{"title":"Interventional Nerve Procedures for Pain Related to Head-and-Neck Cancer: A Systematic Review.","authors":"Alexandre Yamada Fujimura Júnior, Dayse Mirian Nunes Araujo, Jairo Pinheiro da Silva","doi":"10.25259/IJPC_180_2025","DOIUrl":"10.25259/IJPC_180_2025","url":null,"abstract":"<p><p>To systematically review the evidence on the use of peripheral nerve interventions, including anaesthetic blocks, neurolysis and radiofrequency techniques, for the management of cancer-related pain in patients with head-and-neck malignancies. The review aimed to assess their clinical efficacy, access routes, safety profiles and associated complications. This systematic review was registered in PROSPERO (CRD42024564969) and conducted according to the Cochrane Handbook and Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. A comprehensive search was performed in PubMed, Embase and the Cochrane Library through July 2024. Included studies evaluated peripheral nerve interventions in head-and-neck cancer (HNC) patients reporting at least one predefined outcome. Data on pain relief, duration of effect, medication use and adverse events were extracted. Risk of bias (ROB) was assessed using the Joanna Briggs Institute tools and ROB 2, depending on study design. Twenty-eight studies involving 536 patients were included. Of these, 298 received anaesthetic nerve blocks, 74 underwent neurolytic procedures, and 164 were treated with radiofrequency-based interventions. Sphenopalatine ganglion block and glossopharyngeal nerve block were the most frequently reported anaesthetic techniques, both demonstrating good efficacy and favourable safety profiles. Neurolytic procedures targeting superficial nerves (e.g., sphenopalatine, occipital, auriculotemporal) were generally effective and well tolerated. Neurolysis of the glossopharyngeal nerve showed promising results but was associated with greater anatomical risk and limited safety data. Pulsed and thermal radiofrequency (PRF/TRF) targeting the glossopharyngeal and trigeminal nerves were effective, with PRF showing a better safety profile. TRF was associated with transient dysphagia, sensory changes and reduced gag reflex. No major complications were reported across studies. However, outcomes and techniques varied widely, and most studies were case reports or small case series, often with a high ROB. Peripheral nerve interventions, particularly sphenopalatine and glossopharyngeal blocks, may be effective and safe options for pain management in HNC patients. Larger, high-quality trials are needed to confirm these findings and support broader clinical use.</p>","PeriodicalId":13319,"journal":{"name":"Indian Journal of Palliative Care","volume":"32 2","pages":"121-128"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Translation and Validation of the Khasi version of European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C-30) and Oesophageal Cancer module (EORTC QLQ-OES-18).","authors":"Samapti Debnath, Caleb Harris, Shanthosh Priyan Sundaram","doi":"10.25259/IJPC_192_2025","DOIUrl":"10.25259/IJPC_192_2025","url":null,"abstract":"<p><strong>Objectives: </strong>Oesophageal cancer (OC) is characterised by poor prognosis, a significant reduction in Quality of Life (QoL) and requirement for morbid therapy. The highest age-adjusted rate of OC incidence in India was seen in the East Khasi Hills district of Meghalaya, being 10 times the national average. This study aimed to develop and validate Khasi translations of the European Organisation for Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C-30) Version 3.0 and EORTC QLQ-OES-18 questionnaires for use in the Khasi-speaking population of Meghalaya.</p><p><strong>Materials and methods: </strong>This study was conducted as a part of a hospital-based cross-sectional study to develop and validate a Khasi-translated version of the QLQ-C-30 and QLQ-OES-18 questionnaires. The questionnaire was translated into the local (Khasi) language and validated (two-phase process: Two forward translations, two backward translations, followed by pilot testing). Reliability assessment was done using Cronbach's alpha. The construct validity and the correlation of each scale of the QLQ-C30 and QLQ-OES18 were evaluated using Spearman's correlation coefficient (r).</p><p><strong>Results: </strong>Cronbach's alpha was satisfactory (>0.70) for all the scales of QLQ-C-30 and QLQ-OES-18. Convergent validity was moderate to high (r = 0.541 to 0.995) (Global health domain convergent validity r = 0.983-0.995), whereas discriminant validity was acceptably low (Global health domain divergent validity of r = 0.006-0.474) for all scales. Correlation coefficient values for each scale between QLQ-C-30 and QLQ-OES-18 ranged from 0.001 to 0.557.