{"title":"miR-144 在炎症性疾病中的作用:综述","authors":"Shukun Hong, Hongye Wang, Lujun Qiao","doi":"10.1002/iid3.70172","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Inflammation, often caused by various stimuli, is a common response to tissue homeostasis disruptions and is considered a key driver of many pathological conditions. MicroRNA-144 (miR-144) has emerged as a critical regulator in inflammatory diseases, with its dysregulation implicated in various pathological conditions. Understanding its role and mechanisms is essential for developing therapeutic strategies.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>This article aimed to evaluate the role of miR-144 in inflammatory diseases through a literature review.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Electronic databases including PubMed, Web of Science, Springer Link, China Knowledge Resource Integrated Database, and Wanfang Data were searched for relevant literature. The following keywords were used and combined differently according to the rules of the databases: “miR-144,” “inflammation,” “inflammatory,” and “immune response.” Studies investigating miR-144 in the context of inflammation were included. Data were extracted to assess miR-144's expression patterns and its association with disease severity and outcomes.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>miR-144 was found to be differentially expressed in a range of inflammatory diseases, including sepsis, infectious diseases, respiratory diseases, cardiovascular diseases, digestive diseases, neuropsychiatric diseases, arthritis, and pregnancy complications. The expression patterns varied depending on the disease, with both upregulation and downregulation observed. miR-144 was implicated in the modulation of inflammatory responses through direct and indirect targeting of key proteins and pathways. The review also highlighted the potential of miR-144 as a diagnostic and prognostic biomarker.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>miR-144 plays a significant role in the pathogenesis of inflammatory diseases and holds promise as a biomarker. Its expression patterns and regulatory mechanisms offer insights into disease processes and may guide future therapeutic strategies. However, further clinical studies are needed to validate miR-144's utility as a biomarker and to explore its therapeutic potential in a clinical setting.</p>\n </section>\n </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":"13 3","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iid3.70172","citationCount":"0","resultStr":"{\"title\":\"The Role of miR-144 in Inflammatory Diseases: A Review\",\"authors\":\"Shukun Hong, Hongye Wang, Lujun Qiao\",\"doi\":\"10.1002/iid3.70172\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Inflammation, often caused by various stimuli, is a common response to tissue homeostasis disruptions and is considered a key driver of many pathological conditions. MicroRNA-144 (miR-144) has emerged as a critical regulator in inflammatory diseases, with its dysregulation implicated in various pathological conditions. Understanding its role and mechanisms is essential for developing therapeutic strategies.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This article aimed to evaluate the role of miR-144 in inflammatory diseases through a literature review.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Electronic databases including PubMed, Web of Science, Springer Link, China Knowledge Resource Integrated Database, and Wanfang Data were searched for relevant literature. The following keywords were used and combined differently according to the rules of the databases: “miR-144,” “inflammation,” “inflammatory,” and “immune response.” Studies investigating miR-144 in the context of inflammation were included. Data were extracted to assess miR-144's expression patterns and its association with disease severity and outcomes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>miR-144 was found to be differentially expressed in a range of inflammatory diseases, including sepsis, infectious diseases, respiratory diseases, cardiovascular diseases, digestive diseases, neuropsychiatric diseases, arthritis, and pregnancy complications. The expression patterns varied depending on the disease, with both upregulation and downregulation observed. miR-144 was implicated in the modulation of inflammatory responses through direct and indirect targeting of key proteins and pathways. The review also highlighted the potential of miR-144 as a diagnostic and prognostic biomarker.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>miR-144 plays a significant role in the pathogenesis of inflammatory diseases and holds promise as a biomarker. Its expression patterns and regulatory mechanisms offer insights into disease processes and may guide future therapeutic strategies. 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引用次数: 0
摘要
炎症通常由各种刺激引起,是对组织稳态破坏的常见反应,被认为是许多病理条件的关键驱动因素。MicroRNA-144 (miR-144)已成为炎症疾病的关键调节因子,其失调与各种病理状况有关。了解其作用和机制对于制定治疗策略至关重要。目的通过文献综述,探讨miR-144在炎性疾病中的作用。方法检索PubMed、Web of Science、施普林格Link、中国知识资源综合数据库、万方数据等电子数据库的相关文献。根据数据库的规则不同地使用和组合以下关键词:“miR-144”,“炎症”,“炎症”和“免疫反应”。研究纳入了炎症背景下miR-144的研究。提取数据以评估miR-144的表达模式及其与疾病严重程度和结局的关联。结果miR-144在脓毒症、传染病、呼吸系统疾病、心血管疾病、消化系统疾病、神经精神疾病、关节炎和妊娠并发症等一系列炎症性疾病中均存在差异表达。表达模式因疾病而异,可观察到上调和下调。miR-144通过直接和间接靶向关键蛋白和通路参与炎症反应的调节。该综述还强调了miR-144作为诊断和预后生物标志物的潜力。结论miR-144在炎症性疾病的发病机制中发挥重要作用,有望成为一种生物标志物。它的表达模式和调控机制提供了对疾病过程的见解,并可能指导未来的治疗策略。然而,需要进一步的临床研究来验证miR-144作为生物标志物的效用,并探索其在临床环境中的治疗潜力。
The Role of miR-144 in Inflammatory Diseases: A Review
Background
Inflammation, often caused by various stimuli, is a common response to tissue homeostasis disruptions and is considered a key driver of many pathological conditions. MicroRNA-144 (miR-144) has emerged as a critical regulator in inflammatory diseases, with its dysregulation implicated in various pathological conditions. Understanding its role and mechanisms is essential for developing therapeutic strategies.
Objective
This article aimed to evaluate the role of miR-144 in inflammatory diseases through a literature review.
Methods
Electronic databases including PubMed, Web of Science, Springer Link, China Knowledge Resource Integrated Database, and Wanfang Data were searched for relevant literature. The following keywords were used and combined differently according to the rules of the databases: “miR-144,” “inflammation,” “inflammatory,” and “immune response.” Studies investigating miR-144 in the context of inflammation were included. Data were extracted to assess miR-144's expression patterns and its association with disease severity and outcomes.
Results
miR-144 was found to be differentially expressed in a range of inflammatory diseases, including sepsis, infectious diseases, respiratory diseases, cardiovascular diseases, digestive diseases, neuropsychiatric diseases, arthritis, and pregnancy complications. The expression patterns varied depending on the disease, with both upregulation and downregulation observed. miR-144 was implicated in the modulation of inflammatory responses through direct and indirect targeting of key proteins and pathways. The review also highlighted the potential of miR-144 as a diagnostic and prognostic biomarker.
Conclusion
miR-144 plays a significant role in the pathogenesis of inflammatory diseases and holds promise as a biomarker. Its expression patterns and regulatory mechanisms offer insights into disease processes and may guide future therapeutic strategies. However, further clinical studies are needed to validate miR-144's utility as a biomarker and to explore its therapeutic potential in a clinical setting.
期刊介绍:
Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including:
• cellular and molecular immunology
• clinical immunology
• allergy
• immunochemistry
• immunogenetics
• immune signalling
• immune development
• imaging
• mathematical modelling
• autoimmunity
• transplantation immunology
• cancer immunology