Indian Journal of Psychiatry最新文献

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Evaluating the impact of Extension of Community Healthcare Outcome (ECHO) telementoring on enhancing knowledge and perceived skills in alcohol use disorders among the nonmedical District Mental Health Programme healthcare providers in Karnataka. 评估社区卫生保健结果延伸(ECHO)远程监控对提高卡纳塔克邦非医疗区精神卫生方案卫生保健提供者在酒精使用障碍方面的知识和感知技能的影响。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2025-05-02 DOI: 10.4103/indianjpsychiatry_525_24
Prabhat K Chand, Channaveerachari Naveen Kumar, Rajani Parthasarathy, Pratima Murthy, Sanjeev Arora
{"title":"Evaluating the impact of Extension of Community Healthcare Outcome (ECHO) telementoring on enhancing knowledge and perceived skills in alcohol use disorders among the nonmedical District Mental Health Programme healthcare providers in Karnataka.","authors":"Prabhat K Chand, Channaveerachari Naveen Kumar, Rajani Parthasarathy, Pratima Murthy, Sanjeev Arora","doi":"10.4103/indianjpsychiatry_525_24","DOIUrl":"10.4103/indianjpsychiatry_525_24","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use disorder (AUD) is a public health problem. In India, about 5.2% of the population aged 10-75 years, that is, approximately 5.7 crore individuals, need help for their alcohol use problems, and around 20 lakhs from Karnataka. As per the studies, among people dependent on alcohol who tried quitting, about 75% did not receive any treatment. One potential approach to reducing this gap is enhancing the knowledge and skills of the existing District Mental Health Programme (DMHP) Health Care Providers (HCPs) on a large scale by integrating a case-based tele-ECHO (Extension of Community Healthcare Outcome) mentoring model.</p><p><strong>Aim: </strong>This study evaluates the effectiveness of the ECHO telementoring in improving knowledge and perceived skills related to AUD among nonmedical HCPs in Karnataka's DMHP.</p><p><strong>Methods: </strong>A digital-driven curriculum of the Foundation of Alcohol Management was designed and implemented with 84 DMHP healthcare providers (44 ECHO group, 40 waitlist) from 26 districts in Karnataka. The ECHO intervention comprised 27 weekly telementoring sessions over 9 months, combining case-based learning with didactic presentations. Knowledge and perceived skills were assessed at baseline and 3, 6, and 9 months using semistructured questionnaires apart from engagement and satisfaction.</p><p><strong>Results: </strong>At baseline, both groups showed comparable knowledge levels (ECHO: 5.84 ± 1.89, waitlist: 6.65 ± 2.67, <i>P</i> = .110). The ECHO group demonstrated significantly higher knowledge scores at 3 months (8.41 ± 2.84 vs 6.35 ± 2.07, <i>P</i> < .001) and 9 months (9.31 ± 2.48 vs 6.13 ± 1.82, <i>P</i> < .001). Self-perceived skills similarly improved in the ECHO group, showing significant enhancement from baseline (20.25 ± 5.62) to 9 months (25.10 ± 4.52, <i>P</i> = .004), with a large effect size (Cohen's d = 1.040). Program engagement was high, with 42 participants attending more than 60% of sessions, and 104 cases were discussed during tele-ECHO sessions. The waitlist group showed no significant improvements in either domain.</p><p><strong>Conclusion: </strong>The ECHO telementoring program effectively improves the knowledge and perceived skills of the DMHP nonmedical HCPs in AUD. The ECHO model can be a valuable tool for exponential enhancement in capacity in addictive disorder, especially in low-resource settings, by leveraging technology.</p>","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 Suppl 2","pages":"S374-S382"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translation and validation of the reasons for living inventory (RFLI) for use in India. 翻译和验证在印度使用的生活清单(RFLI)的原因。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-02-17 DOI: 10.4103/indianjpsychiatry_752_24
Ram Pratap Beniwal, Anushrut Misra, Triptish Bhatia, Smita N Deshpande