</p><p><strong>Conclusion: </strong>The Khasi versions of the QLQ-C-30 and QLQ-OES-18 demonstrate good psychometric validity, proving to be a reliable and culturally appropriate valuable tool for assessing QoL in OC patients in the Khasi-speaking population of North-East India.</p>","PeriodicalId":13319,"journal":{"name":"Indian Journal of Palliative Care","volume":"32 2","pages":"175-182"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Effectiveness of Pharmacotherapy, Cognitive Behavioural Therapy and their Combination for Depression and Anxiety in Newly Diagnosed Cancer Patients: A 6-week Prospective Observational Study.","authors":"Prashant Babubhai Patel, Nisheet Patel, Rajesh Hadia, Aastha Dave, Yatri Dave, Niyati Jayeshbhai Patel","doi":"10.25259/IJPC_235_2025","DOIUrl":"10.25259/IJPC_235_2025","url":null,"abstract":"<p><strong>Objectives: </strong>Despite the recent rise in cancer prevalence in India, psychological support is largely ignored. There is very less research on effectiveness of cognitive behavioural therapy (CBT) and pharmacotherapy (PT) as treatment options for psychological distress in cancer patients in India. So, this study was planned to evaluate the relative efficacy of PT, CBT, and their combination in reducing anxiety and depressive symptoms in newly diagnosed cancer patients referred for psychiatric evaluation at a tertiary care hospital in India.</p><p><strong>Materials and methods: </strong>Between January 2022 and December 2024, newly diagnosed adult cancer patients referred for psychiatric evaluation were enrolled in the study. Of the 456 patients, 32 (6.9%) had a positive screening for generalised anxiety disorder and 75 (16.4%) for major depressive disorder. The Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 5<sup>th</sup> Edition Disorders, Clinician Version was used to confirm the diagnosis for these patients. Patients selected (1) eight sessions of CBT, (2) selective serotonin reuptake inhibitors (SSRIs) (PT) or (3) both (combination therapy [COMB]). Depression and anxiety severity were assessed using the Hamilton Depression Rating Scale (HAM-D) and Hamilton Anxiety Rating Scale (HAM-A), respectively. The minimal clinically important difference (MCID) was defined as a ≥3-point reduction in HAM-D and a ≥2-point reduction in HAM-A. A comparison of reductions in scale scores was made at baseline and at 6 weeks.</p><p><strong>Results: </strong>In the depression cohort (<i>n</i> <b>=</b> 75), for PT (<i>n</i> = 38), CBT (<i>n</i> = 19) and COMB (<i>n</i> = 18), mean HAM-D change was -2.8 ± 0.7 (standard error [SE] 0.12, 95% confidence interval [CI] [2.57, 3.03]), -0.8 ± 0.5 (SE 0.12, 95% CI [0.53, 1.01]) and -9.3 ± 8.9 (SE 2.10, 95% CI [5.14, 13.36]); baseline-adjusted Analysis of Covariance F(2,72) = 48.1, <i>p</i> < 0.001, partial h<sup>2</sup> = 0.57. COMB exceeded HAM-D MCID in every participant and achieved 33% remission. The mean change in HAM-A (<i>n</i> = 32) was -3.9 ± 1.9 (SE 0.56, 95% CI [2.79, 4.99]) (PT, <i>n</i> = 12), -3.8 ± 1.7 (SE 0.49, 95% CI [2.79, 4.71]) (CBT, <i>n</i> = 12) and -3.5 ± 1.4 (SE 0.50, 95% CI [2.52, 4.48]) (COMB, <i>n</i> = 8); the difference between the groups was not significant (F(2,29)=0.54, <i>p</i> = 0.59). All arms exceeded the HAM-A MCID threshold; however, response rates (≥50% reduction) remained ≤13%.</p><p><strong>Conclusion: </strong>Combined PT (SSRI) and CBT showed the most significant improvement in depression symptoms, while all treatment approaches provided comparable relief for anxiety. The study underlines the importance of integrated care in oncology and advocates a combined approach to treating cancer patients with depression and anxiety. Further research is needed to optimise treatments for anxiety, particularly in settings with limi","PeriodicalId":13319,"journal":{"name":"Indian Journal of Palliative Care","volume":"32 2","pages":"198-206"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kavi Nila David Retina, Sonu Hangma Subba, Manish Taywade
