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Il Farmaco; edizione scientifica最新文献

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Influence of some ergot alkaloids on the cerebral reduced glutathione. 麦角生物碱对大脑还原性谷胱甘肽的影响。
Il Farmaco; edizione scientifica Pub Date : 1988-11-01
A Gorini, R Arnaboldi, L Vercesi, M Dossena
{"title":"Influence of some ergot alkaloids on the cerebral reduced glutathione.","authors":"A Gorini,&nbsp;R Arnaboldi,&nbsp;L Vercesi,&nbsp;M Dossena","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dose-related changes of the reduced glutathione were evaluated in forebrains from male Wistar rats aged 10 months after chronic i.p. treatment for two months with the ergot alkaloids dihydroergocristine and dihydroergocriptine. The results indicate that, within a specific dose-range, the concentration of the cerebral reduced glutathione may be modified by exogenous intervention.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 11","pages":"887-90"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14282348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N,N-disubstituted 4-amino-(6-methoxy)-3-phenyl-2H-naphtho [1,2-b]pyran-2-ones with antiarrhythmic, platelet antiaggregating and local anesthetic activities. 具有抗心律失常、抗血小板聚集和局部麻醉活性的N,N-二取代4-氨基-(6-甲氧基)-3-苯基- 2h -萘[1,2-b]吡喃-2- 1。
Il Farmaco; edizione scientifica Pub Date : 1988-11-01
A Bargagna, M Longobardi, E Mariani, P Schenone, S Russo, S Vilagliano, V De Novellis, E Marmo
{"title":"N,N-disubstituted 4-amino-(6-methoxy)-3-phenyl-2H-naphtho [1,2-b]pyran-2-ones with antiarrhythmic, platelet antiaggregating and local anesthetic activities.","authors":"A Bargagna,&nbsp;M Longobardi,&nbsp;E Mariani,&nbsp;P Schenone,&nbsp;S Russo,&nbsp;S Vilagliano,&nbsp;V De Novellis,&nbsp;E Marmo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The synthesis of title compounds (VI) by 1,4-cycloaddition of phenylchloroketene to N,N-disubstituted (E)-2-aminomethylene-3,4-dihydro-(6-methoxy)-1(2H)naphthalenones, followed by dehydrochlorination with DBN and dehydrogenation with Pd/C of the resulting cycloadducts, is described. Some compounds (VI) showed antiarrhythmic activity in rats higher or like that of quinidine and platelet antiaggregating activity in vitro like that of acetylsalycilic acid, as well as moderate infiltration anesthesia in mice and weak hypotensive, bradicardic and antiinflammatory activities in rats.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 11","pages":"857-77"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14379506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure]. [一些芳基硫甲基吡啶结构新化合物的合成及其抗溃疡活性]。
Il Farmaco; edizione scientifica Pub Date : 1988-11-01
S Evangelista, M Ghelardoni, A Meli, V Pestellini, G Viti
{"title":"[Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure].","authors":"S Evangelista,&nbsp;M Ghelardoni,&nbsp;A Meli,&nbsp;V Pestellini,&nbsp;G Viti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the results of the antiulcer activity of some arylthiomethylpyridine compounds. Some of these showed gastroprotective activity against 96% ethanol-induced gastric lesions greater than Omeprazole. However they possess antiulcer properties lower than the reference compound against Indomethacin-induced gastric ulcers.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 11","pages":"901-8"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14381853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1,2,3,4,-Tetrahydro-1,2-diazepine derivatives: synthesis and evaluation of antileukemic activity. 1,2,3,4，-四氢-1,2-二氮卓衍生物:抗白血病活性的合成和评价。
Il Farmaco; edizione scientifica Pub Date : 1988-11-01
V Dal Piaz, G Ciciani
{"title":"1,2,3,4,-Tetrahydro-1,2-diazepine derivatives: synthesis and evaluation of antileukemic activity.","authors":"V Dal Piaz,&nbsp;G Ciciani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A series of 3-aryl or etheroaryl-6-cyano-7-phenyl-1,2,3,4-tetrahydro-1,2-diazepin- 5-ones was synthesized and evaluated for its antitumor activity against P388 leukemic tumor system in mice. None of the tested compounds showed significant antitumor properties.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 11","pages":"943-9"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14381856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1,2,3,4,-Tetrahydro-1,2-diazepine derivatives: synthesis and evaluation of antileukemic activity. 1,2,3,4，-四氢-1,2-二氮卓衍生物:抗白血病活性的合成和评价。
Il Farmaco; edizione scientifica Pub Date : 1988-11-01 DOI: 10.1002/CHIN.198923209
V. Dal Piaz*, G. Ciciani
{"title":"1,2,3,4,-Tetrahydro-1,2-diazepine derivatives: synthesis and evaluation of antileukemic activity.","authors":"V. Dal Piaz*, G. Ciciani","doi":"10.1002/CHIN.198923209","DOIUrl":"https://doi.org/10.1002/CHIN.198923209","url":null,"abstract":"A series of 3-aryl or etheroaryl-6-cyano-7-phenyl-1,2,3,4-tetrahydro-1,2-diazepin- 5-ones was synthesized and evaluated for its antitumor activity against P388 leukemic tumor system in mice. None of the tested compounds showed significant antitumor properties.","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"6 1","pages":"943-9"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74623415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aminoethers of 1,3,3-trimethyl-5-(phenylmethylene)-2-oxabicyclo[2.2.2]octan-6-h ydroxy imine with antiarrhythmic activity. 具有抗心律失常活性的1,3,3-三甲基-5-(苯基亚甲基)-2-氧沙比环辛烷-6-h羟基亚胺的氨基醚。
Il Farmaco; edizione scientifica Pub Date : 1988-11-01 DOI: 10.1002/CHIN.198923179
E. Mariani, A. Bargagna, M. Longobardi, P. Schenone, S. Russo, W. Filippelli, L. Molinario, E. Marmo
