Indian Journal of Pharmaceutical Sciences最新文献

{"title":"Association of Bile Acid with White Matter Hyperintensity in Cognitively Normal Older Adults","authors":"X. K. Xu, Yueqi Zhang, X. J. Lu, Baolin Shi","doi":"10.36468/pharmaceutical-sciences.spl.698","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.698","url":null,"abstract":"This study aimed to detect associations of bile acid profile with white matter hyperintensity and quantify the risk of cerebral small vessel disease with high level of bile acid among cognitively normal individuals. All data were obtained from the patients with Alzheimer’s disease neuroimaging initiative with a 10 y follow-up. Multivariate linear regressions were performed with variable selection using the least absolute shrinkage and selection operator method and the linear mixed model was used to analyze longitudinal relationship between non-zero coefficient variables and white matter hyperintensity volume. Four predictors (age, deoxycholic acid, glucose, total intracranial volume) were identified by least absolute shrinkage and selection operator regression analysis and multivariate linear regressions. Age (p value<0.001, mean difference, 1.03 cm 3 [95 % interval: 1.02, 1.04]) and deoxycholic acid (p value<0.05, mean difference, 1.05 cm 3 [95 % confidence interval: 1.00, 1.10]) were significantly associated with white matter hyperintensity. When divided into two groups by the median deoxycholic acid level (1.38 µM), participants with higher deoxycholic acid levels had a higher white matter hyperintensity volume at the 4 th y than those with lower deoxycholic acid levels (mean difference, 0.1 points [95 % confidence interval: -0.17, -0.03]; p<0.05). We found that increased deoxycholic acid levels may lead to the progression of white matter hyperintensity, which suggest that higher deoxycholic acid burden may play a possible role in the pathogenesis of cerebral small vessel disease in cognitively normal older adults. Besides, the study indicates a possible role for inflammation in the pathogenesis of cerebral small vessel disease.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Study to Observe the Efficacy of External Treatment with Qingluo San on Phlebitis from Peripheral Venous Catheter","authors":"Jiayue Li, Yuan Zhang, Ying Zhang, Peng Guo, Ning Guo, Xiaoyan Zheng, Yuan Tian","doi":"10.36468/pharmaceutical-sciences.spl.708","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.708","url":null,"abstract":"The purpose of this study is to evaluate the efficacy of the Chinese herbal ointment Qingluo San in preventing phlebitis in patients with peripheral venous catheters. We conducted a single-center randomized controlled trial, in which 127 eligible patients were assigned randomly to one of two groups; the experimental group or the control group. The degrees of pain intensity and phlebitis were measured at baseline, 24 h, 48 h and 72 h. Demographic information (age, gender, body mass index) and phlebitis sites, catheter dwell time, hemoglobin and white blood cells were obtained from all patients. Compared with the control group, the experimental group showed significantly lower incidence of phlebitis and pain intensity at 24 h, 48 h and 72 h after intervention. However, there were no significant differences about the demographic information (age, gender, body mass index) and phlebitis sites, catheter dwell time, hemoglobin and white blood cells between these two groups. In patients with peripheral venous catheters, external treatment with Qingluo San was an effective method for decreasing the incidence of phlebitis.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"265 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Expression Profile of circRNA-miRNA-mRNA in Osteoporosis upon Treatment with Denosumab","authors":"H. M. Niu, L. C. Wei, L. He","doi":"10.36468/pharmaceutical-sciences.spl.705","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.705","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Effect of Dietary Flavonoid Intake and Risk of Preeclampsia: A Research Study","authors":"Bingrui Liu, Yanhua Liu, Ting Kang, Xianlan Zhao, Y. Cao, Quanjun Lyu","doi":"10.36468/pharmaceutical-sciences.spl.718","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.718","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Effects of Heterocyclic Schiff Base Ligands and Their Metal Complexes on Leukemia Cells","authors":"B. Shekhany, F. Ozer, E. Aytar, S. W. Bradosty, M. U. Boyraz, A. O. Gurol, F. K. Shaikh, F. Suzergoz","doi":"10.36468/pharmaceutical-sciences.1161","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1161","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135400279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of