Indian Journal of Pediatrics最新文献_第2页

Diagnostic Value of the Cerebrospinal Fluid Heparin-binding Protein for Pediatric Bacterial Intracranial Infections. 脑脊液肝素结合蛋白对小儿颅内细菌性感染的诊断价值。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-18 DOI: 10.1007/s12098-025-05615-6

Andika Priamas Nugrahanto, Agung Triono, Dian Kesumapramudya Nurputra, Rais Alliffandy Damroni, Elisabeth Siti Herini

引用次数: 0

Short-Term Efficacy of Eculizumab Therapy in Atypical Hemolytic Uremic Syndrome. Eculizumab治疗非典型溶血性尿毒症综合征的短期疗效。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-18 DOI: 10.1007/s12098-025-05595-7

Tanvi Bindal, Aditi Sinha, Anand N Tiwari, Pankaj Hari, Arvind Bagga

引用次数: 0

Management of Cyclic Vomiting Syndrome with Valproate in a Child with Severe Motor and Intellectual Disabilities. 丙戊酸钠治疗重度运动和智力障碍儿童的周期性呕吐综合征。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-26 DOI: 10.1007/s12098-025-05630-7

Hiroaki Hitomi, Yuji Fujita, Sonoe Kaneko, Hirofumi Hamada, Shun Watanabe, Yoshiyuki Watabe, Kan Suzuki, George Imataka, Shigemi Yoshihara

引用次数: 0

Effective but Elusive: Emicizumab for Hemophilia A in India. 有效但难以捉摸：Emicizumab在印度治疗血友病A。

IF 2 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 DOI: 10.1007/s12098-025-05696-3

Swetha Palla, Deepak Bansal

引用次数: 0

Valproate Induced Thrombocytopenia and Pseudo-Pelger-Huët Anomaly: A Diagnostic Clue from Peripheral Smear. 丙戊酸诱发的血小板减少症和Pseudo-Pelger-Huët异常：外周涂片的诊断线索。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2025-05-31 DOI: 10.1007/s12098-025-05597-5

Ananya Mullick, Ipsita Mahapatra, Sajal Jain, Pamali Mahasweta Nanda

引用次数: 0

Clinico-Radiological and Genotypic Spectrum of Nuclear Mitochondriopathies: Correspondence. 核线粒体病的临床放射学和基因型谱：对应。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI: 10.1007/s12098-025-05598-4

Josef Finsterer

引用次数: 0

Recurrent Neurotoxicity in Cobra Envenomation: Correspondence. 眼镜蛇中毒的复发性神经毒性：对应。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1007/s12098-025-05613-8

Santosh Govind Rathod, Raksha Thakur

引用次数: 0

Diagnostic Value of Single LH and LH/FSH Ratio at 60-minute after GnRHa Stimulation Test for Central Precocious Puberty. GnRHa 刺激试验后 60 分钟的单次 LH 和 LH/FSH 比率对中枢性性早熟的诊断价值。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2024-05-13 DOI: 10.1007/s12098-024-05137-7

Qingling Wang, Dan Wu, Qian Zeng, Chuanwei Ban, Ling Wang, Xin Lv

{"title":"Diagnostic Value of Single LH and LH/FSH Ratio at 60-minute after GnRHa Stimulation Test for Central Precocious Puberty.","authors":"Qingling Wang, Dan Wu, Qian Zeng, Chuanwei Ban, Ling Wang, Xin Lv","doi":"10.1007/s12098-024-05137-7","DOIUrl":"10.1007/s12098-024-05137-7","url":null,"abstract":"Objectives: To evaluate the diagnostic value of luteinizing hormone (LH) and LH/follicle stimulating hormone (FSH) ratio at 60 min after gonadotropin-releasing hormone analogs (GnRHa) stimulation test for central precocious puberty (CPP) in girls.Methods: Two hundred and fifty-seven girls, aged 3 to 7.5 y, suspected of precocious puberty at authors' hospital from April 2020 through November 2023 were enrolled in the study. The blood was taken at 0, 30, 60 min after GnRHa stimulation test, and LH and LH/FSH were detected by chemiluminescence assay. The diagnostic efficacy was analysed by Mann-Whitney U test, spearman's correlation analysis and receiver operating characteristic (ROC) analysis. The proportion of obesity was analysed by Chi-square test.Results: LH and LH/FSH at different times were statistically significantly different (P <0.05) between the CPP and non-CPP groups. Spearman's correlation analysis showed that the level of LH and LH/FSH at 60 min had the strongest consistency with the peak of LH (r = 0.9988, P <0.001) and LH/FSH (r = 0.9981, P <0.001). ROC curve analysis showed that the area under the ROC curves at 60 min of LH and LH/FSH were 0.975 and 0.997 with a cut-off value of 5.70 IU/L and 0.609, respectively.Conclusions: The peak of LH and LH/FSH in the diagnosis of CPP can be determined by LH and LH/FSH at 60 min after the triptorelin acetate is injected. This will reduce the number of blood draws required compared with the traditional stimulation test, which is more effective and acceptable for children.","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"853-859"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of PaO₂/FiO₂ (PF ratio) to SpO₂/FiO₂ (SF ratio) and OI to OSI for Predicting Short Term Outcomes in Children with Acute Hypoxemic Respiratory Distress: A Prospective Observational Study. 比较 PaO2/FiO2（PF 比值）与 SpO2/FiO2（SF 比值）和 OI 与 OSI，以预测急性低氧血症呼吸窘迫儿童的短期预后：一项前瞻性观察研究。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2024-06-07 DOI: 10.1007/s12098-024-05134-w

