Indian Journal of Pharmacy and Pharmacology最新文献

{"title":"Overhydration: A boon or bane","authors":"D. Kalra","doi":"10.18231/j.ijpp.2023.017","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.017","url":null,"abstract":"Water is necessary for human cells to function properly. However, consuming more water than necessary might lead to overhydration, which could have major negative effects on one's health. Water intoxication, also known as dilutional hyponatremia, only occurs when a person consumes more water than their kidneys can ordinarily excrete. If the balance between water (fluid) and electrolytes is not kept, dehydration and overhydration can cause morbidity and mortality. Overhydration is associated with cardiopulmonary problems, hyponatremia, edoema, gastrointestinal dysfunction, and surgical complications. To gain a thorough understanding of the causes of and effects of overhydration on human health, a literature study was conducted.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88681420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of conditioning safflower oil shampoo","authors":"S. S. Shaikh, Vishnu Kocharya Padvi, Tejaswini Lalchand Asawe","doi":"10.18231/j.ijpp.2023.025","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.025","url":null,"abstract":"Frequent use of synthetic hair care products and overuse of grooming results in damaged hair. This leads to growing demand for natural hair care products. Many synthetic harsh chemicals in liquid shampoo leads to dry and damaged hair. An attempt was made to formulate a conditioning shampoo bar with safflower oil. The nutrient rich, weightless oil imparted good conditioning and smoothness to rough hair surface indicated by SEM studies of treated hair with conditioning shampoo bar containing 5% oil. Formulated shampoo bars are found to have various desirable properties like moisturizing, conditioning and nourishing effect on the dry and damaged hair with good grooming, luster, manageability and shine.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87405383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical childhood Takayasu arteritis – A case report","authors":"Shruti Appaswamy, N. Pandey, R. Ghildiyal","doi":"10.18231/j.ijpp.2023.026","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.026","url":null,"abstract":"Childhood Takayasu arteritis is one of the most common vasculitis in paediatric age group. It predominantly involves the greater vessels such as aorta and its branches, leading to granulomatous inflammation. The process of inflammation gives rise to the symptoms based on thrombotic or aneurysmal phenomena. This is a case report of a 11-year-old girl diagnosed in an urban tertiary care centre in India with childhood Takayasu arteritis. The said child had first presented with non-specific symptoms such as leg ache, back ache and fever. Over the course of illness, the child developed hypertension and had also suffered from PRES (posterior reversible encephalopathy syndrome). Clinical examination was consistent with Takayasu arteritis, however with predominant medium-sized vessel involvement on imaging. Since this is a relatively atypical presentation, it was mandatory to rule out other causes of medium-vessel arteritis, especially DADA2 (deficiency of ADA2).","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"264 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84616782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on malaria","authors":"Rutuja R. Sumbe, Ganesh D. Barkade","doi":"10.18231/j.ijpp.2023.014","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.014","url":null,"abstract":"Millions of people die from the parasitic disease malaria each year. This illness is difficult to diagnose in a clinical environment and arises when the red blood cells in the blood are harmed. Malaria is caused by Plasmodium parasites, which are the main global cause of mortality and morbidity. Both in their hosts, the vertebrates, and their carriers, the mosquitoes, these parasites have a complicated life cycle.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88353994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of phytoconstituents in treatment of polycystic ovarian syndrome: An study","authors":"B. Premkumar, Chandrasekar Leela Priyanka, C. Nalini, Mahalakshmi.","doi":"10.18231/j.ijpp.2023.020","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.020","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a prevalent condition among women of reproductive age, characterised by hyperinsulinemia, hyperandrogenism, menstrual irregularities, and long-term metabolic disturbances. At present, the conventional approach to managing PCOS involves implementing lifestyle changes, administering pharmacological interventions, and performing surgical procedures. Nevertheless, these therapies do not exhibit promising outcomes for the comprehensive eradication of it. Consequently, natural sources have been regarded as a highly esteemed means of medication and aid in enhancing and regulating PCOS conditions. The