Immunity, Inflammation and Disease最新文献

{"title":"Correction to “NR5A2 Promotes Malignancy Progression and Mediates the Effect of Cisplatin in Cutaneous Squamous Cell Carcinoma”","authors":"","doi":"10.1002/iid3.70125","DOIUrl":"10.1002/iid3.70125","url":null,"abstract":"<p>W. Ye, C. Ya-Xuan, T. Shan-Shan, L. Qiu, M. Ting, C. Shao-Jie, and C. Yu, “NR5A2 Promotes Malignancy Progression and Mediates the Effect of Cisplatin in Cutaneous Squamous Cell Carcinoma,” <i>Immunity, Inflammation and Disease</i> 12, no. 2 (2024): e1172, https://doi.org/10.1002/iid3.1172.</p><p>In the original version of this paper, the images in the wound healing experiment for two cell lines were inadvertently duplicated in Figure 4D. The authors have since reviewed the original scans and repeated the experiment. The figures have been corrected accordingly, and this revision does not impact the conclusions of the article in any way. The corrected Figure 4 is shown below. We apologize for this error.</p>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NRF2 Antioxidant Response and Interferon-Stimulated Genes Are Differentially Expressed in SARS-CoV-2-Positive Young Subjects","authors":"Toscanelli Walter,&nbsp;Fracella Matteo,&nbsp;De Angelis Marta,&nbsp;Scagnolari Carolina,&nbsp;Sorrentino Leonardo,&nbsp;Piselli Elena,&nbsp;Marcocci Maria Elena,&nbsp;Midulla Fabio,&nbsp;Mancino Enrica,&nbsp;Nenna Raffaella,&nbsp;Petrarca Laura,&nbsp;Palamara Anna Teresa,&nbsp;Antonelli Guido,&nbsp;Pierangeli Alessandra,&nbsp;Nencioni Lucia","doi":"10.1002/iid3.70109","DOIUrl":"10.1002/iid3.70109","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Several respiratory viruses, including Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), suppress nuclear factor-E2-related factor-2 (NRF2) antioxidant response, generating oxidative stress conditions to its advantage. NRF2 has also been reported to regulate the innate immune response through the inhibition of the interferon (IFN) pathway. However, its modulation in younger individuals and its correlation with the IFN response remain to be elucidated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The NRF2 and redox-related genes expression was examined in nasopharyngeal swabs from children attending the pediatric hospital for SARS-CoV-2 molecular testing. Expression levels were analyzed by stratifying the population according to the SARS-CoV-2 positivity, age, or the presence of symptoms. The results were correlated with Types I and III IFN genes and IFN-stimulated genes (ISGs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that NRF2 expression was markedly diminished in positive patients compared to negative. Moreover, it correlated with higher expression of IFNα2 and IFNλ3, as well as ISG15 and ISG56. Interestingly, symptomatic patients with anosmia/ageusia showed pronounced expression of apurinic/apyrimidinic endonuclease1/redox factor 1 (APE1), together with Type I IFNs, ISG56, and the inflammasome component NLRP3.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results indicate an interdependence between NRF2 antioxidant pathway and IFN-mediated response during SARS-CoV-2 infection in young subjects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Novel Inflammatory Markers and Serum 25-Hydroxyvitamin D Among US Adults","authors":"Hang Zhao,&nbsp;Yangyang Zhao,&nbsp;Yini Fang,&nbsp;Weibang Zhou,&nbsp;Wenjing Zhang,&nbsp;Jiecheng Peng","doi":"10.1002/iid3.70115","DOIUrl":"10.1002/iid3.70115","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vitamin D is the focus of extensive medical research globally. Recent studies have investigated the correlation between serum 25-hydroxyvitamin D (25(OH)D) and common inflammatory markers. However, few studies have incorporated novel inflammatory markers such as the platelet-to-lymphocyte ratio (PLR), platelet-to-high density lipoprotein cholesterol ratio (PHR), systemic inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response (SIRI), and neutrophil-to-high-density lipoprotein cholesterol ratio (NHR). This study investigated these correlations among adults in the USA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We ultimately included a total of 5308 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning 2007 to 2018. A multivariable linear regression model assessed the links between serum 25(OH)D and these novel inflammatory markers, with subgroup analyses for hypertension and diabetes. To further explore the relationship between the two, we applied smooth curve fittings and generalized additive models. Upon detecting nonlinear relationships, we used a recursive algorithm to pinpoint the inflection point.