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Prognostic value of peripheral blood neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, pan-immune-inflammation value and systemic immune-inflammation index for the efficacy of immunotherapy in patients with advanced gastric cancer 外周血中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、泛免疫炎症值和全身免疫炎症指数对晚期胃癌患者免疫疗法疗效的预后价值
IF 2.8 4区 医学
Immunotherapy Pub Date : 2024-04-05 DOI: 10.2217/imt-2024-0031
Maodong Fu, Xiuping Zhang, Feng Shen, Jun Ma, Zhiyong Li
{"title":"Prognostic value of peripheral blood neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, pan-immune-inflammation value and systemic immune-inflammation index for the efficacy of immunotherapy in patients with advanced gastric cancer","authors":"Maodong Fu, Xiuping Zhang, Feng Shen, Jun Ma, Zhiyong Li","doi":"10.2217/imt-2024-0031","DOIUrl":"https://doi.org/10.2217/imt-2024-0031","url":null,"abstract":"Aim: The study aimed to assess the value of pretreatment peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), pan-immune-inflammation value (PIV) and systemic immune-inflammation index (SII) for predicting immunotherapy prognosis and efficacy in advanced gastric cancer (GC). Methods: A total of 84 advanced GC patients received immunotherapy were retrospectively collected. The optimal cut-off values were determined by receiver operating characteristic curves. The univariate and multivariate analysis investigated the effects of NLR, PLR, PIV and SII on patients prognosis. Results: NLR, PLR, PIV and SII had predictive value of efficacy. NLR ≥3.65 was an independent risk factor for worse outcomes. Conclusion: NLR, PLR, PIV and SII have predictive value of efficacy and NLR ≥3.65 suggests a poor prognosis following immunotherapy in advanced GC.","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":"50 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation-induced coronary artery disease during immune checkpoint inhibitor therapy: a case report. 免疫检查点抑制剂治疗期间辐射诱发的冠状动脉疾病：病例报告。
IF 2.8 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-02-05 DOI: 10.2217/imt-2023-0084
Xiajing Qian, Kequan Ding, Yi Lu
{"title":"Radiation-induced coronary artery disease during immune checkpoint inhibitor therapy: a case report.","authors":"Xiajing Qian, Kequan Ding, Yi Lu","doi":"10.2217/imt-2023-0084","DOIUrl":"10.2217/imt-2023-0084","url":null,"abstract":"<p><p>Radiation-induced coronary artery disease (RICAD) poses a serious concern for cancer patients post radiotherapy, typically emerging after over a decade. Immune checkpoint inhibitors (ICIs), known for cardiotoxicity, are increasingly recognized for causing cardiovascular complications. Here we report the case of a 63-year-old man with metastatic lung cancer who developed coronary artery disease during his third-line therapy with an ICI (nivolumab) and an antiangiogenic agent (bevacizumab), 3 years post chest radiotherapy. Angiography revealed relatively isolated stenosis in the left main coronary artery ostium, consistent with the radiotherapy site, with no other risk factors, suggesting RICAD. The potential for ICIs to accelerate RICAD development should be considered and necessitates careful surveillance in patients receiving both radiotherapy and ICIs.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"359-370"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic gastric cancer: synergizing and sequencing targeted therapy with first-line immunotherapy. 转移性胃癌：靶向治疗与一线免疫疗法的协同和排序。
IF 2.8 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-03-12 DOI: 10.2217/imt-2024-0040
Gina Colarusso, Hiba Mechahougui, Thibaud Koessler, Alex Friedlaender
{"title":"Metastatic gastric cancer: synergizing and sequencing targeted therapy with first-line immunotherapy.","authors":"Gina Colarusso, Hiba Mechahougui, Thibaud Koessler, Alex Friedlaender","doi":"10.2217/imt-2024-0040","DOIUrl":"10.2217/imt-2024-0040","url":null,"abstract":"","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"427-430"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease? 免疫检查点抑制剂对已有间质性肺病的肺癌患者是否安全有效？
IF 2.7 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-03-21 DOI: 10.2217/imt-2023-0147
Lin Zhu, Rong Gao, Han Li, Yahui Zheng, Junling Yang
{"title":"Are immune checkpoint inhibitors safe and effective in lung cancer patients with pre-existing interstitial lung disease?","authors":"Lin Zhu, Rong Gao, Han Li, Yahui Zheng, Junling Yang","doi":"10.2217/imt-2023-0147","DOIUrl":"10.2217/imt-2023-0147","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to clarify the efficacy and adverse effects of immune checkpoint inhibitors (ICIs) in the lung cancer patients with a history of interstitial lung disease (ILD). <b>Methods:</b> From the inception of the database to 4 April 2023, we systematically searched the four databases. <b>Results:</b> The objective remission rate, disease control rate, incidence of immune-associated pneumonitis (ICIP) in the combined ILD group were significantly higher than those in the non-combined ILD group. There were no significant differences between the two groups in progression-free survival, overall survival, renal insufficiency, thyroid dysfunction and gastrointestinal toxicity. <b>Conclusion:</b> Generally, a pre-existing ILD history can increase the efficacy and incidence of ICIs' adverse reactions. Therefore, ICIs should be administered with caution.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"465-480"},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of neurological adverse events among a retrospective cohort of patients receiving immune checkpoint inhibitors. 接受免疫检查点抑制剂治疗的回顾性队列中神经系统不良事件的模式。
