Indian Journal of Pediatrics最新文献

{"title":"Nutritional Status Assessment and its Association with Rotavirus Positivity Among Children Aged Under 5 Years Hospitalized with Diarrhea in Odisha, India.","authors":"Prasantajyoti Mohanty, Pravakar Mishra, Subal Kumar Pradhan, Lipsa Roul, Rajib Kumar Ray, Varsha Sudhir Chaudhary, Anupama Machathi, Namrata Kharat, Tintu Varghese, Ayyappan Vellathur Ramasamy","doi":"10.1007/s12098-025-05781-7","DOIUrl":"https://doi.org/10.1007/s12098-025-05781-7","url":null,"abstract":"<p><strong>Objectives: </strong>Diarrhea and malnutrition contribute substantially to morbidity and mortality in children aged under 5 y. Rotavirus infection is the leading cause of diarrhea-associated death in children, and malnutrition can aggravate diarrhea severity. This study aimed to assess the nutritional status and its association with rotavirus positivity among children aged under 5 y hospitalized with acute gastroenteritis in Odisha.</p><p><strong>Methods: </strong>This prospective observational study was conducted between January and December 2023 among children aged under 5 y hospitalized with acute gastroenteritis in tertiary care hospitals in Odisha. Data were collected on children's sociodemographic and clinical characteristics and nutritional status, and stool samples were tested for rotavirus. Nutritional status (underweight, stunting, and wasting) was assessed following World Health Organization anthropometry guidelines.</p><p><strong>Results: </strong>Of the 365 children enrolled, 68.5% were aged 0-23 mo, 33.7% were underweight, 49% had stunting, and 20% had wasting. Rotavirus was detected in 23.3% of the stool samples tested. Nutritional status was not significantly associated with rotavirus positivity. Stunting was more prevalent among children aged 24-59 mo, whereas underweight and wasting were more prevalent among children aged 0-23 mo. Stunting was more prevalent among boys than among girls.</p><p><strong>Conclusions: </strong>Malnutrition remains prevalent among children hospitalized with acute gastroenteritis in Odisha. However, nutritional status was not associated with rotavirus positivity. The results imply that, to improve child health outcomes, integrated strategies that address both malnutrition and rotavirus infection, focusing on nutrition, vaccination, and improved sanitation, are required.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Diabetic Hyperglycemic Emergencies in Children: Authors' Reply.","authors":"Aanandi Dhavan, Vishal Guglani, Vidushi Mahajan","doi":"10.1007/s12098-025-05761-x","DOIUrl":"https://doi.org/10.1007/s12098-025-05761-x","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red Ear Syndrome as a Precursor to Migraine in an Adolescent.","authors":"Esra Ulgen Temel","doi":"10.1007/s12098-025-05797-z","DOIUrl":"https://doi.org/10.1007/s12098-025-05797-z","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Structural and Functional Assessment in Fetal Growth Restriction Infants-A Cohort Study.","authors":"Vidya Nayak, Ashwal A Jayaram, Leslie Edward Lewis, Jyothi Samanth, Krishnananda Nayak, Karthik A Naik, Mullaguri Sruthi, Sona R N","doi":"10.1007/s12098-025-05762-w","DOIUrl":"https://doi.org/10.1007/s12098-025-05762-w","url":null,"abstract":"<p><p>In this study, cardiac changes and catch-up growth were assessed in neonates with fetal growth restriction (FGR) over six months. A total of 77 FGR and 73 adequate-for-gestational age (AGA) neonates underwent biophysical profiling and echocardiographic assessment, including myocardial deformation analysis, within the first week of life. Follow-up evaluations were conducted at six months. Findings revealed that FGR neonates had smaller cardiac dimensions and reduced myocardial function, with significantly lower left ventricular global longitudinal strain and early diastolic strain rate, despite preserved ejection fraction. These abnormalities persisted at six months, even as biophysical profiles approached normal. However, the improvement in myocardial deformation was still lower than in AGA neonates, indicating ongoing subclinical myocardial dysfunction. The study highlights that while FGR infants may show catch-up growth, underlying cardiac functional differences remain, emphasizing the importance of long-term cardiac monitoring in this population to detect subtle but significant functional impairments.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vardenafil vs. Sildenafil for the Treatment of Persistent Pulmonary Hypertension in Newborns.","authors":"Sania El-Hindi","doi":"10.1007/s12098-025-05787-1","DOIUrl":"https://doi.org/10.1007/s12098-025-05787-1","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial Ornithine Transcarbamylase (OTC) Deficiency.","authors":"Mugundhakumar Balashanmugam, Daisy Khera, Ashwini Chityala, Lokesh Kumar, Mahesh Maddimani, Sarbesh Tiwari, Lokesh Saini","doi":"10.1007/s12098-025-05790-6","DOIUrl":"https://doi.org/10.1007/s12098-025-05790-6","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Hand Hygiene Compliance Among the Healthcare Personnel in the Neonatal Intensive Care Unit: A Quality Improvement Study.","authors":"Mandeep Goriya, Vimlesh Soni, Shalini Dhiman, Animesh