{"title":"Translation and validation of the reasons for living inventory (RFLI) for use in India.","authors":"Ram Pratap Beniwal, Anushrut Misra, Triptish Bhatia, Smita N Deshpande","doi":"10.4103/indianjpsychiatry_752_24","DOIUrl":"10.4103/indianjpsychiatry_752_24","url":null,"abstract":"<p><strong>Background: </strong>Suicide is a major public health concern in India, while reasons for living may act as protective factors against self-harm. Reasons for living inventory (RFLI) for evaluating such factors is not available in Hindi.</p><p><strong>Aim: </strong>We aimed to translate and validate RFLI in Hindi and test on persons with depression.</p><p><strong>Methods: </strong>In this four-step cross-sectional study, International Test Commission (ITC) guidelines were followed for translation and validation. Healthy participants aged 18-60 years, all genders, proficient in both Hindi and English, participated in the three-step process (sample I; <i>n</i> = 10, II; <i>n</i> = 40, and III; <i>n</i> = 20). Subscales, total, and mean scores were calculated. Another sample IV (<i>n</i> = 130) of persons with depression was recruited to evaluate the association of reasons for Living (RFL) with depression (Beck Depression Inventory). Correlation between depression and RFLI subscales was calculated.</p><p><strong>Results: </strong>After due translation, back-translation and finalization of items, the scale was administered on sample I. Items were modified if needed. In sample II, Cronbach alpha for Hindi version was 0.721 (Total RFL). Intraclass correlation of translated Hindi version was examined with a 95% confidence interval. Mental health and language experts modified it. In sample III, the Cronbach alpha improved to 0.775. There was a significant correlation between Hindi and English versions of final scale and statistically significant negative correlation between Survival Coping Beliefs Subscale (SCBS) score of RFLI and scores on BDI (r = -.383, <i>P</i> < .0001), BSS (r = -.474, <i>P</i> < .0001) and HAM-D (r = -.218, <i>P</i> < .0001).</p><p><strong>Conclusion: </strong>RFLI was translated into simple, comprehensible Hindi, had high Cronbach alpha. Higher the SCBS, the lower the depression (BDI) and suicidality (BSS).</p>","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 Suppl 2","pages":"S407-S414"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The missing numbers: Why India needs more data on deaths by suicide in severe mental illness. 缺失的数据:为什么印度需要更多关于严重精神疾病自杀死亡的数据。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-08-20 DOI: 10.4103/indianjpsychiatry_981_26
Vikas Menon, Sujit Sarkel, Chittaranjan Andrade
{"title":"The missing numbers: Why India needs more data on deaths by suicide in severe mental illness.","authors":"Vikas Menon, Sujit Sarkel, Chittaranjan Andrade","doi":"10.4103/indianjpsychiatry_981_26","DOIUrl":"10.4103/indianjpsychiatry_981_26","url":null,"abstract":"","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 8","pages":"669-671"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmasking the invisible: Proteomic traces of depression in human serum - A pilot study. 揭开看不见的面纱:人类血清中抑郁症的蛋白质组学痕迹-一项初步研究。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-08-20 DOI: 10.4103/indianjpsychiatry_975_25
Jiya Singh, Sabyasachi Bandyopadhyay, Anindya Das, Anissa A Mirza, Sarama Saha
{"title":"Unmasking the invisible: Proteomic traces of depression in human serum - A pilot study.","authors":"Jiya Singh, Sabyasachi Bandyopadhyay, Anindya Das, Anissa A Mirza, Sarama Saha","doi":"10.4103/indianjpsychiatry_975_25","DOIUrl":"10.4103/indianjpsychiatry_975_25","url":null,"abstract":"<p><strong>Background: </strong>Depression is a major cause of reduced productivity and increased morbidity.</p><p><strong>Aim: </strong>Given its complex and multifactorial pathophysiology, this study investigated serum proteomic profiles in individuals with depression and healthy controls to identify differentially expressed proteins and their functional significance.