Stability-indicating High-Performance Liquid Chromatography Method for Estimation of Organic Impurities of Carvedilol from Bulk and its Dosage Form","authors":"M. M. Desai, Anna Pratima G. Nikalje","doi":"10.36468/pharmaceutical-sciences.1162","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1162","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135401429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Polyherbal Formulation: Impact of Antioxidants on In Vivo Antidepressant Activity in Animal Models","authors":"A. R. Surana, M. R. Kumbhare, H. I. Narkhede","doi":"10.36468/pharmaceutical-sciences.1188","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1188","url":null,"abstract":"In Ayurveda, single or multiple herbs are used as medication for various ailments. Depression is often manifesting with various symptoms at the behavioral, psychological and physiological levels. Therefore, the investigation for therapeutic alternative is important. Oxidative stress has shown important biochemical aspects in the depression. This study evaluated effect of natural antioxidant on antidepressant activity of polyherbal formulation on the performance of male mice. Mice were given orally polyherbal formulation without antioxidant and with antioxidant daily for 7 d and then subjected to forced swim test and tail suspension test. After 1 w treatment, both polyherbal formulation significantly reduced immobility time in forced swim test and tail suspension test compared with vehicle treated control group. The immobility time in tail suspension test of polyherbal formulation without antioxidant and with antioxidant was found to be 151.17±4.46 s and 116.33±8.84 s respectively. The immobility time in tail suspension test of polyherbal formulation without antioxidant and with antioxidant was found to be 137.17±5.93 s, 113.50±5.40 s respectively. These results indicate that the antidepressant when given along with antioxidant in mice it gives significant antidepressant effect. The experimental results suggest that the intake of antioxidant may help in reducing the symptoms of depression, via supplementation of antioxidant.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Anticancer and Antioxidant Potential of Pittosporum dasycaulon Leaves extract Against the Human Liver and Lymphoma Cancer","authors":"C. Riyas, Swapna Thacheril Sukumaran","doi":"10.36468/pharmaceutical-sciences.1076","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1076","url":null,"abstract":"Cancers are the uncontrolled growth of cells or tumors, and it is one of the leading causes of death all over the world. Currently, available synthetic drugs such as cisplatin, doxorubicin and fluorouracil are reported to have notable side effects in living tissues (skin irritations, dry and cracked skin, and mouth sores). So researchers are scrutinizing for alternative medications to overcome these side effects. Plants are one of the vital sources of alternative medicines with less toxicity and may overcome these side-effects of synthetic drugs. The study evaluated cytotoxicity and antioxidant potential on methanolic and aqueous extract of Pittosporum dasycaulon leaves. In the present study of cytotoxicity, the selected extracts were screened against two cancer cell lines (human liver cancer cells and Lymph cancer cell-Dalton's lymphoma ascites ascites). Two normal cells, intestinal epithelial-6, and Rat spleen were used to test cytotoxicity by using the trypan blue exclusion method and 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide assay. The antiradical activity was also evaluated with its half maximal inhibitory concentration. The content of total phenolic, flavonoid and saponins was also estimated. The present study displayed leaves methanolic extract found to have a significant rate of cell death against cancer cell lines (Dalton's lymphoma ascites and human liver cancer cells) with lethal concentration 50 values ranging from 8.21±0.3 to 55.65±0.11 µg/ml. However, the same extract had very less cytotoxicity even in higher doses against non-cancerous intestinal cell lines (intestinal epithelial-6) and rat spleen cell lines ranging from 389.50±0.6 to 1800.00±0.1 μg/ml. The quantitative analysis of leaf methanolic extract showed a high level of saponins and phenolic compounds. Therefore, leaves of Pittosporum dasycaulon Miq are a promising candidate for natural antioxidant as well as anticancer components. Hence, further extensive study urges to evaluate the mechanism as well as to investigate of individual components responsible for cytotoxicity and antiradical potential.