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In our multivariate linear regression model, serum 25(OH)D concentrations were negatively correlated with NHR (<i>β</i> = −0.003, 95% CI: −0.005 to −0.001), NLR (<i>β</i> = −0.002, 95% CI: −0.003 to 0.000), SII (<i>β</i> = −0.579, 95% CI: −0.954 to −0.205), PHR (<i>β</i> = −0.171, 95% CI: −0.249 to −0.093), and PLR (<i>β</i> = −0.096, 95% CI: −0.051 to −0.040) among adults in the USA. Nevertheless, no significant association was found with SIRI (<i>β</i> = −0.001, 95% CI: −0.002 to 0.000). Subgroup analysis by hypertension and diabetes showed that in the hypertensive group, serum 25(OH)D was significantly and negatively associated with NHR, NLR, SII, SIRI, PHR, and PLR. However, no correlation was found in the diabetic group between serum 25(OH)D levels and these inflammatory markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our research confirms that serum 25(OH)D levels are negatively correlated with several novel inflammatory markers among adults in the USA, suggesting potential directions for further research into vitamin D's role in inflammation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrahepatic CD161hiCD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection","authors":"Jianfei Li,&nbsp;Qian Liu,&nbsp;Wanlu Duan,&nbsp;Zhi Duan,&nbsp;Futing Liu,&nbsp;Mengqi Ruan,&nbsp;Qiyin Zong,&nbsp;Hao Zhang,&nbsp;Qiang Zhou,&nbsp;Qin Wang","doi":"10.1002/iid3.70118","DOIUrl":"10.1002/iid3.70118","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Backgrounds and Aims</h3>\u0000 \u0000 <p>CD8+T cells are crucially associated with the fight against hepatitis B virus (HBV) infection. CD161 has been shown to express remarkably on HCV-specific CD8+T cells. However, the accurate function of CD161+CD8+T cells in HBV immunity or pathogenesis remains undetermined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Blood samples were collected from 25 chronic hepatitis B (CHB) patients. Peripheral blood levels of CD161+CD8+T cells and their correlation with serum ALT levels were analyzed in CHB patients. To analyze the in vivo CD161+CD8+T cell's number, function, and intrahepatic recruitment characteristics, HBV replication mouse models were established. The expression of CD161 on HBV-specific CD8+T cells was also detected by analyzing CD161+CD8+T cell functions during infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with CHB infection had a markedly lower peripheral blood frequency of CD161+CD8+T cells than did healthy controls and negatively correlated with serum ALT level. Furthermore, compared to the control mice, the frequency of CD161+CD8+T cells was significantly decreased in the blood of acute and chronic HBV-replicating mice. Moreover, CHB-replicating mice had significantly increased hepatic levels of CD161+CD8+T cells, which was not observed in the acute group of mice. Additionally, the CD161+CD8+T cells were categorized into CD161^hi and CD161^intCD8+T cells and it was revealed that in the liver of CHB-replicating mice the primary recruited cells were CD161^hiCD8+T. Intrahepatic CD161^hiCD8+T cells demonstrated increased CXCR6 expression, enhanced production of cytokine IL-17 and TNF-ɑ, and reduced IFN-γ secretion. Accordingly, the CXCL16 mRNA expression in the liver tissue of CHB-replication mice was markedly higher than in acute HBV-replicating and control mice. The study also revealed that HBV-specific CD8+T cells were mainly CD161-CD8+T cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>During HBV infection, the intrahepatic recruitment of CD161+CD8+T cells was mainly CD161^hiCD8+T cell subpopulation, which has a weak antiviral response, but increased pro-inflammatory effect, suggesting that CD161 may serve as a potential marker of liver-damaging T cells.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A-Mediated NLRP3 Inflammasome","authors":"Wu Jingrui,&nbsp;Yang Haihui,&nbsp;Yan Jinjin,&nbsp;Fang Le","doi":"10.1002/iid3.70121","DOIUrl":"10.1002/iid3.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Recent studies show that N6-methyladenosine (m6A) plays an important role in the pathogenesis of the Alzheimer's disease (AD), while the mechanisms involved were studied insufficiently.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The present study aimed to explore the effect of human insulin-like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2), one of the m6A-binding proteins on the progression of AD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials &amp; Methods</h3>\u0000 \u0000 <p>The mRNA and protein expression level were determined using RT-qPCR and western blot, respectively. MTT assay was carried out to evaluate cell viability. The content of ROS, antioxidant enzymes, IL-1β and pyroptosis, as well as m6A contents were determined using relative commercial kit. The AD models were built using Aβ1-42 -stimulated hippocampal neuron in vitro and AD mice in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our results showed that IGF2BP2 was significantly