Indian Journal of Pharmaceutical Sciences最新文献

{"title":"Protective Effect of Sodium Hydrosulfide on Lipopolysaccharide Induced Myocardial Cell Injury Model: Involvement of Oxidative Stress and Endoplasmic Reticulum Stress","authors":"Xin Peng, G. Cao, Y. Zeng, Q. Cheng","doi":"10.36468/pharmaceutical-sciences.spl.625","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.625","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69634350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Dosage of Asari Radix et Rhizoma in Traditional Chinese Medicine and its Application in Rheumatoid Arthritis","authors":"W. Jiang, S. Sun, X. Xin, Linjiang Li","doi":"10.36468/pharmaceutical-sciences.spl.665","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.665","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69634923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Antioxidant Assay of Different Phytoconstituents and Extraction Optimization of Phenolics from Cyperus rotundus L","authors":"Nidhi Varshney, A. Prakash, D. Singh, Pracheta Janmeda","doi":"10.36468/pharmaceutical-sciences.1072","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1072","url":null,"abstract":"Varshney et al. : Quantitative Estimation and Antioxidant Activity of Cyperus rotundus Oxidative stress related disorders occur as a result of free radicals in the cellular organs. Antioxidants provide protection contrary to oxidative stress by counteracting free radicals through the help of different bioactive constituents present in the plants. The aim of this study is to find out the quantitative estimation of phytochemicals (phenolics, tannins, flavonoid, non-tannins, alkaloid and saponins), in vitro antioxidant activity (2, 2-diphenyl-1-picryl-hydrazyl-hydrate, metal chelating, ferric reducing, superoxide dismutase and total antioxidant activity) of different parts of Cyperus rotundus . Along with this, the extraction of polyphenolic compounds by conventional and non-conventional methods and their optimization by response surface methodology technique were also studied. As the outcomes of the study, maximum amount of total phenolics content was found in the ethanolic fraction of stem (37.88±0.94 mg gallic acid equivalent/g). The root has shown the highest flavonoid (0.24±0.03 mg QAE/g) and non-tannin content (21.55±2.43 mg gallic acid equivalent/g) in the extract of petroleum ether. The total alkaloids and tannin content in flower and root i.e., 5.05±0.08 mg caffeine equivalent/g and 76.28±0.62 mg tannic acid equivalent/g was found to be better in aqueous extract respectively. The fraction of ethyl acetate has reported the greatest saponin content (39.2±3.8 mg gallic acid equivalent/g). In case of flower part half-maximal inhibitory concentration value of 2, 2-diphenyl-1-picryl-hydrazyl-hydrate and superoxide dismutase antioxidant activity varies from 0.57-1.90 mg/ml and from 0.053-1.401 mg/ml respectively. Antioxidant activity of each part of the plant was reported in the fraction of ethanol and water by fluorescence recovery after photobleaching (0.403±0.009-0.886±0.02 mg/ml), metal chelation activity (0.010±0.0-0.306±0.001 mg/ml) and total antioxidant capacity (0.030±0.0-0.317±0.002 mg/ml). Microwave assisted extraction method was found to be the suitable one for optimization of total phenolic content. So, the relationship between different parameter was determined through response surface methodology technique and evaluated by plotting the graphs. Polar extracts have found to show the maximum quantity of secondary bioactive metabolites and antioxidant activity as compared to non-polar one. And among the comparison between conventional and non-conventional methods, ultra sonication (non-conventional method) has shown the highest yield of bioactive phenolic compound. So, this study shows that Cyperus rotundus has wide range of secondary metabolites showing antioxidant properties that can be applied for different therapeutic applications.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70214768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Drug Utilization Pattern among Pregnant Women in a Tertiary Care Teaching Hospital","authors":"E. T., N. S, Pai Mv, Thunga G, Kunhikatta V","doi":"10.36468/pharmaceutical-sciences.1074","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1074","url":null,"abstract":"A retrospective study was conducted in a tertiary care teaching hospital to evaluate the drug utilization pattern in pregnant women. A total of 876 pregnant women were enrolled in the study. Parameters such as demography, gravidity, comorbid illness, neonatal outcome, drugs prescribed and their utilization details were collected. The mean age of the study population was found to be 29.4±4.4 y (mean±standard deviation). Majority of them underwent caesarean section (68.2 %) compared to normal vaginal delivery (31.8 %). Most of the neonates were healthy (94.3 %) whereas 0.8 % of the neonates expired during the postnatal period. Diabetes mellitus (33.6 %) was the most common comorbidity, followed by hypertension (28.3 %) and thyroid disorders (18.3 %). Folic acid (15.7 %) and calcium (15.2 %) were the most prescribed drugs, followed by ferrous fumarate (7.1 %), vitamin B12 (5.3 %) and vitamin B6 (3.4 %). In terms of defined daily dose/100 bed d, levothyroxine (369.3) was the most frequently utilized drug, followed by digoxin (53.6), dydrogesterone (27.4) and salbutamol (20.5). Estradiol was only the food and drug administration pregnancy category X drug prescribed, as estradiol supplement as this was required to improve pregnancy rates after in vitro fertilization.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70214960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Changes in Cardiac Function in Chronic Obstructive Pulmonary Disease Treated with Acetylcysteine by Three-Dimensional Ultrasound Spot Tracking Technique","authors":"Xin Wang, T. Fan, Y. Hou, Aixiang Liu","doi":"10.36468/pharmaceutical-sciences.spl.714","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.714","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis of Ketorolac Tromethamine on Postoperative Analgesia for Colorectal Cancer","authors":"G. Ji, Huanhuan Zhang, Xiulan Liu, Y. Zhang","doi":"10.36468/pharmaceutical-sciences.spl.723","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.723","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Interventions Combined with Drugs on Serum 5-Hydroxytryptamine and Gamma-Aminobutyric Acid Levels in Neurological Tinnitus","authors":"Wusiman Zumureti, Ting Zhao","doi":"10.36468/pharmaceutical-sciences.spl.720","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.720","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Propofol Pretreatment on Microglial Pyroptosis in the Ischemic Penumbra of Rats Subjected to Cerebral Ischemia-Reperfusion","authors":"Pengdan Ying, Shurong Liu, Yichuan Tian, Yang Cao","doi":"10.36468/pharmaceutical-sciences.1173","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1173","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135400309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phellinus igniarius Represses Oral Squamous Cell Carcinoma Cell Development via Up-Regulating microRNA-655-3p","authors":"Deying Li, Tingting Xu, Sujun Wu","doi":"10.36468/pharmaceutical-sciences.1181","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1181","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135401404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walnut Green Husk Extract Suppresses Ovarian Cancer Cell Proliferation Migration and Invasion via Modulating microRNA-144-3p","authors":"Yanan Liu, Lin Yang, Y. Gu, L. Guo, Qi Guo","doi":"10.36468/pharmaceutical-sciences.1163","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1163","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135402038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}