</p><p><strong>Methods: </strong>This is a cross-sectional observational study. Individuals with depression (<i>n</i> = 6) were enlisted from the outpatient department of psychiatry at AIIMS Rishikesh, while age-matched healthy controls (<i>n</i> = 6) were included for comparison. Peripheral whole blood samples were obtained from all participants under fasting conditions. Baseline characteristics were analyzed using Statistical Package for the Social Sciences, (IBM) 21. Continuous and categorical variables were expressed as mean ± SD and number (%), respectively. Proteomic data were analyzed and visualized using MetaboAnalyst 6.0, Cytoscape v3.10.3, Reactome Pathway, and SR plots.</p><p><strong>Result: </strong>In our main finding of the liquid chromatography-tandem mass spectrometry (LC-MS/MS) study of serum samples, a total of 242 proteins were identified, out of that 9 were upregulated and 11 were downregulated in the serum from the depression group and in the healthy control group. Receiver operating characteristic (ROC) analysis of significantly altered proteins showed strong discriminatory ability for fibrinogen, <i>PSG9</i>, and <i>AarF</i>, with area under the curves (AUCs) of 0.944, 0.889, and 0.861, respectively.</p><p><strong>Conclusion: </strong>This study identifies a distinct molecular signature of depression, with <i>PSG9, FGB, ADCK5, C8B</i>, and <i>SORCS1</i> emerging as key proteins. These markers reflect dysregulation of immune, vascular, mitochondrial, and signaling pathways, highlighting depression as a multisystem disorder, and offering potential targets for biomarker-based diagnosis and personalized therapeutic strategies.</p>","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 8","pages":"709-717"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The demand-side challenges in public mental health: A narrative study in a rural South Indian community. 公共心理健康的需求方挑战:南印度农村社区的叙事研究。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-08-17 DOI: 10.4103/indianjpsychiatry_997_24
Apurva Mittal, Lakshmi Nirisha, Channaveerachari Naveen Kumar, Nithesh Kulal, Suhas Satish, Nisha R Harshitha, Rahul Patley, Barikar C Malathesh, Ferose Azeez Ibrahim, Narayana Manjunatha, Rajani Parthasarathy, Adarsha Alur Manjappa, Jagadisha Thirthalli, Prabhat Kumar Chand, Sanjeev Arora, Suresh Bada Math
{"title":"The demand-side challenges in public mental health: A narrative study in a rural South Indian community.","authors":"Apurva Mittal, Lakshmi Nirisha, Channaveerachari Naveen Kumar, Nithesh Kulal, Suhas Satish, Nisha R Harshitha, Rahul Patley, Barikar C Malathesh, Ferose Azeez Ibrahim, Narayana Manjunatha, Rajani Parthasarathy, Adarsha Alur Manjappa, Jagadisha Thirthalli, Prabhat Kumar Chand, Sanjeev Arora, Suresh Bada Math","doi":"10.4103/indianjpsychiatry_997_24","DOIUrl":"10.4103/indianjpsychiatry_997_24","url":null,"abstract":"<p><strong>Background: </strong>In the context of public mental healthcare delivery in India, in contrast to the often highlighted challenges related to the supply side, the demand-side challenges (DSC) are rarely examined systematically.</p><p><strong>Objective: </strong>To assess the DSC in patients with psychiatric disorders and their caregivers in a rural South Indian community.</p><p><strong>Methods: </strong>This study was conducted as part of a larger implementation research in which all adults in a predefined catchment area were screened for mental disorders, followed by confirmation of diagnosis by mental health professionals. The patients were counseled about (a) the need to start/resume/continue treatment and (b) the availability of services at the nearest health facility. DSC were evaluated by a targeted question to the patient/family members on reasons for not accessing/continuing treatment.