Niyati Shah, Bhakti U Sarangi, Guruprasad Hassan Shankar, Ajay Walimbe

{"title":"Comparison of PaO2/FiO2 (PF ratio) to SpO2/FiO2 (SF ratio) and OI to OSI for Predicting Short Term Outcomes in Children with Acute Hypoxemic Respiratory Distress: A Prospective Observational Study.","authors":"Niyati Shah, Bhakti U Sarangi, Guruprasad Hassan Shankar, Ajay Walimbe","doi":"10.1007/s12098-024-05134-w","DOIUrl":"10.1007/s12098-024-05134-w","url":null,"abstract":"Objectives: To compare PaO2/FiO2 (PF ratio) to SpO2/FiO2 (SF ratio) and oxygenation index (OI) to oxygenation saturation index (OSI) for predicting short term outcomes [mortality, progression to ventilation and ventilator free days (VFD)] and compare trends of S/F and OSI in predicting early mortality in children with acute hypoxemic respiratory distress.Methods: This prospective observational study included 200 consecutive children with acute hypoxemic respiratory distress. Serial PF and SF ratios calculated at 0, 6, 24 and 48 h were compared and their trends were utilized for prediction of 28 d mortality. Same was done in ventilated patients using OI and OSI.Results: SF ratio at admission had a 72% sensitivity and 60% specificity while PF had a sensitivity of 78% and a specificity of 75% for prediction of mortality. The area under the curve (AUC) for SF ratio was 0.82 (CI: 0.688-0.915). Serial SF ratios accurately predicted mortality. OI had sensitivity of 92% and specificity of 95% in predicting 24 and 48 h mortality. OSI had 95% sensitivity and 92% specificity in predicting mortality with AUC 1.000 (CI- 1.00-1.00) at 24 and 48 h post ventilation. Serially increasing OI and OSI trends had an inverse correlation with VFDs (p <0.01).Conclusions: SF is a reliable surrogate for PF and a useful predictor of progression to ventilation and survival at discharge while OSI is a useful marker of worsening hypoxia and mortality in ventilated patients.","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"823-829"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal Onset Seizures and Hypotonia Due to D-Bifunctional Protein Deficiency. d -双功能蛋白缺乏引起的新生儿癫痫发作和肌张力低下。

IF 2.1 4区医学

Indian Journal of Pediatrics Pub Date : 2025-08-01 Epub Date: 2025-05-22 DOI: 10.1007/s12098-025-05582-y

Sohier Yahia, Dina Ghozzy, Yahya Wahba, Zahraa Abdelmoneim

{"title":"Neonatal Onset Seizures and Hypotonia Due to D-Bifunctional Protein Deficiency.","authors":"Sohier Yahia, Dina Ghozzy, Yahya Wahba, Zahraa Abdelmoneim","doi":"10.1007/s12098-025-05582-y","DOIUrl":"10.1007/s12098-025-05582-y","url":null,"abstract":"Peroxisomal disorders (PDs) are a diverse group of inherited conditions arising from impaired function of a specific peroxisomal enzyme, metabolite transporter, or defect in the peroxisome biogenesis system. Peroxisomal D-bifunctional protein (DBP) deficiency is generally classified as a Zellweger-like syndrome. This disorder is caused by mutations in the HSD17B4 gene, and only a limited number of confirmed cases have been reported to date.The authors report case of a 6-mo-old female infant presenting with neonatal-onset intractable seizures, characteristic facial features, hypotonia, and progressive hepatomegaly. An acylcarnitine profile revealed elevated very long-chain fatty acids, prompting the initiation of a medium-chain triglyceride (MCT) formula. Remarkably, this treatment led to seizure control, improved muscle tone, and a reduction in liver size. Whole exome sequencing identified a homozygous missense mutation in the HSD17B4 gene (c.1444A>T).This case suggests that MCT-containing formulas may offer therapeutic potential in the treatment of D-bifunctional protein deficiency.","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"860-862"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0