Implant DentistryPub Date : 2022-02-01DOI: 10.5455/medarh.2022.76.17-22
Nabil Naser
{"title":"Clinical Implications of Functional Mitral Regurgitation Severity in Patients with Heart Failure with Reduced Ejection Fraction (HFrEF).","authors":"Nabil Naser","doi":"10.5455/medarh.2022.76.17-22","DOIUrl":"10.5455/medarh.2022.76.17-22","url":null,"abstract":"<p><strong>Background: </strong>An estimated 64.3 million people are living with heart failure worldwide. Functional MR in chronic HFrEF reflects primarily the severity of LV dysfunction and is not related to structural alterations of the mitral valvular apparatus. FMR in patients with HFrEF independently of the etiology of HFrEF and its underlying mechanisms, contributes to progression of the symptoms of HF and is independent predictor of worse clinical outcomes.</p><p><strong>Objective: </strong>The purpose of this study was to assess the severity of functional mitral regurgitation (FMR) and its clinical implications in patients with chronic heart failure with reduced ejection fraction (HFrEF).</p><p><strong>Methods: </strong>We enrolled 146 consecutive adult patients with CHF with reduced ejection fraction (HFrEF) who presented to outpatient clinics. All patients underwent clinical and physical examination. Baseline examination included medical history, detailed assessment of current medication, electrocardiogram recording, transthoracic echocardiogram and comorbidities. Heart failure with reduced ejection fraction was defined in line with the new guidelines as history of HF signs and symptoms as well as a LV ejection fraction (LVEF) below 40%. Cardiovascular risk factors were recorded according to the respective guidelines. FMR was defined and graded according to the ESC/EACTS Guidelines for the management of valvular heart disease. The extent of FMR was assessed at baseline and after a median follow-up period of 4 years in 146 consecutive HFrEF patients (left ventricular ejection fraction <40%). All of the patients received the heart failure (HF) medications in agreement with 2016 and 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Major adverse cardiac events were defined as a composite of all-cause death and the need for admission for HF.</p><p><strong>Results: </strong>A total of 146 chronic HFrEF patients (mean age of 63±11 years, 62% male, mean LVEF of 25±11%) of which 19% patients had severe FMR at baseline, with a mean EROA of 31.4±2.7 mm2 and a mean Reg Vol of 45.9±5.3 ml. There was a significant interaction between FMR and NYHA functional class in predicting death or need for hospitalization, (P < 0.0001 for the interaction term FMR NYHA III-IV). During a median follow-up period of 4.2 (IQR) 3.1-5.8) years, the primary endpoint occurred in 52 (36%) patients (21 HF admissions, and 31 deaths). There was a strong graded association between the presence and degree of FMR and risk of death or admission (P <0.0001) at 4 years follow-up period. Regarding HF therapy, 129 patients (88%) received RAAS antagonists, 17 patients (12%) received ARNI, 86 patients (59%) received beta-blockers, 75 patients (51%) were treated with MRA. 31 patients (21%) underwent cardiac resynchronization therapy (CRT) with a response rate of 64%. 24 patients (16%) underwent ICD implantation.</p><p><strong>Conclusion: </strong>","PeriodicalId":13309,"journal":{"name":"Implant Dentistry","volume":"26 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90121538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Implant DentistryPub Date : 2019-12-01DOI: 10.1097/ID.0000000000000919
Andrea Ravidà, I-Ching Wang, Gilberto Sammartino, Shayan Barootchi, Mustafa Tattan, Giuseppe Troiano, Luigi Laino, Gaetano Marenzi, Ugo Covani, Hom-Lay Wang
{"title":"Prosthetic Rehabilitation of the Posterior Atrophic Maxilla, Short (≤6 mm) or Long (≥10 mm) Dental Implants? A Systematic Review, Meta-analysis, and Trial Sequential Analysis: Naples Consensus Report Working Group A.","authors":"Andrea Ravidà, I-Ching Wang, Gilberto Sammartino, Shayan Barootchi, Mustafa Tattan, Giuseppe Troiano, Luigi Laino, Gaetano Marenzi, Ugo Covani, Hom-Lay Wang","doi":"10.1097/ID.0000000000000919","DOIUrl":"https://doi.org/10.1097/ID.0000000000000919","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the clinical and patient-reported outcomes of ≤6-mm implants with those of ≥10-mm implants placed after both lateral and transcrestal sinus floor elevation.</p><p><strong>Materials and methods: </strong>Using PubMed (MEDLINE), EMBASE, and Cochrane, a literature search for randomized controlled trials was performed. All the outcome variables were evaluated through a quantitative meta-analysis, and the influence of other clinical covariates were determined with a metaregression. For the survival outcomes, trial sequential analysis (TSA) was performed to adjust results for type I and II errors and to analyze the power of the available evidence.