</p><p><strong>Results: </strong>Among the 268 confirmed treatment-naïve patients at baseline, only 6 (0.02%) could be convinced to contact a treatment facility within the next 8 weeks. Regarding DSCs, for all disorders put together, factors related to the illnesses themselves (aggression, hostility, intoxication with substances, absence of insight, and, in instances specific to substance use, lack of motivation to stop its use were present in almost all (98.7%) patients. Lack of perceived dysfunction/disability (42.3%) and poor awareness (24.9%) formed the other two common factors. Disorder-wise breakup showed that poor awareness was predominant in Common Mental Disorders (CMDs; 60%). Illness-related factors predominated in Severe Mental Disorders (SMDs; 66.6%) and Substance Use Disorders (SUDs; 98.7%). Lack of perceived dysfunction mattered next for SUDs (42.3%), followed by poor awareness (24.9%). For SMDs, family support-related factors (47.9%) ranked second, followed by poor awareness (25%).</p><p><strong>Conclusion: </strong>DSCs significantly contribute to the treatment gap. Merely making the treatment available and accessible will not be sufficient for people to accept it. Aggressive and sustained public health measures/campaigns need to be incorporated to effectively tackle DSCs.</p>","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 Suppl 2","pages":"S436-S444"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study of cognitive impairment in the elderly: Missteps, and opportunities missed. 老年人认知障碍的研究:失误和错失的机会。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-08-20 DOI: 10.4103/indianjpsychiatry_1256_25
Harish M Tharayil, Yugesh Rai, Bheemsain Tekkalaki, Chittaranjan Andrade
{"title":"The study of cognitive impairment in the elderly: Missteps, and opportunities missed.","authors":"Harish M Tharayil, Yugesh Rai, Bheemsain Tekkalaki, Chittaranjan Andrade","doi":"10.4103/indianjpsychiatry_1256_25","DOIUrl":"10.4103/indianjpsychiatry_1256_25","url":null,"abstract":"","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 8","pages":"768-769"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Care facilitation by Accredited Social Health Activists (ASHAs) to improve outcomes of persons with psychiatric disorders: Results from a randomized controlled trial in South India. 经认可的社会健康积极分子(ASHAs)促进护理以改善精神障碍患者的预后:来自南印度一项随机对照试验的结果
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-08-17 DOI: 10.4103/indianjpsychiatry_1013_24
Gajanan G Sabhahit, R Madan, Aishwarya John, P Lakshmi Nirisha, Rahul Patley, Nithesh Kulal, Nisha R Harshitha, Sivakami S Subramanian, Narayana Manjunatha, Jagadisha Thirthalli, Naveen Kumar, Adarsha A Manjappa, Rajani Parthasarathy, Prabhat K Chand, Sanjeev Arora, Suresh B Math
{"title":"Care facilitation by Accredited Social Health Activists (ASHAs) to improve outcomes of persons with psychiatric disorders: Results from a randomized controlled trial in South India.","authors":"Gajanan G Sabhahit, R Madan, Aishwarya John, P Lakshmi Nirisha, Rahul Patley, Nithesh Kulal, Nisha R Harshitha, Sivakami S Subramanian, Narayana Manjunatha, Jagadisha Thirthalli, Naveen Kumar, Adarsha A Manjappa, Rajani Parthasarathy, Prabhat K Chand, Sanjeev Arora, Suresh B Math","doi":"10.4103/indianjpsychiatry_1013_24","DOIUrl":"10.4103/indianjpsychiatry_1013_24","url":null,"abstract":"<p><strong>Background: </strong>The role of Accredited Social Health Activists (ASHAs) in improving short-term outcomes-symptoms, burden, and disability-for individuals with severe mental disorders (SMDs), common mental disorders (CMDs), and alcohol use disorders (AUDs) remains inadequately studied.</p><p><strong>Methods: </strong>This randomized controlled trial compared enhanced ASHA training (one-day in-person plus seven online modules over 18 months; Study Group (SG), <i>n</i> = 35) to training-as-usual (one-day in-person; Control Group (CG), <i>n</i> = 36). Both groups supported persons with SMDs (SG = 24; CG = 37), CMDs (SG = 15; CG = 20), and AUDs (SG = 31; CG = 20). Outcomes were measured using standardized disability (Indian Disability Evaluation and Assessment Scale; IDEAS), burden (Burden Assessment Scale; BAS), quality of life [EuroQol 5-Dimension 5-Level Questionnaire (EQ-5D-5L)], and disorder-specific scales (Clinical Global Impression-Schizophrenia; CGI-SCH, Kessler Psychological Distress Scale (K-10); Brief Addiction Rating Scale (BARS) and Timeline Follow back scores; TLFB) at baseline and 6-8 weeks post-baseline.