upregulated in the Aβ1-42 -stimulated hippocampal neuron. IGF2BP2 inhibition reversed the decreased cell viability and the increased cell apoptosis induced by Aβ1-42. IGF2BP2 siRNA transfection alleviated Aβ1-42 induced pyroptosis and pyroptosis-related proteins upregulation. we also found that IGF2BP2 inhibition downregulated the expression of NLRP3 through m6A methylation. Furthermore, overexpression of NLRP3 partly reversed the effect of IGF2BP2 inhibition on Aβ1-42 -induced hippocampal neuron injury. In addition, IGF2BP2 improved cognitive function and alleviated Aβ1-42 neuronal injury in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Knockdown of IGF2BP2 inhibit neuronal damage and pyroptosis in the hippocampus cells, and improve cognitive function in AD partly through m6A-mediated NLRP3 inflammasome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats","authors":"Tongxia Zhang,&nbsp;Tao Zhang,&nbsp;Han Yu,&nbsp;Lingyi Chi","doi":"10.1002/iid3.70110","DOIUrl":"10.1002/iid3.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Traumatic spinal cord injury (SCI) is an incurable condition that is the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>STVNa was given intraperitoneally after SCI to see if it had any neuroprotective benefits. On Days 7, 14, 21, and 28 post-SCI, functional recovery was measured using the Basso, Beattie, and Bresnahan (BBB) scoring system along with the oblique plate test. Following these evaluations, spinal cord tissues were harvested for analysis. All behavioral testing occurred between 8 a.m. and 3 p.m.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that STVNa improved spinal cord functional recovery in rats, as evidenced by enhanced BBB locomotor rating scale, angle of inclination, decreased cavity of spinal cord damage, and neuron death in vivo. In addition, STVNa reduced inflammation in rats following SCI, as demonstrated by a reduction in proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and interleukin (IL)-1β. STVNa also reduced oxidative damage in SCI rats by lowering ROS while raising SOD levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that STVNa protects SCI rats through a variety of pathways. STVNa, in particular, may benefit the recovery of SCI by reducing oxidative stress and inflammation, leading to enhanced locomotor activity in rats with SCI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Predictive Significance of Platelet-to-Lymphocyte Ratio for Miscarriage: A Systematic Review and Meta-Analysis","authors":"Xiaoyi Wang,&nbsp;Yanfang Zhao,&nbsp;Yangyang Fan,&nbsp;Yun Liu","doi":"10.1002/iid3.70119","DOIUrl":"10.1002/iid3.70119","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Miscarriage is a common complication of pregnancy, and its underlying pathophysiologic mechanisms remains unclear. The platelet-to-lymphocyte ratio (PLR), a prothrombotic and inflammatory marker, has been controversially discussed as a potential predictor of miscarriage. This systematic review and meta-analysis aimed to assess the predictive significance of the PLR in women with miscarriage compared to healthy pregnancies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Relevant studies were systematically searched in PubMed, Embase, Web of Sciencey, and Cochrane Library up to December 31, 2023. A systematic review and meta-analysis following PRISMA guidelines was conducted. Articles were identified, screened, and evaluated for quality to determine the predictive value of PLR for miscarriage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fourteen eligible articles, comprising a total of 3745 patients, were included in the meta-analysis. The pooled analysis found comparable PLR levels between miscarriage and non-miscarriage groups (SMD = 0.25; 95% Confidence Interval (CI): −0.05 to 0.54). Subgroup analysis revealed significant differences in PLR levels in the missed miscarriage group (SMD = 0.29; 95% CI: 0.01–0.56). and in studies with sample sizes smaller than 200 (SMD = 0.31; 95% CI: 0.05–0.56). Other subgroups did not exhibit significant differences. Subgroup analysis of PLR levels and miscarriage risk demonstrated no significant differences across all subgroups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PLR is not a reliable predictor of miscarriage in general. However, for missed miscarriage cases, elevated PLR levels may serve as a practical and cost-effective marker for prediction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis","authors":"Ada Corrado,&nbsp;Ilaria Guadagni,&nbsp;Giovanna Picarelli,&nbsp;Angela Variola","doi":"10.1002/iid3.70080","DOIUrl":"10.1002/iid3.