</p><p><strong>Results: </strong>After full-text reading, 12 studies were included in the analyses. No statistically significant difference was found after 3 years between the 2 study groups (P = 0.36). Short implants displayed fewer biological complications (P = 0.05), less marginal bone loss (MBL) from implant placement (P < 0.01), and reduced surgical time and treatment cost. However, long implants showed a statistically significant smaller number of prosthetic complications (P = 0.03). TSA confirmed the results of the meta-analysis, revealing that additional studies are needed due to low statistical power of the available evidence.</p><p><strong>Conclusion: </strong>The placement of short implants is a predictable option in treating patients with maxillary atrophy up to a 3-year follow-up. Studies with a longer observational period are needed to study the long-term performance of these implants.</p>","PeriodicalId":13309,"journal":{"name":"Implant Dentistry","volume":"28 6","pages":"590-602"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/ID.0000000000000919","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37395289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Implant DentistryPub Date : 2019-12-01DOI: 10.1097/ID.0000000000000935
E. Anitua, M. Alkhraisat
{"title":"Fifteen-Year Follow-up of Short Dental Implants in the Completely Edentulous Jaw: Submerged Versus Nonsubmerged Healing.","authors":"E. Anitua, M. Alkhraisat","doi":"10.1097/ID.0000000000000935","DOIUrl":"https://doi.org/10.1097/ID.0000000000000935","url":null,"abstract":"PURPOSE\u0000Short implants are a minimally invasive alternative in the management of alveolar bone atrophy. This study aimed to assess the influence of the surgical approach (1-stage vs 2-stage) on the 15-year survival and marginal bone loss of short implants in a fixed complete denture.\u0000\u0000\u0000MATERIALS AND METHODS\u0000A retrospective clinical study was conducted in a single private dental clinic that included short implants placed between January 2001 and December 2002.\u0000\u0000\u0000RESULTS\u0000Forty-one short implants supported 18 screw-retained complete dentures. The mean follow-up time was 15 ± 3 years. The surgical approach (1-stage vs 2-stage) did not significantly affect implant survival and marginal bone loss. The implant survival rate was 90.2%.\u0000\u0000\u0000CONCLUSIONS\u0000Short dental implants could be predictably indicated to support fixed complete dentures. The implants could be placed through a 1- or 2-stage surgery.","PeriodicalId":13309,"journal":{"name":"Implant Dentistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/ID.0000000000000935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61733197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Implant DentistryPub Date : 2019-12-01DOI: 10.1097/ID.0000000000000925
Abhishek Patel, Henry Greenwell, Margaret Hill, Brian Shumway, Aaron Radmall
{"title":"Ridge Augmentation Comparing an Allograft Plus Autogenous Bone Chips to an Osteoinductive Demineralized Bone Matrix: A Clinical and Histologic Study in Humans.","authors":"Abhishek Patel, Henry Greenwell, Margaret Hill, Brian Shumway, Aaron Radmall","doi":"10.1097/ID.0000000000000925","DOIUrl":"https://doi.org/10.1097/ID.0000000000000925","url":null,"abstract":"<p><strong>Purpose: </strong>The primary aim of this randomized, controlled, blinded, clinical trial was to compare a mix of particulate allograft and harvested autogenous particles (Autogenous) to an osteoinductive demineralized bone matrix (DBM) allograft on clinical and histologic outcomes for horizontal ridge augmentation procedure.</p><p><strong>Materials and methods: </strong>Fourteen patients with a horizontal ridge defect with at least 1 adjacent tooth were entered into this study. The test group of 7 subjects received corticocancellous particulate allograft (Mineross) mixed with autogenous bone chips (70:30) harvested using a bone scraper (SafeScraper TWIST). Seven subjects in the control group received DBM (Optecure-CCC). Both groups had a corticocancellous particulate allograft overlay and an acellular dermis membrane (ADMG) (AlloDerm GBR) to cover the grafts.</p><p><strong>Results: </strong>For the Autogenous group, there was a gain of 3.5 ± 1.4 mm while the DBM group gained 3.8 ± 1.6 mm (P < 0.05). Vertical change was minimal for both groups (P > 0.05). The Autogenous group had a mean of 35% vital bone while the DBM had 39% (P > 0.05).</p><p><strong>Conclusions: </strong>Both treatments provided similar gain of ridge width and minimal loss of ridge height. The autogenous bone chips did not provide any additional benefit when compared with allograft alone that had lot verified osteoinductive activity.</p>","PeriodicalId":13309,"journal":{"name":"Implant Dentistry","volume":"28 6","pages":"613-620"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/ID.0000000000000925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37372999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Implant DentistryPub Date : 2019-12-01DOI: 10.1097/ID.0000000000000915