Debbarma","doi":"10.1007/s12098-025-05789-z","DOIUrl":"https://doi.org/10.1007/s12098-025-05789-z","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotyping of Rotavirus Gastroenteritis in Kerala, India, in the Postvaccination Period (2020-2023).","authors":"Aparna Namboodiripad, Rose Xavier, Priya Sreenivasan, Vellani Thamunni Ajithkumar, Madona Devassikutty Fiji, Shermin Nasreen Abdul Jaleel, Gibi George, Nithya Thuruthiyath, Varsha Sudhir Chaudhary, Namrata Kharat, Anupama Machathi, Ragavi Lingam, Tintu Varghese, Meera Mary Alappat","doi":"10.1007/s12098-025-05771-9","DOIUrl":"https://doi.org/10.1007/s12098-025-05771-9","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Clinical Profile of Rotavirus Diarrhea in Children Aged Under 5 Years in Kerala, India After the Introduction of Rotavirus Vaccination: A Surveillance Study.","authors":"Vellani Thamunni Ajithkumar, Madona Devassikutty Fiji, Shermin Nasreen Abdul Jaleel, Aparna Namboodiripad, Priya Sreenivasan, Rose Xavier, Varsha Sudhir Chaudhary, Tintu Varghese, Namrata Kharat, Anupama Machathi, Ragavi Lingam","doi":"10.1007/s12098-025-05775-5","DOIUrl":"https://doi.org/10.1007/s12098-025-05775-5","url":null,"abstract":"<p><strong>Objectives: </strong>ROTASIIL^®, an indigenous oral pentavalent rotavirus vaccine, was included in the Universal Immunization Program of Kerala in September 2019. This study aimed to describe the epidemiology and clinical profile of rotavirus diarrhea among children aged under 5 y in Kerala in the postvaccination period.</p><p><strong>Methods: </strong>This prospective observational study was conducted at three tertiary-care hospitals in Kerala from November 2020 to December 2023. Children aged under 5 y who were hospitalized with acute diarrhea were enrolled. Stool samples were collected from participants and tested for rotavirus using an enzyme-linked immunosorbent assay. Rotavirus-positive samples were genotyped.</p><p><strong>Results: </strong>Of the 666 children enrolled, 643 had a stool sample tested for rotavirus, of which 17.9% tested positive. Rotavirus diarrhea occurred throughout the year, with a small peak between December and February. Most children with acute rotavirus diarrhea (56.5%) were aged 24-59 mo. The incidence of rotavirus-positive and rotavirus-negative acute diarrhea was higher among boys than among girls (male-to-female ratio of 1.3:1 and 1.5:1, respectively). The prevalence of rotavirus positivity was lower in children who had received three doses of oral rotavirus vaccine, ROTASIIL^® than in unvaccinated children (13.9% vs. 26.4%). G3P[8] was the dominant rotavirus genotype throughout the study period. No fatal cases of rotavirus diarrhea were reported.</p><p><strong>Conclusions: </strong>In children hospitalized with acute diarrhea, the prevalence of rotavirus was lesser among vaccinated than unvaccinated children. Monitoring of age shift, breakthrough infections in vaccinated children, and genotypic surveillance of emerging rotavirus genotypes are required to inform the development of next-generation vaccines.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Lateralized Overgrowth - Phenotypic Spectrum and Molecular Alterations.","authors":"Sakshi Yadav, R C Madhumita, Neerja Gupta, Sandeepa Chauhan, Shweta Kusmakar, Prahlad Balakrishnan, Manisha Jana, Ratna D Puri, Shubha R Phadke, Madhulika Kabra","doi":"10.1007/s12098-024-05273-0","DOIUrl":"10.1007/s12098-024-05273-0","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the molecular aberrations at 11p15.5 locus in thirty-two patients with isolated lateralized overgrowth (ILO).</p><p><strong>Methods: </strong>Among selected 32 cases of ILO, methylation-sensitive multiplex ligation-dependent probe amplification (MS-MLPA) was performed initially followed by short tandem repeats (STR) marker analysis to confirm uniparental disomy (UPD). In those patients with normal MLPA reports, cyclin dependent kinase inhibitor 1C (CDKN1C) gene and whole exome sequencing was performed.</p><p><strong>Results: </strong>Molecular analysis by MS-MLPA showed methylation aberrations in 28% (9/32) of patients. Gain of methylation at IC1 imprinting center (H4, H7) and loss of methylation at IC2 (H6, H9) was observed in 2 patients each. Uniparental disomy was observed in 9% cases. Except one, all patients with methylation aberration had more than one limb hypertrophy. Two patients (H22/H29) also had loss of methylation at IC1. Though this molecular alteration is specifically associated with Silver Russel syndrome (SRS), but the affected children did not completely fulfill the diagnostic criteria for SRS. In a recent study, a discrepancy was reported between the diagnosis of Beckwith-Wiedemann syndrome (BWS)/SRS and the molecular findings in the patients. Many times, it is very difficult to differentiate between hemi hypertrophy/hemi hypotrophy. Patients, in whom no aberrations were detected on MS-MLPA, whole exome sequencing (WES) was performed and no pathogenic variant was identified.</p><p><strong>Conclusions: </strong>Thus, ILO may be considered as a mild presentation on the extreme edge of BWS spectrum with methylation aberration and UPD in one third of cases which has implications in follow up.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"1049-1055"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}