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Synthesis, structure and activity of a few open models related to classic H2-antagonists. 几种经典h2拮抗剂开放模型的合成、结构和活性。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
R Fruttero, G Sorba, A Gasco
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引用次数: 0
Synthesis, binding affinities for alpha-adrenoceptor and eudismic analysis of chiral benzodioxane derivatives and their chiral opened analogues. 手性苯并二氧杂环衍生物及其手性开放类似物的合成、与肾上腺素受体的结合亲和性及流行病学分析。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01 DOI: 10.1002/chin.198929333
V. Ferri, M. Pallavicini, D. Piccini, E. Valoti, L. Villa, N. Brunello, G. Racagni
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引用次数: 0
Thiazinoquinolones in benzothiazine research. 噻嗪喹诺酮类药物在苯并噻唑类药物中的研究。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
A Fravolini
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引用次数: 0
S-Aryl(tetramethyl)isothiouronium salts as possible antimicrobial agents--III. s-芳基(四甲基)异硫脲盐作为可能的抗菌剂——III。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
A Tait, M G Giovannini, M Di Bella, M Bondi, G P Quaglio
{"title":"S-Aryl(tetramethyl)isothiouronium salts as possible antimicrobial agents--III.","authors":"A Tait,&nbsp;M G Giovannini,&nbsp;M Di Bella,&nbsp;M Bondi,&nbsp;G P Quaglio","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A series of S-Aryl(tetramethyl)isothiouronium salts were prepared and evaluated in vitro for antimicrobial activity. Some compounds revealed interesting inhibiting action on Gram-positive bacteria which is noteworthy in view of the large number of strains antagonized and of the low MIC values. The possible influence of decomposition kinetics to the corresponding mercaptoderivatives was intestigated and compared with those of salts previously studied.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14279734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benzodioxanes and quinazolines: probes for characterizing alpha-adrenoreceptors. 苯并二氧嘧啶和喹唑啉:表征肾上腺素受体的探针。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
C Melchiorre, D Giardinà, U Gulini, M Pigini, W Quaglia
{"title":"Benzodioxanes and quinazolines: probes for characterizing alpha-adrenoreceptors.","authors":"C Melchiorre,&nbsp;D Giardinà,&nbsp;U Gulini,&nbsp;M Pigini,&nbsp;W Quaglia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14043854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, structure and activity of a few open models related to classic H2-antagonists. 几种经典h2拮抗剂开放模型的合成、结构和活性。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01 DOI: 10.1002/CHIN.198929332
R. Fruttero, G. Sorba, A. Gasco
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引用次数: 0
How medicinal chemistry triggers fundamental research in heterocyclic chemistry. The chemistry of 4-hydroxy-2-pyrones and a new imidazole antifungal agent. 药物化学如何引发杂环化学的基础研究。4-羟基-2-吡咯酮和一种新型咪唑类抗真菌剂的化学性质。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
M Moreno-Mañas
{"title":"How medicinal chemistry triggers fundamental research in heterocyclic chemistry. The chemistry of 4-hydroxy-2-pyrones and a new imidazole antifungal agent.","authors":"M Moreno-Mañas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results herein described point out that the efforts devoted to the preparation of significant molecules can not be separated from those devoted to the discovery of new synthetic methodologies and to the solution of fundamental chemical problems. The border between basic and applied research vanishes very frequently.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14374678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thiazinoquinolones in benzothiazine research. 噻嗪喹诺酮类药物在苯并噻唑类药物中的研究。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01 DOI: 10.1002/CHIN.198929327
A. Fravolini
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引用次数: 0
3d meeting on heterocyclic structures in pharmaceutic research. Palermo, May 15-18, 1988. Proceedings. 药物研究中的杂环结构三维会议。巴勒莫，1988年5月15日至18日。程序。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
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引用次数: 0
Synthesis and antimicrobial activity of some pyrrole derivatives. III--2-(4-arylpiperazino)-3-ethoxycarbonyl-5-aryl-pyrrole derivatives. 吡咯衍生物的合成及其抑菌活性研究。(III - 2) - 4-arylpiperazino 3-ethoxycarbonyl-5-aryl-pyrrole衍生品。
Il Farmaco; edizione scientifica Pub Date : 1988-12-01
M T Cocco, C Congiu, A Maccioni, M L Schivo, A De Logu, G Palmieri
{"title":"Synthesis and antimicrobial activity of some pyrrole derivatives. III--2-(4-arylpiperazino)-3-ethoxycarbonyl-5-aryl-pyrrole derivatives.","authors":"M T Cocco,&nbsp;C Congiu,&nbsp;A Maccioni,&nbsp;M L Schivo,&nbsp;A De Logu,&nbsp;G Palmieri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The synthesis of 3-ethoxycarbonyl-5-aryl-pyrrole derivatives with an arylpiperazine group in position 2 is described. The in vitro biological investigation showed that compound (XVIII) had considerable antibacterial activity against gram-positive microorganisms and antifungal activity against Candida rugosa, while the other compounds did not show any significative activity.</p>","PeriodicalId":13279,"journal":{"name":"Il Farmaco; edizione scientifica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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