current study was designed to conduct a screening of various phytoconstituents with a focus on their potential interaction with androgenic targets (1E3G & 2PIV), estrogenic receptors (1U3S), and insulin receptors (3EKK). An assessment was conducted on a compilation of phytoconstituents documented in PCOS with the aim of forecasting drug-like characteristics through an methodology. Thirteen phytoconstituents were selected for the study, namely apigenin, berberine, erdosteine, colchicine, diacerin, mogroside V, naringenin, quercetin, resveratrol, rhamnocitrin, silibinin, tanshinone IIA, and troxerutin. The phytoconstituents were subjected to molecular docking studies using AutoDock Vina to investigate their binding interactions with proposed targets. Additionally, in silico prediction of the toxicity of these phytoconstituents was conducted. The phytoconstituents that were chosen exhibited favourable pharmacokinetic characteristics for oral bioavailability and drug-likeness, as determined by Lipinski's rule of five. As per the docking results, it was observed that four compounds, namely Apigenin, Tanshinone IIA, Naringenin, and Berberine, exhibited significant binding interactions with the allosteric site residues of the targets. The identified phytoconstituents that underwent screening exhibit potential as prospective candidates for subsequent development. However, it is imperative to validate the findings through in vitro and in vivo investigations.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79886190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of herbal hand wash using neem and aloevera extract","authors":"Komal Tikariya, Arpit Gawshinde, A. Dabeer, Sonu Mishra, U. Atneriya, Dharmendra Solanki","doi":"10.18231/j.ijpp.2023.019","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.019","url":null,"abstract":"The herbal cosmetics are natural and free from all the harmful synthetic chemicals which generally may turn out to be lethal to the skin, the natural ingredient used assures no side effect one can applied them any time. So, herbal cosmetic are more referable as compared to synthetics one.The purpose of the present work is to formulate and evaluated herbal hand wash using natural ingredients to promote the personal hygiene. The formulated hand wash was evaluated for different parameters like pH, colors, foaming efficiency, viscosity and stability. The herbal hand wash formulated using neem extract for antibacterial property, aloevera juice for soothing property, glycerine for moisturization, sodium lauryl sulphate as a surfactant, carbopol 934 as a jellying agent, rose oil for fragrance and distilled water, the hand wash is prepared and evaluated then the result was documented. 5 People were asked for acceptability of fragrance and their opinion was taken. The fragrance was found to be good as compared to reference hand wash.: The hand wash was found to be light green aromatic and homogeneous with rosy fragrance. pH was 6.0 which is similar to the skin pH. The hand wash was found to be stable in all evaluation parameters with good cleaning property.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86981223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levobupivacaine versus ropivacaine in patients undergoing lower abdominal surgeries","authors":"Yatish Byndoor, Tamilisetti Vidya Sagar","doi":"10.18231/j.ijpp.2023.023","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.023","url":null,"abstract":"Regional anesthesia, like Peripheral nerve block, is commonly used for peripheral surgeries to reduce severe intraoperative and postoperative pain relief. .Some studies with levobupivacaine have shown that duration of analgesia of levobupivacaine are longer compared to that of an equivalent dose of bupivacaine or ropivacaine.This study is done to compare efficacy and safety of levobupivacaine with ropivacaine. In this study we tried to compare efficacy and clinical characteristics of isobaric forms of intrathecal levobupivacaine 0.5% and ropivacaine 0.75% in lower abdominal surgeries.This prospective, observational and open labeled, comparative study done for a period of one year in a tertiary care health centre, in South India, prior approval from Institutional ethics committee was taken. 60 patients were included and each of 60 patients was randomized (sealed, numbered and opaque envelopes) to one of two groups of 30 patients. Each of the patients enrolled in the study received one of two solutions: levobupivacaine or Ropivacaine, patient was turned supine immediately after injection, time of which was defined as ‘zero’. Thereafter, investigator, assessed upper and lower limits of sensory block (analgesia to pinprick), degree of motor block and recorded heart rate and arterial pressure. The patients were then transferred into the operating theatre and assessments were continued at 30 min intervals thereafter until complete motor and sensory blocks regression. Data were analysed using a standard computer-based statistics package.Mean time of onset of sensory blockade for levobupivacaine