{"title":"Aminoethers of 1,3,3-trimethyl-5-(phenylmethylene)-2-oxabicyclo[2.2.2]octan-6-h ydroxy imine with antiarrhythmic activity.","authors":"E. Mariani, A. Bargagna, M. Longobardi, P. Schenone, S. Russo, W. Filippelli, L. Molinario, E. Marmo","doi":"10.1002/CHIN.198923179","DOIUrl":"https://doi.org/10.1002/CHIN.198923179","url":null,"abstract":"The synthesis of beta-dialkylaminoethyl ethers (III a-f) and gamma-dialkylaminopropyl ethers (III g-l) starting from 1,3,3-trimethyl-5-(phenylmethylene)-2-oxabicyclo[2.2.2]octan-6- hydroxyimine (II) is described. beta-Diisopropylaminoethyl ether (III b) and gamma-piperidinopropyl ether (III i) showed an antiarrhythmic activity in rats similar to that of quinidine. Moreover, a number of ethers (III) showed weak hypotensive and bradycardic activity in rats and moderate infiltration anesthesia in mice.","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"28 1","pages":"879-86"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75490002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benzodiazepine receptor ligands. Synthesis and pharmacological evaluation of 6-aryl-3,8-disubstituted-1,2,4-triazolo[3,4-a]phthalazines. 苯二氮卓类受体配体。6-芳基-3,8-二取代-1,2,4-三唑[3,4-a]酞嗪的合成及药理评价。
Il Farmaco; edizione scientifica Pub Date : 1988-11-01
G Tarzia, E Occelli, D Barone
{"title":"Benzodiazepine receptor ligands. Synthesis and pharmacological evaluation of 6-aryl-3,8-disubstituted-1,2,4-triazolo[3,4-a]phthalazines.","authors":"G Tarzia,&nbsp;E Occelli,&nbsp;D Barone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A series of 6-aryl-3,8-disubstituted-1,2,4-triazolo[3,4-a]phthalazines was synthesised starting from suitable o-benzoylbenzoic acids. The compounds were tested in vitro for inhibition of the specific binding of 3H-Diazepam to benzodiazepine receptors in preparations of membranes from rat brain synaptosomes. None of the compounds was notably active in this test.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 11","pages":"921-33"},"PeriodicalIF":0.0,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13992699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine]. [9- r -八氢吲哚喹诺嗪的合成及药理活性]。
Il Farmaco; edizione scientifica Pub Date : 1988-10-01
C Boido-Canu, V Boido, F Sparatore, A Sparatore, V Susanna, S Russo, M L Cenicola, E Marmo
{"title":"[Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine].","authors":"C Boido-Canu,&nbsp;V Boido,&nbsp;F Sparatore,&nbsp;A Sparatore,&nbsp;V Susanna,&nbsp;S Russo,&nbsp;M L Cenicola,&nbsp;E Marmo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By acid induced cyclization of quinolizidin-1-one 4-R-phenylhydrazones several derivatives of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (1), bearing a substituent on position 9, were prepared. When R = Cl this reaction gave rise also to a red-orange compound to which the structure (V) of 1-(p-chloro)phenylazo-3,4,6,7,8,9-hexahydroquinolizine was assigned. Substances (1 b)-(1-f) were tested for spontaneous locomotor, muscle relaxant, analgesic, antiinflammatory, diuretic and cardiovascular activities and for influence on pentylentetrazole and sodium pentobarbital actions. Interesting levels of activity were exhibited in several cases.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 10","pages":"819-37"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14395187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Synthesis and antidepressive effects of diaryl-4,6-amino-3-pyridazine analogs of minaprine]. [米那普利二芳基-4,6-氨基-3-吡嗪类似物的合成及抗抑郁作用]。
Il Farmaco; edizione scientifica Pub Date : 1988-10-01
P Coudert, C Rubat, J M Couquelet, J Bastide
{"title":"[Synthesis and antidepressive effects of diaryl-4,6-amino-3-pyridazine analogs of minaprine].","authors":"P Coudert,&nbsp;C Rubat,&nbsp;J M Couquelet,&nbsp;J Bastide","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The reaction of 3-chloro pyridazines with various amines led to a series of minaprine analogues. Most of them exhibited significant antidepressant activity. The influence of the substituents attached to the pyridazine ring was discussed.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 10","pages":"793-800"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14370556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and photobiological activity of new N,N-disubstituted 4-amino-3-chloroangelicins. 新型N,N-二取代4-氨基-3-氯angelicins的合成及光生物活性研究。
Il Farmaco; edizione scientifica Pub Date : 1988-10-01
L Mosti, G Menozzi, P Schenone, F Carlassare, F Baccichetti, F Bordin
{"title":"Synthesis and photobiological activity of new N,N-disubstituted 4-amino-3-chloroangelicins.","authors":"L Mosti,&nbsp;G Menozzi,&nbsp;P Schenone,&nbsp;F Carlassare,&nbsp;F Baccichetti,&nbsp;F Bordin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The synthesis of a series of new N,N-disubstituted 4-amino-3-chloroangelicins (4-amino-3-chloro-2H-furo[2,3-h]-1-benzopyran-2-ones) starting from N,N-disubstituted (E)-5-aminomethylene-6,7-dihydrobenzo[b]furan-4(5H)-ones is described. Their capacity of inhibiting DNA synthesis in Ehrlich ascites tumor cells by U.V.-A light irradiation as well as their phototoxic activity on guinea-pig skin have been studied and the data computed by probit analysis; the results are discussed in the light of the modifications introduced in the molecular structure.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":"43 10","pages":"775-92"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14370555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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