1,2,3,4,-Tetrahydro-1,2-diazepine derivatives: synthesis and evaluation of antileukemic activity.

Abstract

A series of 3-aryl or etheroaryl-6-cyano-7-phenyl-1,2,3,4-tetrahydro-1,2-diazepin- 5-ones was synthesized and evaluated for its antitumor activity against P388 leukemic tumor system in mice. None of the tested compounds showed significant antitumor properties.