Suya Chen, Qianmin Ou, Xuefeng Lin, Yan Wang
{"title":"Comparison Between a Computer-Aided Surgical Template and the Free-Hand Method: A Systematic Review and Meta-Analysis.","authors":"Suya Chen, Qianmin Ou, Xuefeng Lin, Yan Wang","doi":"10.1097/ID.0000000000000915","DOIUrl":"https://doi.org/10.1097/ID.0000000000000915","url":null,"abstract":"<p><strong>Background: </strong>During implantation planning, dentists should be able to make an informed decision regarding whether to use an implant template to assist the surgery.</p><p><strong>Purpose: </strong>The aim of this meta-analysis was to assess the results of implantation with or without an implant template based on the accuracy, survival rate, and other considerations.</p><p><strong>Materials and methods: </strong>In January 2018, a systematic review was undertaken for randomized controlled trials and retrospective and prospective cohort studies with relevance to implant accuracy and the survival rate between the implant template and free-hand method. The odds ratios (ORs) of the survival rate and the mean difference of accuracy deviation from the selected papers were estimated by meta-analysis.</p><p><strong>Results: </strong>Of the 362 screened articles, 6 studies were included in the meta-analysis. Comparison of the survival rate of implant surgery with or without an implant template revealed no significant result (OR = 1.71, 95% confidence interval [CI] 0.65-4.51). Significant differences in accuracy were observed in angular (mean difference = -5.45 degrees, 95% CI -0.66 to -4.24 degrees) and apical deviation (mean difference = -0.83 mm, 95% CI -1.12 to -0.54).</p><p><strong>Conclusions: </strong>With the technology of computer-aided surgical template, implant placement can be more accurate than free-hand operation. No significant difference is observed in the survival rate between template and free-hand.</p>","PeriodicalId":13309,"journal":{"name":"Implant Dentistry","volume":"28 6","pages":"578-589"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/ID.0000000000000915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37340319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Implant DentistryPub Date : 2019-12-01DOI: 10.1097/ID.0000000000000937
S. Qi, Jinjin Wu, Yiwen Xu, Yiming Zhang, Raorao Wang, Kai Li, Yuanzhi Xu
{"title":"Chemical Stability and Antimicrobial Activity of Plasma-Sprayed Cerium Oxide-Incorporated Calcium Silicate Coating in Dental Implants.","authors":"S. Qi, Jinjin Wu, Yiwen Xu, Yiming Zhang, Raorao Wang, Kai Li, Yuanzhi Xu","doi":"10.1097/ID.0000000000000937","DOIUrl":"https://doi.org/10.1097/ID.0000000000000937","url":null,"abstract":"PURPOSE\u0000The aim of this study is to investigate the biological activity and antibacterial property of cerium oxide-incorporated calcium silicate coatings (CeO2-CS) in dental implants.\u0000\u0000\u0000MATERIALS AND METHODS\u0000In this study, MC3T3-E1 cells cultured on the plastic, Ti-6Al-4V, and the cerium oxide-incorporated calcium silicate coatings (CeO2-CS) coating served as the blank, control, and CeO2-CS groups, respectively. A cell counting kit-8 (CCK-8) and flow cytometry were used to evaluate the biocompatibility. The osteoblastic differentiation of the MC3T3-E1 cells was also analyzed by quantitative real-time polymerase chain reaction analysis. The CCK-8 and counts of colony-forming units (CFUs) were used to detect the antibacterial activity of the coating on Enterococcus faecalis. The study showed that the cerium oxide-incorporated calcium silicate coating (CeO2-CS) has better biocompatibility. Meanwhile, the ALP, OCN, and BSP mRNA expression levels in the CeO2-CS group were significantly upregulated (P < 0.05). The number of viable bacteria and the CFU results were significantly reduced in the CeO2-CS group (P < 0.05).\u0000\u0000\u0000CONCLUSION\u0000The cerium oxide-incorporated calcium silicate coatings (CeO2-CS) may promote the osteoblastic differentiation of osteoblasts. Meanwhile, the cerium oxide-incorporated calcium silicate coating (CeO2-CS) showed strong antimicrobial activity on E. faecalis, with good biocompatibility.","PeriodicalId":13309,"journal":{"name":"Implant Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/ID.0000000000000937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49478975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}