</p><p><strong>Results: </strong>For CMDs, the SG showed significant improvements (<i>P</i> < 0.05) across IDEAS, WHO-DAS, BAS and K-10 than CG (only IDEAS and WHO-DAS had improved significantly), though no group-by-time interaction emerged. For SMDs, both groups improved (<i>P</i> < 0.05) on IDEAS, WHO-DAS and BAS; CG did better on CGI-SCH and EuroQol-5 as well. Additionally, only CG had a significant group-by-time effect for CGI-SCH (<i>P</i> < 0.05). In AUDs, both groups improved (<i>P</i> < 0.05) on BARS, WHO-DAS and EuroQol-5, with SG showing additional gains (<i>P</i> < 0.05) in TLFB, BAS, and IDEAS. Time*Group interaction was not significant for any of these scores.</p><p><strong>Conclusion: </strong>Trained ASHAs, with or without supplementary support, can facilitate notable short-term clinical improvements for psychiatric disorders in community settings.</p>","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 Suppl 2","pages":"S383-S391"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers for mood disorders: A scoping review of research from India. 情绪障碍的生物标志物:印度研究的范围综述。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-08-20 DOI: 10.4103/indianjpsychiatry_282_26
Varshitha Tholasappa, Varna P Baidebettu, Hariprasad G Vijaykumar, Preethi V Reddy, Rashmi Arasappa, Muralidharan Kesavan
{"title":"Biomarkers for mood disorders: A scoping review of research from India.","authors":"Varshitha Tholasappa, Varna P Baidebettu, Hariprasad G Vijaykumar, Preethi V Reddy, Rashmi Arasappa, Muralidharan Kesavan","doi":"10.4103/indianjpsychiatry_282_26","DOIUrl":"10.4103/indianjpsychiatry_282_26","url":null,"abstract":"<p><strong>Background: </strong>Mood disorders pose significant diagnostic and therapeutic challenges. While biomarkers can improve diagnostic accuracy and personalize treatment, their geographic validation remains limited.</p><p><strong>Objectives: </strong>This scoping review synthesizes evidence from biomarker studies on depressive disorder (MDD) and bipolar disorder (BD) in India to map methodological trends and identify research gaps.</p><p><strong>Methodology: </strong>Studies conducted in India evaluating biomarkers in individuals with MDD or BD diagnosed via ICD-10 or DSM-IV/DSM-5 criteria were eligible. A systematic literature search was executed across PubMed and Scopus for studies published between January 2000 and December 2024. Screening was done in Covidence. Data charting was done independently by three reviewers. Newcastle-Ottawa Scale and AXIS tools were used for quality assessment.</p><p><strong>Results: </strong>Fifty-six studies were included. In MDD, elevated levels of interleukin-6 and cortisol were consistently reported. Inflammatory markers decreased, while brain-derived neurotrophic factor levels increased following treatment. C-reactive protein, neutrophil-to-lymphocyte ratio, malondialdehyde, and cortisol levels were associated with depression severity. Neuroimaging and electroencephalography studies demonstrated fronto-limbic circuit involvement in both MDD and BD. In BD, cognitive studies consistently reported impairments in executive function, learning, and memory. Additional novel findings included abnormalities in retinal arteriolar tortuosity and eye movement.</p><p><strong>Conclusion: </strong>Biomarker findings from Indian studies largely align with evidence reported in Western Population. Methodological differences and clinical heterogeneity limit interpretation and comparability of findings. Future research should emphasize standardized methodologies, larger multicentric cohorts, and multimodal biomarker approaches as combining biological markers may offer greater diagnostic, predictive, and prognostic utility than individual biomarkers.</p>","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 8","pages":"672-682"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-blind, parallel-group randomized sham-controlled trial to evaluate the efficacy of a single-session Intervention for caregiver affiliate stigma REduction (i-CARE) in severe mental illnesses. 单盲、平行组随机假对照试验,评估重度精神疾病护理者相关污名减少(i-CARE)单期干预的疗效。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-08-20 DOI: 10.4103/indianjpsychiatry_26_26