{"title":"Needs Assessment of Patients Requiring End-of-Life Care: A Community-based Cross-sectional Study.","authors":"Kavi Nila David Retina, Sonu Hangma Subba, Manish Taywade","doi":"10.25259/IJPC_223_2025","DOIUrl":"10.25259/IJPC_223_2025","url":null,"abstract":"<p><strong>Objectives: </strong>The first step in implementing comprehensive palliative care is to assess the need for it within the community. Therefore, our study aimed to determine the number of individuals requiring end-of-life care in the rural sectors in the peri-urban area and to evaluate the unmet needs of the identified patients.</p><p><strong>Materials and methods: </strong>Data triangulation was conducted using information from health workers in the respective villages, cancer registry data from the District Headquarters Hospital, and snowball sampling. The identified patients were interviewed using a semi-structured questionnaire that included socio-demographic information, disease details and assessments across four domains of palliative care.</p><p><strong>Results: </strong>A total of 225 patients were identified. Among these patients, 55.9% were over the age of 60 years, while 8.0% were children and adolescents. The most common diseases identified included cerebrovascular disease, heart disease, frailty, cancer and chronic kidney disease among adults and cerebral palsy among children. The prevalent physical issues reported were immobility, pain, fatigue, breathlessness and constipation. Approximately two-thirds of the patients expressed concerns regarding their future and financial issues. Three out of four patients reported difficulties in performing daily activities. Most of the patients attributed their source of strength to their relationships with others, followed by their faith in God. Socioeconomic factors such as education, occupation, family type and income were found to influence various domains of palliative care, except the spiritual domain.</p><p><strong>Conclusion: </strong>In the studied population, 4.3 individuals/1,000 required end-of-life care. In addition, all four domains of care exhibited unmet needs. These needs can be addressed through policy implementation and the integration of palliative care into primary care services.</p>","PeriodicalId":13319,"journal":{"name":"Indian Journal of Palliative Care","volume":"32 2","pages":"152-158"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Spirituality as a Coping Method for Psychological Distress in People Living with HIV/AIDS.","authors":"Eleanor Melinda Joseph, Sunil Abraham, Jessie Lionel","doi":"10.25259/IJPC_174_2025","DOIUrl":"10.25259/IJPC_174_2025","url":null,"abstract":"<p><strong>Objectives: </strong>Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome disease is one of the most devastating illnesses, which has a significant negative impact on the biopsychosocial and spiritual well-being, with a high prevalence of psychological distress (PD). Spiritual coping is observed to reduce PD. This study aimed to identify the presence of PD among patients living with HIV (PLHIV), assess their spirituality and spiritual coping, and the association with PD.</p><p><strong>Materials and methods: </strong>This descriptive study employed a cross-sectional design. A sample of 50 PLHIV was selected from the Infectious Disease Clinic and the antiretroviral therapy (ART) Centre of a tertiary hospital. Selected demographic and clinical data were collected. The general health questionnaire (GHQ), World Health Organization quality of life (QOL)-100 Domain VI, with QOL 100 additional spiritual, religious and personal beliefs questionnaire, and Spiritual Coping Methods Assessment Questionnaire were administered to measure PD, spirituality and utilisation of spiritual coping methods, respectively. The data were analysed using frequency, percentage and Chi-square.</p><p><strong>Results: </strong>The findings indicated that 28% of PLHIV had PD, and 92% had a high spirituality score. The spirituality was inversely related to PD (X<sup>2</sup> = 13.8, <i>p</i> < 0.001). The majority (86%) of patients had high utilisation of personal and corporate spiritual coping methods. Those patients who utilised more personal and corporate coping methods were found to have less PD. Gender, marital status, occupation, time of diagnosis, stage of disease and ART status showed no significant association with PD.</p><p><strong>Conclusion: </strong>PD prevalent in PLHIV is significant, and patients who had a high spirituality score and used more spiritual coping methods were found to have less PD. Therefore, PD among PLHIV must be evaluated and spiritual needs addressed as a part of HIV care. Patient-centred spiritual coping strategies can be considered during counselling of PLHIV.</p>","PeriodicalId":13319,"journal":{"name":"Indian Journal of Palliative Care","volume":"32 2","pages":"183-189"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vijayakanth Subramanian, Bharath V S S K Talagadadeevi, Subhadra Goala, Kapil Malik, Ravi Kannan