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Immune-mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and persistent inflammation. Rheumatoid arthritis (RA), spondyloarthritis (SpA), and ulcerative colitis (UC) exemplify prominent IMIDs, each presenting unique challenges for their management, that impact patient's quality of life (QoL). Obesity, marked by persistent low-grade inflammation, influences the progression, response to treatment, and clinical management of patients with RA, SpA, and UC. Besides, the emerging role of sarcopenic obesity, a special subtype of obesity with malnutrition, should be considered in the definition of the appropriated therapeutic interventions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This narrative literature review summarizes recent evidence on the interplay between obesity-induced inflammation and IMIDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Obesity contributes to elevated levels of proinflammatory cytokines, influencing the inflammatory pathways common to IMIDs. White adipose tissue, acting as an endocrine organ, produces cytokines like TNF-α and IL-6, fueling chronic inflammation. The dysregulation of adipokines, such as leptin and adiponectin, further complicates this interplay, impacting immune responses and metabolic processes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Understanding the cross-talk between inflammatory pathways in obesity and IMIDs can provide insight into potential targets for intervention. This includes lifestyle modifications aimed to regulate weight gain, paving the way for comprehensive strategies to manage IMIDs in the context of obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Adipose Tissue IL-18 Production Is Independent of Caspase-1 and Caspase-11”","authors":"","doi":"10.1002/iid3.70095","DOIUrl":"10.1002/iid3.70095","url":null,"abstract":"<p>L. Román-Domínguez, J. Salazar-León, K. F. Meza-Sosa, L. Pérez-Martínez, and G. Pedraza-Alva, “Adipose Tissue IL-18 Production Is Independent of Caspase-1 and Caspase-11,” <i>Immunity, Inflammation and Disease</i> 12, no. 4 (2024): e1241, https://doi.org/10.1002/iid3.1241.</p><p>In the “2.3 Glucose and insulin tolerance tests” section of the article, Tai's formula is incorrect. Please find the corrected formula below:</p><p>The authors provided the original raw data, which confirmed that despite the erroneously presented formula, the authors calculations were performed correctly, therefore the experimental results and corresponding conclusions mentioned in the paper remain unaffected.</p><p>We apologize for this mistake.</p>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"12 12","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and Allelic Frequencies of ABO and Rh(D) Blood Antigens in Ghana: A Systematic Review","authors":"Charles Nkansah,&nbsp;Felix Osei-Boakye,&nbsp;Samuel K. Appiah,&nbsp;Gabriel Abbam,&nbsp;Moses Banyeh,&nbsp;Samira Daud,&nbsp;Richard V. Duneeh,&nbsp;Simon B. Bani,&nbsp;Boniface N. Ukwah,&nbsp;Charles A. Derigubah,&nbsp;Victor U. Usanga,&nbsp;Emmanuel Appiah-Kubi,&nbsp;Ejike F. Chukwurah","doi":"10.1002/iid3.70112","DOIUrl":"10.1002/iid3.70112","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>ABO and Rh blood group systems are the most significant blood group systems recognized by the International Society of Blood Transfusion and are widely used for clinical and anthropological purposes. This systematic review determined the distribution and allelic frequency of ABO and Rh(D) antigens in Ghana.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Literature searches were performed in PubMed, Google Scholar, Web of Science, and ScienceDirect, up to February 20, 2024, and included studies published from 2000 to 2024 in all regions of Ghana. The search terms used to retrieve the preferred literature were “Blood Group/Antigen” and “ABO and Rh(D)” and “Distribution/Frequency/Prevalence,” coupled with the names of the different regions/districts/municipalities in Ghana. Similar blood group individuals from all the regions were added, and countrywide data were gathered. The Hardy−Weinberg model was used to estimate the allelic frequency of blood antigens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Blood group O (54.72%) was the predominant group in the Ghanaian population, followed by B (21.74%), A (19.65%), and AB (3.89%). Rh(D) antigen was present in 92.28% of the population, and only 7.72% were Rh(D) negative. The calculated allelic frequencies of A, B, O, Rh(D) positive, and Rh(D) negative were 0.1227, 0.1376, 0.7397, 0.7222, and 0.2778 for I^A(p), I^B(q), i(r), I^D(v), and I^d(u), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The phenotypic frequency of the ABO blood group occurred in the pattern O&gt;B&gt;A&gt;AB, and the prevalence of the Rh(D) negative blood group was 7.72% in Ghana. Future nationwide studies are recommended to assess the distribution of ABO, Rh, and other blood group systems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"12 12","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}