe and USA. The combined highest prevalence of osteoporosis is of America and Europe, which is of around 51 percent of the total global population. This rapid increase in the number of cases every year makes it important for us to gain information","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84101587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Acute Dermal Irritation, Sensitization and Acute Dermal Toxicity of Leather Cream in Laboratory Animals","authors":"Atul Adhikari, Himal Barakoti, Biplab Kumar Dey","doi":"10.35652/igjps.2021.113001","DOIUrl":"https://doi.org/10.35652/igjps.2021.113001","url":null,"abstract":"Unused leather products attract fungal invasion and deteriorate the product lifespan. The development of antifungal leather cream/polish can solve this array considered that the prepared formulation is skin friendly. Possible adhesion of leather cream to the skin may provide a route for entry of hazardous and harmful ingredients. In this study, leather cream prepared in the laboratory and a marketed product of leather cream were tested for acute dermal irritation in rabbits, skin sensitization in guinea pigs, and acute dermal toxicity in rats. Draize dermal irritation scoring system was used to examine the condition of erythema and edema in rabbits at intervals of 24, 48 and 72 hours. Percentage sensitization rate, sensitization grade, sensitization classifications were accessed in guinea pigs after 24 hours of dermal exposure. Rats were observed daily for 14 days to detect any signs of irritation, change in general behavior, toxicity, morbidity and mortality. Histological examination of rat’s skin was performed at the end of the study. No any kind of dermal responses or any observable signs of systemic toxicity were detected in rabbits treated with either of the leather cream samples. No sensitization, erythema or edema was observed in guinea pigs. In the case of rats, the skin was normal with negative signs of toxicity, erythema or edema. Histological study also failed to show any damage in skin tissue layers of rats applied with test materials. The result provides a base for development of anti-fungal leather cream/polish which can enhance the life of leather and avoid the fungal invasion upon storing for a period of time. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76426099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Updates to Increase the Residence Time of Drug in the Stomach for Gastro Retentive Drug Delivery System","authors":"Abhishek Kumar, M. Bharkatiya","doi":"10.35652/igjps.2021.112008","DOIUrl":"https://doi.org/10.35652/igjps.2021.112008","url":null,"abstract":"Orally-administered controlled-release drug delivery systems are associated with the shortcomings of relatively short residence times in the human stomach as well as highly variable gastrointestinal (GI) transit times. Thus, considerable intra-individual and inter-individual differences in the bioavailability of drugs are observable. There are numerous drug substances which may benefit from prolonged and controlled GI passage times. As a solution to the problem, gastroretentive drug delivery systems (GRDDS), which feature an enhanced gastric residence time (GRT), were developed. Several approaches are currently used including Floating Drug Delivery System (FDDS), swelling and expanding system, polymeric bioadhesive systems, modified-shape systems, high density system and other delayed gastric emptying devices. The drugs having absorption window in the upper part of Gastro Intestinal Tract (GIT) have enhanced bioavailability when formulated through these techniques. The recent technological development for enhancing GRT including the physiological and formulation variables affecting gastric retention, patented delivery systems, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Despite the extensive research performed in the field of GRDDS, the development, the production, and the evaluation of floating devices are still challenging. The purpose of writing this review was to compile recent literature on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Enhancing the GRT may explore new potentials of stomach as drug-absorbing organ. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83022200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Conventional and Fatty Acid Vesicular Systems – An Overview","authors":"Gayathri Devi K, Lakshmi Pk","doi":"10.35652/igjps.2021.112011","DOIUrl":"https://doi.org/10.35652/igjps.2021.112011","url":null,"abstract":": Fatty acid vesicles are suspensions of closed lipid bilayers that are composed of fatty acids and their ionized species which are restricted to a narrow pH range. The fatty acid molecules are oriented in such a way that their hydrocarbon tails are directed toward the membrane interior and the carboxyl groups are in contact with water. Recent innovations provide an opportunity to formulate fatty acid vesicles with distinguishing features such as extension of pH range, insensitivity toward divalent cations, easy alteration in membrane composition, very simple systems in terms of chemical nature and enhanced stability properties. This review contains detail about the present stature of fatty acid vesicles, comparative study of fatty acid vesicles with conventional liposomes, unique features of fatty acid vesicles (dynamicity, stability, matrix effect etc.,) and key evaluation parameters of fatty acid vesicles. Fatty acid vesicles were found to have high penetration capacity, good bio-distribution properties, increased diffusion rate and optimum drug deposition nature than other vesicular forms. They have various applications in transdermal delivery, follicular delivery and in brain targeting drug delivery systems (drugs that are unable to cross blood brain barrier due to high solubility). This review focuses on various researches conducted on fatty acid vesicles with reference to its formulation and evaluation parameters. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90511021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory Effect of Neuracanthus Sphaerostachyus Dalz. Leaves on Experimental Colitis in Rats","authors":"Dang Dk, Patel Nj","doi":"10.35652/igjps.2021.111002","DOIUrl":"https://doi.org/10.35652/igjps.2021.111002","url":null,"abstract":"essential ABSTRACT: Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder with unknown etiology affecting the GI tract. Neuracanthus sphaerostachyus has been traditionally used for the treatment of skin diseases, cough, and asthma in various forms orally. Lack of sufficient scientific evidence indicating the utility of this plant in the treatment of ulcerative colitis prompted us to investigate the anti-inflammatory activity of the plant on experimental colitis in rats. In-vivo pharmacological screening method for evaluation of anti-inflammatory activity of the methanolic and aqueous extract of Neuracanthus sphaerostachyus leaves at doses of 125, 250, and 500 mg/kg was assessed by TNBS-induced ulcerative colitis in Wistar rats. Colitis was induced by intra-rectal instillation of 10 mg of tri-nitro benzene sulphonic acid (TNBS) in 0.25 ml of 50% ethanol (v/v) followed by treatments with 7 d for various extracts and then animals were sacrificed to remove colon for histopathology, macroscopic scoring, and biochemical assays. The 7 d treatment with a methanolic and aqueous extract of Neuracanthus sphaerostachyus significantly improved feed intake and body weight with a decrease in macroscopical score, colonic MPO, LPO and, TNF-α. The findings from the histopathological study support the above results by its potential to protect the colonic mucosal damage. The present study exhibits anti-inflammatory potential of methanolic and aqueous extracts of Neuracanthus sphaerostachyus leaves in TNBS induced experimental colitis and it can be beneficial for patients suffering from ulcerative colitis. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83502577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}