IF 2.7 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-01-10 DOI: 10.2217/imt-2023-0273
John C Hunting, Andrew T Faucheux, Sarah N Price, Catherine A Elko, Alexander Quattlebaum, Chance Bloomer, Eric Olson, William J Petty, Thomas W Lycan
{"title":"Patterns of neurological adverse events among a retrospective cohort of patients receiving immune checkpoint inhibitors.","authors":"John C Hunting, Andrew T Faucheux, Sarah N Price, Catherine A Elko, Alexander Quattlebaum, Chance Bloomer, Eric Olson, William J Petty, Thomas W Lycan","doi":"10.2217/imt-2023-0273","DOIUrl":"10.2217/imt-2023-0273","url":null,"abstract":"<p><p><b>Aim:</b> Neurological adverse events (NAEs) are infrequent immune checkpoint inhibitor (ICI) outcomes poorly characterized in extant research, complicating their clinical management. <b>Methods:</b> This study characterized the frequency, severity, patterning and timing of NAEs using a large retrospective registry, including all patients who received at least one dose of an ICI from 2/1/2011-4/7/2022 within our health network. <b>Results:</b> Among 3137 patients, there were 54 NAEs (1.72% any grade; 0.8% grade 3-4). Most NAEs were peripheral (57.4%) versus central (42.6%). Melanoma and renal cell carcinoma were significantly associated with NAEs. <b>Conclusion:</b> The incidence of NAEs was rare though higher than many prior case estimates; the timing was consistent with other AEs. NAEs frequently occurred in tumor types known to favor brain metastases.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"381-390"},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facilitated subcutaneous immunoglobulin treatment patterns in pediatric patients with primary immunodeficiency diseases. 原发性免疫缺陷病儿科患者的皮下注射免疫球蛋白治疗模式。
IF 2.8 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-02-16 DOI: 10.2217/imt-2023-0305
Monika Mach-Tomalska, Anna Pituch-Noworolska, Ewa Bień, Magdalena Malanowska, Edyta Machura, Anna Pukas-Bochenek, Ewelina Chrobak, Małgorzata Pac, Barbara Pietrucha, Szymon Drygała, Marta Kamieniak, Jakub Kasprzak, Edyta Heropolitańska-Pliszka
{"title":"Facilitated subcutaneous immunoglobulin treatment patterns in pediatric patients with primary immunodeficiency diseases.","authors":"Monika Mach-Tomalska, Anna Pituch-Noworolska, Ewa Bień, Magdalena Malanowska, Edyta Machura, Anna Pukas-Bochenek, Ewelina Chrobak, Małgorzata Pac, Barbara Pietrucha, Szymon Drygała, Marta Kamieniak, Jakub Kasprzak, Edyta Heropolitańska-Pliszka","doi":"10.2217/imt-2023-0305","DOIUrl":"10.2217/imt-2023-0305","url":null,"abstract":"<p><p><b>Aim:</b> This retrospective study investigated real-world hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) treatment patterns in pediatric patients with primary immunodeficiency diseases (PIDs) in Poland. <b>Methods:</b> Clinical and demographic information, fSCIG treatment parameters and clinical outcomes were extracted from medical records of 28 participants (aged ≤18 years) with PIDs who received fSCIG. <b>Results:</b> 18 participants (64.3%) started fSCIG with a ramp-up (median duration: 35.5 days). 27 patients (96.4%) were administered fSCIG every 4 weeks and one patient every 3 weeks. 25 patients (89.3%) used one infusion site. No serious bacterial infections occurred. <b>Conclusion:</b> Data support the feasibility of administering fSCIG to children and adolescents with PIDs every 3-4 weeks using a single infusion site and indicate flexibility in modifying fSCIG infusion parameters. <b>Clinical Trial Registration:</b> NCT04636502 (ClinicalTrials.gov).</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"391-403"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare case of daratumumab-associated encephalopathy in multiple myeloma. 一例罕见的多发性骨髓瘤达拉曲单抗相关脑病病例。
IF 2.8 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-03-05 DOI: 10.2217/imt-2023-0321
Jingjing Xiang, Zirui Hong, Yu Zhang, Junfa Chen, Jianping Shen, Ni Zhu