was 3.85±0.5 min and in Ropivacaine was 3.90 ± 0.6 min. Mean time of onset of motor blockade in levobupivacaine group was 3.65 ± 0.72 min and in Ropivacaine group was 3.82 ± 0.88 min, mean duration of motor blockade in Levobupivacaine group was 201.15±22.06 min and in Ropivacaine group was 204 ± 21.20 min. Mean time for regression for levobupivacaine was 98.27±10.18 min and for ropivacaine was 96.33 ±8.21min. There is no significant difference, Mean time for first request of analgesic for Levobupivacaine was 262.22 ±36.60 and for Ropivacaine was 261.20 ± 32.71 min. There is no statistically significant difference; there was no statistically significant difference in the incidence of adverse events in both the groups. So both the drugs are considered to be safe in spinal anesthesia.In conclusion, Ropivacaine and Levobupivacaine has similar onset of sensory and motor blockade with comparable hemodynamic parameters and time for rescue analgesic administration was comparable between two groups and incidence of post- operative complications is not significant with both drugs.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85077556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant, Antimicrobial and Antidiabetic activities of Insulin plant rhizome extracts - A comparative study","authors":"G. Sivakumar, R. Sathish Kumar, P. Aruna, Laksmana Perumal","doi":"10.18231/j.ijpp.2023.024","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.024","url":null,"abstract":"retained the name as Insulin plant through traditional practice, further phytochemical and pharmacological evaluation of leaves of the plant has proven record on wider therapeutic potential such as antioxidant, antimicrobial and antidiabetic activity. Our interest of current research is to explore the rhizome by multiple extraction and to screen and find out the specific therapeutic potential of the specific extracts through relevant phytochemical and pharmacological evaluation. DPPH, Disc Diffusion and DNS methods were chosen to evaluate antioxidant and antibacterial and antidiabetic activity on various rhizome extracts (ethyl acetate, methanol, ethanol and aqueous). The anti-oxidant effect is significantly high and almost same for all rhizome extracts. ethyl acetate, ethanol, methanol has moderate antibacterial activity against gram positive ( and) and gram negative organism ( and ) by disc diffusion method as compare to the standard drug (Ceftrioxone sodium). However, aqueous extract lacs antibacterial activity. The α-amylase inhibition activity by DNS method result infers, high antidiabetic activity for ethyl acetate and ethanolic rhizome extracts whereas mild activity for methanolic and aqueous rhizome extracts. Thereby e thonolicrhizome extract might be a good choice for antioxidant, antibacterial and antidiabetic therapeutic segments among the rhizome extracts.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"12 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83773995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern applications of artificial intelligence to health care: An editorial review","authors":"S. Swain, B. R. Jena","doi":"10.18231/j.ijpp.2023.001","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.001","url":null,"abstract":"","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76630375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing anesthesia medication errors for improved quality care","authors":"A. Shetti, Shrey Goel, Shramana M. Banerjee, A. Nagaraj, Safdhar Hasmi Raveendran, Aarati Thakur","doi":"10.18231/j.ijpp.2023.006","DOIUrl":"https://doi.org/10.18231/j.ijpp.2023.006","url":null,"abstract":"Medication errors in anesthesia can have serious consequences for patients, including morbidity and mortality. These errors can occur at any stage of the medication administration process, from prescribing and preparation to administration and monitoring. Learning from medication errors is essential to improving patient safety in anesthesia. To address medication errors in anesthesia, various strategies have been developed, including the use of checklists, protocols, and simulation training. The implementation of technology, such as barcode scanning and automated dispensing systems, has also been effective in reducing medication errors. Learning from medication errors involves identifying the root causes of the error, analyzing the factors that contributed to the error, and implementing strategies to prevent similar errors from occurring in the future. A culture of safety that encourages reporting and analysis of errors is crucial for learning from medication errors. Improving patient safety in anesthesia requires a collaborative effort among healthcare professionals, including anesthesiologists, nurses, and pharmacists, as well as a commitment to continuous improvement through learning from errors.","PeriodicalId":13313,"journal":{"name":"Indian Journal of Pharmacy and Pharmacology","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90751046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}