{"title":"Reducing Treatment Deferral in Head and Neck Cancer Patients: A Quality Improvement Study.","authors":"Vijayakanth Subramanian, Bharath V S S K Talagadadeevi, Subhadra Goala, Kapil Malik, Ravi Kannan","doi":"10.25259/IJPC_58_2025","DOIUrl":"10.25259/IJPC_58_2025","url":null,"abstract":"<p><strong>Objectives: </strong>Head and neck cancer (HNC) is a significant health burden in India, with high rates of treatment deferral leading to poorer outcomes. Treatment deferral, in a resource constraint settings, is a critical issue due to sociocultural, economic and logistical challenges. The study aimed to reduce the treatment deferral rate for HNC patients at Cachar Cancer Hospital and Research Centre (CCHRC) from 40% to 20% over 6 months through a systematic quality improvement initiative.</p><p><strong>Materials and methods: </strong>The study was conducted under the EQuIP India 2022 program, employing a mixed-methods approach. Baseline data from February to April 2022 were analysed to assess the deferral rate. Root cause analysis (RCA) identified key factors contributing to deferrals, including financial barriers, logistical challenges and psychological factors. Interventions included financial support, patient and family motivation programs, workshops and improved communication strategies. Progress was monitored through weekly tracking and evaluations.</p><p><strong>Results: </strong>The intervention successfully reduced the deferral rate from 40% to 18% within 6 months. Key contributing factors identified through Pareto analysis were financial constraints and family dependency on patient earnings. Addressing these challenges through targeted strategies including financial assistance, caregiver job opportunities, patient motivation workshops and active patient navigation targeted interventions led to increased patient compliance and engagement.</p><p><strong>Conclusion: </strong>This study highlights the importance of targeted, data-driven interventions in reducing treatment deferrals. The findings underscore the need for systemic changes, including improved financial support mechanisms and awareness programs, to ensure timely cancer treatment in resource-constrained settings.</p>","PeriodicalId":13319,"journal":{"name":"Indian Journal of Palliative Care","volume":"32 2","pages":"159-166"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vinutha Suresh, Meenakshi V Venketeswaran, Thendral Ramasamy, Priya Rajendran
{"title":"Visions at Life's End: Normalising and Validating Distressing End-of-Life Experiences - A Case Report.","authors":"Vinutha Suresh, Meenakshi V Venketeswaran, Thendral Ramasamy, Priya Rajendran","doi":"10.25259/IJPC_401_2025","DOIUrl":"10.25259/IJPC_401_2025","url":null,"abstract":"<p><p>The end-of-life phase in individuals with chronic and life-threatening illnesses such as cancer is a clinically significant and emotionally vulnerable period. During this time, patients may report vivid dreams and visions that typically occur in the hours, days or weeks preceding death, which are deeply subjective. There is a lacuna in the literature about end-of-life dreams and visions (ELDV), as they often go unreported due to fear of stigma. This case describes the experience of a young female with metastatic cancer who encountered disturbing and distressing ELDV. This case highlights the therapeutic value of basic counselling skills in palliative care, particularly validation and normalisation, to alleviate the psychological distress and ensure patient comfort during the final stages of life. As one of the few cases reported from India, this report contributes to existing literature and underscores the need for open dialogue about ELDVs in palliative care.</p>","PeriodicalId":13319,"journal":{"name":"Indian Journal of Palliative Care","volume":"32 2","pages":"222-225"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reflections on the ICMR 2020 Consensus Guidelines on Do Not Attempt Resuscitation.","authors":"Pooja Thaware, Anshu Priyanka Lakra, Saurabh Trivedi, Ankita, Jitendra Kushwaha, Md Yunus","doi":"10.25259/IJPC_416_2025","DOIUrl":"10.25259/IJPC_416_2025","url":null,"abstract":"<p><p>The Indian Council of Medical Research's 2020 Consensus Guidelines on Do Not Attempt Resuscitation filled a critical gap in Indian clinical practice by introducing standardized protocols, documentation, and legal clarity. Prior inconsistencies like futile CPR, slow codes, and ethical uncertainty often prolonged patient suffering despite poor prognosis. The guidelines emphasize shared decision-making with surrogates, continued compassionate care, and maintenance of patient dignity. However, limited dissemination hampers awareness and uniform adoption. Hospitals must promote education via training and policies. A revised edition incorporating field insights and barriers is essential for ethical, equitable end-of-life care nationwide.</p>","PeriodicalId":13319,"journal":{"name":"Indian Journal of Palliative Care","volume":"32 2","pages":"231-232"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}