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70215535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Formononetin on PTEN/AKT Signaling Pathway and Angiogenesis of Transplanted Tumor in Nude Mice with Breast Cancer Cells","authors":"Y. Dai, YuXin Chen, Y. Chen, Zheng Xu, Jinhuan Ding","doi":"10.36468/pharmaceutical-sciences.1128","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1128","url":null,"abstract":"To investigate the effect of formononetin on phosphatase and tensin homology deleted on chromosome ten/protein kinase B signaling pathway and angiogenesis of transplanted tumor in nude mice with breast cancer cells. Nude mice with breast cancer cell transplanted tumors were established and randomly divided into control group, low (0.1 mg/g) and medium (0.2 mg/g) doses of formononetin, high (0.4 mg/g) and taxol (10 µg/g) groups, after grouping treatment, the transplanted tumor volumes of nude mice in each group were measured; terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining was used to detect the apoptosis of transplanted tumor cells; the angiogenesis (proportion of cluster of differentiation 31 positive cells) of transplanted tumors was detected by immunohistochemical staining; serum vascular endothelial growth factor levels in nude mice were detected by enzyme-linked immunosorbent assay; the expressions of vascular endothelial growth factor and phosphatase and tensin homology deleted on chromosome ten/protein kinase B pathway related proteins in transplanted tumors were detected by Western blot assay. Compared to the control group, the volumes of transplanted tumors, the proportion of cluster of differentiation 31 positive cells, serum vascular endothelial growth factor levels, vascular endothelial growth factor protein expression, and phosphorylated-protein kinase B/protein kinase B of nude mice were decreased, while the proportion of apoptotic cells and phosphatase and tensin homology deleted on chromosome ten protein expression were increased in a dose-dependent manner (p<0.05) in low, medium and high doses of formononetin or taxol groups; however, there were no differences in all indexes between taxol group and high dose group of formononetin (p>0.05). Formononetin up-regulates phosphatase and tensin homology deleted on chromosome ten expression, decreases protein kinase B phosphorylation and inhibits transplanted tumor growth and angiogenesis of transplanted tumor in nude mice with breast cancer cells","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethno-Medicinal and Therapeutic Applications of Natural Anthraquinones: Recent Trends and Advancements","authors":"M. Mohapatra, U. Basak","doi":"10.36468/pharmaceutical-sciences.1122","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1122","url":null,"abstract":"Pharmacological Uses of Certain Anthraquinones Traditional and ethno-medicinal use of plants enforces a holistic approach towards human health by wittily utilizing the synergistic potency of the bioactive compounds. Quinones are unique molecules with several therapeutic properties that lead them as most vital compound in pharmaceutical system. They can easily undergo reduction reaction paving the path for many biological processing. This class of molecules helps in treatment of several chronic ailments. Many of the drugs in Ayurvedic formulations and/or modern medicinal sectors are having one or more types of quinone groups as a major bio-active compound. However these aforementioned properties of quinones make them unique and versatile. The biochemical knowledge of these compounds is necessary to understand their physiological and toxicological properties. Amongst all quinones found naturally, anthraquinones are one of its kinds due to wide spectrum utilization in several drug formulations. In this review a brief detail of six unique yet ethno-botanically and pharmacologically versatile quinone compounds are depicted with their natural resources, structural characterization and ethno-pharmacological activities. The gathered information regarding the above mentioned bio-active compounds would be helpful in identification and isolation of these compounds from a wide range of natural sources with structural characterization and pharmacological potency. These data would be pivotal in their precise identification for further use in both Ayurvedic and modern drug formulation sectors thereby lessening the threat status of the frequently used rare, endangered and threatened plants.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}