{"title":"A rare case of daratumumab-associated encephalopathy in multiple myeloma.","authors":"Jingjing Xiang, Zirui Hong, Yu Zhang, Junfa Chen, Jianping Shen, Ni Zhu","doi":"10.2217/imt-2023-0321","DOIUrl":"10.2217/imt-2023-0321","url":null,"abstract":"<p><p><b>Aim:</b> Daratumumab, a CD38 monoclonal antibody, has been widely used in patients with multiple myeloma. Although a variety of adverse events have been reported, consciousness impairment has not been reported yet. We report a case of encephalopathy associated with daratumumab. <b>Case presentation:</b> A 57-year-old male, diagnosed with relapsed multiple myeloma, was treated with daratumumab. He developed a loss of consciousness after the first administration. Cerebral spinal fluid and magnetic resonance imaging of the brain suggested encephalopathy. <b>Conclusion:</b> It is recommended to be aware of rare but life threatening side effects of daratumumab. We present a case of rare encephalopathy characterized by consciousness disorder associated with daratumumab, which was successfully resolved on prompt institution of steroids, although the mechanism was unknown.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"447-452"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Established and emerging biomarkers of immunotherapy in renal cell carcinoma. 肾细胞癌免疫疗法的既有和新兴生物标记物。
IF 2.8 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-01-24 DOI: 10.2217/imt-2023-0267
Yash Jani, Caroline S Jansen, Margo B Gerke, Mehmet Asim Bilen
{"title":"Established and emerging biomarkers of immunotherapy in renal cell carcinoma.","authors":"Yash Jani, Caroline S Jansen, Margo B Gerke, Mehmet Asim Bilen","doi":"10.2217/imt-2023-0267","DOIUrl":"10.2217/imt-2023-0267","url":null,"abstract":"<p><p>Immunotherapies, such as immune checkpoint inhibitors, have heralded impressive progress for patient care in renal cell carcinoma (RCC). Despite this success, some patients' disease fails to respond, and other patients experience significant side effects. Thus, development of biomarkers is needed to ensure that patients can be selected to maximize benefit from immunotherapies. Improving clinicians' ability to predict which patients will respond to immunotherapy and which are most at risk of adverse events - namely through clinical biomarkers - is indispensable for patient safety and therapeutic efficacy. Accordingly, an evolving suite of therapeutic biomarkers continues to be investigated. This review discusses biomarkers for immunotherapy in RCC, highlighting current practices and emerging innovations, aiming to contribute to improved outcomes for patients with RCC.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"405-426"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sex and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis. 性别与免疫检查点抑制剂疗效之间的关系：系统综述与荟萃分析。
IF 2.8 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI: 10.2217/imt-2023-0307
Jianxiong Lai, Xiaohong Kuang, Yi Fu, Jian Li
{"title":"Association between sex and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis.","authors":"Jianxiong Lai, Xiaohong Kuang, Yi Fu, Jian Li","doi":"10.2217/imt-2023-0307","DOIUrl":"10.2217/imt-2023-0307","url":null,"abstract":"<p><p><b>Aim:</b> To explore the association between sex and immune checkpoint inhibitors (ICIs). <b>Materials & methods:</b> We assessed the difference in survival outcomes from ICIs between sexes using an interaction test. <b>Results:</b> 108 studies representing 70,243 patients were included. In the first-line setting, the pooled interaction HR was 0.97 (95% CI: 0.91-1.04). In the subsequent-line setting, the pooled interaction HR was 0.85 (95% CI: 0.77-0.95). When ICIs were given as perioperative therapy or as systemic therapy in patients with positive PD-L1 expression, both men and women obtained equal survival benefits. <b>Conclusion:</b> Both sex, line of therapy, cancer (sub)type and PD-L1 status should be taken into account in the assessment of risk versus benefit when deciding to offer ICIs to patients.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"481-495"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upadacitinib for the treatment of moderate-to-severe Crohn's disease. 用于治疗中重度克罗恩病的奥帕他替尼。
IF 2.8 4区 医学
Immunotherapy Pub Date : 2024-04-01 Epub Date: 2024-02-16 DOI: 10.2217/imt-2023-0293
Jurij Hanzel, Christopher Ma, Vipul Jairath
{"title":"Upadacitinib for the treatment of moderate-to-severe Crohn's disease.","authors":"Jurij Hanzel, Christopher Ma, Vipul Jairath","doi":"10.2217/imt-2023-0293","DOIUrl":"10.2217/imt-2023-0293","url":null,"abstract":"<p><p>Despite an increasing number of therapies for Crohn's disease (CD), half of patients do not respond to initial treatment or lose response over time, highlighting the need for novel therapies. Inhibition of Janus kinases (JAKs) has emerged as an important therapeutic target for CD. Upadacitinib is an orally administered selective JAK1 inhibitor, which is effective for the induction and maintenance of remission in moderately-to-severely active CD, including in patients with prior failure of biological therapy. Nonselective JAK inhibition has been associated with thromboembolic disease, cardiovascular events and malignancy in patients older than 50 years with rheumatoid arthritis and pre-existing cardiovascular risk factors, which should be considered upon prescription. Upadacitinib is the first and currently only oral advanced therapy for CD.</p>","PeriodicalId":13328,"journal":{"name":"Immunotherapy","volume":" ","pages":"345-357"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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