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Protective effects of ursolic acid on cyclophosphamide induced hemorrhagic cystitis in rats 熊果酸对环磷酰胺致出血性膀胱炎的保护作用
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-06-01 DOI: 10.56042/ijeb.v61i06.1939
Sevimli
{"title":"Protective effects of ursolic acid on cyclophosphamide induced hemorrhagic cystitis in rats","authors":"Sevimli","doi":"10.56042/ijeb.v61i06.1939","DOIUrl":"https://doi.org/10.56042/ijeb.v61i06.1939","url":null,"abstract":"Cyclophosphamide (CP) is a commonly used antineoplastic agent despite its adverse effects. Hemorrhagic cystitis (HC) is one of the most common side effects of CP. Although Mesna is commonly used to prevent HC, it suffers from few side effects. Therefore, search for better alternate substance still continues. In this study, we studied the effects of ursolic acid (UA), one of the active ingredients of Plantago major , commonly called plantain or white man’s foot, in CP-induced hemorrhagic cystitis in rats. Forty-nine Sprague − Dawley rats in seven equal groups viz. control (C); cyclophosphamide (CP); cyclophosphamide+Mesna (CPMesna); cyclophosphamide+ursolic acid [100 (CPUA100) and 200 mg (CPUA200)], and cyclophosphamide+ mesna+ ursolic acid (100, (CPMesnaUA100) and (200 mg (CPMesnaUA200) were investigated for inducible nitric oxide synthetase (iNOs), total antioxidant status (TAS), total antioxidant status (TOS), TNF– α , interleukin 10 (IL–10) and interleukin 6 (IL–6) levels from blood samples. The data obtained were statistically analyzed using SPSS and both Kruskall Wallis and Dunn tests were performed. Value of P <0.05 was considered as statistically significant. Our results have revealed that the UA applied groups better preserve compared to CP group. However, it was observed that this protection is comparatively weaker than the Mesna and UA-Mesna combinations. Hence, it is suggested that the urosilic acid could prevent cyclophosphamide induced hemorrhagic cystitis, and also extends support to Mesna applications. Overall, it has been observed that ursolic acid has limited protective effects against CP-induced hemorrhagic cystitis, and can serve as a supportive agent in inhibiting hemorrhagic cystitis.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49007795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A topical formulation of Anacardium occidentale L. leaves extract enhances wound healing via mediating TNF-α and TGF- β 西洋Anacardium occidentale L.叶提取物的局部制剂通过介导TNF-α和TGF-β促进伤口愈合
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-06-01 DOI: 10.56042/ijeb.v61i06.1926
M. Nehete, Suparna S. De, M. Degani, P. Tatke
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引用次数: 0
Autophagy in antitumor activity of aloin for breast cancer cells compared with doxorubicin 自噬作用下芦荟素与阿霉素对乳腺癌细胞抗肿瘤活性的比较
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-03-31 DOI: 10.56042/ijeb.v61i04.179
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引用次数: 0
Anti-inflammatory effects of Gracilaria vermiculophylla Papenfuss extracts on Porphyromonas gingivalis stimulated RAW 264.7 cells 钩藤提取物对牙龈卟啉单胞菌刺激的RAW 264.7细胞的抗炎作用
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-03-31 DOI: 10.56042/ijeb.v61i04.192
{"title":"Anti-inflammatory effects of Gracilaria vermiculophylla Papenfuss extracts on Porphyromonas gingivalis stimulated RAW 264.7 cells","authors":"","doi":"10.56042/ijeb.v61i04.192","DOIUrl":"https://doi.org/10.56042/ijeb.v61i04.192","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47410072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of smoking and alcohol intake in semen profile among infertile men 吸烟和饮酒对不育男性精液特征的影响
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-03-31 DOI: 10.56042/ijeb.v61i04.169
{"title":"Impact of smoking and alcohol intake in semen profile among infertile men","authors":"","doi":"10.56042/ijeb.v61i04.169","DOIUrl":"https://doi.org/10.56042/ijeb.v61i04.169","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42071785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probiotic treatment with Kefir reduces vascular oxidative stress while suppressing COX2 mediated relaxation in intestinal arteries of an animal model of menopause Kefir益生菌治疗可降低血管氧化应激，同时抑制COX2介导的更年期动物模型肠动脉舒张
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-03-31 DOI: 10.56042/ijeb.v61i04.176
{"title":"Probiotic treatment with Kefir reduces vascular oxidative stress while suppressing COX2 mediated relaxation in intestinal arteries of an animal model of menopause","authors":"","doi":"10.56042/ijeb.v61i04.176","DOIUrl":"https://doi.org/10.56042/ijeb.v61i04.176","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41768806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Trichoderma asperellum against different pathogens of medicinal plants 木霉对药用植物不同病原菌的药效研究
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-03-31 DOI: 10.56042/ijeb.v61i04.172
{"title":"Efficacy of Trichoderma asperellum against different pathogens of medicinal plants","authors":"","doi":"10.56042/ijeb.v61i04.172","DOIUrl":"https://doi.org/10.56042/ijeb.v61i04.172","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41356115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Disease Activity Score (DAS 28) with subsets of Rheumatoid Factor and Anti-cyclic Citrullinated Peptidesamong -Rheumatoid Arthritis patients in North India 疾病活动评分（DAS 28）与类风湿因子和抗环瓜氨酸肽亚群的相关性——印度北部类风湿性关节炎患者
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-03-31 DOI: 10.56042/ijeb.v61i04.175
{"title":"Association of Disease Activity Score (DAS 28) with subsets of Rheumatoid Factor and Anti-cyclic Citrullinated Peptidesamong -Rheumatoid Arthritis patients in North India","authors":"","doi":"10.56042/ijeb.v61i04.175","DOIUrl":"https://doi.org/10.56042/ijeb.v61i04.175","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46873920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effects of grape seed proanthocyanidins on podocytes against injury induced by glucolipotoxicity 葡萄籽原花青素对足细胞抗糖脂毒性损伤的保护作用
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-03-31 DOI: 10.56042/ijeb.v61i04.177
{"title":"Protective effects of grape seed proanthocyanidins on podocytes against injury induced by glucolipotoxicity","authors":"","doi":"10.56042/ijeb.v61i04.177","DOIUrl":"https://doi.org/10.56042/ijeb.v61i04.177","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46362218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Graphene monolayer as an appropriate substrate for mesenchymal stem cells support in regenerative medicine 石墨烯单层作为再生医学中间充质干细胞支持的合适基质
IF 0.6 4区 生物学
Indian journal of experimental biology Pub Date : 2023-03-31 DOI: 10.56042/ijeb.v61i04.174
{"title":"Graphene monolayer as an appropriate substrate for mesenchymal stem cells support in regenerative medicine","authors":"","doi":"10.56042/ijeb.v61i04.174","DOIUrl":"https://doi.org/10.56042/ijeb.v61i04.174","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42672529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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