Tanve Garg, Vishal Dhiman, Anindya Das, Naveen Grover
{"title":"Single-blind, parallel-group randomized sham-controlled trial to evaluate the efficacy of a single-session Intervention for caregiver affiliate stigma REduction (i-CARE) in severe mental illnesses.","authors":"Tanve Garg, Vishal Dhiman, Anindya Das, Naveen Grover","doi":"10.4103/indianjpsychiatry_26_26","DOIUrl":"10.4103/indianjpsychiatry_26_26","url":null,"abstract":"<p><strong>Background: </strong>Affiliate stigma among caregivers of individuals with severe mental illnesses remains a significant yet underaddressed issue, with limited evidence from randomized controlled trials evaluating targeted stigma-reduction interventions.</p><p><strong>Aim: </strong>To evaluate the effectiveness of the Intervention for Caregiver Affiliate Stigma REduction (i-CARE) in reducing affiliate stigma among caregivers of individuals with severe mental illnesses (SMIs), compared with a time- and attention-matched sham intervention, using a randomized controlled design.</p><p><strong>Methods: </strong>A single-center, randomized, single-blind, parallel-group superiority trial was conducted among 80 caregivers of individuals with SMIs, and 57 completed the 3-week follow-up assessment. The intervention group received i-CARE, a structured program targeting affiliate stigma. The control group received a sham intervention consisting of time-matched general interaction and clinical evaluation without stigma-focused components. Affiliate stigma was measured using the Affiliate Stigma Scale (ASS) at baseline and post intervention.</p><p><strong>Results: </strong>Of the enrolled participants, 54 were allocated to the intervention group and 26 to the sham group. Intention-to-treat analysis using mixed-model ANOVA demonstrated a significant main effect of time and a significant time × intervention interaction (<i>P</i> < 0.001). The intervention group showed a significant reduction in ASS scores from 48.57 ± 14.52 to 42.56 ± 11.62 (<i>P</i> < 0.001), with a moderate effect size (0.44). Improvements were sustained at the 3-week follow-up. No adverse events were reported.</p><p><strong>Conclusions: </strong>i-CARE demonstrated promising short-term effectiveness in reducing affiliate stigma among caregivers of individuals with SMIs. However, longer-term evaluations are needed to develop interventions capable of producing more durable effects.<b>Trial Registration:</b> CTRI/2022/01/039333.</p>","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 8","pages":"724-731"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of the grantathon partnership - An experiment in capacity building for mental health research. 马拉松伙伴关系的成果——精神卫生研究能力建设实验。
IF 2.4 4区 医学
Indian Journal of Psychiatry Pub Date : 2026-08-01 Epub Date: 2026-08-17 DOI: 10.4103/indianjpsychiatry_616_26
Smita N Deshpande, Ashoo Grover, Mary E Hawk, Vishwajit L Nimgaonkar
{"title":"Outcomes of the grantathon partnership - An experiment in capacity building for mental health research.","authors":"Smita N Deshpande, Ashoo Grover, Mary E Hawk, Vishwajit L Nimgaonkar","doi":"10.4103/indianjpsychiatry_616_26","DOIUrl":"10.4103/indianjpsychiatry_616_26","url":null,"abstract":"","PeriodicalId":13345,"journal":{"name":"Indian Journal of Psychiatry","volume":"68 Suppl 2","pages":"S311-S313"},"PeriodicalIF":2.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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